Abstract：
:Allopregnanolone is a neuroactive steroid present in the brain, but also measurable in systemic circulation. It exhibits anxiolytic and anticonvulsant effects and is able to produce hyperphagia. Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported in obese subjects, the present study investigated allopregnanolone and catecholamine (epinephrine and norepinephrine) responses to corticotropin-releasing hormone (CRH) in obese subjects. Blood was sampled from 39 obese (14 men and 25 women) and 57 normal-weight subjects (20 men and 37 women) and assayed for cortisol, allopregnanolone and catecholamines concentrations. In addition, 13 obese patients (5 men and 8 women) and 18 control subjects (9 men and 9 women) were submitted to a CRH test. Plasma allopregnanolone and norepinephrine levels were significantly higher in obese than in control subjects (p < 0.01), but plasma cortisol and epinephrine concentrations were comparable in both groups. No correlation was found in any group between plasma allopregnanolone and norepinephrine or epinephrine levels. Acute CRH administration significantly stimulated allopregnanolone secretion, with peak levels at 15 min in obese subjects, whereas maximal concentrations were reached after 60 min only in controls. In obese patients the allopregnanolone secretory incremental area was significantly higher than in controls (p < 0.02). CRH injection increased cortisol levels to a comparable extent in both groups. Plasma norepinephrine or epinephrine levels did were not significantly affected by CRH test in either group. In conclusion, obese subjects present higher allopregnanolone levels and a greater response to CRH than normal subjects. Since allopregnanolone has hyperphagic effects in rats, hypersecretion of the hormone in obese patients may represent one of the mechanisms underlying obesity.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Menozzi R,Florio P,Bondi M,Luisi S,Cobellis L,Genazzani AR,Del Rio G,Petraglia Fdoi
10.1159/000048228subject
Has Abstractpub_date
2002-02-01 00:00:00pages
124-9issue
2eissn
0028-3835issn
1423-0194pii
nen75124journal_volume
75pub_type
临床试验,杂志文章,随机对照试验abstract：:The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (NIL); occasionally, BBS/GRP-like material was localiz...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126858
更新日期：1995-04-01 00:00:00
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journal_title：Neuroendocrinology
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更新日期：2001-11-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126847
更新日期：1995-03-01 00:00:00
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journal_title：Neuroendocrinology
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更新日期：2010-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125186
更新日期：1989-06-01 00:00:00
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doi：10.1159/000124190
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journal_title：Neuroendocrinology
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123566
更新日期：1983-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1979-01-01 00:00:00
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更新日期：1998-02-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122949
更新日期：1979-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124269
更新日期：1986-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123141
更新日期：1981-02-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126516
更新日期：1993-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000441897
更新日期：2017-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122925
更新日期：1979-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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更新日期：1994-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-03-01 00:00:00
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更新日期：2017-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124844
更新日期：1987-10-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000048216
更新日期：2002-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000371808
更新日期：2016-01-01 00:00:00
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journal_title：Neuroendocrinology
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更新日期：1996-12-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123326
更新日期：1982-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000497214
更新日期：2019-01-01 00:00:00
abstract：:To determine the possible physiological role of endogenous growth hormone-releasing factor (GRF) in the neuronal content and release of cerebral somatostatin (SS), we studied the effect of endogenous GRF blockade on the immunoreactive SS (IR-SS) content of cells and media in fetal rat cerebral cortical and hypothalami...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126118
更新日期：1992-02-01 00:00:00
