Abstract：
:The effect of sonicated suspensions of phosphatidylserine (PS), an acidic phospholipid, was investigated on prolactin secretion utilizing in vivo and in vitro approaches. Acute and chronic administration of PS reduced plasma prolactin levels during different phases of circadian rhythms. The phospholipid was able to inhibit the plasma prolactin surge, which occurs in cycling female rats on the afternoon of proestrus. The time course of PS on prolactin secretion was characterized by a short latency (15 min) and a long duration of action (6 h). In rats with hypothalamic deafferentation PS partially reduced the increase of circulating prolactin induced by pretreatment with alpha-methyltyrosine. An inhibition of prolactin release was observed if anterior pituitary glands were incubated in presence of PS. This effect was prevented by the addition of the dopamine antagonist sulpiride to the medium. In conclusion, PS decreases prolactin secretion both in vivo and in vitro. The inhibition of the hormone secretion appears to be due to the action of PS at the level of the pituitary; however, a concomitant stimulatory action on the turnover of the tuberoinfundibular neurons cannot be ruled out.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Canonico PL,Annunziato L,Toffano G,Bernardini R,Stanzani S,Foti M,Clementi G,Drago F,Scapagnini Udoi
10.1159/000123261subject
Has Abstractpub_date
1981-12-01 00:00:00pages
358-62issue
6eissn
0028-3835issn
1423-0194journal_volume
33pub_type
杂志文章abstract：:Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126717
更新日期：1994-07-01 00:00:00
abstract：:To elucidate the mechanisms of the impaired pituitary response to growth hormone-releasing hormone (GHRH) in aged animals on a cellular basis, a reverse hemolytic plaque assay was performed on dispersed pituitary cells from young (8-month-old) and old (26-month-old) male F344 rats. The proportion of growth hormone (GH...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126799
更新日期：1994-12-01 00:00:00
abstract：:An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126645
更新日期：1994-02-01 00:00:00
abstract：:This study was carried out to clarify the central effects of neuropeptide Y (NPY) on gonadotropin and prolactin (PRL) release in the male rat and to evaluate the hypothesis that it may play a role in negative feedback regulation of gonadotropin secretion in the male. NPY (4 micrograms in 2 microliters 0.9% NaCl) or an...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126481
更新日期：1993-06-01 00:00:00
abstract：:Previous studies have shown that prepubertal olfactory bulbectomy will prevent the testicular regression associated with short photoperiod in golden hamsters. The gonadal regression which normally occurs in hamsters on short photoperiod is known to be due in part to an increased responsiveness of the reproductive neur...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124839
更新日期：1987-10-01 00:00:00
abstract：:The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma L...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125743
更新日期：1991-04-01 00:00:00
abstract：:Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123294
更新日期：1982-03-01 00:00:00
abstract：:The acute effects of hypothalamic electrical stimulation on the secretion of FSH and LH have been examined in anestrous and estrous ferrets. Basal levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were higher in the anestrous than in the estrous animals; the anestrous animals showed a more mark...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122674
更新日期：1977-01-01 00:00:00
abstract：:In man and other mammals, starvation is accompanied by a severe suppression of luteinizing hormone-releasing hormone (LHRH) and luteinizing-hormone (LH) secretion, which is caused by unknown alterations in hypothalamic functions. Prostaglandin E2 (PGE2), endorphins and testosterone (T) are know to be strongly involved...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124034
更新日期：1984-12-01 00:00:00
abstract：:Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126940
更新日期：1996-01-01 00:00:00
abstract：:A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124479
更新日期：1986-01-01 00:00:00
abstract：:The effect of catecholamines on plasma levels of immunoreactive ACTH (ACTHi), alpha-MSH (alpha-MSHi), beta-endorphin (beta-ENDi), arginine-vasopressin (AVPi) and of corticosterone (B) was studied in female rats. Intravenous infusion of the specific beta-adrenoceptor-stimulating agent l-isoproterenol in Wistar rats und...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123529
更新日期：1983-08-01 00:00:00
abstract：:The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123090
更新日期：1980-10-01 00:00:00
abstract：:The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122912
更新日期：1979-01-01 00:00:00
abstract：:Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of ex...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125182
更新日期：1989-06-01 00:00:00
abstract：:Distribution and properties of receptors for gonadotropin-releasing hormone (GnRH) were analyzed in the brain of adult male rats. Binding of the iodinated GnRH agonist Des-Gly10-(D-Ala6)-GnRH ethylamide was studied in hippocampus and anterior pituitary using three convergent approaches: quantitative autoradiography on...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125053
更新日期：1988-11-01 00:00:00
abstract：:The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123288
更新日期：1982-02-01 00:00:00
abstract：BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000493686
更新日期：2018-01-01 00:00:00
abstract：:We report the development of a radioimmunoassay for prepro-TRH(160-169) (PS4), a thyrotropin-releasing hormone (TRH) enhancing peptide, and its use in characterizing the effect of electroconvulsive seizures on the levels of this peptide in various brain regions of male Wistar rats. We found that electroconvulsive seiz...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127199
更新日期：1997-05-01 00:00:00
abstract：:As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123586
更新日期：1983-12-01 00:00:00
abstract：:Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122865
更新日期：1979-01-01 00:00:00
abstract：:The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000502776
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000505921
更新日期：2020-01-01 00:00:00
abstract：:The mu-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by mu-ORs are steroid hormone-dependent, few studies have shown how steroid hormones su...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000065953
更新日期：2002-10-01 00:00:00
abstract：:Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000126831
更新日期：1995-02-01 00:00:00
abstract：:The relationship between the steroid hormone 17 beta-estradiol and the muscarinic cholinergic receptors present in the preoptic area (POA), median hypothalamus and posterior hypothalamus of female rats was examined in vitro at various stages of the estrous cycle. Muscarinic receptors varied in a cyclic manner, specifi...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124103
更新日期：1985-05-01 00:00:00
abstract：:The push-pull perfusion technique, in conjunction with specific radioimmunoassays, was used to monitor the release of both arginine vasopressin (AVP) and oxytocin (OXT) within distinct limbic brain areas of conscious female rats. In pregnant rats near term, the release of AVP was greater than that of virgin rats in bo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125917
更新日期：1991-10-01 00:00:00
abstract：:The developmental pattern of hypophyseal luteinizing hormone (LH) during fetal and early postnatal life, and the capacity of fetal and early postnatal pituitaries to synthesize, release and store LH in the absence of any hypothalamic influence were investigated. Pituitary radioimmunoassayable LH was detectable by feta...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123923
更新日期：1984-05-01 00:00:00
abstract：:Previous reports have shown that dopamine (DA) in the zona incerta (ZI) has a stimulatory effect on gonadotrophin release. We have now investigated the possibility that steroids exert their feedback effects on the release of luteinizing hormone (LH) via catecholamine systems in the ZI. Since the same steroid regimes a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125708
更新日期：1991-02-01 00:00:00
abstract：:The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000354701
更新日期：2013-01-01 00:00:00
