Abstract：
:Accumulating evidence in rodents suggests that a prolactin locally synthesized and released within the brain can act together with that taken up from the circulation to modulate neuroendocrine responses. The present study was designed to identify the regional patterns of prolactin expression in the adult and developing sheep brain. Specifically, we tested the hypothesis that prolactin is expressed in regions of the adult and fetal sheep brain that are critical in the development of neuroendocrine homeostatic and behavioral functions. The expression of prolactin protein in sheep brain was demonstrated by Western blot analysis and brain prolactin mRNA was detected and sequenced using RT-PCR. In situ hybridization histochemistry revealed that prolactin mRNA was expressed in the medial preoptic area, periventricular preoptic nucleus, bed nucleus of the stria terminalis, and in the paraventricular nucleus of the hypothalamus, particularly the ventral region. The neuroanatomical distribution of prolactin mRNA was best visualized in the fetus and prolactin-immunoreactive neurons could also be identified in late gestation fetuses. Brain prolactin mRNA was expressed as early as day 60 of gestation and increased as the fetus aged and peaked at day 135 (term = 147 days). Prolactin mRNA expression did not exhibit a sex difference in the preoptic area, but in the amygdala prolactin mRNA was significantly higher in females than in males at day 100 of gestation. We conclude that prolactin expressed in adult and fetal sheep brain could be involved in neurodevelopment and/or modulation of the neuroendocrine stress axis, although it is too early to rule out other possibilities given the diverse actions that have been attributed to prolactin.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Roselli CE,Bocklandt S,Stadelman HL,Wadsworth T,Vilain E,Stormshak Fdoi
10.1159/000114643subject
Has Abstractpub_date
2008-01-01 00:00:00pages
206-15issue
4eissn
0028-3835issn
1423-0194pii
000114643journal_volume
87pub_type
杂志文章abstract：:The effects of acute stress exposure upon cholecystokinin (CCK) and substance P (SP) concentrations in discrete hypothalamic regions of the adult male rat brain were studied. Animals were exposed to foot shock stress for periods of 2, 4, 10, 30 or 60 min duration; immediately afterwards they were decapitated; brains w...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124799
更新日期：1987-06-01 00:00:00
abstract：:The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123011
更新日期：1980-05-01 00:00:00
abstract：:The obese gene (OB) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide Y (NPY) neurotransmission. More recently, leptin has been shown to control several neuroendocrine axes, modulating pituitary hormone secretions in...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054326
更新日期：1998-05-01 00:00:00
abstract：:The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122357
更新日期：1975-01-01 00:00:00
abstract：:To assess the neuroendocrine correlates of menstrual status migrainosus (MSM) and menstrual migraine (MM), we evaluated the prolactin (PRL) and cortisol responses to the direct central serotoninergic (5-HT) agonist meta-chlorophenylpiperazine (m-CPP) administered orally (0.5 mg/kg) during the follicular (FP: +6, +8) a...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1159/000071706
更新日期：2003-07-01 00:00:00
abstract：:An enriched population of cells immunoreactive to antiserum against S-100 protein, a marker of folliculo-stellate (FS) cells in the rat pituitary, was obtained by separation of dispersed pituitary cells from adult female rats by gradient sedimentation at unit gravity. The effect of FS cells on the stimulation and inhi...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125146
更新日期：1989-04-01 00:00:00
abstract：:Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127172
更新日期：1997-02-01 00:00:00
abstract：:Rats bearing transplanted prolactin-secreting tumors are known to have very high prolactin levels in the serum, reduced hypothalamic opiate concentrations, increasing hypothalamic dopamine synthesis and increased hypophyseal portal blood dopamine levels. Further, it has been shown that incubation in 3H-leucine of ante...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123211
更新日期：1981-08-01 00:00:00
abstract：:The in vitro release of LHRH from hypothalami of adult male rats (intact, 5-day castrates, 5-day castrates replaced with various doses of testosterone) was measured under basal conditions and after the addition of KCl, the opiate antagonist naloxone or the opiate agonist DAGO to the perifusion medium. Hypothalami from...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124662
更新日期：1986-01-01 00:00:00
abstract：:The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats. Lordosis behavior triggered by...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123983
更新日期：1984-09-01 00:00:00
abstract：:The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127068
更新日期：1996-05-01 00:00:00
abstract：:Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124922
更新日期：1988-03-01 00:00:00
abstract：:Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123200
更新日期：1981-07-01 00:00:00
abstract：:Using specific antibodies to corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) we have immunocytochemically located cells and fibres containing these peptides in sheep fetuses. CRF neurones were first detected, in low frequency, in the paraventricular nuclei of fetuses of 90 days of gestation (term ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124860
更新日期：1987-11-01 00:00:00
abstract：:The arcuate nucleus-median eminence complex (AM) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. Those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary glan...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124775
更新日期：1987-06-01 00:00:00
abstract：:Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122441
更新日期：1975-01-01 00:00:00
abstract：:Hyponatremia due to elevated arginine vasopressin (AVP) secretion increases mortality in liver failure patients. The mechanisms causing dysregulation of AVP secretion are unknown. Our hypothesis is that inappropriate AVP release associated with liver failure is due to increased brain-derived neurotrophic factor (BDNF)...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000503723
更新日期：2020-01-01 00:00:00
abstract：:Serotonin and dopamine neurons have been shown to exert a stimulatory and inhibitory control, respectively, over pituitary release of beta-endorphin-like immunoreactivity (beta-END-LI). In the present study we sought to determine whether an interaction exists between these two reciprocal mechanisms regulating beta-END...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124439
更新日期：1986-01-01 00:00:00
abstract：:Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000064428
更新日期：2002-08-01 00:00:00
abstract：:We have investigated the effects of exposure to short-term constant light (LL) on the spontaneous, proestrous luteinizing hormone (LH) surge in the female rat. Exposure to LL during the 3 days preceding proestrus delayed and reduced the magnitude of the LH surge which was measured in blood samples taken from conscious...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123225
更新日期：1981-09-01 00:00:00
abstract：:Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126583
更新日期：1993-11-01 00:00:00
abstract：:The growth hormone secretagogue receptor subtype 1a (GHSR-1a) is involved in biological actions of ghrelin by triggering intracellular second messengers coupled to heterotrimeric G-protein complex involving Galpha(q/11). Adenosine is a partial agonist of the GHSR-1a, binding to a binding pocket distinct from the one d...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000076042
更新日期：2004-01-01 00:00:00
abstract：:Steroid autoradiography was undertaken to determine the neuroanatomical loci which might be involved in the activation of steroid-sensitive behaviors in the Japanese quail (Coturnix japonica). Male and female quail were either surgically gonadectomized or photically regressed and implanted with androgen or estrogen to...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125091
更新日期：1989-01-01 00:00:00
abstract：:Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126159
更新日期：1992-04-01 00:00:00
abstract：:The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123577
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000472717
更新日期：2018-01-01 00:00:00
abstract：:Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124668
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, and molecular approach could be used for thei...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000508376
更新日期：2020-05-04 00:00:00
abstract：:Pregnancy and parturition are associated with opioid-mediated elevations in maternal pain thresholds. This analgesia is subserved by a spinal cord dynorphin/kappa-opiate receptor system. During gestation, elevated pain thresholds are paralleled by a significant increase in the content of dynorphin (1-17 and 1-8) in th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126555
更新日期：1993-09-01 00:00:00
abstract：:The mu-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by mu-ORs are steroid hormone-dependent, few studies have shown how steroid hormones su...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000065953
更新日期：2002-10-01 00:00:00
