Growth hormone synthesis decreased after anterolateral deafferentation of the medial basal hypothalamus in the rat.

Abstract:

:To study the role of the hypothalamus in the regulation of growth hormone (GH) synthesis, the rate of amino acid incorporation into GH in vitro was examined in rats with anterolateral deafferentation of the medial basal hypothalamus. Amino acid incorporation into GH (GH synthesis) decreased significantly 7 days after the deafferentation, although prolactin synthesis did not show any significant fluctuations. The serum GH was increased, while the pituitary GH content was decreased. Somatostatin in the stalk median eminence of such deafferentated animals decreased markedly, while GH-releasing hormone was decreased slightly but not significantly. Immunohistochemical examinations revealed that the number of somatostatin nerve terminals in the median eminence decreased markedly, while GH-releasing hormone nerve terminals in the same area remained intact. These findings suggest that neural factor(s) outside the medial basal hypothalamus plays an important role in the regulation of GH synthesis.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Ieiri T,Ishikawa K,Suzuki M,Shimoda S

doi

10.1159/000124946

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

431-6

issue

5

eissn

0028-3835

issn

1423-0194

journal_volume

47

pub_type

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