Abstract:
:It has been recently demonstrated that luteinizing hormone-releasing hormone (LHRH) can inhibit LHRH release by the hypothalamus, suggesting an ultrashort feedback of LHRH on LHRH neurons. In order to test this hypothesis, immunocytochemical localization of LHRH was conducted in the preoptic area of the rat brain. Contacts between endings and neuronal cell bodies staining for LHRH were observed. This direct interaction between LHRH neurons might be well the morphological basis for an autoregulation of the LHRH system in the rat brain.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Pelletier Gdoi
10.1159/000124861subject
Has Abstractpub_date
1987-11-01 00:00:00pages
457-9issue
5eissn
0028-3835issn
1423-0194journal_volume
46pub_type
杂志文章abstract:BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000109664
更新日期:2008-01-01 00:00:00
abstract::The in vitro release of LHRH from hypothalami of adult male rats (intact, 5-day castrates, 5-day castrates replaced with various doses of testosterone) was measured under basal conditions and after the addition of KCl, the opiate antagonist naloxone or the opiate agonist DAGO to the perifusion medium. Hypothalami from...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124662
更新日期:1986-01-01 00:00:00
abstract::The facilitation of sexual receptivity by oxytocin (OT) in female rats is related to the regulation of oxytocin receptors (OTR) by ovarian steroids in the ventromedial nuclei (VMN) of the hypothalamus. In a previous study, we have shown that estradiol benzoate (EB) causes a twofold increase in OTR binding in the VMN. ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126125
更新日期:1992-03-01 00:00:00
abstract::Intestinal gluconeogenesis is a recently described function in intestinal glucose metabolism. In particular, the intestine contributes around 20-25% of total endogenous glucose production during fasting. Intestinal gluconeogenesis appears to regulate energy homeostasis via a neurally mediated mechanism linking the ent...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369070
更新日期:2014-01-01 00:00:00
abstract::The known occurrence of opiates in the adrenals stimulated us to determine whether Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), an endogenous peptide that can act as an antiopiate, is present in these glands and whether adrenalectomy affects its concentrations in plasma. The presence of Tyr-MIF-1 in the adrenals of the rat was sh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126403
更新日期:1993-03-01 00:00:00
abstract::The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H3 receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats wi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054402
更新日期:1999-01-01 00:00:00
abstract::The effect of altering gamma-aminobutyric acid (GABA) activity on growth hormone (GH) secretion of freely moving chronically cannulated male rats was studied. Systemic injection of the GABA agonist muscimol (2 mg/kg i.v.) inhibited the anticipated secretory episode. Increasing brain GABA levels by gamma-acetylenic-GAB...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124031
更新日期:1984-12-01 00:00:00
abstract::Glucocorticoid hormones have important effects on brain function in the context of acute and chronic stress. Many of these are mediated by the glucocorticoid receptor (GR). GR has transcriptional activity which is highly context-specific and differs between tissues and even between cell types. The outcome of GR-mediat...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000499659
更新日期:2019-01-01 00:00:00
abstract::An initial study was performed to ascertain the effects of anisomycin, a reversible inhibitor of protein synthesis, on pulsatile luteinizing hormone (LH) release in adult, ovarietomized (OVX) rats. For this experiment, rats OVX 3-4 weeks earlier were fitted with indwelling atrial cannulae. On the next day (approximate...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125195
更新日期:1989-07-01 00:00:00
abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124998
更新日期:1988-08-01 00:00:00
abstract::Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000089749
更新日期:2005-01-01 00:00:00
abstract::The effect of estrogen on prolactin (PRL) synthesis at a single-cell level was studied by in situ hybridization and immunohistochemistry. Long-term estrogen treatment increased PRL-containing cells from 10-20% of total cell population to 80-90%, as revealed by immunohistochemistry. PRL mRNA containing cells also incre...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124493
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The amygdala receives afferent sensory input and processes information related to hydromineral balance. Angiotensin acts on and through the amygdala to stimulate thirst and sodium appetite. In addition, different angiotensins seem to play a role in cognition and learning mechanisms by acting on and through t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000328128
更新日期:2011-01-01 00:00:00
abstract::The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124164
更新日期:1985-08-01 00:00:00
abstract::The present study was undertaken in order to better characterize the functional state of anterior pituitary gland in young and old rats by using prolactin secretion and incorporation of radioactive phosphate into phosphatidylinositol (PI) as markers. The in vitro incorporation of radiolabeled phosphate into anterior p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124714
更新日期:1987-02-01 00:00:00
abstract::Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122441
更新日期:1975-01-01 00:00:00
abstract::In this study, radiolabeled recombinant rat interleukin-1 beta (r125I-IL-1 beta) was used to localize and characterize IL-1 beta binding in rat hypothalamus and pituitary gland by quantitative autoradiography. The ability of this ligand to bind to type I IL-1 receptor was first tested on murine lymphoma cells (EL-4). ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127026
更新日期:1995-10-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the patho...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000455233
更新日期:2017-01-01 00:00:00
abstract::The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124516
更新日期:1986-01-01 00:00:00
abstract::The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000495806
更新日期:2019-01-01 00:00:00
abstract::Pathologies involving the pituitary stalk (PS) are generally revealed by the presence of diabetes insipidus. The availability of MRI provides a major diagnostic contribution by enabling the visualization of the site of the culprit lesion, especially when it is small. However, when only an enlarged PS is found, the eti...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000506641
更新日期:2020-01-01 00:00:00
abstract::The hypophysial portal vessels and anterior pituitary glands of adult male rats were surgically exposed, cannulated and infused for 1 min with saline, growth hormone-releasing factor (GH-RF), and dbcAMP. After cessation of infusion, anterior pituitary glands were collected at 1, 5, 15, 30 or 60 min for electron micros...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122421
更新日期:1975-01-01 00:00:00
abstract::The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagon...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126516
更新日期:1993-07-01 00:00:00
abstract::Neuroanatomical attempts have been made to determine the synapses between luteinizing hormone-releasing hormone (LHRH)-containing neurons and substance P (SP)-containing neurons in the hypothalamus of female rats. Wheat germ agglutinin was injected into the septo-preoptic area (SPA) and found to be incorporated into c...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125724
更新日期:1991-03-01 00:00:00
abstract::Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123294
更新日期:1982-03-01 00:00:00
abstract::Corticotropin-releasing factor (CRF) has been characterized on the basis of its intrinsic activity to release corticotropin from cultured rat anterior pituitary cells. Injected in intact rats, CRF increases adrenocorticotropic hormone (ACTH) release. Endogenous CRF-like immunoreactivity was detected in the cytoplasm a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125186
更新日期:1989-06-01 00:00:00
abstract::We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125920
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,多中心研究
doi:10.1159/000472717
更新日期:2018-01-01 00:00:00
abstract::The injection of purified alpha-bungarotoxin (alpha-BTX), an antagonist of the muscle nicotinic cholinergic receptors, into the third ventricle (3rd V) of ovariectomized rats decreased the frequency of pulses of luteinizing hormone (LH) but had no significant effect on the amplitude or nadir of LH secretion. Approxima...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125153
更新日期:1989-05-01 00:00:00
abstract::Peptidyl-glycine alpha-amidation activity has been detected in human cerebrospinal fluid (CSF) and in several regions of the central nervous system. Activity was monitored by measuring conversion of mono-125I-D-Tyr-Val-Gly into mono-125I-D-Tyr-Val-NH2. The alpha-amidation activity in CSF is dependent on molecular oxyg...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124223
更新日期:1985-12-01 00:00:00