Evidence that serotonin stimulates a prolactin-releasing factor in the rat.

Abstract:

:Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulation of plasma PRL levels, respectively. Fluoxetine, a serotonin reuptake inhibitor, plus 5-hydroxytryptophan, the immediate precursor of serotonin, markedly stimulated both plasma PRL and plasma PRF-like activity. Neither fluoxetine, 5-hydroxytryptophan, nor the combination directly stimulated PRL release from rat pituitary tissue in vitro. We conclude that serotonergic stimulation augments PRL release via a PRF.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Garthwaite TL,Hagen TC

doi

10.1159/000122925

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

215-20

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

29

pub_type

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