Abstract:
:A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for maintaining luteal function during the first half of pregnancy. In order to understand the neuronal mechanisms controlling the proestrous- and mating-induced PRL surges, we examined patterns of Fos expression by immunocytochemistry in specific brain regions as a measure of neuronal activity. Intact female rats were sacrificed at 09.00, 15.00, and 18.00 h on the day of proestrus and the day of diestrus. Brain tissues were also collected at 21.00 h on the day of proestrus from rats receiving intromissions or mounts from males or taken directly from their homecage. On the day of proestrus, the number of neurons expressing Fos in the medial preoptic area (mPOA), medial amygdaloid nucleus (mAMYG), and ventromedial nucleus of the hypothalamus (VMH) was few and was associated with low plasma PRL levels at 09.00 h; however, the number of Fos-positive cells in these brain regions significantly increased at 15.00 and 18.00 h when the proestrous PRL surge occurred. Mating during the evening of proestrus resulted in a dramatic increase in the number of Fos-positive cells in the mPOA, mAMYG, and VMH as well as in the arcuate nucleus (ARC). Nonmated animals in diestrus showed low and unchanged PRL levels and Fos expression in all the brain areas throughout the day. These results suggest that the mPOA, mAMYG, VMH and ARC may be important brain sites for the integration of stimuli associated with proestrous- and mating-induced PRL surges.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Yang S,Lee Y,Voogt JLdoi
10.1159/000054429subject
Has Abstractpub_date
1999-04-01 00:00:00pages
281-9issue
4eissn
0028-3835issn
1423-0194pii
54429journal_volume
69pub_type
杂志文章abstract::Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054629
更新日期:2001-02-01 00:00:00
abstract::As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123586
更新日期:1983-12-01 00:00:00
abstract::The influence of the hypothalamus on the development of the anterior pituitary cells was studied in normal and anencaphalic human fetuses. An immunocytological method was applied to study the quantitative evolution of the size of the cells during gestation. The somatotropic and corticotropic cells appeared at the end ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122709
更新日期:1977-01-01 00:00:00
abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122489
更新日期:1976-01-01 00:00:00
abstract::The secretion of gonadotropins and the role exerted by the endogenous opioid system on luteinizing hormone (LH) secretion were investigated in 6 postmenopausal women affected by idiopathic Parkinson's disease (PD) as well as in 6 age- and weight-matched normal postmenopausal women as controls. The mean plasma follicle...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125773
更新日期:1991-06-01 00:00:00
abstract::The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122357
更新日期:1975-01-01 00:00:00
abstract::We measured the concentration of oxytocin and vasopressin in microdissected areas of the hypothalamus and posterior pituitary in weanling and adult female rats. Oxytocin concentration was significantly less in adult rats as compared to weanling rats in the supraoptic nucleus, median eminence, and retrochiasmatic area ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123067
更新日期:1980-08-01 00:00:00
abstract::Studies were undertaken to investigate the nature of receptors involved in the prolactin-releasing action of histamine in male rats. The increase of plasma prolactin levels induced by third-ventricle injection of histamine was blocked by intraventricular injection of ranitidine, an H2-antagonist, but not by systemic a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123495
更新日期:1983-06-01 00:00:00
abstract::We have investigated the effects of hyperprolactinemia, produced by pituitary isografts under the kidney capsule (16-20 days), on the LH releasing action and priming effect of LH-releasing hormone (LHRH) in normal and hypogonadal (hpg) female mice. The pituitary grafts increased the plasma prolactin concentrations abo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124585
更新日期:1986-01-01 00:00:00
abstract::The A1 and A2 brainstem noradrenergic cell groups project to the hypothalamic paraventricular nucleus (PVN), which is involved in integrating the stress response. Bi-directional communication between the brain and immune system is well established, with both neuroendocrine and immune responses being activated by lipop...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054474
更新日期:1999-09-01 00:00:00
abstract::Progesterone is readily reduced in humans to its A-ring metabolites, allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one) and pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one). The latter have been reported to have anxiolytic, hypnotic and anesthetic actions when administered to laboratory animals and (or) hum...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126579
更新日期:1993-10-01 00:00:00
abstract::We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124188
更新日期:1985-09-01 00:00:00
abstract::In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were ex...
