Abstract:
:Introduction The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol on arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as food intake, sexual receptivity and lordosis behavior. Objective To assess GPER distribution in the rat hypothalamus. Methods GPER immunoreactivity was assessed in different anatomical subdivisions of five selected hypothalamic regions of young adult male and cycling female rats: the arcuate nucleus, the lateral hypothalamus, the paraventricular nucleus, the supraoptic nucleus and the ventromedial hypothalamic nucleus. GPER immunoreactivity was colocalized with NeuN as a marker of mature neurons, GFAP as a marker of astrocytes and CC1 as a marker of mature oligodendrocytes. Results GPER immunoreactivity was detected in hypothalamic neurons, astrocytes and oligodendrocytes. Sex and regional differences and changes during the estrous cycle were detected in the total number of GPER immunoreactive cells and in the proportion of neurons, astrocytes and oligodendrocytes that were GPER immunoreactive. Conclusions These findings suggest that estrogenic regulation of hypothalamic function through GPER may be different in males and in females and may fluctuate during the estrous cycle in females.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Marraudino M,Carrillo B,Bonaldo B,Llorente R,Campioli E,Garate I,Pinos H,Garcia-Segura LM,Collado P,Grassi Ddoi
10.1159/000509583subject
Has Abstractpub_date
2020-06-22 00:00:00eissn
0028-3835issn
1423-0194pii
000509583pub_type
杂志文章abstract:BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to ki...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000227806
更新日期:2009-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124871
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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doi:10.1159/000124134
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journal_title:Neuroendocrinology
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doi:10.1159/000125920
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pub_type: 杂志文章,评审
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journal_title:Neuroendocrinology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1159/000123886
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054548
更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1159/000122489
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更新日期:1992-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124581
更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1159/000125222
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pub_type: 杂志文章
doi:10.1159/000123299
更新日期:1982-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125111
更新日期:1989-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125408
更新日期:1990-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000332128
更新日期:2012-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124905
更新日期:1988-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124205
更新日期:1985-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123892
更新日期:1984-03-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00