Abstract:
:Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 micrograms/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (greater than or equal to 2.5 mg/kg). This effect was recently found to be enhanced by increasing doses of progesterone. In contrast, small doses of LSD (5-30 micrograms/kg) have been shown to increase LR activated by estrogen alone. The effects of various hormone treatments on the stimulatory action of LSD were tested in the present study. When the lordosis behavior was activated by estradiol benzoate (EB) alone (25 or 7 X 2 micrograms/kg), LR increased 10 min after injection of LSD in a dose of 10 micrograms/kg. There were no detectable effects in animals treated with estrogen alone when the dose of LSD was lowered to 1 microgram/kg. LSD in the latter dose gave an increased response, however, when LR was activated by EB (5 micrograms/kg) in combination with progesterone (4.0 mg/rat). An analogous study was conducted with L-5-HTP, after pretreatment with pargyline and R04-4602. Small doses of L-5-HTP (0.25 and 0.05 mg/kg) stimulated the LR and the influence of progesterone was the same as for small doses of LSD. Possible mechanisms underlying the observed influence of progesterone on serotonergic mechanisms involved in the lordosis behavior are discussed.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Sietnieks A,Meyerson BJdoi
10.1159/000123499subject
Has Abstractpub_date
1983-06-01 00:00:00pages
462-7issue
6eissn
0028-3835issn
1423-0194journal_volume
36pub_type
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journal_title:Neuroendocrinology
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更新日期:1995-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126098
更新日期:1992-01-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000122536
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journal_title:Neuroendocrinology
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更新日期:1991-11-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1988-08-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000126170
更新日期:1992-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1983-11-01 00:00:00
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1988-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-12-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126648
更新日期:1994-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1983-02-01 00:00:00
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...
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更新日期:2014-01-01 00:00:00