Abstract：
:Observations of long standing have suggested that the 'stress' of chair restraint inhibits the GnRH pulse generator in normal female monkeys while this phenomenon is rarely observed in ovariectomized animals. The role of the ovary in the response of the GnRH pulse generator to the stress of insulin hypoglycemia was investigated in both intact and ovariectomized rhesus monkeys. Following an overnight fast the animals, previously habituated to restraint, were placed in primate chairs and GnRH pulse generator activity monitored electrophysiologically. Insulin-induced reductions in mean blood glucose concentrations of 10-40% of control values interrupted pulse generator activity in intact monkeys but were without effect in ovariectomized animals. With larger reductions in blood glucose, pulse generator activity was interrupted in both groups but the inhibition was twice as long in intact than in ovariectomized animals. The reduced responsiveness of ovariectomized animals to insulin hypoglycemia was significantly reversed by estradiol replacement. Naloxone administration did not prevent the hypoglycemia-induced inhibition of pulse generator activity in either intact or ovariectomized rhesus monkeys. It is concluded that hypoglycemic 'stress' inhibits the GnRH pulse generator by a nonopioidergic mechanism and that ovarian products, most probably estradiol, exacerbate this effect.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Chen MD,O'Byrne KT,Chiappini SE,Hotchkiss J,Knobil Edoi
10.1159/000126291subject
Has Abstractpub_date
1992-11-01 00:00:00pages
666-73issue
5eissn
0028-3835issn
1423-0194journal_volume
56pub_type
杂志文章abstract：:The role of endogenous corticoids in fever responses caused by recombinant murine interleukin (IL)-1 beta and IL-6 was studied in adult male Wistar rats. Adrenalectomy diminished the development of fever after intracerebroventricular (icv) injection of these ILs and lowered body temperature. Intraperitoneal administra...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126682
更新日期：1994-04-01 00:00:00
abstract：:Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical mu agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in additio...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125762
更新日期：1991-05-01 00:00:00
abstract：:Accumulating evidence in rodents suggests that a prolactin locally synthesized and released within the brain can act together with that taken up from the circulation to modulate neuroendocrine responses. The present study was designed to identify the regional patterns of prolactin expression in the adult and developin...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000114643
更新日期：2008-01-01 00:00:00
abstract：:A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126847
更新日期：1995-03-01 00:00:00
abstract：:In order to search for candidate genes related to pituitary adenoma aggressiveness, the present investigation was intended to compare the mRNA expression profile from a pool of four nonfunctional pituitary adenomas (NFPA) with a spinal cord metastasis of a nonfunctional pituitary carcinoma (MNFPC). The metallothionein...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000092521
更新日期：2005-01-01 00:00:00
abstract：:The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127019
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. OBJECTIVE:We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcome...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000500687
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND/AIMS:The medial amygdala (MeA) responds to olfactory stimuli and alters reproductive physiology. However, the neuronal circuit that relays signals from the MeA to the reproductive axis remains poorly defined. This study aimed to test whether MeA kisspeptin (MeAKiss) neurons in male mice are sensitive to sexu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000496106
更新日期：2019-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125294
更新日期：1989-12-01 00:00:00
abstract：:A prolactin (PRL) surge occurs in the female rat during proestrus in response to elevated estradiol levels. The elevated release of ovarian steroids on the day of proestrus is also associated with sexual receptivity. Mating triggers twice-daily PRL surges that supplant the proestrous PRL surge and are responsible for ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054429
更新日期：1999-04-01 00:00:00
abstract：:The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122357
更新日期：1975-01-01 00:00:00
abstract：:Pregnant rats were kept on an ethanol-containing (6% w/v) liquid diet from the 13th day of gestation and serum growth hormone (GH) levels were determined in the offspring after four different experimental paradigms. In controls, administration of cyproheptadine (a serotonin-blocking agent), or insulin, or exposure to ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123910
更新日期：1984-04-01 00:00:00
abstract：:Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126555
更新日期：1993-09-01 00:00:00
abstract：:It is not known where melatonin acts to influence the neuroendocrine axis of seasonally breeding mammals. However, since the pars tuberalis (PT) contains the highest density of melatonin receptors, this adenohypophyseal subdivision is a potential target. Gonadotropes are the only immunocytochemically detectable adenoh...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127247
更新日期：1997-10-01 00:00:00
abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000499693
更新日期：2019-01-01 00:00:00
abstract：:The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124164
更新日期：1985-08-01 00:00:00
abstract：:Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124922
更新日期：1988-03-01 00:00:00
abstract：:Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122350
更新日期：1975-01-01 00:00:00
abstract：:The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000076631
更新日期：2004-02-01 00:00:00
abstract：:Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124638
更新日期：1986-01-01 00:00:00
abstract：:In goldfish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1, 2, 3, and 6 often result in an antagonist in goldfish, an observation w...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126706
更新日期：1994-06-01 00:00:00
abstract：:Previous studies have indicated that 30 min of swimming in room temperature water is a potent stimulus for the secretion of beta-endorphin (beta E) from the intermediate lobe (IL) of the pituitary in rodents. Repeated daily challenge with this paradigm over days to weeks leads to a progressive increase in proopiomelan...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126553
更新日期：1993-09-01 00:00:00
abstract：:Blood samples were removed via chronic intra-atrial cannulae every 15 min in female rats during the estrous cycle, the last week of pregnancy, parturition and suckling. Growth hormone (GH) secretion during the estrous cycle is characterized by episodic release, occurring approximately once hourly. The surges in GH inc...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122525
更新日期：1976-01-01 00:00:00
abstract：:The relationship between the steroid hormone 17 beta-estradiol and the muscarinic cholinergic receptors present in the preoptic area (POA), median hypothalamus and posterior hypothalamus of female rats was examined in vitro at various stages of the estrous cycle. Muscarinic receptors varied in a cyclic manner, specifi...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124103
更新日期：1985-05-01 00:00:00
abstract：:The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124008
更新日期：1984-11-01 00:00:00
abstract：UNLABELLED:Mediobasal hypothalamic slices of adult ovariectomized (OVX) rats treated or not with 17 beta-estradiol (E2) were superfused in buffered (pH 7.2) Locke medium containing bacitracin. A 6-min pulse of K+ (56 m M) was less effective in releasing luteinizing hormone releasing hormone (LH-RH) from mediobasal hypo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123883
更新日期：1984-02-01 00:00:00
abstract：:Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126717
更新日期：1994-07-01 00:00:00
abstract：:Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054339
更新日期：1998-06-01 00:00:00
abstract：:A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125853
更新日期：1991-07-01 00:00:00
abstract：:The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125562
更新日期：1990-08-01 00:00:00
