Vasectomy modulates the local effect of intratesticular opioids on the gonad of immature rats.

Abstract:

:Previous studies indicate that 7 days after testicular administration of naloxone, serum testosterone (T) concentration and basal T secretion in vitro decrease significantly. In neonatal rats, short-term (2 h) intratesticular treatment with 0.3 micrograms (D-Met2-Pro5)-enkephalinamide suppresses steroidogenesis. In the present study, testicular treatment with naloxone or enkephalinamide was combined with hemivasectomy (which also includes transection of the inferior spermatic nerve). When local treatment with naloxone was combined with vasectomy in 15-day-old rats, the opioid antagonist-induced increase in testicular weight, the decrease in basal T secretion of the treated gonad and the drop in serum T level could not be observed 7 days postsurgery, despite the fact that in immature rats, hemivasectomy, by itself, also reduces steroid secretion. Similarly, in 5-day-old animals, the short-term (2 h) effect of testicular enkephalinamide on T secretion was prevented by vasectomy. These data suggest that local testicular actions exerted by endogenous opioid peptides might be modulated by the inferior spermatic nerve.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Gerendai I,Nemeskéri A,Csernus V

doi

10.1159/000126242

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

295-9

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

56

pub_type

杂志文章
  • 17-beta-estradiol potentiates luteinizing hormone glycosylation and release induced by veratridine, diacylglycerol, and phospholipase C in rat anterior pituitary cells.

    abstract::We determined the effect of 17 beta-estradiol (E2) on synthesis and release of luteinizing hormone (LH) induced by drugs which activate intracellular signal transduction mechanisms in rat anterior pituitary cells. Cells were pretreated with E2 (6 x 10(-10) M) or diluent for 24 h, then washed and incubated for 4 h with...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125405

    authors: Liu TC,Jackson GL

    更新日期:1990-06-01 00:00:00

  • Progesterone enhancement of lysergic acid diethylamide and levo-5-hydroxytryptophan stimulation of the copulatory response in the female rat.

    abstract::Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123499

    authors: Sietnieks A,Meyerson BJ

    更新日期:1983-06-01 00:00:00

  • Impact of endocrine manipulations on brain-based rat growth hormone.

    abstract::Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124668

    authors: Hojvat S,Emanuele NV,Kirsteins L,Lawrence AM

    更新日期:1986-01-01 00:00:00

  • MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?

    abstract::The worldwide obesity epidemic is increasing, yet at this time, no long-acting and specific pharmaceutical therapies are available. Peripheral hormonal signals communicate metabolic status to the hypothalamus by activating their corresponding receptors in the arcuate nucleus (ARC). In this brain region, a variety of G...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000334903

    authors: Rediger A,Piechowski CL,Habegger K,Grüters A,Krude H,Tschöp MH,Kleinau G,Biebermann H

    更新日期:2012-01-01 00:00:00

  • Sex and estrous cycle variations of rat striatal dopamine uptake sites.

    abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126507

    authors: Morissette M,Di Paolo T

    更新日期:1993-07-01 00:00:00

  • Stimulatory versus inhibitory effects of progesterone on estrogen-induced phasic LH and prolactin secretion correlated with estrogen nuclear and progestin cytosol receptor concentrations in brain and pituitary gland.

    abstract::The purpose of these studies was to determine the temporal requirements and time of day required for progesterone (P4) to amplify versus extinguish LH surges. The experimental animal model used in these studies was the 7-day ovariectomized rat (day 0) treated continuously with estradiol (E2) for 2-4 days (days 2, 3 or...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124241

    authors: Barraclough CA,Camp P,Weiland N,Akabori A

    更新日期:1986-01-01 00:00:00

  • Early expression of the glycoprotein hormone alpha-subunit in the pars tuberalis of the rat pituitary gland during ontogenesis.

    abstract::The expression of the alpha-subunit of the glycoprotein hormones was studied in the developing rat pituitary by in situ hybridization and immunocytochemical techniques. The alpha-subunit mRNA labelling was detected in Rathke's pouch at 12 days' gestation (E12); at E13, it was exclusively concentrated in the pars tuber...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126600

    authors: Stoeckel ME,Hindelang C,Klein MJ,Poissonnier M,Félix JM

    更新日期:1993-12-01 00:00:00

  • Circadian adrenocortical rhythm in the adrenalectomized rat with or without autotransplanted adrenal gland.

    abstract::Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123294

    authors: Murakami N,Takahashi K

    更新日期:1982-03-01 00:00:00

  • GnRH release from the mediobasal hypothalamus: in vitro inhibition by corticotropin-releasing factor.

