Opioid receptor subtype involvement in maternal behavior in lactating rats.

Abstract:

:Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical mu agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in addition to morphine, to disrupt maternal behavior in primiparous lactating rats following intracerebroventricular (i.c.v.) infusions in order to characterize opioid receptor subtype involvement in maternal behavior in the female rat. Virgin, Sprague-Dawley rats were mated and implanted with lateral ventricle cannulae on days 13-15 of gestation. On postpartum day 5, mothers were tested for maternal behavior 30 min after i.c.v. vehicle infusion (5 microliters). On day 6, rats received one of the following opioid receptor agonists 30 min before testing: beta-endorphin (mu/epsilon receptor subtype; 0.29, 0.72, 1.45, 2.9 nmol), DAGO (mu; 0.29, 0.72, 1.45, 2.9 nmol), morphine (mu; 0.29, 0.72, 1.45, 2.9, 14.5 nmol), DPDPE (delta; 2.9, 29 nmol), U50488H (kappa l; 2.9, 29, 145 nmol) and SKF10047 (sigma; 2.9, 29, 145 nmol). Only activation of mu opioid receptors dose-dependently disrupted maternal behavior in primiparous lactating rats. DPDPE, U50488 and SKF10047 had no discernible effect on maternal behavior. DAGO, a highly selective mu agonist, was even more potent than beta-endorphin and morphine in disrupting maternal behavior suggesting that maternal behavior is regulated by opioids interacting with the mu opioid receptor.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Mann PE,Kinsley CH,Bridges RS

doi

10.1159/000125762

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

487-92

issue

5

eissn

0028-3835

issn

1423-0194

journal_volume

53

pub_type

杂志文章
  • Gene transfer of vasostatin, a calreticulin fragment, into neuroendocrine tumor cells results in enhanced malignant behavior.

    abstract::Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000089749

    authors: Liu M,Imam H,Oberg K,Zhou Y

    更新日期:2005-01-01 00:00:00

  • Facilitation of sexual receptivity in the female rat by a fragment of the LHRH decapeptide, Ac-LHRH.

    abstract::The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. A...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123503

    authors: Dudley CA,Vale W,Rivier J,Moss RL

    更新日期:1983-06-01 00:00:00

  • The release of prolactin in the lactating rat: effect of chloroquine.

    abstract::The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123957

    authors: Grosvenor CE

    更新日期:1984-07-01 00:00:00

  • Hippocampal estrogen receptor-alpha splice variant TADDI in the human brain in aging and Alzheimer's disease.

    abstract:BACKGROUND/AIMS:Estrogen receptor-alpha (ER alpha) splice variants are important for understanding estrogen effects on the brain and estrogen therapy pitfalls. We addressed the question whether a novel ER alpha splice variant TADDI is expressed at the protein level in the human brain and whether it changes in relation ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000158573

    authors: Ishunina TA,Swaab DF

    更新日期:2009-01-01 00:00:00

  • Hypoglycemic 'stress' and gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: role of the ovary.

    abstract::Observations of long standing have suggested that the 'stress' of chair restraint inhibits the GnRH pulse generator in normal female monkeys while this phenomenon is rarely observed in ovariectomized animals. The role of the ovary in the response of the GnRH pulse generator to the stress of insulin hypoglycemia was in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126291

    authors: Chen MD,O'Byrne KT,Chiappini SE,Hotchkiss J,Knobil E

    更新日期:1992-11-01 00:00:00

  • Interactions of delta 9-tetrahydrocannabinol (THC) with hypothalamic neurotransmitters controlling luteinizing hormone and prolactin release.

    abstract::The effects of delta 9-tetrahydrocannabinol (THC) on hypothalamic norepinephrine (NE) and dopamine (DA) turnover and hypothalamic serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) and LHRH content preceding and during a progesterone- (P) induced LH and prolactin (PRL) surge were investigated in ovariectomized est...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123576

    authors: Steger RW,DePaolo L,Asch RH,Silverman AY

    更新日期:1983-11-01 00:00:00

  • Role of serotonin in feedback control of hypothalamic-pituitary-testicular complex in male rats.

    abstract::Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122791

    authors: Naumenko EV,Shishkina GT

    更新日期:1978-01-01 00:00:00

  • Evidence for a modulatory role of catecholamines on hypothalamic somatostatin in the rat.

