Treatment of gastroenteropancreatic neuroendocrine tumors with peptide receptor radionuclide therapy.

abstract：:An enriched population of cells immunoreactive to antiserum against S-100 protein, a marker of folliculo-stellate (FS) cells in the rat pituitary, was obtained by separation of dispersed pituitary cells from adult female rats by gradient sedimentation at unit gravity. The effect of FS cells on the stimulation and inhi...

journal_title：Neuroendocrinology

authors： Allaerts W,Denef C

更新日期：1989-04-01 00:00:00

abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...

journal_title：Neuroendocrinology

authors： Anesten F,Mishra D,Dalmau Gasull A,Engström-Ruud L,Bellman J,Palsdottir V,Zhang F,Trapp S,Skibicka KP,Poutanen M,Jansson JO

更新日期：2019-01-01 00:00:00

abstract：:The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...

journal_title：Neuroendocrinology

authors： Döhler KD,Coquelin A,Davis F,Hines M,Shryne JE,Sickmöller PM,Jarzab B,Gorski RA

更新日期：1986-01-01 00:00:00

abstract：:Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons. Therefore, we tested the hypothesis ...

journal_title：Neuroendocrinology

authors： Conde K,Meza C,Kelly MJ,Sinchak K,Wagner EJ

更新日期：2016-01-01 00:00:00

abstract：:Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...

journal_title：Neuroendocrinology

authors： Grove KL,Cook VI,Speth RC

更新日期：1992-08-01 00:00:00

abstract：:Peptidyl-glycine alpha-amidation activity has been detected in human cerebrospinal fluid (CSF) and in several regions of the central nervous system. Activity was monitored by measuring conversion of mono-125I-D-Tyr-Val-Gly into mono-125I-D-Tyr-Val-NH2. The alpha-amidation activity in CSF is dependent on molecular oxyg...

journal_title：Neuroendocrinology

authors： Wand GS,Ney RL,Mains RE,Eipper BA

更新日期：1985-12-01 00:00:00

abstract：:Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...

journal_title：Neuroendocrinology

authors： Haun CK,Haltmeyer GC

更新日期：1975-01-01 00:00:00

abstract：:It has been well documented that interleukin-1beta (IL-1beta) is a major mediator for recruiting the hypothalamo-pituitary-adrenal (HPA) axis following infectious disease. The recent localization of IL-1beta receptors in neurons of the hippocampus provides further support for the role of IL-1beta as a neurotransmitter...

journal_title：Neuroendocrinology

authors： Mélik Parsadaniantz S,Daugé V,Roques BP,Kerdelhué B

更新日期：1999-02-01 00:00:00

abstract：:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...

journal_title：Neuroendocrinology

authors： Kasajima A,Konukiewitz B,Oka N,Suzuki H,Sakurada A,Okada Y,Kameya T,Ishikawa Y,Sasano H,Weichert W,Klöppel G

更新日期：2019-01-01 00:00:00

abstract：:In the present study the effect of methadone (M) on gonadotropin-releasing hormone in the rat hypothalamus was investigated. The specificity of the M effect was demonstrated by injecting M (100 ng) and the M antagonist, naloxone (5 ng), into the ventromedial hypothalamus. A significant drop in the blood testosterone l...

journal_title：Neuroendocrinology

authors： Singh HH,Purohit V,Ahluwalia BS

更新日期：1982-01-01 00:00:00

abstract：:The studies reported in this paper were undertaken to investigate the effect of chronic (10 day) alcohol consumption on female pituitary-gonadal function. The immature female rat model treated with pregnant mare serum gonadotropin (PMSG) was used since it results in a highly reproducible luteinizing hormone (LH) surge...

journal_title：Neuroendocrinology

authors： Sundberg DK,Bo WJ,Reilly J

更新日期：1987-10-01 00:00:00

abstract：:Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...

journal_title：Neuroendocrinology

authors： Grossman A,Moult PJ,Cunnah D,Besser M

更新日期：1986-01-01 00:00:00

abstract：:Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the C...

journal_title：Neuroendocrinology

authors： Ferrari E,Magri F,Dori D,Migliorati G,Nescis T,Molla G,Fioravanti M,Solerte SB

更新日期：1995-04-01 00:00:00

abstract：:This study compares the processing of pro-opiomelanocortin (POMC) at two Lys-Lys cleavage sites, located in the carboxy-terminal domain of the precursor, one site marking the amino terminus of beta-melanocyte-stimulating hormone (beta-MSH) and the other in the carboxy-terminus of beta-endorphin (beta E). These compari...

journal_title：Neuroendocrinology

authors： Lin HL,Day NC,Ueda Y,Martin DK,Dixon JE,Seidah NG,Akil H

更新日期：1993-07-01 00:00:00

abstract：:Previous research has shown an increase in hypothalamo-pituitary-adrenal axis activity following naloxone administration to morphine-dependent rats. In the present study, we investigated the adaptive changes in the noradrenaline (NA) and dopamine (DA) systems in the hypothalamic paraventricular nucleus (PVN) during mo...

journal_title：Neuroendocrinology

authors： Fuertes G,Laorden ML,Milanés MV

更新日期：2000-01-01 00:00:00

abstract：:Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...

