Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells.

abstract：:Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might...

journal_title：Neuroendocrinology

authors： Marchetti B,Cioni M

更新日期：1988-09-01 00:00:00

abstract：AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...

journal_title：Neuroendocrinology

authors： Rapa I,Votta A,Felice B,Righi L,Giorcelli J,Scarpa A,Speel EJ,Scagliotti GV,Papotti M,Volante M

更新日期：2015-01-01 00:00:00

abstract：:Brain corticosteroid receptors, the type 1 mineralocorticoid receptor (MR) and the type 2 glucocorticoid receptor (GR), are involved in the regulation of neuroendocrine and behavioral responses during ongoing and stressful conditions. To further investigate the role of MR in these responses, we treated male Wistar rat...

journal_title：Neuroendocrinology

authors： Reul JM,Probst JC,Skutella T,Hirschmann M,Stec IS,Montkowski A,Landgraf R,Holsboer F

更新日期：1997-03-01 00:00:00

abstract：:Molecules of astrocyte origin influence gonadotropin-releasing hormone (GnRH) release and GnRH neuronal growth and differentiation. Furthermore, type 1 astrocytes express steroid receptors, presenting the possibility that steroid actions on GnRH neurons might occur via astrocytes. Utilizing GT1-7 cells, a GnRH-secreti...

journal_title：Neuroendocrinology

authors： Zwain IH,Arroyo A,Amato P,Yen SS

更新日期：2002-06-01 00:00:00

abstract：:This study was carried out to clarify the central effects of neuropeptide Y (NPY) on gonadotropin and prolactin (PRL) release in the male rat and to evaluate the hypothesis that it may play a role in negative feedback regulation of gonadotropin secretion in the male. NPY (4 micrograms in 2 microliters 0.9% NaCl) or an...

journal_title：Neuroendocrinology

authors： Reznikov AG,McCann SM

更新日期：1993-06-01 00:00:00

abstract：:The effects of the dopamine (DA) receptor antagonist metoclopramide on the plasma thyroid stimulating hormone (TSH) and prolactin (PRL) levels were studied in 8 patients with subclinical hypothyroidism (defined as absence of clinical signs of hypothyroidism with normal thyroid hormone levels, normal or slightly increa...

journal_title：Neuroendocrinology

authors： Lombardi G,Iodice M,Miletto P,Merola B,Panza N,Annunziato L

更新日期：1986-01-01 00:00:00

abstract：:Hypothalamic dopamine (DA) tonically inhibits prolactin (PRL) release from the anterior pituitary gland. Transient escapes from this DA tone elicit a pronounced potentiation of the PRL-releasing action of secretagogues such as thyrotropin-releasing hormone (TRH). Previous evidence has suggested that modulation of Ca(2...

journal_title：Neuroendocrinology

authors： del Mar Hernández M,García Ferreiro RE,García DE,Hernández ME,Clapp C,Martínez de la Escalera G

更新日期：1999-07-01 00:00:00

abstract：:The possible implication of the amygdaloid central nucleus (ACE) of the rat in the control of ACTH secretion in response to immobilization stress was assessed. The ACTH secretion, in response to stress and/or bilateral lesions of the ACE, was correlated with the serotoninergic activity in specific hypothalamic and amy...

journal_title：Neuroendocrinology

authors： Beaulieu S,Di Paolo T,Barden N

更新日期：1986-01-01 00:00:00

abstract：:It is known that the neonatal treatment of rats with monosodium L-glutamate (MSG) induces several metabolic abnormalities, resulting in enhanced adiposity and hyperleptinemia. Our study was designed to explore the consequences of MSG-induced chronic hyperleptinemia on adrenal sensitivity to the inhibitory effect of ex...

journal_title：Neuroendocrinology

authors： Perelló M,Gaillard RC,Chisari A,Spinedi E

更新日期：2003-09-01 00:00:00

abstract：:The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...

journal_title：Neuroendocrinology

authors： Wray S,Hoffman G

更新日期：1986-01-01 00:00:00

abstract：:Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...

journal_title：Neuroendocrinology

authors： Bouillé C,Baylé JD

更新日期：1978-01-01 00:00:00

abstract：:An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...

journal_title：Neuroendocrinology

authors： Layton BS,Lafontaine S,Renaud LP

更新日期：1981-01-01 00:00:00

abstract：:The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...

journal_title：Neuroendocrinology

authors： Vincent SR,Hökfelt T,Wu JY

更新日期：1982-02-01 00:00:00

abstract：:17 alpha-hydroxyprogesterone (up to 200 mug/day) and 11 beta-hydroxyandrostenedione (up to 500 mug) had no effect on PMS-induced ovulation in intact immature rats. 10 mug/day of testosterone propoinate (TP) on days 28-30 of life decreased the percent of animals ovulating and the number of ova produced; this effect per...

