Abstract:
:Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was investigated in the cerebella of postnatal rats at different hormone levels. Animals were treated from postnatal day 4 until days 7, 14, and 21, by i.p. injection of 1 microg thyroxine (T(4))/10 g body weight/4 days, or p.o. with 100 microg 6-n-propyl-2-thyouracil (PTU)/10 g body weight/day. Control groups consisted of i.p. and p.o. vehicle controls and PTU/T(4)-treated animals. Measurement of serum fT(4), TSH as well as total T(3) and T(4) concentration of the cerebellar tissue indicated the changed thyroid status. nNOS extensively expressed in growing parallel fibers revealed by quantitative Western blot and layer analysis of immunohistochemically labeled coronal sections. Simultaneously, the cGMP concentration increased and the distribution of cGMP-immunoreactive (cGMP-IR) material in Purkinje cell perikarya and in the molecular layer expanded during cerebellar development. T(4) increased nNOS and cGMP level, and accelerated the development of nNOS-IR parallel fibers and cGMP-IR molecular layer. In contrast, PTU retarded the development by decreasing nNOS and cGMP concentration and slowing down layer formation. A single dose of T(4) could rescue the PTU-induced changes. Results suggest that the contribution of nNOS- NO/cGMP signaling in thyroid hormone regulated structural maturation of the cerebellum. The possible involvement of neurotrophins, calcium, and apoptotic events in this process was discussed.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Serfozo Z,de Vente J,Elekes Kdoi
10.1159/000203644subject
Has Abstractpub_date
2009-01-01 00:00:00pages
337-50issue
3eissn
0028-3835issn
1423-0194pii
000203644journal_volume
89pub_type
杂志文章abstract:BACKGROUND/AIMS:Tryptophan is the precursor of serotonin and niacin (vitamin B3). The latter is critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin-producing neuroendocrine tumors (NETs). Niacin deficiency may lead to severe symptoms including pellagra. In patients...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125873
更新日期:1991-08-01 00:00:00
abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126605
更新日期:1993-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122372
更新日期:1975-01-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1983-06-01 00:00:00
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更新日期:1994-04-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1985-08-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1977-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000126098
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000101693
更新日期:2007-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000341810
更新日期:2013-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123548
更新日期:1983-09-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124762
更新日期:1987-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125111
更新日期:1989-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123011
更新日期:1980-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126648
更新日期:1994-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123529
更新日期:1983-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125387
更新日期:1990-05-01 00:00:00
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doi:10.1159/000439434
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-08-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2020-06-22 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124775
更新日期:1987-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123902
更新日期:1984-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123886
更新日期:1984-03-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123579
更新日期:1983-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126539
更新日期:1993-08-01 00:00:00
abstract::A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00