Determination of guanine nucleotide sensitivity of [125-I]-neuropeptide Y binding in the rat pituitary gland by quantitative autoradiography.

Abstract:

:[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no specific binding in the intermediate or anterior lobe. Increasing concentrations of guanine nucleotide analogues and peptide YY inhibited neuropeptide Y binding. In addition, neuropeptide Y binding was pertussis-toxin-sensitive. These results add additional information about a possible neuronal (through neuropeptide Y) and hormonal (through peptide YY) regulation of posterior pituitary function, which is most probably GTP-dependent.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Torda T,Saavedra JM

doi

10.1159/000125608

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

361-7

issue

4

eissn

0028-3835

issn

1423-0194

journal_volume

52

pub_type

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