journal_title:Neuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000091980
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000350790
更新日期:2013-01-01 00:00:00
abstract::Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agen...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000095338
更新日期:2006-01-01 00:00:00
abstract::17 alpha-hydroxyprogesterone (up to 200 mug/day) and 11 beta-hydroxyandrostenedione (up to 500 mug) had no effect on PMS-induced ovulation in intact immature rats. 10 mug/day of testosterone propoinate (TP) on days 28-30 of life decreased the percent of animals ovulating and the number of ova produced; this effect per...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122338
更新日期:1975-01-01 00:00:00
abstract::This study compares the processing of pro-opiomelanocortin (POMC) at two Lys-Lys cleavage sites, located in the carboxy-terminal domain of the precursor, one site marking the amino terminus of beta-melanocyte-stimulating hormone (beta-MSH) and the other in the carboxy-terminus of beta-endorphin (beta E). These compari...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126518
更新日期:1993-07-01 00:00:00
abstract::Thymic neuroendocrine neoplasms are rare tumours, but their management can often be highly problematic. While previously assumed to be essentially variants of bronchopulmonary (lung) carcinoids, they are generally more aggressive and more difficult to treat. Some 25% are associated with multiple endocrine neoplasia-1,...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000472255
更新日期:2017-01-01 00:00:00
abstract::The properties of neuronal-type nicotinic acetylcholine receptors (nAChRs) present on the neuroendocrine cells of the porcine pars intermedia of the pituitary were studied in intact single cell using measurements of the free intracellular Ca2+ concentration ([Ca]i) with the calcium-sensitive dye fura 2. Local applicat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126772
更新日期:1994-10-01 00:00:00
abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124998
更新日期:1988-08-01 00:00:00
abstract:AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000381454
更新日期:2015-01-01 00:00:00
abstract::The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125064
更新日期:1988-11-01 00:00:00
abstract::Hypophysitis is a relatively rare disease that exerts a strong autoimmune component encompassing different etiologies. Immunomodulatory drugs, such as interferon-α, are known to rarely induce hypophysitis. In recent years, a large number of new biological and immunomodulatory agents have been introduced into clinical ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000480086
更新日期:2018-01-01 00:00:00
abstract::Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125081
更新日期:1988-12-01 00:00:00
abstract::Allopregnanolone is a neuroactive steroid present in the brain, but also measurable in systemic circulation. It exhibits anxiolytic and anticonvulsant effects and is able to produce hyperphagia. Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported in obese subjects,...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000048228
更新日期:2002-02-01 00:00:00
abstract::Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124668
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:We previously presented data of this multicentric, phase II study showing that everolimus plus octreotide long-acting repeatable (LAR) for advanced neuroendocrine neoplasms (NENs), in the first line setting, is an active and safe treatment. We now present updated data at 5 years. METHODS:Patients with advan...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000479587
更新日期:2018-01-01 00:00:00
abstract::Interleukin-1 (IL-1) and glucocorticoid hormones represent two key mediators involved in the modulation of the neuroimmunoendocrine response to stress. IL-1 is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis in rodents. In the immune system, glucocorticoids modulate IL-1 production and a number of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126648
更新日期:1994-02-01 00:00:00
abstract::The present study was undertaken to evaluate the 24-hour periodicity in serum prolactin levels subsequent to transecting the ascending serotonergic system or ablating the suprachiasmatic nuclei (SCN) of adult (185 g) female rats. The ascending serotonergic system was transected at the level of the rostral mesencephalo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123055
更新日期:1980-08-01 00:00:00
abstract::The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126418
更新日期:1993-04-01 00:00:00