Abstract：
:Somatostatin receptors on lactotroph cells of the anterior pituitary are positively regulated by estradiol. In the present work, we investigated whether estradiol regulation of somatostatin receptors also occurred in the female rat brain. 125I-Tyr0-DTrp8-somatostatin (125I-SRIF: 780 Ci/mM) was used as a ligand. Female adult rats were ovariectomized and treated or not with estradiol benzoate (20 micrograms/day for 1 or 8 days). In female brains, 125I-SRIF binding, as assessed by film radioautography, was high in the basolateral amygdala, CA1 field and dentate gyrus of the hippocampus and locus coeruleus, moderate in the median habenula and deep layers all through the cortex. Castration or estradiol treatment did not modify 125I-SRIF binding in these regions. By light-microscopic radioautography, a subpopulation of 125I-SRIF-labeled cells was localized in the ventrolateral portion of the arcuate nucleus. Ovariectomy alone did not significantly affect the number and binding density of 125I-SRIF-labeled cells in the arcuate nucleus. However, estradiol treatment in ovariectomized animals significantly increased both parameters. Along the estrus cycle, the number of 125I-SRIF-labeled cells was not significantly modified but 125I-SRIF binding density was significantly higher in proestrus as compared to diestrus I, diestrus II and estrus. These results demonstrate that brain 125I-SRIF binding sites are positively regulated by estradiol only in the arcuate nucleus of the hypothalamus.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Slama A,Videau C,Kordon C,Epelbaum Jdoi
10.1159/000126234subject
Has Abstractpub_date
1992-08-01 00:00:00pages
240-5issue
2eissn
0028-3835issn
1423-0194journal_volume
56pub_type
杂志文章abstract：:Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054339
更新日期：1998-06-01 00:00:00
abstract：:The effect of intravertebral infusion of angiotensin II on cardiac vagal efferent activity was studied in anesthetized mongrel dogs. Unilateral infusion of doses of angiotensin II as low as 5 ng/kg/min inhibited basal vagal tone and also decreased the slope of the relationship between cardiac vagal efferent activity a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124120
更新日期：1985-06-01 00:00:00
abstract：:The aim of this study was to examine the occurrence of endogenous oscillations of Per1, Per2, Bmal1 and Rev-erbα genes in rat pineal explants and to investigate their regulation by adrenergic ligands. Our results show a significant and sustained rhythm of Per2,Bmal1 and Rev-erbα gene expression for up to 48 h in cultu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000327430
更新日期：2011-01-01 00:00:00
abstract：:The primary treatment of gastroenteropancreatic neuroendocrine tumors (GEPNETs) is surgery with curative intent or debulking of the tumor mass. In case of metastatic disease, cytoreductive options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatos...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000335018
更新日期：2013-01-01 00:00:00
abstract：:There is extensive evidence that serotonin (5-HT) is implicated in the neuroendocrine control regulating the secretion of several anterior pituitary hormones. It has also been reported that the posterior pituitary is necessary for prolactin (PRL) response to 5-HT as well as to suckling, in which 5-HT implication has b...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054381
更新日期：1998-11-01 00:00:00
abstract：:The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125294
更新日期：1989-12-01 00:00:00
abstract：:Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000095548
更新日期：2006-01-01 00:00:00
abstract：:The present study provides evidence of a novel neuronal pathway for the control of GnRH secretion involving bradykinin neurons. Bradykinin neurons were shown by immunohistochemistry to be densely localized in several regions of the brain including the cortex, hippocampus and supraoptic nucleus, as well as two regions ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054316
更新日期：1998-04-01 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive respo...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000328226
更新日期：2011-01-01 00:00:00
abstract：:The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later....
