Progesterone enhancement of lysergic acid diethylamide and levo-5-hydroxytryptophan stimulation of the copulatory response in the female rat.

Abstract:

:Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 micrograms/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (greater than or equal to 2.5 mg/kg). This effect was recently found to be enhanced by increasing doses of progesterone. In contrast, small doses of LSD (5-30 micrograms/kg) have been shown to increase LR activated by estrogen alone. The effects of various hormone treatments on the stimulatory action of LSD were tested in the present study. When the lordosis behavior was activated by estradiol benzoate (EB) alone (25 or 7 X 2 micrograms/kg), LR increased 10 min after injection of LSD in a dose of 10 micrograms/kg. There were no detectable effects in animals treated with estrogen alone when the dose of LSD was lowered to 1 microgram/kg. LSD in the latter dose gave an increased response, however, when LR was activated by EB (5 micrograms/kg) in combination with progesterone (4.0 mg/rat). An analogous study was conducted with L-5-HTP, after pretreatment with pargyline and R04-4602. Small doses of L-5-HTP (0.25 and 0.05 mg/kg) stimulated the LR and the influence of progesterone was the same as for small doses of LSD. Possible mechanisms underlying the observed influence of progesterone on serotonergic mechanisms involved in the lordosis behavior are discussed.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Sietnieks A,Meyerson BJ

doi

10.1159/000123499

subject

Has Abstract

pub_date

1983-06-01 00:00:00

pages

462-7

issue

6

eissn

0028-3835

issn

1423-0194

journal_volume

36

pub_type

杂志文章
  • Phase relation between episodic fluctuations of spontaneous locomotor activity and plasma corticosterone in rats with suprachiasmatic nuclei lesions.

    abstract::Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123200

    authors: Watanabe K,Hiroshige T

    更新日期:1981-07-01 00:00:00

  • Innate Obesity, Revealed by Selection Markers, Confers Significant Imprint of Hypothalamic Genes Controlling Energy Expenditure.

    abstract::The incidence of obesity is rapidly escalating and has reached epidemic proportions. In all species, including rodents, humans, and sheep, there is large variation in the degree of weight gain across individuals in response to an obesogenic environment. This individual variation is, at least in part, determined by inn...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000455232

    authors: Henry BA

    更新日期:2017-01-01 00:00:00

  • Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

    abstract::The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000080795

    authors: D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

    更新日期:2004-01-01 00:00:00

  • In vivo and in vitro regulation of pituitary transcription factor-1 (Pit-1) by changes in the hormone environment.

    abstract::Pituitary transcription factor-1 (Pit-1 or GHF-1) is a transcription factor specific to the anterior pituitary and is involved in the expression and regulation of the growth hormone (GH), prolactin (PRL) and thyroid-stimulating hormone (TSH) beta-subunit genes. The expression of these three genes can be modulated by c...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126930

    authors: González-Parra S,Chowen JA,García-Segura LM,Argente J

    更新日期:1996-01-01 00:00:00

  • Splenic denervation blocks leptin-induced enhancement of humoral immunity in Siberian hamsters (Phodopus sungorus).

    abstract::Nontropical rodents have evolved adaptations to maximize winter survival, including alterations in reproduction, energy balance and immunity. Short-day-housed Siberian hamsters display reductions in body fat and decreases in humoral immunity compared with long-day hamsters. The hormone leptin, secreted by adipose tiss...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000064527

    authors: Demas GE

    更新日期:2002-09-01 00:00:00

  • Glutamate receptor agonists modulate [Ca2+]i in isolated rat melanotropes.

    abstract::Although glutamate is the predominant excitatory amino acid in the vertebrate central nervous system (CNS) where it affects a variety of physiological processes and pathophysiological states, the role that glutamate receptors may play outside the CNS has not been clearly established. In the present study, the effects ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126995

    authors: Giovannucci DR,Stuenkel EL

    更新日期:1995-08-01 00:00:00

  • Models of gastroenteropancreatic neuroendocrine neoplasms - Current status and future directions.

    abstract::Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000509864

    authors: Detjen K,Hammerich L,Özdirik B,Demir M,Wiedenmann B,Tacke F,Jann H,Roderburg C

    更新日期:2020-07-02 00:00:00

  • New Molecular, Biological, and Immunological Agents Inducing Hypophysitis.