    abstract::The influence of catecholamines (CA) on hypothalamic somatostatin (HPT-SRIF) was investigated in rats by using several drugs which interfere with brain CA metabolism. Depletion of brain CA stores by alpha-methyl-rho-tyrosine (AMT) increased HPT-SRIF, while augmented brain CA levels following L-dopa administration decr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123374

    authors: Torres I,Guaza C,Fernandez-Durango R,Borrell J,Charro AL

    更新日期:1982-01-01 00:00:00

  • Potential Clinical Use of Kisspeptin.

    abstract::Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000439133

    authors: Prague JK,Dhillo WS

    更新日期:2015-01-01 00:00:00

  • Memory performance and the growth hormone/insulin-like growth factor axis in elderly: a positron emission tomography study.

    abstract::The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000084872

    authors: Arwert LI,Veltman DJ,Deijen JB,Lammertsma AA,Jonker C,Drent ML

    更新日期:2005-01-01 00:00:00

  • A role for neurokinin B in pulsatile GnRH secretion in the ewe.

    abstract::The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this tachykinin in the control of GnRH secretion. In a number of species, NKB neurons in the arcuate nucleus also produce two other neuropept...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000355285

    authors: Goodman RL,Coolen LM,Lehman MN

    更新日期:2014-01-01 00:00:00

  • MYC up-regulation confers resistance to everolimus and establishes vulnerability to cyclin dependent kinase inhibitors in pancreatic neuroendocrine neoplasms cells.

    abstract::Introduction Dysregulation of the mTORC1-dependent pathways in pancreatic neuroendocrine neoplasms (PanNENs) underlies the introduction of the mTORC1 inhibitor everolimus as treatment of advanced progressive PanNENs. Although everolimus significantly increases progression free survival, most patients acquire secondary...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000509865

    authors: Terracciano F,Capone A,Montori A,Rinzivillo M,Partelli S,Panzuto F,Pilozzi E,Arcidiacono PG,Sette C,Capurso G

    更新日期:2020-07-02 00:00:00

  • Median raphe stimulation and sham procedures inhibit the LH surge.

    abstract::Acute electrolytic stimulation of the median raphe (MR) nucleus (MR Stim) between 13:00 and 16:00 h on proestrus blocked ovulation in 10 of the 21 rats tested, whereas all sham-treated (MR Sham, no current) animals ovulated normally (n = 12). MR Stim at 16:00 h on proestrus in individual cannulated rats 'turned off' t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122884

    authors: Barofsky AL

    更新日期:1979-01-01 00:00:00

  • Preoptic LH-RH and somatostatin in the rat median eminence. An experimental light and electron microscopic immunocytochemical study.

    abstract::Glass microknife lesions and immunocytochemistry were used to evaluate luteinizing hormone-releasing hormone (LH-RH)- and somatostatin (SS)-immunoreactive pathways from the preoptic region to the rat median eminence. Cuts were so placed that axons of more caudally located neurons in the periventricular hypothalamic ar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123886

    authors: Jew JY,Léránth C,Arimura A,Palkovits M

    更新日期:1984-03-01 00:00:00

  • Preferential distribution of C-terminal fragments of [hydroxyproline9]LHRH in the rat hippocampus and olfactory bulb.

    abstract::Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126539

    authors: Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon C

    更新日期:1993-08-01 00:00:00

  • Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.

    abstract::Brain corticosteroid receptors, the type 1 mineralocorticoid receptor (MR) and the type 2 glucocorticoid receptor (GR), are involved in the regulation of neuroendocrine and behavioral responses during ongoing and stressful conditions. To further investigate the role of MR in these responses, we treated male Wistar rat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127272

    authors: Reul JM,Probst JC,Skutella T,Hirschmann M,Stec IS,Montkowski A,Landgraf R,Holsboer F

    更新日期:1997-03-01 00:00:00

  • Effects of neutralization of circulating melatonin and N-acetylserotonin on plasma prolactin levels.

    abstract::The effect of pinealectomy or immunization against melatonin (Mel) and N-acetylserotonin (NAS) on plasma prolactin (Prl) levels was studied in rats following pineal stimulation induced by blinding or exposure to short photoperiods (1 h light and 23 h darkness daily). Blinding alone or together with pinealectomy or imm...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122650

    authors: Niles LP,Brown GM,Grota LJ

    更新日期:1977-01-01 00:00:00

  • Autoradiographic identification of prolactin binding sites in rat median eminence.

