Abstract：
:The present study was undertaken to evaluate the 24-hour periodicity in serum prolactin levels subsequent to transecting the ascending serotonergic system or ablating the suprachiasmatic nuclei (SCN) of adult (185 g) female rats. The ascending serotonergic system was transected at the level of the rostral mesencephalon using a 1.5 mm wide knife and the SCN was ablated with a modified Halász-Pupp knife. The effect of raphe transection (RT) or SCN ablation on the circadian rhythm in nonstress serum prolactin levels was assessed 45 days after surgery by measuring with radioimmunoassay the serum prolactin concentration in serial blood samples obtained from the tail vein of lightly restrained rats. Serum prolactin concentration in control and RT animals showed circadian periodicity; peak levels occurred during the midafternoon, 4 h prior to the dark phase of the lighting regime (lights on at 4 a.m., off at 6 p.m.). The amplitude of the fluctuations of both groups varied markedly and were related to the estrous cycle. However, RT animals showed a reduced amplitude in the rhythm. In controls peak prolactin levels on days of proestrus and estrus were 15-20 times higher than on days of diestrus. In contrast, serum prolactin levels in SCN-ablated rats did not vary with a circadian periodicity but rather showed random, low amplitude fluctuations. Reproductive cyclicity was also abolished by SCN ablation, i.e., SCN-ablated rats presented persistent vaginal cornification. These data indicate that circadian periodicity in serum prolactin levels is not compromised by sectioning the ascending serotonergic fibers but is abolished after ablating the SCN.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Dunn JD,Johnson DC,Castro AJ,Swenson Rdoi
10.1159/000123055subject
Has Abstractpub_date
1980-08-01 00:00:00pages
85-91issue
2eissn
0028-3835issn
1423-0194journal_volume
31pub_type
杂志文章abstract：:In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were ex...
journal_title：Neuroendocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000091980
更新日期：2005-01-01 00:00:00
abstract：:Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126159
更新日期：1992-04-01 00:00:00
abstract：:The known occurrence of opiates in the adrenals stimulated us to determine whether Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), an endogenous peptide that can act as an antiopiate, is present in these glands and whether adrenalectomy affects its concentrations in plasma. The presence of Tyr-MIF-1 in the adrenals of the rat was sh...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126403
更新日期：1993-03-01 00:00:00
abstract：:The acute effects of hypothalamic electrical stimulation on the secretion of FSH and LH have been examined in anestrous and estrous ferrets. Basal levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were higher in the anestrous than in the estrous animals; the anestrous animals showed a more mark...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122674
更新日期：1977-01-01 00:00:00
abstract：:Grafts of normal mouse preoptic area (POA) tissue into the third ventricle of gonadotrophin-releasing hormone (GnRH)-deficient hypogonadal (hpg) mice resulted in an elevation of pituitary GnRH receptors, an increased synthesis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland, a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124762
更新日期：1987-05-01 00:00:00
abstract：:The effects of acute and chronic administration of a combination of lynestrenol-mestrenol, a widely employed contraceptive medication, on the dopaminergic system of the rat forebrain and striatum were investigated to better understand the biochemical basis of the neurological side-effects of steroid contraceptive drug...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122643
更新日期：1976-01-01 00:00:00
abstract：:The present studies were undertaken to investigate the effect of gender on thyrotropin-releasing hormone (TRH) gene expression in cultured anterior pituitary (AP) cells. AP cells derived from 15-day-old male, female, or female pups that had been neonatally treated with testosterone propionate (TP), were cultured for u...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126815
更新日期：1995-01-01 00:00:00
abstract：:We have examined the effect of electrical stimulation in the subfornical organ (SFO) on the activity of neurons in the medial septum and diagonal band of Broca (MS-DBB) which project to the median eminence in the rat. Previous studies have suggested that septal neurons with such projections are luteinizing hormone rel...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124991
更新日期：1988-07-01 00:00:00
abstract：INTRODUCTION:The pituitary gland has a high expression of somatostatin receptors (SSTRs) and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment. OBJECTIVE:To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000507761
更新日期：2020-04-08 00:00:00