    abstract::Hypophysitis is a relatively rare disease that exerts a strong autoimmune component encompassing different etiologies. Immunomodulatory drugs, such as interferon-α, are known to rarely induce hypophysitis. In recent years, a large number of new biological and immunomodulatory agents have been introduced into clinical ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000480086

    authors: Angelousi A,Chatzellis E,Kaltsas G

    更新日期:2018-01-01 00:00:00

  • Pyridostigmine potentiates L-dopa- but not arginine- and galanin-induced growth hormone secretion in children.

    abstract::The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125536

    authors: Ghigo E,Bellone J,Imperiale E,Arvat E,Mazza E,Valetto MR,Boffano GM,Cappa M,Loche S,De Sanctis C

    更新日期:1990-07-01 00:00:00

  • Stimulation of prolactin secretion by neuroleptics in rats with medial basal hypothalamic lesions.

    abstract::The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123188

    authors: Cheung CY,Neill AC,Weiner RI

    更新日期:1981-06-01 00:00:00

  • Effects of progesterone on prolactin, hypothalamic beta-endorphin, hypothalamic substance P, and midbrain serotonin in guinea pigs.

    abstract::Unlike rats, but similar to primates, guinea pigs exhibit prolonged function of the corpus luteum and elevated progesterone secretion after ovulation. The gonadotropins, estrogen (E) and progesterone (P) have been examined throughout the guinea pig estrous cycle. However, neither prolactin secretion nor its regulation...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126897

    authors: Bethea CL,Hess DL,Widmann AA,Henningfeld JM

    更新日期:1995-06-01 00:00:00

  • Fetal development of delta-sleep-inducing-peptide-like immunoreactivity in hypothalamus of guinea pig with special regard to the prenatal colocalization with gonadotropin-releasing-hormone-like immunoreactivity.

    abstract::Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126098

    authors: Pu LP,Dubois PM

    更新日期:1992-01-01 00:00:00

  • Regional brain variations of tryptophan, monoamines, monoamine oxidase activity, plasma free and total tryptophan during the estrous cycle of the rat.

    abstract::Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122536

    authors: Kueng W,Wirz-Justice A,Menzi R,Chappuis-Arndt E

    更新日期:1976-01-01 00:00:00

  • Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats.

    abstract::Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125951

    authors: Mendelson SD,McEwen BS

    更新日期:1991-11-01 00:00:00

  • Positive feedback in hypogonadal female mice with preoptic area brain transplants.

    abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124998

    authors: Gibson MJ,Kokoris GJ,Silverman AJ

    更新日期:1988-08-01 00:00:00

  • Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms.

    abstract::The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000502776

    authors: Oka N,Kasajima A,Konukiewitz B,Sakurada A,Okada Y,Kameya T,Weichert W,Ishikawa Y,Suzuki H,Sasano H,Klöppel G

    更新日期:2020-01-01 00:00:00

  • Distribution of a renin-releasing factor in the central nervous system of the rat.

    abstract::We have previously shown that the serotonergic regulation of renin secretion from the kidneys is mediated by a renin-releasing factor (RRF) that is present in both plasma and hypothalamus. The present studies were designed to determine the distribution of RRF in the brain and peripheral tissues and to test whether RRF...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126170

    authors: Urban JH,Brownfield MS,Levine JE,Van de Kar LD

    更新日期:1992-05-01 00:00:00

  • The pineal gland and mammalian photoperiodism.

    abstract::The mammalian pineal gland appears to be a major endocrine component in the regulation of photoperiodic responses. The circadian pattern of secretion of the pineal hormone, melatonin, is regulated by the nervous system. Changes in photoperiod, acting via the nervous system, alter the temporal pattern of melatonin secr...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123579

    authors: Goldman BD,Darrow JM

    更新日期:1983-11-01 00:00:00

  • Comparative studies of prolactin secretion in estradiol-primed and normal male rats induced by ether stress, pimozide and TRH.

    abstract::The differences in plasma prolactin concentration between normal and estradiol-implanted male rats were compared after treatment with 3 different stimulating agents of prolactin secretion [ether anesthesia, pimozide (a "specific' dopaminergic receptor blocking agent) and TRH] using conscious, free-moving rats implante...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123087

    authors: Piercy M,Shin SH

    更新日期:1980-10-01 00:00:00

  • Dynamic studies of growth hormone and prolactin secretion in the female rat.

