Evidence for a common neural mechanism mediating growth hormone-releasing factor-induced and somatostatin-induced feeding.

Abstract:

:We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding effects, together with indirect evidence suggesting that these peptides interact functionally within the hypothalamus, suggests that GRF and SS may induce feeding via a common neural mechanism. The present studies sought to investigate this possibility. In the first experiment combined intracerebroventricular (icv) injections of optimal doses of GRF and SS were found to be less potent than icv injections of GRF or SS alone, suggesting that the mechanisms mediating GRF-induced and SS-induced feeding are not totally independent. In further studies, icv injections of antiserum raised against SS blocked GRF-induced feeding. In contrast, icv injections of antiserum raised against GRF were ineffective in blocking SS-induced feeding. These results suggest that SS may act downstream to GRF in a putative neural feeding mechanism which utilizes both peptides. The possible anatomical basis for such a feeding mechanism involving GRF and SS is discussed.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Feifel D,Vaccarino FJ,Rivier J,Vale WW

doi

10.1159/000126372

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

299-305

issue

2

eissn

0028-3835

issn

1423-0194

journal_volume

57

pub_type

杂志文章
  • Pituitary Stalk Enlargement in Adults.

    abstract::Pathologies involving the pituitary stalk (PS) are generally revealed by the presence of diabetes insipidus. The availability of MRI provides a major diagnostic contribution by enabling the visualization of the site of the culprit lesion, especially when it is small. However, when only an enlarged PS is found, the eti...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000506641

    authors: Hána V,Salenave S,Chanson P

    更新日期:2020-01-01 00:00:00

  • Chromogranin A in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms: a large series from a single institution.

    abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000369818

    authors: Massironi S,Rossi RE,Casazza G,Conte D,Ciafardini C,Galeazzi M,Peracchi M

    更新日期:2014-01-01 00:00:00

  • Photoperiodic effects in the Djungarian hamster. Rate of testicular regression and extension of pineal melatonin pattern depend on the way of change from long to short photoperiods.

    abstract::In the Djungarian hamster, short photoperiods induce regression of testes and accessory glands. There is evidence that the length of time melatonin levels are elevated is the signal conveying the photoperiodic effects to the neuroendocrine axis. When the temporal course of decompression of the pattern of pineal melato...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124562

    authors: Hoffmann K,Illnerová H

    更新日期:1986-01-01 00:00:00

  • In vivo activity of the LHRH pulse generator as determined with push-pull perfusion of the anterior pituitary gland of unrestrained intact and castrate male rats.

    abstract::In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-p...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124748

    authors: Dluzen DE,Ramirez VD

    更新日期:1987-04-01 00:00:00

  • Differential suppression of follicle-stimulating hormone and luteinizing hormone secretion in vivo by a gonadotropin-releasing hormone antagonist.

    abstract::Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124081

    authors: Grady RR,Shin L,Charlesworth MC,Cohen-Becker IR,Smith M,Rivier C,Rivier J,Vale W,Schwartz NB

    更新日期:1985-03-01 00:00:00

  • Comparison of luteinizing hormone and prolactin levels in cycling and anestrous ewes.

    abstract::Concentrations of luteinizing hormone (LH) and prolactin (Prl) in the serum of anestrous and cycling ewes were compared. The concentration of LH in serum and the frequency of episodic releases of LH were lower in anestrous than in cycling ewes. Concentrations of LH in serum rose as rapidly after ovariectomy of anestro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122870

    authors: Jackson GL,Davis SL

    更新日期:1979-01-01 00:00:00

  • Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro.

    abstract::The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126466

    authors: Auernhammer CJ,Renner U,Müller OA,Stalla J,Stalla GK

    更新日期:1993-06-01 00:00:00

  • Thyroid hormone level positively regulates NOS and cGMP in the developing rat cerebellum.

    abstract::Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000203644

    authors: Serfozo Z,de Vente J,Elekes K

    更新日期:2009-01-01 00:00:00

  • Effects of adrenalectomy and glucocorticoids on rat brain dopamine receptors.

    abstract::The effects of adrenalectomy (ADX) and dexamethasone (DEX) treatment on brain dopamine (DA) receptors of ovariectomized (OVX) rats were investigated by autoradiography using binding of the D1 and D2 antagonists ligands [3H]SCH 23390 and [3H]spiperone, respectively. Fourteen days after ADX, D1 receptors decreased in th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126158

    authors: Biron D,Dauphin C,Di Paolo T

    更新日期:1992-04-01 00:00:00

  • Effects of melatonin on thyroid physiology of female hamsters.

    abstract::The effects of melatonin administration on thyroid physiology of female hamsters was investigated. A protocol of 25 micrograms given daily as subcutaneous injections late in the light period was found to inhibit blood levels of thyroxin (T4), triiodothyronine (T3) and thyrotropin (TSH). The free T4 index (FT4I) and th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123359

    authors: Vriend J,Richardson BA,Vaughan MK,Johnson LY,Reiter RJ

    更新日期:1982-01-01 00:00:00

  • In vivo and in vitro effects of arginine-vasopressin receptor antagonists on the hypothalamic-pituitary-adrenal axis in the rat.

    abstract::Arginine-vasopressin (AVP) is regarded as a potent stimulator of pituitary adrenocorticotropin (ACTH) secretion and participates therefore in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis function in concert with the physiological activator of the axis, hypothalamic corticotropin-releasing hormone (C...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126787

    authors: Bernardini R,Chiarenza A,Kamilaris TC,Renaud N,Lempereur L,Demitrack M,Gold PW,Chrousos GP

