Abstract：
:The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a stimulus which is known to effectively release PRL (exposure of the mother to the exteroceptive stimuli emanating from 2 pups) but which is not of sufficient strength to influence the conversion of storage PRL. We found that the concentration of PRL could be repeatedly elevated to the same extent in the plasma with repetitive 10-min applications of this stimulus. With continuous 75 min of exposure to 2 pups, the plasma PRL concentration of the mother rose to maximum within 15 min which then was sustained for the remaining 60 min, suggesting a steady release of PRL into the circulation had occurred. These data indicate that, unlike the storage form of PRL, the discharge of the releasable form occurs in relation to the length of time the stimulus is applied and exhibits neither summation nor refractoriness. Subsequently it was noted that PRL could be released up to 8 h after the releasable pool had been formed and that the plasma concentration curves were not altered by injecting 5 mg of the lysosome inhibitor, chloroquine.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Grosvenor CEdoi
10.1159/000123957subject
Has Abstractpub_date
1984-07-01 00:00:00pages
64-7issue
1eissn
0028-3835issn
1423-0194journal_volume
39pub_type
杂志文章abstract：:Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126583
更新日期：1993-11-01 00:00:00
abstract：:Introduction Dysregulation of the mTORC1-dependent pathways in pancreatic neuroendocrine neoplasms (PanNENs) underlies the introduction of the mTORC1 inhibitor everolimus as treatment of advanced progressive PanNENs. Although everolimus significantly increases progression free survival, most patients acquire secondary...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000509865
更新日期：2020-07-02 00:00:00
abstract：:Observations in experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis (MS), have indicated that a low activity of the hypothalamo-pituitary-adrenal (HPA) system is accompanied by a high susceptibility for EAE in rat strains and that elevated corticosteroid levels are necessary for spontaneous r...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126989
更新日期：1995-07-01 00:00:00
abstract：:We have examined the effect of electrical stimulation in the subfornical organ (SFO) on the activity of neurons in the medial septum and diagonal band of Broca (MS-DBB) which project to the median eminence in the rat. Previous studies have suggested that septal neurons with such projections are luteinizing hormone rel...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124991
更新日期：1988-07-01 00:00:00
abstract：:In addition to the magnocellular hypothalamic nuclei, arginine vasopressin (AVP)-containing neurons have also been identified in limbic structures, including the hippocampus and amygdala. In the present study, we compared the qualitative properties of the in vitro release of AVP from the dissected hypothalamus with th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126661
更新日期：1994-03-01 00:00:00
abstract：:The A1 and A2 brainstem noradrenergic cell groups project to the hypothalamic paraventricular nucleus (PVN), which is involved in integrating the stress response. Bi-directional communication between the brain and immune system is well established, with both neuroendocrine and immune responses being activated by lipop...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054474
更新日期：1999-09-01 00:00:00
abstract：:The effect of steroids on the two gonadotropin-releasing hormone (GnRH) forms present in the eel (mammalian GnRH, mGnRH and chicken GnRH-II, cGnRH-II), as well as on gonadotropin (GTH), was studied using specific radioimmunoassays. Female silver eels received chronic treatments with various steroids (estradiol, testos...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126876
更新日期：1995-05-01 00:00:00
abstract：:Introduction Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic neuroendocrine neoplastic (pNEN) cells l...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000512567
更新日期：2020-10-27 00:00:00
abstract：:The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125064
更新日期：1988-11-01 00:00:00
abstract：:Secretion of the growth hormone (GH) in spontaneously hypertensive (SH) male rats has been determined and compared with that of normotensive Wistar-Kyoto (WKY) controls. In a first set of experiments, plasma GH concentration and pituitary GH content were measured in SH rats 30, 60 and 90 days old. 30-day rats showed r...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125617
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000497336
更新日期：2019-01-01 00:00:00
abstract：:High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123533
更新日期：1983-08-01 00:00:00
abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000499693