abstract：:An enriched population of cells immunoreactive to antiserum against S-100 protein, a marker of folliculo-stellate (FS) cells in the rat pituitary, was obtained by separation of dispersed pituitary cells from adult female rats by gradient sedimentation at unit gravity. The effect of FS cells on the stimulation and inhi...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125146
更新日期：1989-04-01 00:00:00
abstract：:The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats. Lordosis behavior triggered by...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123983
更新日期：1984-09-01 00:00:00
abstract：:Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126717
更新日期：1994-07-01 00:00:00
abstract：:Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054339
更新日期：1998-06-01 00:00:00
abstract：:The c-fos protein is rapidly induced in hypothalamic magnocellular nuclei following hemorrhage. We used specific antibodies directed against c-fos and either vasopressin (AVP) or oxytocin (OT) neurophysin to investigate c-fos activation in individual AVP and OT neurons. AVP and OT neurons expressed c-fos in response t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126384
更新日期：1993-03-01 00:00:00
abstract：:Chronic hyperprolactinemia in the rat is associated with suppression of plasma gonadotropin concentrations. The reduction of gonadotropins is considered to be due to either an inhibitory effect of prolactin (PRL) on pituitary gonadotropin secretion and/or suppression of hypothalamic gonadotropin-releasing hormone (GnR...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126355
更新日期：1993-01-01 00:00:00
abstract：:Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122865
更新日期：1979-01-01 00:00:00
abstract：INTRODUCTION:Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological therapy is often required. Unfortunately, many patients are/become unresponsive to available drugs (somatostati...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000505923
更新日期：2020-01-01 00:00:00
abstract：:After in vivo treatment, progesterone initially decreases tyrosine hydroxylase (TH) activity in the TIDA neurons, but subsequently increases TH activity with prolonged treatment. In order to explore the cellular mechanism for progesterone's effect, this study examined the acute inhibitory action of progesterone on TH ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000057336
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000441897
更新日期：2017-01-01 00:00:00
abstract：:The hypothalamic GnRH pulse generator activity, which was assessed by the characteristic increases in the multiple unit activity (MUA) specifically associated with the pulsatile LH secretion (MUA volleys), was monitored throughout the estrous cycle of the female goat. Blood samples were collected daily for analysis of...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127051
更新日期：1995-12-01 00:00:00
abstract：:The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the horm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123566
更新日期：1983-10-01 00:00:00
abstract：:Rats bearing transplanted prolactin-secreting tumors are known to have very high prolactin levels in the serum, reduced hypothalamic opiate concentrations, increasing hypothalamic dopamine synthesis and increased hypophyseal portal blood dopamine levels. Further, it has been shown that incubation in 3H-leucine of ante...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123211
更新日期：1981-08-01 00:00:00
abstract：:The arcuate nucleus-median eminence complex (AM) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. Those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary glan...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124775
更新日期：1987-06-01 00:00:00
abstract：:We have investigated the effects of exposure to short-term constant light (LL) on the spontaneous, proestrous luteinizing hormone (LH) surge in the female rat. Exposure to LL during the 3 days preceding proestrus delayed and reduced the magnitude of the LH surge which was measured in blood samples taken from conscious...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123225
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000508376
更新日期：2020-05-04 00:00:00
abstract：:To determine the possible physiological role of endogenous growth hormone-releasing factor (GRF) in the neuronal content and release of cerebral somatostatin (SS), we studied the effect of endogenous GRF blockade on the immunoreactive SS (IR-SS) content of cells and media in fetal rat cerebral cortical and hypothalami...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126118
更新日期：1992-02-01 00:00:00
abstract：:This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127113
更新日期：1996-08-01 00:00:00
abstract：:Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126098
更新日期：1992-01-01 00:00:00
abstract：:Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124172
更新日期：1985-08-01 00:00:00
abstract：:The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000080795
更新日期：2004-01-01 00:00:00