    更新日期:1994-11-01 00:00:00

  • Grade Increases in Gastroenteropancreatic Neuroendocrine Tumor Metastases Compared to the Primary Tumor.

    abstract:BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000439434

    authors: Grillo F,Albertelli M,Brisigotti MP,Borra T,Boschetti M,Fiocca R,Ferone D,Mastracci L

    更新日期:2016-01-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • Androgen regulation of immunological and biological activities of pituitary follicle-stimulating hormone isoforms in male rats.

    abstract::Follicle-stimulating hormone (FSH) is involved in the regulation and maintenance of gametogenesis. It exists in multiple molecular forms with different oligosaccharide structures which in turn are influenced by the hormonal milieu. Previous studies from our laboratory demonstrated that antiandrogen administration to i...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054484

    authors: Rulli SB,Creus S,Pellizzari E,Cigorraga SB,Calandra RS,Campo S

    更新日期:1999-10-01 00:00:00

  • Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus.

    abstract::Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000499693

    authors: Anesten F,Mishra D,Dalmau Gasull A,Engström-Ruud L,Bellman J,Palsdottir V,Zhang F,Trapp S,Skibicka KP,Poutanen M,Jansson JO

    更新日期:2019-01-01 00:00:00

  • Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats.

    abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122865

    authors: Davis PG,Barfield RJ

    更新日期:1979-01-01 00:00:00

  • Demonstration of contacts between neurons staining for LHRH in the preoptic area of the rat brain.

    abstract::It has been recently demonstrated that luteinizing hormone-releasing hormone (LHRH) can inhibit LHRH release by the hypothalamus, suggesting an ultrashort feedback of LHRH on LHRH neurons. In order to test this hypothesis, immunocytochemical localization of LHRH was conducted in the preoptic area of the rat brain. Con...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124861

    authors: Pelletier G

    更新日期:1987-11-01 00:00:00

  • Corticotropin-releasing factor: evidence for a neurotransmitter role in the locus ceruleus during hemodynamic stress.

    abstract::Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125081

    authors: Valentino RJ,Wehby RG

    更新日期:1988-12-01 00:00:00

  • Muscarinic receptors in the preoptic area are sensitive to 17 beta-estradiol during the critical period.

    abstract::The relationship between the steroid hormone 17 beta-estradiol and the muscarinic cholinergic receptors present in the preoptic area (POA), median hypothalamus and posterior hypothalamus of female rats was examined in vitro at various stages of the estrous cycle. Muscarinic receptors varied in a cyclic manner, specifi...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124103

    authors: Egozi Y,Kloog Y

    更新日期:1985-05-01 00:00:00

  • Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

    abstract::The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000080795

    authors: D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

    更新日期:2004-01-01 00:00:00

  • Distribution and release of immunoreactive thyroid-stimulating hormone in the rat hypothalamus: effects of thyroidectomy, hypophysectomy and treatment with thyroid hormones.

    abstract::Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124149

    authors: De Vito WJ,Connors JM,Hedge GA

    更新日期:1985-07-01 00:00:00

  • Effect of adrenalectomy and demedullation on the stress-induced impairment of long-term potentiation.

    abstract::In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further r...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125318

    authors: Shors TJ,Levine S,Thompson RF

    更新日期:1990-01-01 00:00:00

  • Cerebrospinal fluid levels of acetylcholinesterase, monoamines and oxytocin during labour, parturition, vaginocervical stimulation, lamb separation and suckling in sheep.

    abstract::Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124638

    authors: Kendrick KM,Keverne EB,Baldwin BA,Sharman DF

    更新日期:1986-01-01 00:00:00

  • Effect of interleukin-1 on ACTH and corticosterone secretion in dexamethasone and adrenalectomized pretreated male rats.

    abstract::The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125294

    authors: Weidenfeld J,Abramsky O,Ovadia H

    更新日期:1989-12-01 00:00:00

  • Inhibitory effect of amylin on growth hormone responsiveness to growth-hormone-releasing hormone in the rat.

    abstract::The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127019

    authors: Netti C,Sibilia V,Pagani F,Lattuada N,Coluzzi M,Pecile A,Guidobono F

    更新日期:1995-09-01 00:00:00

  • Infusion of prepro-VIP derived peptides in man: effect on secretion of prolactin.

    abstract::Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,0...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125071

    authors: Yiangou Y,Gill JS,Chrysanthou BJ,Burrin J,Bloom SR

    更新日期:1988-12-01 00:00:00

  • Postnatal morphological changes in rat LHRH neurons correlated with sexual maturation.

    abstract::The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124516

    authors: Wray S,Hoffman G

    更新日期:1986-01-01 00:00:00

  • Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro.

    abstract:BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000341810

    authors: Somnay Y,Chen H,Kunnimalaiyaan M

    更新日期:2013-01-01 00:00:00

  • Non-N-methyl-D-aspartate glutamate receptors in glial cells and neurons of the pineal gland in a higher primate.

    abstract::A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126847

    authors: Mick G

    更新日期:1995-03-01 00:00:00

  • Release of pro-opiomelanocortin-derived peptides from the pars intermedia and pars distalis of the rat pituitary: effect of corticotrophin-releasing factor and somatostatin.

    abstract::The parenchymal cells of the pars intermedia (PI) and corticotrophs of the pars distalis (PD) synthesize pro-opiomelanocortin (POMC), which, through posttranslational processing, gives rise to a group of structurally related peptides, including MSHs, ACTH, CLIP, LPHs and endorphins. We investigated the control of rele...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124203

    authors: Kraicer J,Gajewski TC,Moor BC

    更新日期:1985-11-01 00:00:00