Thyroxine 5'-deiodinase and thyroid hormone metabolism in intermediate and neural lobes of rat posterior pituitary.

Abstract:

:We have found thyroxine 5'-deiodinase in rat posterior pituitary. The isozyme pattern was different in intermediate and neural lobes. The former contained only type I enzyme. In the neural lobe, in euthyroidism only type I was found while in hypothyroidism type II was a prominent form. Since type II 5'-deiodinase has a high affinity for thyroxine and is a more tissue-specific isozyme than type I, our results suggest there may be a previously unrecognized role of thyroid hormone in posterior pituitary physiology.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Tanaka K,Murakami M,Greer MA

doi

10.1159/000124871

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

494-8

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

46

pub_type

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