Abstract:
:Histamine (HA) stimulates the release of the pro-opiomelanocortin (POMC)-derived peptides ACTH, beta-endorphin (beta-END), beta-lipotropin and alpha-melanocyte-stimulating hormone, and HA is involved in the mediation of the stress-induced release of these peptides. The effect of HA is indirect and may involve the hypothalamic regulating factors, corticotropin-releasing hormone (CRH) and/or arginine-vasopressin (AVP). We studied the effect of immunoneutralization with specific antisera against CRH or AVP on the response of ACTH and beta-END to HA, restraint stress, CRH, AVP or a posterior pituitary extract in male rats. Intracerebroventricular infusion of HA (34-540 nmol) increased the plasma levels of ACTH and beta-END immunoreactivity (beta-ENDir) in a dose-dependent manner. Pretreatment with antiserum to CRH or AVP prevented the ACTH response to 270 nmol HA and inhibited the beta-ENDir response by 30-60%. One to five minutes of restraint stress caused an increase in the plasma levels of ACTH and beta-ENDir. The increase was dependent on the duration of stress exposure. Pretreatment with CRH antiserum abolished the ACTH response to 5 min of restraint stress and inhibited the beta-ENDir response by 60%. Immunoneutralization with AVP antiserum had only half the inhibitory effect of that seen with CRH antiserum. CRH (100 pmol i.v.) increased the plasma levels of ACTH and beta-ENDir. This effect was abolished by pretreatment with CRH antiserum, whereas pretreatment with AVP antiserum prevented the CRH-induced ACTH release and inhibited the beta-ENDir response by 50%. AVP (24-800 pmol i.v.) stimulated ACTH and beta-ENDir in a dose-dependent manner. CRH and AVP antisera each prevented the effect of AVP (800 pmol) on ACTH secretion, whereas the beta-ENDir response to AVP was only inhibited by about 60% by the antisera. An extract of the posterior pituitary gland administered in a dose corresponding to 0.15 or 0.5 pituitary equivalents had no effect on ACTH secretion, while 1.0 pituitary equivalent increased the ACTH concentration in plasma. This effect was abolished by AVP antiserum. The posterior pituitary extract caused a dose-dependent rise in plasma beta-ENDir which might be due to an unavoidable contamination of the posterior pituitary extract by a small amount of beta-END from the intermediate lobe. Consistent with this view, AVP antiserum had no effect on the rise in the plasma concentration of beta-ENDir following administration of the posterior pituitary extract.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Kjaer A,Knigge U,Bach FW,Warberg Jdoi
10.1159/000126258subject
Has Abstractpub_date
1992-09-01 00:00:00pages
419-28issue
3eissn
0028-3835issn
1423-0194journal_volume
56pub_type
杂志文章abstract::Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical mu agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in additio...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125762
更新日期:1991-05-01 00:00:00
abstract::In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124748
更新日期:1987-04-01 00:00:00
abstract::Brain sexual differentiation is mediated through testosterone, which acts during the perinatal period in the form of both 5alpha-dihydrotestosterone and estradiol. In order to gain insight into the molecular mechanisms involved, we studied induction of c-fos, an index of functional neuronal activation, in the 2-day-ol...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054657
更新日期:2001-06-01 00:00:00
abstract::It has been recently demonstrated that luteinizing hormone-releasing hormone (LHRH) can inhibit LHRH release by the hypothalamus, suggesting an ultrashort feedback of LHRH on LHRH neurons. In order to test this hypothesis, immunocytochemical localization of LHRH was conducted in the preoptic area of the rat brain. Con...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124861
更新日期:1987-11-01 00:00:00
abstract::Prolactin (PRL) secretion from the anterior pituitary is tonically controlled by the activity of the hypothalamic tuberoinfundibular dopaminergic (TIDA) system. Changes in TIDA activity have been associated with the decrease in basal PRL levels shown by hamsters exposed to a short-day photoperiod. Potential concurrent...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127153
更新日期:1996-12-01 00:00:00
abstract::In the Siberian hamster the pituitary content of bioassayable MSH has been shown to be seasonally variable, being greater during the long days of spring and summer than during the short days of autumn and winter. Similar changes in the pituitary content of both bioassayable MSH and immunoreactive alpha MSH can be indu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123019
更新日期:1980-05-01 00:00:00
abstract:BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000493686
更新日期:2018-01-01 00:00:00
abstract::Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125222
更新日期:1989-08-01 00:00:00
abstract::The involvement of histaminergic transmission in the rapid and sustained plasma ACTH and corticosterone (CORT) responses induced in conscious rats by intra-arterial infusions of 25 micrograms.kg-1 Escherichia coli lipopolysaccharide (LPS) was investigated. LPS challenge produced a rapid and transient increase (+ 62%) ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126961
