Abstract:
:The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over 30 min) and galanin (GAL; 15 micrograms/kg infused intravenously over 60 min) when administered alone or combined with pyridostigmine (PD; 60 mg orally), a cholinergic agonist that likely acts via inhibition of endogenous somatostatin secretion, was studied in children with familial short stature. The GH-releasing effect of PD was also evaluated. In 8 children, PD and L-dopa when administered alone induced an equivalent GH rise (area under the response curve, mean +/- SEM: 241.4 +/- 31.1 vs. 202.9 +/- 38.6 micrograms/l/h) while their coadministration had an additive effect (435.4 +/- 41.4 micrograms/l/h; p less than 0.02 vs. PD and L-dopa alone). On the contrary, in other 8 children, PD and Arg induced similar GH increases either when administered alone (394.2 +/- 68.5 vs. 405.8 +/- 103.9 micrograms/l/h) or in combination (535.8 +/- 97.3 micrograms/l/h). GH increases almost superimposable were also observed when PD and GAL were administered alone (405.2 +/- 72.3 vs. 412.6 +/- 94.1 micrograms/l/h) or in combination (537.9 +/- 139.0 micrograms/l/h) in other 7 children. These data show that the enhancement of the cholinergic activity by PD increases the L-dopa-induced GH release but fails to modify both Arg- and GAL-induced GH release in short children.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Ghigo E,Bellone J,Imperiale E,Arvat E,Mazza E,Valetto MR,Boffano GM,Cappa M,Loche S,De Sanctis Cdoi
10.1159/000125536subject
Has Abstract,Author List Incompletepub_date
1990-07-01 00:00:00pages
42-5issue
1eissn
0028-3835issn
1423-0194journal_volume
52pub_type
杂志文章abstract::Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124196
更新日期:1985-10-01 00:00:00
abstract::Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000089749
更新日期:2005-01-01 00:00:00
abstract::The primary treatment of gastroenteropancreatic neuroendocrine tumors (GEPNETs) is surgery with curative intent or debulking of the tumor mass. In case of metastatic disease, cytoreductive options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatos...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000335018
更新日期:2013-01-01 00:00:00
abstract::The mu-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by mu-ORs are steroid hormone-dependent, few studies have shown how steroid hormones su...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000065953
更新日期:2002-10-01 00:00:00
abstract::The effects of delta 9-tetrahydrocannabinol (THC) on hypothalamic norepinephrine (NE) and dopamine (DA) turnover and hypothalamic serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) and LHRH content preceding and during a progesterone- (P) induced LH and prolactin (PRL) surge were investigated in ovariectomized est...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123576
更新日期:1983-11-01 00:00:00
abstract::In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000071963
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000368607
更新日期:2014-01-01 00:00:00
abstract::Previous work has demonstrated that N-methyl-D-aspartate (NMDA) is capable of stimulating luteinizing hormone release in a variety of species. Interestingly, the ability of NMDA to stimulate luteinizing hormone release is significantly compromised in castrated male and female rats as compared to intact animals. The pu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126607
更新日期:1993-12-01 00:00:00
abstract::Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122864
更新日期:1979-01-01 00:00:00
abstract::The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122711
更新日期:1977-01-01 00:00:00
abstract::Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000064527
更新日期:2002-09-01 00:00:00
abstract::In the present study the effect of methadone (M) on gonadotropin-releasing hormone in the rat hypothalamus was investigated. The specificity of the M effect was demonstrated by injecting M (100 ng) and the M antagonist, naloxone (5 ng), into the ventromedial hypothalamus. A significant drop in the blood testosterone l...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123326
更新日期:1982-01-01 00:00:00
abstract::The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000502776
更新日期:2020-01-01 00:00:00
abstract::Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000068653
更新日期:2003-02-01 00:00:00
abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123087
更新日期:1980-10-01 00:00:00
abstract::We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125751
更新日期:1991-04-01 00:00:00
abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126576
更新日期:1993-10-01 00:00:00
abstract::The effect of catecholamines on plasma levels of immunoreactive ACTH (ACTHi), alpha-MSH (alpha-MSHi), beta-endorphin (beta-ENDi), arginine-vasopressin (AVPi) and of corticosterone (B) was studied in female rats. Intravenous infusion of the specific beta-adrenoceptor-stimulating agent l-isoproterenol in Wistar rats und...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123529
更新日期:1983-08-01 00:00:00
abstract::We have investigated the variations in growth hormone (GH) and somatostatin (SOM) mRNAs in adult, middle-aged and aging rats of both sexes using quantitative in situ hybridization. cDNA probes complementary to GH mRNA and SOM mRNA were used on fixed pituitary and hypothalamic sections, respectively. A clear sexual dim...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125967
更新日期:1991-12-01 00:00:00
abstract::Concentrations of luteinizing hormone (LH) and prolactin (Prl) in the serum of anestrous and cycling ewes were compared. The concentration of LH in serum and the frequency of episodic releases of LH were lower in anestrous than in cycling ewes. Concentrations of LH in serum rose as rapidly after ovariectomy of anestro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122870
更新日期:1979-01-01 00:00:00
abstract::Insulin-deficient states are associated with an impaired function of the hypothalamic-pituitary-gonadal axis, but the mechanisms underlying hypothalamic alterations in experimental diabetes are still unknown. We investigated the effect of glucose concentrations, in the presence and absence of insulin, on LHRH release ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126257
更新日期:1992-09-01 00:00:00
abstract::The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123957
更新日期:1984-07-01 00:00:00
abstract::The hypothalamic neurons containing substance P (SP) were examined immunohistochemically in rats with a normal estrous cycle or persistent estrus (PE), in pregnancy and in lactating state. In PE animals, the neurons increased in number 1 week after ovariectomy, but then decreased and disappeared. During pregnancy, the...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124764
更新日期:1987-05-01 00:00:00
abstract::The properties of neuronal-type nicotinic acetylcholine receptors (nAChRs) present on the neuroendocrine cells of the porcine pars intermedia of the pituitary were studied in intact single cell using measurements of the free intracellular Ca2+ concentration ([Ca]i) with the calcium-sensitive dye fura 2. Local applicat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126772
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). OBJECTIVE:This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain and disability. METHODS:Thirty-eight ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000511811
更新日期:2020-09-25 00:00:00
abstract::The present study was undertaken in order to better characterize the functional state of anterior pituitary gland in young and old rats by using prolactin secretion and incorporation of radioactive phosphate into phosphatidylinositol (PI) as markers. The in vitro incorporation of radiolabeled phosphate into anterior p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124714
更新日期:1987-02-01 00:00:00
abstract::The present study was undertaken to evaluate the 24-hour periodicity in serum prolactin levels subsequent to transecting the ascending serotonergic system or ablating the suprachiasmatic nuclei (SCN) of adult (185 g) female rats. The ascending serotonergic system was transected at the level of the rostral mesencephalo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123055
更新日期:1980-08-01 00:00:00
abstract::The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125064
更新日期:1988-11-01 00:00:00
abstract::Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000314297
更新日期:2010-01-01 00:00:00
abstract::Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122517
更新日期:1976-01-01 00:00:00