Facilitation of sexual receptivity in the female rat by a fragment of the LHRH decapeptide, Ac-LHRH.

Abstract:

:The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. Ac-LHRH5-10, des-Tyr5 LHRH and des-Gly10-LHRH significantly elevated lordotic responding compared to saline-infused controls. The results suggest that the elements contained in the LHRH structure may be functionally differentiated and indicate that the active sequence for facilitation of mating behavior is contained in the last half of the LHRH molecule.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Dudley CA,Vale W,Rivier J,Moss RL

doi

10.1159/000123503

subject

Has Abstract

pub_date

1983-06-01 00:00:00

pages

486-8

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

36

pub_type

杂志文章
  • CELL-FREE DNA AND CLINICAL CHARACTERISTICS IN PATIENTS WITH SMALL INTESTINAL OR PANCREATIC NEUROENDOCRINE TUMORS.

    abstract:BACKGROUND:Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low g...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000514457

    authors: Oversoe SK,Sorensen BS,Tabaksblat EM,Gronbaek H,Kelsen J

    更新日期:2021-01-18 00:00:00

  • MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?

    abstract::The worldwide obesity epidemic is increasing, yet at this time, no long-acting and specific pharmaceutical therapies are available. Peripheral hormonal signals communicate metabolic status to the hypothalamus by activating their corresponding receptors in the arcuate nucleus (ARC). In this brain region, a variety of G...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000334903

    authors: Rediger A,Piechowski CL,Habegger K,Grüters A,Krude H,Tschöp MH,Kleinau G,Biebermann H

    更新日期:2012-01-01 00:00:00

  • Growth hormone-secreting tumors: genetic aspects and data from animal models.

    abstract::Hereditary cases of growth hormone (GH)-secreting tumors have been classified into three clinical entities: the multiple endocrine neoplasia type 1 (MEN1) syndrome, the Carney complex (CNC) and the isolated familial somatotropinomas (IFS). The genomic defects associated with MEN1 are all linked to various mutations of...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000095525

    authors: Lytras A,Tolis G

    更新日期:2006-01-01 00:00:00

  • Regulation of dopamine release in vitro from the posterior pituitary by opioid peptides.

    abstract:UNLABELLED:Opioid peptides are present in both the posterior pituitary (PP) and stalk-median eminence (SME). Their effects on the dopaminergic neurons in the SME are well documented, but little is known concerning their role in the regulation of dopamine (DA) release from the PP. The objectives of this study were (1) t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125612

    authors: Garris PA,Ben-Jonathan N

    更新日期:1990-10-01 00:00:00

  • Diurnal rhythms in pineal N-acetyltransferase and hippocampal norepinephrine: effects of water deprivation, blinding and hypothalamic lesions.

    abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122489

    authors: Moore RY,Traynor ME

    更新日期:1976-01-01 00:00:00

  • Differential sensitivity to ACTH, but not stress, in two sources of outbred Sprague-Dawley rats.

    abstract::Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054339

    authors: Matthys L,Castello R,Zilz A,Widmaier EP

    更新日期:1998-06-01 00:00:00

  • The luteinizing hormone but not the cortisol response to arginine vasopressin is prevented by naloxone and a corticotropin-releasing hormone antagonist in the ovariectomized rhesus monkey.

    abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127121

    authors: Xiao E,Xia-Zhang L,Thornell D,Shalts E,Ferin M

    更新日期:1996-09-01 00:00:00

  • Type I gastric carcinoids: a prospective study on endoscopic management and recurrence rate.

    abstract:BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000329043

    authors: Merola E,Sbrozzi-Vanni A,Panzuto F,D'Ambra G,Di Giulio E,Pilozzi E,Capurso G,Lahner E,Bordi C,Annibale B,Delle Fave G

    更新日期:2012-01-01 00:00:00

  • Glucose affects the release of thyrotropin-releasing hormone from the rat hypothalamus.

    abstract::We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125751

    authors: Yamaguchi M,Iriuchijima T,Michimata T,Mori M

    更新日期:1991-04-01 00:00:00

  • Splanchnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats.