    abstract::Blood samples were removed via chronic intra-atrial cannulae every 15 min in female rats during the estrous cycle, the last week of pregnancy, parturition and suckling. Growth hormone (GH) secretion during the estrous cycle is characterized by episodic release, occurring approximately once hourly. The surges in GH inc...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122525

    authors: Saunders A,Terry LC,Audet J,Brazeau P,Martin JB

    更新日期:1976-01-01 00:00:00

  • Comparison between hypothalamic multiple-unit activity and corticotropic function after bilateral destruction of the hippocampus.

    abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122750

    authors: Bouillé C,Baylé JD

    更新日期:1978-01-01 00:00:00

  • The release of prolactin in the lactating rat: effect of chloroquine.

    abstract::The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123957

    authors: Grosvenor CE

    更新日期:1984-07-01 00:00:00

  • Characterization and distribution of receptors for gonadotropin-releasing hormone in the rat hippocampus.

    abstract::Distribution and properties of receptors for gonadotropin-releasing hormone (GnRH) were analyzed in the brain of adult male rats. Binding of the iodinated GnRH agonist Des-Gly10-(D-Ala6)-GnRH ethylamide was studied in hippocampus and anterior pituitary using three convergent approaches: quantitative autoradiography on...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125053

    authors: Leblanc P,Crumeyrolle M,Latouche J,Jordan D,Fillion G,L'Heritier A,Kordon C,Dussaillant M,Rostène W,Haour F

    更新日期:1988-11-01 00:00:00

  • Subfornical organ lesions reduce the pressor effect of systemic angiotensin II.

    abstract::The pressor effect of intravenous angiotensin II (AII) was compared in the unrestrained rat before and after electrolytic lesions of the subfornical organ (SFO), the circumventricular organ of the dorsal third cerebral ventricle. Abdominal aortic and venal caval catheters were used to measure arterial pressure and to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123107

    authors: Mangiapane ML,Simpson JB

    更新日期:1980-12-01 00:00:00

  • Corticosteroid regulation of IL-1 receptors in the mouse hippocampus: effects of glucocorticoid treatment, stress, and adrenalectomy.

    abstract::Interleukin-1 (IL-1) and glucocorticoid hormones represent two key mediators involved in the modulation of the neuroimmunoendocrine response to stress. IL-1 is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis in rodents. In the immune system, glucocorticoids modulate IL-1 production and a number of ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126648

    authors: Betancur C,Lledo A,Borrell J,Guaza C

    更新日期:1994-02-01 00:00:00

  • Pressor responses to central angiotensin II, prostaglandin E1 and prostaglandin E2. Effects of ovarian steroids.

    abstract::The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E1, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123451

    authors: Skoog KM,Kenney NJ

    更新日期:1983-02-01 00:00:00

  • Serotonergic stimulation of prolactin and corticosterone secretion is mediated by different pathways from the mediobasal hypothalamus.

    abstract::In previous studies we obtained evidence that serotonin release by p-chloroamphetamine (PCA) causes an increase in corticosterone secretion but that this effect is not mediated via the raphe nuclei in the midbrain. In contrast, PCA-induced prolactin secretion was abolished by dorsal raphe lesions. In the present study...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124205

    authors: Van de Kar LD,Karteszi M,Bethea CL,Ganong WF

    更新日期:1985-11-01 00:00:00

  • Preoptic LH-RH and somatostatin in the rat median eminence. An experimental light and electron microscopic immunocytochemical study.

    abstract::Glass microknife lesions and immunocytochemistry were used to evaluate luteinizing hormone-releasing hormone (LH-RH)- and somatostatin (SS)-immunoreactive pathways from the preoptic region to the rat median eminence. Cuts were so placed that axons of more caudally located neurons in the periventricular hypothalamic ar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123886

    authors: Jew JY,Léránth C,Arimura A,Palkovits M

    更新日期:1984-03-01 00:00:00

  • Effects of adrenalectomy and glucocorticoids on rat brain dopamine receptors.

    abstract::The effects of adrenalectomy (ADX) and dexamethasone (DEX) treatment on brain dopamine (DA) receptors of ovariectomized (OVX) rats were investigated by autoradiography using binding of the D1 and D2 antagonists ligands [3H]SCH 23390 and [3H]spiperone, respectively. Fourteen days after ADX, D1 receptors decreased in th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126158

    authors: Biron D,Dauphin C,Di Paolo T

    更新日期:1992-04-01 00:00:00

  • Chromogranin A in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms: a large series from a single institution.

    abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000369818

    authors: Massironi S,Rossi RE,Casazza G,Conte D,Ciafardini C,Galeazzi M,Peracchi M

    更新日期:2014-01-01 00:00:00