Abstract:
:Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses the inhibitory effect when given after ANF infusion. The PRL-inhibiting effect is absent as well following inhibition of tyrosine hydroxylase activity. These results suggest that ANF acts centrally at least in part via an interaction with endogenous dopaminergic systems and further suggests potent neuromodulatory actions of the peptide within the hypothalamus.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Samson WK,Bianchi R,Mogg Rdoi
10.1159/000124922subject
Has Abstractpub_date
1988-03-01 00:00:00pages
268-71issue
3eissn
0028-3835issn
1423-0194journal_volume
47pub_type
杂志文章abstract::The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats. Lordosis behavior triggered by...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123983
更新日期:1984-09-01 00:00:00
abstract::We have found thyroxine 5'-deiodinase in rat posterior pituitary. The isozyme pattern was different in intermediate and neural lobes. The former contained only type I enzyme. In the neural lobe, in euthyroidism only type I was found while in hypothyroidism type II was a prominent form. Since type II 5'-deiodinase has ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124871
更新日期:1987-12-01 00:00:00
abstract::Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125138
更新日期:1989-04-01 00:00:00
abstract::Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054304
更新日期:1998-02-01 00:00:00
abstract::Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123294
更新日期:1982-03-01 00:00:00
abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127068
更新日期:1996-05-01 00:00:00
abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124998
更新日期:1988-08-01 00:00:00
abstract::The studies reported in this paper were undertaken to investigate the effect of chronic (10 day) alcohol consumption on female pituitary-gonadal function. The immature female rat model treated with pregnant mare serum gonadotropin (PMSG) was used since it results in a highly reproducible luteinizing hormone (LH) surge...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124834
更新日期:1987-10-01 00:00:00
abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127113
更新日期:1996-08-01 00:00:00
abstract::The involvement of histaminergic transmission in the rapid and sustained plasma ACTH and corticosterone (CORT) responses induced in conscious rats by intra-arterial infusions of 25 micrograms.kg-1 Escherichia coli lipopolysaccharide (LPS) was investigated. LPS challenge produced a rapid and transient increase (+ 62%) ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126961
更新日期:1996-03-01 00:00:00
abstract::In pituitary cells, c-fos transcription induced by releasing hormones and growth factors results from enhanced initiation of transcription, and sustained elongation of transcripts beyond the first intron. We studied the regulatory role of the first intron of the mouse c-fos gene for the control of its transcription in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054606
更新日期:2000-12-01 00:00:00
abstract::The effect of glucocorticoids on corticotropin-releasing factor (CRF) gene expression was studied by combination of in situ hybridization histochemistry and steroid implantation. Dexamethasone micropellets, implanted around the hypothalamic paraventricular nucleus (PVN), caused total inhibition of the hybridizable CRF...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124846
更新日期:1987-10-01 00:00:00
abstract::Somatostatin receptors on lactotroph cells of the anterior pituitary are positively regulated by estradiol. In the present work, we investigated whether estradiol regulation of somatostatin receptors also occurred in the female rat brain. 125I-Tyr0-DTrp8-somatostatin (125I-SRIF: 780 Ci/mM) was used as a ligand. Female...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126234
更新日期:1992-08-01 00:00:00
abstract::Substance P (SP) is known to act on pituitary hormone release either at the hypothalamic level or directly at the pituitary level. In order to investigate whether SP is present in the pituitary gland and to localize the peptide at the cellular and subcellular levels, the immunocytological method was used. Rat pituitar...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123360
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000439434
更新日期:2016-01-01 00:00:00
abstract::The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. A...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123503
更新日期:1983-06-01 00:00:00
abstract::Primary cultures from fetal rat brain contain angiotensin II immunoreactivity in neurons. To study the origin of this immunoreactivity, primary cultures were incubated with [3H]-valine or [3H]-isoleucine. A time-dependent incorporation of radioactivity into immunoprecipitable angiotensin II was observed. Incubation of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123438
更新日期:1983-01-01 00:00:00
abstract::The mechanisms by which leptin influences energy homeostasis are not entirely understood. Several observations indicate that proopiomelanocortin (POMC) is involved in the regulation of food intake and may be a mediator of leptin action. To further study this interaction, a sensitive solution hybridization assay was us...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054499
更新日期:1999-12-01 00:00:00
abstract::In addition to the magnocellular hypothalamic nuclei, arginine vasopressin (AVP)-containing neurons have also been identified in limbic structures, including the hippocampus and amygdala. In the present study, we compared the qualitative properties of the in vitro release of AVP from the dissected hypothalamus with th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126661
更新日期:1994-03-01 00:00:00
abstract::Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122452
更新日期:1975-01-01 00:00:00
abstract::Increases in the level of cAMP stimulate the secretion of GnRH from GT1 GnRH neuronal cells. We hypothesized that cyclic nucleotide phosphodiesterases (PDEs), the enzymes that hydrolyze cAMP, may constitute a negative feedback signaling mechanism for GnRH regulation by decreasing the level of cAMP. GT1 cells were show...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054386
更新日期:1998-12-01 00:00:00
abstract::The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125562
更新日期:1990-08-01 00:00:00
abstract::We have investigated the effects of exposure to short-term constant light (LL) on the spontaneous, proestrous luteinizing hormone (LH) surge in the female rat. Exposure to LL during the 3 days preceding proestrus delayed and reduced the magnitude of the LH surge which was measured in blood samples taken from conscious...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123225
更新日期:1981-09-01 00:00:00
abstract::We have examined the spinal cord for the presence of glucocorticoid-binding sites. For this purpose, cytosol from the spinal cord of adrenalectomized rats was incubated with (3H)-dexamethasone. Maximal binding was obtained after 20 h of incubation at 0 degree C in the presence of 20 mM molybdate, whereas at 20 degrees...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124134
更新日期:1985-03-01 00:00:00
abstract::The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122357
更新日期:1975-01-01 00:00:00
abstract::[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125608
更新日期:1990-10-01 00:00:00
abstract::Studies were conducted to determine if the hypothermic effects of barbiturates were responsible for their ability to suppress luteinizing hormone (LH) secretion in rats following ovariectomy or treatment with gonadal steroids. In both ovariectomized rats and rats treated with estradiol and progesterone, pentobarbital ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124822
更新日期:1987-09-01 00:00:00
abstract::The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000076631
更新日期:2004-02-01 00:00:00
abstract::Serum prolactin was measured in lightly etherized rats between 4 and 5 a.m. and between 11 a.m. and 12 noon at various times after operation in intact rats and rats that had been operated on. Serum prolactin was elevated in the late nocturnal samples from intact rats and this elevation was prevented by pinealectomy. W...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122372
更新日期:1975-01-01 00:00:00
abstract::It is now well documented that various polyclonal antisera to the human growth hormone-releasing factor (hGHRF, somatocrinin) visualize in the brain by immunohistochemistry the classical hypothalamic hypophysiotropic neurons and also antigens present in otherwise characterized peptidergic neuronal systems. The nature ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125370
更新日期:1990-04-01 00:00:00