Evidence for a dopaminergic mechanism for the prolactin inhibitory effect of atrial natriuretic factor.

Abstract:

:Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses the inhibitory effect when given after ANF infusion. The PRL-inhibiting effect is absent as well following inhibition of tyrosine hydroxylase activity. These results suggest that ANF acts centrally at least in part via an interaction with endogenous dopaminergic systems and further suggests potent neuromodulatory actions of the peptide within the hypothalamus.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Samson WK,Bianchi R,Mogg R

doi

10.1159/000124922

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

268-71

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

47

pub_type

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