    abstract::Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of ex...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125182

    authors: Barton AC,Lahti RA,Piercey MF,Moore KE

    更新日期:1989-06-01 00:00:00

  • Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats.

    abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122865

    authors: Davis PG,Barfield RJ

    更新日期:1979-01-01 00:00:00

  • Phase relation between episodic fluctuations of spontaneous locomotor activity and plasma corticosterone in rats with suprachiasmatic nuclei lesions.

    abstract::Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123200

    authors: Watanabe K,Hiroshige T

    更新日期:1981-07-01 00:00:00

  • Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes.

    abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126605

    authors: Heyward PM,Chen C,Clarke IJ

    更新日期:1993-12-01 00:00:00

  • Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro.

    abstract:BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000341810

    authors: Somnay Y,Chen H,Kunnimalaiyaan M

    更新日期:2013-01-01 00:00:00

  • In vivo and in vitro effects of arginine-vasopressin receptor antagonists on the hypothalamic-pituitary-adrenal axis in the rat.

    abstract::Arginine-vasopressin (AVP) is regarded as a potent stimulator of pituitary adrenocorticotropin (ACTH) secretion and participates therefore in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis function in concert with the physiological activator of the axis, hypothalamic corticotropin-releasing hormone (C...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126787

    authors: Bernardini R,Chiarenza A,Kamilaris TC,Renaud N,Lempereur L,Demitrack M,Gold PW,Chrousos GP

    更新日期:1994-11-01 00:00:00

  • Penfluridol decreases secretagogue-induced TSH, GH, and LH secretion in vitro: a possible role for calcium-calmodulin.

    abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123548

    authors: Schettini G,Judd AM,MacLeod RM

    更新日期:1983-09-01 00:00:00

  • Fos expression in the female rat brain during the proestrous prolactin surge and following mating.

    abstract::A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054429

    authors: Yang S,Lee Y,Voogt JL

    更新日期:1999-04-01 00:00:00

  • Intramedullary blood vessels of the spinal cord express V1a vasopressin receptors: visualization by a biotinylated ligand.

    abstract::The neurohypophysial peptide hormone [Arg8]vasopressin (AVP) has well documented pressor effects in the periphery. These are mediated by vasopressin receptors (VPRs) of the V1a subtype, expressed by vascular smooth muscle cells, which induce vascular contraction when activated. AVP also has effects on the vasculature ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127060

    authors: Sermasi E,Howl J,Pyner S,Wheatley M,Coote JH

    更新日期:1995-12-01 00:00:00

  • Bombesin-like immunoreactivity in the forebrain and pituitary and regulation of anterior pituitary hormone release by bombesin in goldfish.

    abstract::The presence and distribution of bombesin (BBS)/gastrin-releasing peptide (GRP)-like immunoreactivity (IR) was examined in the goldfish pituitary and forebrain. BBS/GRP-like IR nerve fibres were consistently observed throughout the pituitary neurointermediate lobe (NIL); occasionally, BBS/GRP-like material was localiz...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126858

    authors: Himick BA,Peter RE

    更新日期:1995-04-01 00:00:00

  • Infusion of prepro-VIP derived peptides in man: effect on secretion of prolactin.

    abstract::Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,0...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125071

    authors: Yiangou Y,Gill JS,Chrysanthou BJ,Burrin J,Bloom SR

    更新日期:1988-12-01 00:00:00

  • Further studies on the effects of testosterone on hypothalamic LH-RH and serum LH levels: castration-induced delayed response.

    abstract::We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124188

    authors: Kalra PS

    更新日期:1985-09-01 00:00:00

  • The Evolution of Neuroendocrine Tumor Treatment Reflected by ENETS Guidelines.

    abstract::In 2016, the third version of guidelines for the diagnosis and treatment of neuroendocrine tumors (NETs) has been published by the European Neuroendocrine Tumor Society (ENETS). These guidelines reflect the progress in treatment of NETs, and by comparing the newest guidelines with the first guidelines of 2001, this pr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000486096

    authors: Zandee WT,de Herder WW

    更新日期:2018-01-01 00:00:00