    abstract::The effects of corticotropin-releasing factor (CRF) on GnRH release from the adult male rat mediobasal hypothalamus (MBH) and median eminence (ME) were studied in an in vitro incubation system. CRF induced a dose-related inhibition of GnRH release from both the MBH and the isolated ME, and this inhibition was blocked ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124578

    authors: Gambacciani M,Yen SS,Rasmussen DD

    更新日期:1986-01-01 00:00:00

  • Stimulation of the Hypothalamus and FSH and LH secretion in the ferret.

    abstract::The acute effects of hypothalamic electrical stimulation on the secretion of FSH and LH have been examined in anestrous and estrous ferrets. Basal levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were higher in the anestrous than in the estrous animals; the anestrous animals showed a more mark...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122674

    authors: Donovan BT,ter Haar MB

    更新日期:1977-01-01 00:00:00

  • Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells.

    abstract::TRPM8 is a member of the melastatin-type transient receptor potential ion channel family. Activation by cold or by agonists (menthol, icilin) induces a transient rise in intracellular free calcium concentration ([Ca(2+)](i)). Our previous study demonstrated that Ca(2+)-permeable cation channels play a role in IGF-1-in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000101693

    authors: Mergler S,Strowski MZ,Kaiser S,Plath T,Giesecke Y,Neumann M,Hosokawa H,Kobayashi S,Langrehr J,Neuhaus P,Plöckinger U,Wiedenmann B,Grötzinger C

    更新日期:2007-01-01 00:00:00

  • Biotransformation of neuropeptides.

    abstract::The ability of neuropeptides to act as precursors for smaller, biologically active fragments is discussed in terms of their biotransformation. This process may involve cleavage of the parent peptide by peptidase enzymes to produce shorter polypeptides with defined biological activity, though other enzymic processes su...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124039

    authors: Griffths EC,McDermott JR

    更新日期:1984-12-01 00:00:00

  • Glucose affects the release of thyrotropin-releasing hormone from the rat hypothalamus.

    abstract::We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125751

    authors: Yamaguchi M,Iriuchijima T,Michimata T,Mori M

    更新日期:1991-04-01 00:00:00

  • Vasopressin is not involved in the catecholamine-induced release of ACTH, alpha-MSH and beta-endorphin from the rat pituitary gland.

    abstract::The effect of catecholamines on plasma levels of immunoreactive ACTH (ACTHi), alpha-MSH (alpha-MSHi), beta-endorphin (beta-ENDi), arginine-vasopressin (AVPi) and of corticosterone (B) was studied in female rats. Intravenous infusion of the specific beta-adrenoceptor-stimulating agent l-isoproterenol in Wistar rats und...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123529

    authors: Berkenbosch F,Vermes I,Buijs RM,Tilders FJ

    更新日期:1983-08-01 00:00:00

  • Growth hormone-secreting tumors: genetic aspects and data from animal models.

    abstract::Hereditary cases of growth hormone (GH)-secreting tumors have been classified into three clinical entities: the multiple endocrine neoplasia type 1 (MEN1) syndrome, the Carney complex (CNC) and the isolated familial somatotropinomas (IFS). The genomic defects associated with MEN1 are all linked to various mutations of...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000095525

    authors: Lytras A,Tolis G

    更新日期:2006-01-01 00:00:00

  • Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats.

    abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122865

    authors: Davis PG,Barfield RJ

    更新日期:1979-01-01 00:00:00

  • Corticosterone effects on long-term potentiation in mouse hippocampal slices.

    abstract::Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126717

    authors: Rey M,Carlier E,Talmi M,Soumireu-Mourat B

    更新日期:1994-07-01 00:00:00

  • Bone remodeling, bone mass and weight gain in patients with stabilized schizophrenia in real-life conditions treated with long-acting injectable risperidone.

    abstract:BACKGROUND:Prolactin-raising antipsychotics, risperidone (antidopaminergic activity), may be associated with low bone mass. On the other hand, risperidone may cause an increase in body weight thought to be favorable for bone. OBJECTIVES:(1) To determine bone remodeling parameters and bone mass in patients with schizop...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000329391

    authors: Doknic M,Maric NP,Britvic D,Pekic S,Damjanovic A,Miljic D,Stojanovic M,Radojicic Z,Jasovic Gasic M,Popovic V

    更新日期:2011-01-01 00:00:00

  • Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.

