Abstract：
:The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later. M. fermentans caused a significant depletion of corticotropin releasing hormone (CRH-41) content in the median eminence (ME), and elevation of serum ACTH and corticosterone (CS) levels, compared to control levels. Pretreatment with dexamethasone (DEX, 40 micrograms/kg) markedly inhibited M. fermentans-induced depletion of ME CRH-41 and the increase in serum ACTH and CS. Injection of the type II corticosteroid receptor antagonist RU-38486, but not the type 1 antagonist RU-28318, enhanced the adrenocortical response and completely abolished the inhibitory effect of DEX following M. fermentans. Injection of the catecholamine neurotoxin 6-hydroxydopamine into the ventral noradrenergic bundle, which significantly depleted hypothalamic norepinephrine content, or i.c.v. injection of the specific alpha 1-adrenergic receptor antagonist prazosin failed to affect the adrenocortical response to M. fermentans. In contrast, these agents markedly inhibited the adrenocortical response following i.c.v. injection of interleukin-1. I.c.v. administration of M. fermentans caused a significant elevation of hypothalamic levels of tumor necrosis factor-alpha (TNF alpha), determined by both bioassay and immunoassay. In rats treated with pentoxifylline, an inhibitor of TNF alpha synthesis, the adrenocortical response to M. fermentans was markedly inhibited. These findings suggest that: (1) M. fermentans-induced activation of the pituitary-adrenal axis, and the inhibitory effect of DEX on this response, are mediated by a reduction of CRH-41 release from the ME. (2) The feedback exerted by glucocorticoids is mediated by type II corticosteroid receptors. (3) In contrast to the adrenocortical response to interleukin-1 beta, the central noradrenergic system does not have an important role in mediating the adrenocortical response to M. fermentans. (4) Hypothalamic TNF alpha production is probably involved in mediating the adrenocortical activation following M. fermentans.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Wohlman A,Gallily R,Yirmiya R,Weidenfeld Jdoi
10.1159/000127241subject
Has Abstractpub_date
1997-09-01 00:00:00pages
221-8issue
3eissn
0028-3835issn
1423-0194journal_volume
66pub_type
杂志文章abstract：BACKGROUND:The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. OBJECTIVE:We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcome...
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doi：10.1159/000500687
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journal_title：Neuroendocrinology
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journal_title：Neuroendocrinology
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doi：10.1159/000125408
更新日期：1990-06-01 00:00:00
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doi：10.1159/000126555
更新日期：1993-09-01 00:00:00
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doi：10.1159/000124650
更新日期：1986-01-01 00:00:00
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doi：10.1159/000123579
更新日期：1983-11-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000126893
更新日期：1995-06-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000124172
更新日期：1985-08-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000123499
更新日期：1983-06-01 00:00:00
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doi：10.1159/000126995
更新日期：1995-08-01 00:00:00
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doi：10.1159/000123107
更新日期：1980-12-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000124585
更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000123891
更新日期：1984-03-01 00:00:00
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更新日期：1991-06-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123261
更新日期：1981-12-01 00:00:00
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doi：10.1159/000122384
更新日期：1975-01-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000123529
更新日期：1983-08-01 00:00:00
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更新日期：1998-02-01 00:00:00
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更新日期：1993-11-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124946
更新日期：1988-05-01 00:00:00
abstract：:Previous work has demonstrated that N-methyl-D-aspartate (NMDA) is capable of stimulating luteinizing hormone release in a variety of species. Interestingly, the ability of NMDA to stimulate luteinizing hormone release is significantly compromised in castrated male and female rats as compared to intact animals. The pu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126607
更新日期：1993-12-01 00:00:00
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journal_title：Neuroendocrinology
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doi：10.1159/000124725
更新日期：1987-03-01 00:00:00
abstract：:Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA trea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123299
更新日期：1982-03-01 00:00:00
abstract：:The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124516
更新日期：1986-01-01 00:00:00
abstract：:The arcuate nucleus-median eminence complex (AM) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. Those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary glan...
journal_title：Neuroendocrinology
pub_type： 杂志文章
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更新日期：1987-06-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126633
更新日期：1994-01-01 00:00:00
abstract：:Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...
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