Endocrine influences on the actions of morphine. III. Responses to hypothalamic hormones.

Abstract:

:As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysectomized rats. Somatostatin significantly antagonized morphine-induced antinociception in intact, but not in hypophysectomized, animals. TRH, on the other hand, had no effect on antinociceptive response to morphine in either intact or hypophysectomized animals. Neither hormone altered hyperthermic response to morphine but TRH antagonized the hypothermic response. Similarly, TRH antagonized the cataleptic actions of morphine whereas somatostatin had no effect. These results indicate that somatostatin and TRH can attenuate certain actions of morphine in vivo and suggest that specific opiate actions may be modulated by specific hypothalamic hormones.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Kasson BG,George R

doi

10.1159/000123586

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

416-20

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

37

pub_type

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