Abstract:
:The effect of intravertebral infusion of angiotensin II on cardiac vagal efferent activity was studied in anesthetized mongrel dogs. Unilateral infusion of doses of angiotensin II as low as 5 ng/kg/min inhibited basal vagal tone and also decreased the slope of the relationship between cardiac vagal efferent activity and systolic blood pressure. Intravenous and intracarotid infusion of similar doses of angiotensin II produced little or no inhibition of vagal tone. These results demonstrate directly that angiotensin II can act centrally to inhibit cardiac vagal efferent activity and provide additional evidence that the increase in blood pressure produced by intravertebral angiotensin II results, at least in part, from decreased vagal tone to the heart.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Potter EK,Reid IAdoi
10.1159/000124120subject
Has Abstractpub_date
1985-06-01 00:00:00pages
493-6issue
6eissn
0028-3835issn
1423-0194journal_volume
40pub_type
杂志文章abstract::Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125638
更新日期:1990-11-01 00:00:00
abstract::Neonatal rats exhibit a period of diminished pituitary and adrenocortical responses to stress during the first 2 weeks of life. Since thyroid hormones are known to affect brain development, modulation of these responses to stress by alterations in thyroid hormone status have been investigated in hypothyroid (Hypo) and...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125232
更新日期:1989-09-01 00:00:00
abstract::To determine whether the inhibitory effect of clonidine (CLON) on renin secretion is due in part to a direct action on the kidneys or due entirely to an action on the brain, the drug was administered intravenously in a dose of 30 microgram/kg to dogs in which the spinal cord had been transected in the cervical region....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122733
更新日期:1978-01-01 00:00:00
abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127068
更新日期:1996-05-01 00:00:00
abstract::The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000495806
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The amygdala receives afferent sensory input and processes information related to hydromineral balance. Angiotensin acts on and through the amygdala to stimulate thirst and sodium appetite. In addition, different angiotensins seem to play a role in cognition and learning mechanisms by acting on and through t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000328128
更新日期:2011-01-01 00:00:00
abstract::Molecules of astrocyte origin influence gonadotropin-releasing hormone (GnRH) release and GnRH neuronal growth and differentiation. Furthermore, type 1 astrocytes express steroid receptors, presenting the possibility that steroid actions on GnRH neurons might occur via astrocytes. Utilizing GT1-7 cells, a GnRH-secreti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000059434
更新日期:2002-06-01 00:00:00
abstract::Recent studies have shown that primary hypothyroidism induced in the rat was able to stimulate the biosynthesis of vasoactive intestinal peptide (VIP) in the anterior pituitary (AP). Since the AP VIP is known to stimulate prolactin (PRL) secretion through a paracrine and/or autocrine mechanism, it is interesting to hy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126842
更新日期:1995-02-01 00:00:00
abstract::The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this tachykinin in the control of GnRH secretion. In a number of species, NKB neurons in the arcuate nucleus also produce two other neuropept...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000355285
更新日期:2014-01-01 00:00:00
abstract::Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124149
更新日期:1985-07-01 00:00:00
abstract::In previous studies, we have shown that male Wistar rats exposed to a single inescapable stressor session (15 min restraint) exhibited 24 h later an anxiogenic-like behavior in the elevated plus-maze (EPM), which was reversed by inhibition of corticosterone (CS) synthesis with metyrapone (75 mg/kg i.p.) 3 h before str...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054643
更新日期:2001-04-01 00:00:00
abstract::The diuretic action of two new narcotic antagonists, oxilorphan and butorphanol, was studied in rats heterozygous for hereditary hypothalmic diabetes insipidus. Both drugs caused a prompt increase in urine volume and a decrease in urine osmolality with an associated decrease in urinary ADH excretion. The effects appea...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122444
更新日期:1975-01-01 00:00:00
abstract::Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000321683
更新日期:2010-01-01 00:00:00
abstract::We have suggested that gamma-aminobutyric acid (GABA) in the hypothalamus plays a tonic inhibitory role in the control of the luteinizing hormone (LH) release in intact male rats. To assess whether feedback from the testis alters the inhibitory GABAergic tone in the medial preoptic area (MPO) of male rats, an in vivo ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000066625