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127241
更新日期：1997-09-01 00:00:00
abstract：:We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125920
更新日期：1991-10-01 00:00:00
abstract：:In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I-induced prolactin (PRL) release is mediated by VIP. In this study, we investigate the mitotropic action of IGF-I and VIP on pituitary lactotr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000070900
更新日期：2003-05-01 00:00:00
abstract：:The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123389
更新日期：1982-10-01 00:00:00
abstract：:Chronic administration of the mineralocorticoid deoxycorticosterone acetate (DOCA) induces a steady and robust increase in salt appetite and plasma Na(+) over the course of treatment. Interestingly, salt appetite behavior persists in rats even with elevated plasma Na(+) levels. Since there is evidence that the pathway...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054559
更新日期：2000-06-01 00:00:00
abstract：:The modulatory actions of ovarian steroids on the norepinephrine (NE) induced alterations in luteinizing hormone (LH) secretion were examined in male and female rats. Long-term (4 weeks) castrated male and female rats bearing chronic third-ventricle cannulae were implanted with intra-atrial catheters. Animals were ble...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124581
更新日期：1986-01-01 00:00:00
abstract：:The effects of the dopamine (DA) receptor antagonist metoclopramide on the plasma thyroid stimulating hormone (TSH) and prolactin (PRL) levels were studied in 8 patients with subclinical hypothyroidism (defined as absence of clinical signs of hypothyroidism with normal thyroid hormone levels, normal or slightly increa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124603
更新日期：1986-01-01 00:00:00
abstract：:Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of ex...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125182
更新日期：1989-06-01 00:00:00
abstract：:We have examined the spinal cord for the presence of glucocorticoid-binding sites. For this purpose, cytosol from the spinal cord of adrenalectomized rats was incubated with (3H)-dexamethasone. Maximal binding was obtained after 20 h of incubation at 0 degree C in the presence of 20 mM molybdate, whereas at 20 degrees...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124134
更新日期：1985-03-01 00:00:00
abstract：:Dexras1, a newly identified member of the Ras superfamily of proteins, was discovered in AtT-20 corticotrope cells because its expression was induced in response to glucocorticoids (dexamethasone; Dex). As yet, the function of Dexras1 is unknown, but its rapid induction in response to glucocorticoids suggests the poss...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054691
更新日期：2001-10-01 00:00:00
abstract：:The in vitro release of LHRH from hypothalami of adult male rats (intact, 5-day castrates, 5-day castrates replaced with various doses of testosterone) was measured under basal conditions and after the addition of KCl, the opiate antagonist naloxone or the opiate agonist DAGO to the perifusion medium. Hypothalami from...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124662
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000472717
更新日期：2018-01-01 00:00:00
abstract：:To assess whether gonadotropin-releasing hormone (GnRH) release from the hypothalamus might be altered by hyperprolactinemia in the male rat, we measured in chronically hyperprolactinemic rats the pituitary GnRH receptor content and described the pattern of luteinizing hormone (LH) release during the postcastration ri...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124844
更新日期：1987-10-01 00:00:00
abstract：:In this study, radiolabeled recombinant rat interleukin-1 beta (r125I-IL-1 beta) was used to localize and characterize IL-1 beta binding in rat hypothalamus and pituitary gland by quantitative autoradiography. The ability of this ligand to bind to type I IL-1 receptor was first tested on murine lymphoma cells (EL-4). ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127026
更新日期：1995-10-01 00:00:00
abstract：:The differential role of porcine follicular fluid (pFF) in regulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release in vivo in situations of different gonadotropin releasing hormone (GnRH) backgrounds was studied. In experiment 1, 2-week ovariectomized rats injected intravenously with 4, 16 o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123891
更新日期：1984-03-01 00:00:00
abstract：:Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-fe...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000155137
更新日期：2008-01-01 00:00:00
abstract：:Serotonin and dopamine neurons have been shown to exert a stimulatory and inhibitory control, respectively, over pituitary release of beta-endorphin-like immunoreactivity (beta-END-LI). In the present study we sought to determine whether an interaction exists between these two reciprocal mechanisms regulating beta-END...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124439
更新日期：1986-01-01 00:00:00
abstract：:Allopregnanolone is a neuroactive steroid present in the brain, but also measurable in systemic circulation. It exhibits anxiolytic and anticonvulsant effects and is able to produce hyperphagia. Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported in obese subjects,...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000048228
更新日期：2002-02-01 00:00:00
abstract：:Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124638
更新日期：1986-01-01 00:00:00
abstract：:Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123292
更新日期：1982-02-01 00:00:00
abstract：:Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125951
更新日期：1991-11-01 00:00:00