更新日期：2019-01-01 00:00:00
abstract：:Previous studies have indicated that 30 min of swimming in room temperature water is a potent stimulus for the secretion of beta-endorphin (beta E) from the intermediate lobe (IL) of the pituitary in rodents. Repeated daily challenge with this paradigm over days to weeks leads to a progressive increase in proopiomelan...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126553
更新日期：1993-09-01 00:00:00
abstract：:The hypothalamic GnRH pulse generator activity, which was assessed by the characteristic increases in the multiple unit activity (MUA) specifically associated with the pulsatile LH secretion (MUA volleys), was monitored throughout the estrous cycle of the female goat. Blood samples were collected daily for analysis of...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127051
更新日期：1995-12-01 00:00:00
abstract：:In rats anesthetized with sodium pentobarbital, adrenal venous blood samples were collected and analyzed for epinephrine and norepinephrine by the fluorometric method. Stimulation of the inferior fovea or adjacent areas resulted in a significant increase in epinephrine secretion. Stimulation of some other areas of the...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122949
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000109664
更新日期：2008-01-01 00:00:00
abstract：:Previous studies indicate that 7 days after testicular administration of naloxone, serum testosterone (T) concentration and basal T secretion in vitro decrease significantly. In neonatal rats, short-term (2 h) intratesticular treatment with 0.3 micrograms (D-Met2-Pro5)-enkephalinamide suppresses steroidogenesis. In th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126242
更新日期：1992-09-01 00:00:00
abstract：:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122452
更新日期：1975-01-01 00:00:00
abstract：:Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122791
更新日期：1978-01-01 00:00:00
abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123296
更新日期：1982-03-01 00:00:00
abstract：:The secretion of gonadotropins and the role exerted by the endogenous opioid system on luteinizing hormone (LH) secretion were investigated in 6 postmenopausal women affected by idiopathic Parkinson's disease (PD) as well as in 6 age- and weight-matched normal postmenopausal women as controls. The mean plasma follicle...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125773
更新日期：1991-06-01 00:00:00
abstract：:We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125920
更新日期：1991-10-01 00:00:00
abstract：:In 2016, the third version of guidelines for the diagnosis and treatment of neuroendocrine tumors (NETs) has been published by the European Neuroendocrine Tumor Society (ENETS). These guidelines reflect the progress in treatment of NETs, and by comparing the newest guidelines with the first guidelines of 2001, this pr...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000486096
更新日期：2018-01-01 00:00:00
abstract：:The orphanin-FQ/nociceptin (OFQ/N) receptor (previously, ORL1, LC132) has been shown to be coupled to an inwardly rectifying K+ conductance in several neuronal populations. Although OFQ/N receptor mRNA is densely expressed in the supraoptic nucleus (SON), little is known about its coupling to effector system(s). The p...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054441
更新日期：1999-05-01 00:00:00
abstract：:The ability of neuropeptides to act as precursors for smaller, biologically active fragments is discussed in terms of their biotransformation. This process may involve cleavage of the parent peptide by peptidase enzymes to produce shorter polypeptides with defined biological activity, though other enzymic processes su...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124039
更新日期：1984-12-01 00:00:00
abstract：:Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054417
更新日期：1999-03-01 00:00:00
abstract：:Pit-1 expression has been reported to be cell-type-specific in the adult human pituitary and in human pituitary adenomas. In contrast, studies of rodent fetal adenohypophysial development as well as mature rodent glands have indicated that the pit-1 mRNA is ubiquitously expressed and the protein is under translational...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126975
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:We previously presented data of this multicentric, phase II study showing that everolimus plus octreotide long-acting repeatable (LAR) for advanced neuroendocrine neoplasms (NENs), in the first line setting, is an active and safe treatment. We now present updated data at 5 years. METHODS:Patients with advan...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000479587
更新日期：2018-01-01 00:00:00
abstract：:A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126847
更新日期：1995-03-01 00:00:00