journal_title：Neuroendocrinology

authors： Hagino N,Goldzieher JW

更新日期：1975-01-01 00:00:00

abstract：:The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...

journal_title：Neuroendocrinology

authors： Clattenburg RE,Montemurro DG,Bruni JE

更新日期：1975-01-01 00:00:00

abstract：:The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...

journal_title：Neuroendocrinology

authors： Grosvenor CE

更新日期：1984-07-01 00:00:00

abstract：:Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...

journal_title：Neuroendocrinology

authors： Medina VM,Dawson-Basoa ME,Gintzler AR

更新日期：1993-09-01 00:00:00

abstract：:Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...

journal_title：Neuroendocrinology

authors： Demas GE

更新日期：2002-09-01 00:00:00

abstract：:There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent ...

journal_title：Neuroendocrinology

authors： Cicero TJ,O'Connor LH,Bell RD

更新日期：1987-08-01 00:00:00

abstract：:His-dTrp-Ala-Trp-dPhe,Lys-NH2(GHRP-6) is a synthetic compound that releases GH in a dose-response and specific manner in several species and that may well be related to an endogenous compound of similar structure. The aim of this study was to investigate the in vivo GH responses to GHRP-6 in pentobarbital anesthetized...

journal_title：Neuroendocrinology

authors： Mallo F,Alvarez CV,Benitez L,Burguera B,Coya R,Casanueva FF,Dieguez C

更新日期：1993-01-01 00:00:00

abstract：:Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...

journal_title：Neuroendocrinology

authors： Deauseault D,Giroux D,Wood CE

更新日期：2000-05-01 00:00:00

abstract：:Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulat...

journal_title：Neuroendocrinology

authors： Garthwaite TL,Hagen TC

更新日期：1979-01-01 00:00:00

abstract：:The parenchymal cells of the pars intermedia (PI) and corticotrophs of the pars distalis (PD) synthesize pro-opiomelanocortin (POMC), which, through posttranslational processing, gives rise to a group of structurally related peptides, including MSHs, ACTH, CLIP, LPHs and endorphins. We investigated the control of rele...

journal_title：Neuroendocrinology

authors： Kraicer J,Gajewski TC,Moor BC

更新日期：1985-11-01 00:00:00

abstract：:In addition to its traditional role as a circulating vasoactive peptide, vasopressin (VP) has been shown to play significant roles in central cardiovascular processing. The recent description of VP receptors within the subfornical organ (SFO) has suggested this circumventricular organ (CVO) as a potential locus for fe...

journal_title：Neuroendocrinology

authors： Smith PM,Ferguson AV

更新日期：1997-08-01 00:00:00

abstract：:Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...

journal_title：Neuroendocrinology

authors： Morel G,Chayvialle JA,Kerdelhue B,Dubois PM

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:The amygdala receives afferent sensory input and processes information related to hydromineral balance. Angiotensin acts on and through the amygdala to stimulate thirst and sodium appetite. In addition, different angiotensins seem to play a role in cognition and learning mechanisms by acting on and through t...

journal_title：Neuroendocrinology

authors： Staschewski J,Kulisch C,Albrecht D

更新日期：2011-01-01 00:00:00

abstract：:The release of the decapeptide gonadotropin-releasing hormone (GnRH) from neuroterminals in the median eminence varies depending upon the stage of development, time of day, reproductive season, and day of the ovarian cycle. With respect to the biosynthetic events responsible for such alterations in GnRH release, we ha...

journal_title：Neuroendocrinology

authors： Gore AC

更新日期：1998-10-01 00:00:00

abstract：:The concentrations in plasma of the biologically active endogenous peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) have not been measured during development or in female rats. By radioimmunoassay, we found that Tyr-MIF-1-like immunoreactivity (Tyr-MIF-1-LI) was first consistently detectable in plasma when the rat was 5 days o...

journal_title：Neuroendocrinology

authors： Kastin AJ,Fabre L,Brown MM,Olson RD

更新日期：1992-12-01 00:00:00

abstract：:Studies were undertaken to investigate the nature of receptors involved in the prolactin-releasing action of histamine in male rats. The increase of plasma prolactin levels induced by third-ventricle injection of histamine was blocked by intraventricular injection of ranitidine, an H2-antagonist, but not by systemic a...

journal_title：Neuroendocrinology

authors： Donoso AO,Zárate MB,Seltzer A

更新日期：1983-06-01 00:00:00

abstract：:The hypothalamic preoptic area (POA) was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Initiation of POA stimulation was followed witin 10-20 min by large increases in plasma levels of prolactin (PRL). The stimulation-induced discharges of PRL were consistently observed in...

journal_title：Neuroendocrinology

authors： Malven PV

更新日期：1975-01-01 00:00:00