Abstract:
:Previous reports have shown that dopamine (DA) in the zona incerta (ZI) has a stimulatory effect on gonadotrophin release. We have now investigated the possibility that steroids exert their feedback effects on the release of luteinizing hormone (LH) via catecholamine systems in the ZI. Since the same steroid regimes also stimulate female sexual behaviour, the possibility that the ZI is also involved in the control of sexual activity was investigated. Lesions in the ZI increased proceptive and receptive behaviour in oestrogen-primed ovariectomised rats that exhibited a low level of lordosis in a pre-lesion test and had no effect in receptive animals. Turnover rates (TR) of DA, noradrenaline (NA) and adrenaline were measured in the ZI, preoptic area (POA), arcuate nucleus (ARC), median eminence (ME) and ventromedial nucleus in ovariectomised rats treated 54 h before with either oil, oestradiol benzoate (OB) at 5, 10 or 50 micrograms/rat, or 5 micrograms/rat OB followed by 0.5 mg/rat progesterone (P) 48 h later. The TR as measured from the decline in concentration after alpha-methyltyrosine and changes in DOPAC concentration were correlated with the effect of the steroids on plasma LH and lordotic activity. Confirming previous reports, NA turnover in the POA and ME was increased, and DA turnover in the ME was decreased by steroids when they enhanced LH release. DA turnover in the ARC and ME was reduced when lordosis behaviour increased. Treatment with OB plus P stimulated LH release and sexual receptivity and at the same time significantly increased DA and NA turnover in the ZI. There was no correlation between these parameters after OB alone. This report shows that the DA system in the ZI may mediate the stimulatory effect of P on LH release in OB-primed rats but is not involved in the feedback effects of oestradiol alone. NA activity in the ZI is increased after OB plus P and may therefore also be concerned with stimulating LH release. The ZI is involved in the control of sexual behaviour, as electrolytic lesions in this area enhance receptivity and proceptivity, but the catecholamine systems in the ZI do not appear to mediate this control.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Wilson CA,James MD,Grierson JP,Hole DRdoi
10.1159/000125708subject
Has Abstractpub_date
1991-02-01 00:00:00pages
113-23issue
2eissn
0028-3835issn
1423-0194journal_volume
53pub_type
杂志文章abstract::Chronic administration of the mineralocorticoid deoxycorticosterone acetate (DOCA) induces a steady and robust increase in salt appetite and plasma Na(+) over the course of treatment. Interestingly, salt appetite behavior persists in rats even with elevated plasma Na(+) levels. Since there is evidence that the pathway...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054559
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000508376
更新日期:2020-05-04 00:00:00
abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126831
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) express insulin-like growth factor (IGF)-related factors [IGF1, IGF2; insulin receptor (IR)-A, IR-B; IGF-binding protein (IGFBP) 1-3] as well as somatostatin (SSTRs) and dopamine D2 receptors (D2Rs). OBJECTIVES:To (1) compare mRNA expression of IGF-rel...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000444280
更新日期:2016-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369070
更新日期:2014-01-01 00:00:00
abstract::In the paraventricular nucleus of normal or adrenalectomized colchicine-treated guinea pigs and rats, corticotropin-releasing factor (CRF), vasopressin (VP) and oxytocin (OX) immunoreactivities were compared. In the control animals, respective stainings for these three peptides are distinct. Adrenalectomy resulted in ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123595
更新日期:1983-12-01 00:00:00
abstract::Blood samples were removed via chronic intra-atrial cannulae every 15 min in female rats during the estrous cycle, the last week of pregnancy, parturition and suckling. Growth hormone (GH) secretion during the estrous cycle is characterized by episodic release, occurring approximately once hourly. The surges in GH inc...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122525
更新日期:1976-01-01 00:00:00
abstract::In addition to the magnocellular hypothalamic nuclei, arginine vasopressin (AVP)-containing neurons have also been identified in limbic structures, including the hippocampus and amygdala. In the present study, we compared the qualitative properties of the in vitro release of AVP from the dissected hypothalamus with th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126661
更新日期:1994-03-01 00:00:00