    abstract::An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126645

    authors: Jasper MS,Engeland WC

    更新日期:1994-02-01 00:00:00

  • Cells co-expressing luteinising hormone and thyroid-stimulating hormone are present in the ovine pituitary pars distalis but not the pars tuberalis: implications for the control of endogenous circannual rhythms of prolactin.

    abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000350790

    authors: Hodson DJ,Townsend J,Tortonese DJ

    更新日期:2013-01-01 00:00:00

  • New Molecular, Biological, and Immunological Agents Inducing Hypophysitis.

    abstract::Hypophysitis is a relatively rare disease that exerts a strong autoimmune component encompassing different etiologies. Immunomodulatory drugs, such as interferon-α, are known to rarely induce hypophysitis. In recent years, a large number of new biological and immunomodulatory agents have been introduced into clinical ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000480086

    authors: Angelousi A,Chatzellis E,Kaltsas G

    更新日期:2018-01-01 00:00:00

  • Validation of the Tuebingen CD-25 Inventory as a Measure of Postoperative Health-Related Quality of Life in Patients Treated for Cushing's Disease.

    abstract:BACKGROUND:To evaluate the construct and criterion validity of the Tuebingen Cushing's disease quality of life inventory (Tuebingen CD-25) for application in patients treated for Cushing's disease (CD). METHODS:A total of 176 patients with adrenocorticotropin hormone-dependent CD (144 of them female, overall mean age ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000431022

    authors: Milian M,Kreitschmann-Andermahr I,Siegel S,Kleist B,Führer-Sakel D,Honegger J,Buchfelder M,Psaras T

    更新日期:2015-01-01 00:00:00

  • Electroconvulsive seizures increase levels of PS4, the TRH-enhancing peptide [prepro-TRH(160-169)], in rat brain.

    abstract::We report the development of a radioimmunoassay for prepro-TRH(160-169) (PS4), a thyrotropin-releasing hormone (TRH) enhancing peptide, and its use in characterizing the effect of electroconvulsive seizures on the levels of this peptide in various brain regions of male Wistar rats. We found that electroconvulsive seiz...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127199

    authors: Pekary AE,Sattin A,Lloyd RL

    更新日期:1997-05-01 00:00:00

  • Differential regulation of the two forms of gonadotropin-releasing hormone (mGnRH and cGnRH-II) by sex steroids in the European female silver eel (Anguilla anguilla).

    abstract::The effect of steroids on the two gonadotropin-releasing hormone (GnRH) forms present in the eel (mammalian GnRH, mGnRH and chicken GnRH-II, cGnRH-II), as well as on gonadotropin (GTH), was studied using specific radioimmunoassays. Female silver eels received chronic treatments with various steroids (estradiol, testos...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126876

    authors: Montero M,Le Belle N,King JA,Millar RP,Dufour S

    更新日期:1995-05-01 00:00:00

  • The secretory activity of the tuberoinfundibular dopaminergic neurons is modulated by the thyroid status in the adult rat: consequence on prolactin secretion.

    abstract::An influence of thyroid status on the secretory activity of hypothalamic dopaminergic neurons was observed in adult rats and its involvement in the regulation of prolactin (PRL) secretion was examined. The secretory activity of the tuberoinfundibular dopaminergic (TIDA) neurons was evaluated by measurement of dopamine...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124797

    authors: Reymond MJ,Benotto W,Lemarchand-Béraud T

    更新日期:1987-06-01 00:00:00

  • Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1beta-induced hypothalamic pituitary adrenal axis responses.

    abstract::Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054629

    authors: Buller K,Xu Y,Dayas C,Day T

    更新日期:2001-02-01 00:00:00

  • Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers.

    abstract::Progesterone is readily reduced in humans to its A-ring metabolites, allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one) and pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one). The latter have been reported to have anxiolytic, hypnotic and anesthetic actions when administered to laboratory animals and (or) hum...

    journal_title:Neuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000126579

    authors: Freeman EW,Purdy RH,Coutifaris C,Rickels K,Paul SM

    更新日期:1993-10-01 00:00:00

  • Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary.

    abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125622

    authors: Lam KS,Srivastava G,Lechan RM,Lee T,Reichlin S

    更新日期:1990-11-01 00:00:00

  • Sex and estrous cycle variations of rat striatal dopamine uptake sites.

    abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126507

    authors: Morissette M,Di Paolo T

    更新日期:1993-07-01 00:00:00

  • Median eminence dopamine and serotonin neuronal activity. Temporal relationship to preovulatory prolactin and luteinizing hormone surges.

    abstract::Using a high-performance liquid chromatography (HPLC) system coupled with an electrochemical detector, the concentrations of dopamine (DA) and 5-hydroxytryptamine (5-HT) and their major specific metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA), respectively, were measured i...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125111

    authors: Kerdelhué B,Bojda F,Lesieur P,Pasqualini C,el Abed A,Lenoir V,Douillet P,Chiueh MC,Palkovits M

    更新日期:1989-02-01 00:00:00

  • Expression of Somatostatin Receptors 1-5 and Dopamine Receptor 2 in Lung Carcinoids: Implications for a Therapeutic Role.

    abstract:OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000381061

    authors: Kanakis G,Grimelius L,Spathis A,Tringidou R,Rassidakis GZ,Öberg K,Kaltsas G,Tsolakis AV

    更新日期:2015-01-01 00:00:00

  • Regional brain variations of tryptophan, monoamines, monoamine oxidase activity, plasma free and total tryptophan during the estrous cycle of the rat.

    abstract::Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122536

    authors: Kueng W,Wirz-Justice A,Menzi R,Chappuis-Arndt E

    更新日期:1976-01-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • The ontogeny of pit-1 expression in the human fetal pituitary gland.

    abstract::Pit-1 expression has been reported to be cell-type-specific in the adult human pituitary and in human pituitary adenomas. In contrast, studies of rodent fetal adenohypophysial development as well as mature rodent glands have indicated that the pit-1 mRNA is ubiquitously expressed and the protein is under translational...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126975

    authors: Puy LA,Asa SL

    更新日期:1996-04-01 00:00:00

  • Glucocorticoids increase excitotoxic injury and inflammation in the hippocampus of adult male rats.

    abstract:BACKGROUND/AIMS:Stress exacerbates neuron loss in many CNS injuries via the actions of adrenal glucocorticoid (GC) hormones. For some injuries, this GC endangerment of neurons is accompanied by greater immune cell activation in the CNS, a surprising outcome given the potent immunosuppressive properties of GCs. METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000367849

    authors: Sorrells SF,Munhoz CD,Manley NC,Yen S,Sapolsky RM

    更新日期:2014-01-01 00:00:00

  • 68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management.

    abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000472717

    authors: Lamarca A,Pritchard DM,Westwood T,Papaxoinis G,Nonaka D,Vinjamuri S,Valle JW,Manoharan P,Mansoor W

    更新日期:2018-01-01 00:00:00

  • In vivo and in vitro interference of phosphatidylserine liposomes on prolactin secretion in the rat.

    abstract::The effect of sonicated suspensions of phosphatidylserine (PS), an acidic phospholipid, was investigated on prolactin secretion utilizing in vivo and in vitro approaches. Acute and chronic administration of PS reduced plasma prolactin levels during different phases of circadian rhythms. The phospholipid was able to in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123261

    authors: Canonico PL,Annunziato L,Toffano G,Bernardini R,Stanzani S,Foti M,Clementi G,Drago F,Scapagnini U

    更新日期:1981-12-01 00:00:00

  • Comparative aspects of GH and metabolic regulation in lower vertebrates.

    abstract::In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000101029

    authors: Rousseau K,Dufour S

    更新日期:2007-01-01 00:00:00

  • Angiotensin II receptor development in the bed nucleus of the stria terminalis and other perihypothalamic brain regions of the female and male rat.

    abstract::Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126225

    authors: Grove KL,Cook VI,Speth RC

    更新日期:1992-08-01 00:00:00