更新日期:1996-03-01 00:00:00
abstract::Hypothalamic norepinephrine (NE) and dopamine content was studied in dogs with spontaneous and iatrogenic hypercortisolism and in untreated normal dogs. The concentration of NE in the hypothalamus was subnormal in 4 of 8 dogs with pituitary-dependent hyperadrenocorticism (PDH), whereas long-term administration of cort...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123158
更新日期:1981-04-01 00:00:00
abstract::Bilateral adrenalectomy (ADX) leads to increased ACTH synthesis and secretion. It is thought that endogenous glucocorticoids exert a feedback mechanism at both pituitary and brain levels. The present study has been performed in order to determine the effect of ADX on the release of hypothalamic neuropeptides with cort...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125713
更新日期:1991-02-01 00:00:00
abstract::Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126583
更新日期:1993-11-01 00:00:00
abstract::As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123586
更新日期:1983-12-01 00:00:00
abstract::Previous studies indicate that 7 days after testicular administration of naloxone, serum testosterone (T) concentration and basal T secretion in vitro decrease significantly. In neonatal rats, short-term (2 h) intratesticular treatment with 0.3 micrograms (D-Met2-Pro5)-enkephalinamide suppresses steroidogenesis. In th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126242
更新日期:1992-09-01 00:00:00
abstract::Previous work has demonstrated that physiological concentrations of 17beta-estradiol can protect the female rat brain against middle cerebral artery occlusion (MCAO)-induced ischemic damage. The present study examined whether therapeutic doses of the clinically relevant selective estrogen receptor modulator (SERM), ta...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000068332
更新日期:2003-01-01 00:00:00
abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126605
更新日期:1993-12-01 00:00:00
abstract::The functions of oxytocin in the female are thought to be confined to the processes of milk ejection and parturition. In this study the role of oxytocin in the body's response to stressful stimuli has been examined. Physical immobilization of rats and forced swimming caused large increases in the secretion of the horm...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123566
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND/AIM:The mode of action of the somatostatin analog octreotide on neuro-endocrine tumour proliferation is largely unknown. Overexpression of the proto-oncogene Akt/PKB (protein kinase B) has been demonstrated in certain neuro-endocrine tumours: Akt activates downstream proteins including mTOR and p70S6K, which...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000111501
更新日期:2008-01-01 00:00:00
abstract::The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123577
更新日期:1983-11-01 00:00:00
abstract::Lewis (LEW) and Fischer 344 (F344) rats differ in responsiveness of the hypothalamo-pituitary-adrenocortical (HPA) axis as well as in their behavioral responses to drugs of abuse. The present experiments were conducted to compare hypothalamic corticotropin-releasing factor (CRF), plasma adrenocorticotropic hormone (AC...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126940
更新日期:1996-01-01 00:00:00
abstract::A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054429
更新日期:1999-04-01 00:00:00
abstract::Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122441
更新日期:1975-01-01 00:00:00
abstract::The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123518
更新日期:1983-07-01 00:00:00
abstract::A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124479
更新日期:1986-01-01 00:00:00
abstract::The effect of altering gamma-aminobutyric acid (GABA) activity on growth hormone (GH) secretion of freely moving chronically cannulated male rats was studied. Systemic injection of the GABA agonist muscimol (2 mg/kg i.v.) inhibited the anticipated secretory episode. Increasing brain GABA levels by gamma-acetylenic-GAB...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124031
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000341810
更新日期:2013-01-01 00:00:00
abstract::Observations of long standing have suggested that the 'stress' of chair restraint inhibits the GnRH pulse generator in normal female monkeys while this phenomenon is rarely observed in ovariectomized animals. The role of the ovary in the response of the GnRH pulse generator to the stress of insulin hypoglycemia was in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126291
更新日期:1992-11-01 00:00:00
abstract::Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-fe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000155137
更新日期:2008-01-01 00:00:00
abstract::Acute electrolytic stimulation of the median raphe (MR) nucleus (MR Stim) between 13:00 and 16:00 h on proestrus blocked ovulation in 10 of the 21 rats tested, whereas all sham-treated (MR Sham, no current) animals ovulated normally (n = 12). MR Stim at 16:00 h on proestrus in individual cannulated rats 'turned off' t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122884
更新日期:1979-01-01 00:00:00
abstract::Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126225
更新日期:1992-08-01 00:00:00