    abstract::We have suggested that gamma-aminobutyric acid (GABA) in the hypothalamus plays a tonic inhibitory role in the control of the luteinizing hormone (LH) release in intact male rats. To assess whether feedback from the testis alters the inhibitory GABAergic tone in the medial preoptic area (MPO) of male rats, an in vivo ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000066625

    authors: Tin-Tin-Win-Shwe,Mitsushima D,Kimura F

    更新日期:2002-11-01 00:00:00

  • Comparison between hypothalamic multiple-unit activity and corticotropic function after bilateral destruction of the hippocampus.

    abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122750

    authors: Bouillé C,Baylé JD

    更新日期:1978-01-01 00:00:00

  • Central electrophysiologic correlates of pulsatile luteinizing hormone secretion in the rhesus monkey.

    abstract::Characteristic increases in neuronal activity coincident with the pulsatile release of luteinizing hormone from the pituitary gland have been recorded from electrodes chronically implanted in the medial basal hypothalamus of the rhesus monkey. This electrophysiologic manifestation of the hypothalamic 'pulse generator'...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123988

    authors: Wilson RC,Kesner JS,Kaufman JM,Uemura T,Akema T,Knobil E

    更新日期:1984-09-01 00:00:00

  • Estrogen receptors are expressed in a subset of tyrosine hydroxylase-positive neurons of the anterior preoptic region in the rainbow trout.

    abstract::A double immunocytochemical procedure, with two different chromogens, was used to compare the respective distribution of estrogen receptor-immunoreactive cells and tyrosine hydroxylase-immunoreactive neurons on the same sections of the preoptic region of adult female rainbow trout (Oncorhynchus mykiss). Estrogen recep...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126952

    authors: Linard B,Anglade I,Corio M,Navas JM,Pakdel F,Saligaut C,Kah O

    更新日期:1996-02-01 00:00:00

  • Dual action of GABAA receptors on the secretory process of melanotrophs of Xenopus laevis.

    abstract::The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagon...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126516

    authors: Jenks BG,de Koning HP,Valentijn K,Roubos EW

    更新日期:1993-07-01 00:00:00

  • Opposite changes of pituitary and ovarian receptors for LHRH in ageing rats: further evidence for a direct neural control of ovarian LHRH receptor activity.

    abstract::Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125018

    authors: Marchetti B,Cioni M

    更新日期:1988-09-01 00:00:00

  • Hypothalamic infusion of activin A increases water consumption and urine volume in the rat.

    abstract::Activin A immunoreactivity has been localized within the nucleus tractus solitarius and its projections into regions of the hypothalamus such as the paraventricular nucleus. However, the function of activin within the central nervous system is unclear. Because these regions of the brain are involved in the regulation ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126399

    authors: Schwall RH,Jakeman LB,Altar CA

    更新日期:1993-03-01 00:00:00

  • Central oxytocin mediates inhibition of sodium appetite by naloxone in hypovolemic rats.

    abstract::Pituitary oxytocin (OT) secretion is inversely related to saline consumption in several experimental models of sodium appetite in rats. Because systemic OT administration does not inhibit sodium appetite, release of OT as a neurotransmitter within the brain, coincident with its secretion from the pituitary, may be rel...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126236

    authors: Blackburn RE,Stricker EM,Verbalis JG

    更新日期:1992-08-01 00:00:00

  • Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.

    abstract::Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons. Therefore, we tested the hypothesis ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000443765

    authors: Conde K,Meza C,Kelly MJ,Sinchak K,Wagner EJ

    更新日期:2016-01-01 00:00:00

  • Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone.

    abstract::Administration of the bovine pineal peptide threonylseryllysine (TSL) to unilaterally ovariectomized (UO) mice as a single intraperitoneal injection on the day of UO reduced the 5-day compensatory ovarian hypertrophy. The same dose of TSL (175 ng/animal) significantly (p less than 0.01) reduced serum follicle stimulat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123056

    authors: Orts RJ,Bruot BC,Sartin JL

    更新日期:1980-08-01 00:00:00

  • Effects of stimulation of the preoptic area on hypothalamic paraventricular nucleus unit activity and corticosterone secretion in freely moving rats.

    abstract::Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124269

    authors: Saphier D,Feldman S

    更新日期:1986-01-01 00:00:00

  • Increased tumor cell multiplication after radiofrequency lesions in median hypothalamus in the mouse and rat.

    abstract::A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124479

    authors: Bindoni M,Belluardo N,Marchese AE,Cardile V,Mudò G,Cella S,Laguidara A,Denatale G

    更新日期:1986-01-01 00:00:00