Abstract：
:Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfield CA1 is well documented. However, it is not known whether corticosteroids produce different effects across the various hippocampal subfields. Therefore, we used intracellular recording techniques to examine the actions of chronic corticosteroid treatment (2 weeks) on the electrophysiological properties of rat hippocampal subfield CA3 pyramidal cells. The treatment groups used in this investigation were: adrenalectomy (ADX), selective mineralocorticoid receptor activation with aldosterone (ALD), mineralocorticoid and glucocorticoid receptor activation with high levels of corticosterone (HCT), and SHAM. Corticosteroid treatment altered the percentage of nonburst and burst firing neurons. The percentages of nonbursting cells were 74 and 62% in tissue from ADX and HCT animals compared to 42 and 41% in ALD and SHAM animals, respectively. The corticosteroid-induced effect on the ratio of nonbursting to bursting cells does not appear to be secondary to changes in the cell's membrane input resistance, resting potential, time constant, action potential, slow-or fast-afterhyperpolarizing potential properties. Based on these results we conclude that corticosteroids are important for maintaining the ratio of nonburst and burst firing pyramidal neurons in subfield CA3. These novel results are distinct from those previously reported for subfield CA1, suggesting that corticosteroids have different effects across hippocampal subfields.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Okuhara DY,Beck SGdoi
10.1159/000054299subject
Has Abstractpub_date
1998-01-01 00:00:00pages
58-66issue
1eissn
0028-3835issn
1423-0194pii
nen67058journal_volume
67pub_type
杂志文章abstract：:The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124755
更新日期：1987-05-01 00:00:00
abstract：:Somatotropes and GC cells, a GH-producing cell line, exhibit [Ca(2+)](i) oscillations that result from rhythmic Ca(2+) action potentials. Determination of this operating mode required simultaneous recording of both parameters by fura-2 imaging and patch-clamp techniques. In order to test whether patch recording induce...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054495
更新日期：1999-11-01 00:00:00
abstract：UNLABELLED:Mediobasal hypothalamic slices of adult ovariectomized (OVX) rats treated or not with 17 beta-estradiol (E2) were superfused in buffered (pH 7.2) Locke medium containing bacitracin. A 6-min pulse of K+ (56 m M) was less effective in releasing luteinizing hormone releasing hormone (LH-RH) from mediobasal hypo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123883
更新日期：1984-02-01 00:00:00
abstract：:Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signalling pathways, facilitating intracellular Ca2+ release and protein kinase C activation. A sixth class of phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCeta) has recently been discovered in mammals. Rece...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000107795
更新日期：2007-01-01 00:00:00
abstract：:Experiments were carried out to increase the endogenous levels of TRH in brain and spinal cord. After 7 days of continuous oral ingestion of TRH analogs (D-pGlu-Leu-ProNH2, pGlu-Leu-Pro, pGlu-Pro-ProNH2, or pGlu-Leu-pyrrolidide), spinal cord and brain levels of TRH were elevated, whereas the content of TRH metabolite,...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125118
更新日期：1989-02-01 00:00:00
abstract：:Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125222
更新日期：1989-08-01 00:00:00
abstract：:Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125387
更新日期：1990-05-01 00:00:00
abstract：:To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122495
更新日期：1976-01-01 00:00:00
abstract：:The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (NIL); occasionally, BBS/GRP-like material was localiz...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126858
更新日期：1995-04-01 00:00:00
abstract：:The timing of the episodic secretion of luteinizing hormone (LH) in ovariectomized ewes was investigated with respect to an ultradian rest-activity cycle. Individual sheep were enclosed in a chamber where their physical activity was continuously monitored, and blood samples for LH analysis were collected at 5-min inte...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123187
更新日期：1981-06-01 00:00:00
abstract：UNLABELLED:Opioid peptides are present in both the posterior pituitary (PP) and stalk-median eminence (SME). Their effects on the dopaminergic neurons in the SME are well documented, but little is known concerning their role in the regulation of dopamine (DA) release from the PP. The objectives of this study were (1) t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125612
更新日期：1990-10-01 00:00:00
abstract：:Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124638
更新日期：1986-01-01 00:00:00
abstract：:Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000126831
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND/AIMS:Stress exacerbates neuron loss in many CNS injuries via the actions of adrenal glucocorticoid (GC) hormones. For some injuries, this GC endangerment of neurons is accompanied by greater immune cell activation in the CNS, a surprising outcome given the potent immunosuppressive properties of GCs. METHODS...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000367849
更新日期：2014-01-01 00:00:00
abstract：:Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000321683
更新日期：2010-01-01 00:00:00
abstract：:Serotonin and dopamine neurons have been shown to exert a stimulatory and inhibitory control, respectively, over pituitary release of beta-endorphin-like immunoreactivity (beta-END-LI). In the present study we sought to determine whether an interaction exists between these two reciprocal mechanisms regulating beta-END...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124439
更新日期：1986-01-01 00:00:00
abstract：:The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126466
更新日期：1993-06-01 00:00:00
abstract：:The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123389
更新日期：1982-10-01 00:00:00
abstract：:Observations in experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis (MS), have indicated that a low activity of the hypothalamo-pituitary-adrenal (HPA) system is accompanied by a high susceptibility for EAE in rat strains and that elevated corticosteroid levels are necessary for spontaneous r...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126989
更新日期：1995-07-01 00:00:00
abstract：:Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122864
更新日期：1979-01-01 00:00:00
abstract：:At present there is no clinical guideline or standardised protocol for the treatment of metastatic or invasive phaeochromocytoma and paraganglioma (collectively known as PPGL) due to the rarity of the disease and the lack of prospective studies or extended national databases. Prognosis is mainly determined by genetic ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000499497
更新日期：2019-01-01 00:00:00
abstract：:Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126424
更新日期：1993-04-01 00:00:00
abstract：:The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123090
更新日期：1980-10-01 00:00:00
abstract：:Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal condit...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122911
更新日期：1979-01-01 00:00:00
abstract：:The role of beta-endorphin in the stimulation of growth hormone secretion elicited by administration of clonidine (Clon), an alpha2-adrenergic agonist, was investigated in awake, freely moving male rats. Animals were infused slowly with either 1 ml of normal rabbit serum (NRS), beta-endorphin antiserum (beta-end-AS) o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125263
更新日期：1989-10-01 00:00:00
abstract：BACKGROUND:Activation of somatostatin receptors (sstr1-5) by somatostatin and its analogues exerts an inhibitory effect on hormone secretion and provides the basis for the treatment of a range of endocrine diseases such as acromegaly, Cushing's disease and neuroendocrine tumors (NET). The lack of well-characterized com...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000330616
更新日期：2012-01-01 00:00:00
abstract：:The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the horm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123566
更新日期：1983-10-01 00:00:00
abstract：:Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122517
更新日期：1976-01-01 00:00:00
abstract：:There is extensive evidence that serotonin (5-HT) is implicated in the neuroendocrine control regulating the secretion of several anterior pituitary hormones. It has also been reported that the posterior pituitary is necessary for prolactin (PRL) response to 5-HT as well as to suckling, in which 5-HT implication has b...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054381
更新日期：1998-11-01 00:00:00
abstract：:The c-fos protein is rapidly induced in hypothalamic magnocellular nuclei following hemorrhage. We used specific antibodies directed against c-fos and either vasopressin (AVP) or oxytocin (OT) neurophysin to investigate c-fos activation in individual AVP and OT neurons. AVP and OT neurons expressed c-fos in response t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126384
更新日期：1993-03-01 00:00:00