journal_title：Neuroendocrinology

authors： Quiñones-Jenab V,Jenab S,Ogawa S,Adan RA,Burbach JP,Pfaff DW

更新日期：1997-01-01 00:00:00

abstract：:The effect of in vivo corticosterone manipulation on binding sites for the excitatory neurotransmitter glutamate was determined using radioligand binding to rat brain cryostat sections and crude synaptic membranes. 3H-glutamate binding to regions of the dorsal hippocampal formation was significantly decreased in adren...

journal_title：Neuroendocrinology

authors： Halpain S,McEwen BS

更新日期：1988-09-01 00:00:00

abstract：:It is known that the neonatal treatment of rats with monosodium L-glutamate (MSG) induces several metabolic abnormalities, resulting in enhanced adiposity and hyperleptinemia. Our study was designed to explore the consequences of MSG-induced chronic hyperleptinemia on adrenal sensitivity to the inhibitory effect of ex...

journal_title：Neuroendocrinology

authors： Perelló M,Gaillard RC,Chisari A,Spinedi E

更新日期：2003-09-01 00:00:00

abstract：:Light deprivation by blinding or exposure to short photoperiod results in depressed prolactin (PRL) cell activity and gonadal regression in the male Syrian hamster after at least 42-56 days of treatment, and both of these events can be prevented if pineal removal accompanies light deprivation. In the present study, we...

journal_title：Neuroendocrinology

authors： Massa JS,Blask DE

更新日期：1989-11-01 00:00:00

abstract：:Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...

journal_title：Neuroendocrinology

authors： Morel G,Chayvialle JA,Kerdelhue B,Dubois PM

更新日期：1982-01-01 00:00:00

abstract：:Distribution and properties of receptors for gonadotropin-releasing hormone (GnRH) were analyzed in the brain of adult male rats. Binding of the iodinated GnRH agonist Des-Gly10-(D-Ala6)-GnRH ethylamide was studied in hippocampus and anterior pituitary using three convergent approaches: quantitative autoradiography on...

journal_title：Neuroendocrinology

authors： Leblanc P,Crumeyrolle M,Latouche J,Jordan D,Fillion G,L'Heritier A,Kordon C,Dussaillant M,Rostène W,Haour F

更新日期：1988-11-01 00:00:00

abstract：:The influence of the hypothalamus on the development of the anterior pituitary cells was studied in normal and anencaphalic human fetuses. An immunocytological method was applied to study the quantitative evolution of the size of the cells during gestation. The somatotropic and corticotropic cells appeared at the end ...

journal_title：Neuroendocrinology

authors： Begeot M,Dubois MP,Dubois PM

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...

journal_title：Neuroendocrinology

authors： Schaub CE,Keller-Wood M,Wood CE

更新日期：2008-01-01 00:00:00

abstract：:Single rat neurohypophyses were impaled on a platinum electrode, perifused with isotonic medium and fractions of perifusate collected each minute. Arginine vasopressin content of the fractions was measured by radioimmunoassay. The basal release of arginine vasopressin varied from 50 to 350 pg (0.02-0.14 mU/min) betwee...

journal_title：Neuroendocrinology

authors： Bicknell RJ,Leng G

更新日期：1981-11-01 00:00:00

abstract：:A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...

journal_title：Neuroendocrinology

authors： de Koning HP,Jenks BG,Scheenen WJ,de Rijk EP,Caris RT,Roubos EW

更新日期：1991-07-01 00:00:00

abstract：:Prolactin-releasing (PRF) activity was found in Pitressin (a commercial extract from posterior pituitary for vasopressin). Injection of Pitressin into conscious free-moving rats implanted with a permanent atrial indwelling cannula, produced a transient increase in prolactin concentration in the circulation. In order t...

journal_title：Neuroendocrinology

authors： Shin SH

更新日期：1982-01-01 00:00:00

abstract：:Our previous studies on annexin 5, a member of the annexin family of proteins, have shown its expression in the anterior pituitary gland, its preferential distribution in gonadotropes, and its increase after ovariectomy. In the present study, we examined (1) whether annexin 5 is synthesized in gonadotropes, (2) whethe...

journal_title：Neuroendocrinology

authors： Kawaminami M,Etoh S,Miyaoka H,Sakai M,Nishida M,Kurusu S,Hashimoto I

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:To evaluate the construct and criterion validity of the Tuebingen Cushing's disease quality of life inventory (Tuebingen CD-25) for application in patients treated for Cushing's disease (CD). METHODS:A total of 176 patients with adrenocorticotropin hormone-dependent CD (144 of them female, overall mean age ...

journal_title：Neuroendocrinology

authors： Milian M,Kreitschmann-Andermahr I,Siegel S,Kleist B,Führer-Sakel D,Honegger J,Buchfelder M,Psaras T

更新日期：2015-01-01 00:00:00

abstract：:Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...

journal_title：Neuroendocrinology

authors： Pannell C,Simonian SX,Gillies GE,Luscher B,Herbison AE

更新日期：2002-08-01 00:00:00

abstract：:Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET...

journal_title：Neuroendocrinology

authors： Detjen K,Hammerich L,Özdirik B,Demir M,Wiedenmann B,Tacke F,Jann H,Roderburg C

更新日期：2020-07-02 00:00:00