更新日期:2002-11-01 00:00:00
abstract::The present study investigates the role of melanotrope proopiomelanocortin-derived peptide in the interrenal stress response to different stressors in male gilthead sea bream, Sparus aurata. Plasma cortisol and acetyl salmon endorphin (acetyl s-EP), as well as pituitary acetyl s-EP contents, were measured during two s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054359
更新日期:1998-08-01 00:00:00
abstract::Pit-1 expression has been reported to be cell-type-specific in the adult human pituitary and in human pituitary adenomas. In contrast, studies of rodent fetal adenohypophysial development as well as mature rodent glands have indicated that the pit-1 mRNA is ubiquitously expressed and the protein is under translational...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126975
更新日期:1996-04-01 00:00:00
abstract::The aim of this study was to verify whether prolonged exposure of cultured rat anterior pituitary cells to high glucose can alter growth hormone (GH) release and responsiveness to secretagogues. Therefore, we cultured anterior pituitary cells obtained from normal male Sprague-Dawley rats in presence of normal (6 mM) o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125947
更新日期:1991-11-01 00:00:00
abstract::The studies reported in this paper were undertaken to investigate the effect of chronic (10 day) alcohol consumption on female pituitary-gonadal function. The immature female rat model treated with pregnant mare serum gonadotropin (PMSG) was used since it results in a highly reproducible luteinizing hormone (LH) surge...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124834
更新日期:1987-10-01 00:00:00
abstract::Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122452
更新日期:1975-01-01 00:00:00
abstract::Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122536
更新日期:1976-01-01 00:00:00
abstract::In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124748
更新日期:1987-04-01 00:00:00
abstract::There is extensive evidence that serotonin (5-HT) is implicated in the neuroendocrine control regulating the secretion of several anterior pituitary hormones. It has also been reported that the posterior pituitary is necessary for prolactin (PRL) response to 5-HT as well as to suckling, in which 5-HT implication has b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054381
更新日期:1998-11-01 00:00:00
abstract::Acute electrolytic stimulation of the median raphe (MR) nucleus (MR Stim) between 13:00 and 16:00 h on proestrus blocked ovulation in 10 of the 21 rats tested, whereas all sham-treated (MR Sham, no current) animals ovulated normally (n = 12). MR Stim at 16:00 h on proestrus in individual cannulated rats 'turned off' t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122884
更新日期:1979-01-01 00:00:00
abstract::Avian prolactin (PRL) secretion is regulated by vasoactive intestinal peptide (VIP) neurons residing in the infundibular nuclear complex (INF) of the hypothalamus. This VIPergic activity is modulated by stimulatory dopaminergic inputs. Dynorphin, serotonin (5-HT), dopamine (DA) and VIP all appear to stimulate PRL secr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000048236
更新日期:2002-03-01 00:00:00
abstract::Measurements of electrical activity and intracellular Ca(2+) levels were performed in perforated-patch clamped GH(3) cells to determine the contribution of large-conductance calcium-activated K(+) (BK) channels to action potential repolarization and size of the associated Ca(2+) oscillations. By examining the dependen...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000069509
更新日期:2003-03-01 00:00:00
abstract::Progesterone is readily reduced in humans to its A-ring metabolites, allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one) and pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one). The latter have been reported to have anxiolytic, hypnotic and anesthetic actions when administered to laboratory animals and (or) hum...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000126579
更新日期:1993-10-01 00:00:00
abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126186
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:Differences in the cardiovascular and hypothalamic-pituitary-adrenal (HPA) axis functions at high altitudes (HAs) between visitors to and natives of HA were examined. METHODS:The cardiovascular functions and peripheral oxygen saturation (SPO2) were monitored, and the cortisol awakening response (CAR) and nig...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000363367
更新日期:2014-01-01 00:00:00
abstract::Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000095548
更新日期:2006-01-01 00:00:00
abstract::In this study, radiolabeled recombinant rat interleukin-1 beta (r125I-IL-1 beta) was used to localize and characterize IL-1 beta binding in rat hypothalamus and pituitary gland by quantitative autoradiography. The ability of this ligand to bind to type I IL-1 receptor was first tested on murine lymphoma cells (EL-4). ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127026
更新日期:1995-10-01 00:00:00