abstract::Hypothalamic dopamine (DA) tonically inhibits prolactin (PRL) release from the anterior pituitary gland. Transient escapes from this DA tone elicit a pronounced potentiation of the PRL-releasing action of secretagogues such as thyrotropin-releasing hormone (TRH). Previous evidence has suggested that modulation of Ca(2...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054456
更新日期:1999-07-01 00:00:00
abstract::After in vivo treatment, progesterone initially decreases tyrosine hydroxylase (TH) activity in the TIDA neurons, but subsequently increases TH activity with prolonged treatment. In order to explore the cellular mechanism for progesterone's effect, this study examined the acute inhibitory action of progesterone on TH ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000057336
更新日期:2002-05-01 00:00:00
abstract::We have investigated the hypothesis that administration of progesterone to estrogen-treated ovariectomized (OVX) rats enhances the stimulatory effects of neuropeptide Y (NPY) on the secretion of luteinizing hormone-releasing hormone (LHRH) from median eminence (ME) fragments in vitro. Adult rats were bilaterally OVX a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125651
更新日期:1990-12-01 00:00:00
abstract::Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509091
更新日期:2020-06-03 00:00:00
abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054299
更新日期:1998-01-01 00:00:00
abstract::Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054685
更新日期:2001-09-01 00:00:00
abstract::The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125536
更新日期:1990-07-01 00:00:00
abstract::Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000203644
更新日期:2009-01-01 00:00:00
abstract::Neuropeptide W (NPW) is a ligand of the recently deorphaned receptor GPR7. Intracerebroventricular injection of this peptide results in reduced serum growth hormone concentration. Using whole-cell patch clamp recordings from somatostatin (SS) neurons in the hypothalamic arcuate nucleus, identified post-hoc using singl...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000117577
更新日期:2008-01-01 00:00:00
abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122865
更新日期:1979-01-01 00:00:00
abstract::Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125138
更新日期:1989-04-01 00:00:00
abstract::Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124015
更新日期:1984-11-01 00:00:00
abstract::Pregnant rats were kept on an ethanol-containing (6% w/v) liquid diet from the 13th day of gestation and serum growth hormone (GH) levels were determined in the offspring after four different experimental paradigms. In controls, administration of cyproheptadine (a serotonin-blocking agent), or insulin, or exposure to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123910
更新日期:1984-04-01 00:00:00
abstract::The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122711
更新日期:1977-01-01 00:00:00
abstract::A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126847
更新日期:1995-03-01 00:00:00
abstract::An influence of thyroid status on the secretory activity of hypothalamic dopaminergic neurons was observed in adult rats and its involvement in the regulation of prolactin (PRL) secretion was examined. The secretory activity of the tuberoinfundibular dopaminergic (TIDA) neurons was evaluated by measurement of dopamine...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124797
更新日期:1987-06-01 00:00:00
abstract::Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000068653
更新日期:2003-02-01 00:00:00
abstract::The role of endogenous corticoids in fever responses caused by recombinant murine interleukin (IL)-1 beta and IL-6 was studied in adult male Wistar rats. Adrenalectomy diminished the development of fever after intracerebroventricular (icv) injection of these ILs and lowered body temperature. Intraperitoneal administra...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126682
更新日期:1994-04-01 00:00:00
abstract::Increases in the level of cAMP stimulate the secretion of GnRH from GT1 GnRH neuronal cells. We hypothesized that cyclic nucleotide phosphodiesterases (PDEs), the enzymes that hydrolyze cAMP, may constitute a negative feedback signaling mechanism for GnRH regulation by decreasing the level of cAMP. GT1 cells were show...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054386
更新日期:1998-12-01 00:00:00
abstract::The effect of frontal deafferentation of the medial basal hypothalamus on pro-opiomelanocortin (POMC) gene expression was studied in the intermediate lobe (IL) and anterior lobe (AL) of the pituitary gland in the absence and presence of corticosterone (CORT). The lesion in the basal hypothalamus removed neural inputs ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124936
更新日期:1988-04-01 00:00:00
abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127113
更新日期:1996-08-01 00:00:00
abstract::The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000354701
更新日期:2013-01-01 00:00:00