Biphasic changes in anterior pituitary Met-enkephalin concentration following reserpine treatment.

Abstract:

:Met-enkephalin concentrations in the anterior pituitary gland were shown to decline dramatically within the first 24 h after reserpine treatment, with effects apparent as early as 6 h. This was followed by subsequent repletion and late augmentation of Met-enkephalin levels 3 weeks following reserpine. Treatment with the alpha-1-adrenergic agonist methoxamine had no effect, whereas the alpha-1-antagonist prazosin lowered Met-enkephalin concentrations. Treatment with the dopamine agonists bromocriptine or apomorphine had no effect, but haloperidol treatment increased anterior pituitary Met-enkephalin which was reversed by concomitant bromocriptine administration. We postulate that the changes in anterior pituitary Met-enkephalin following reserpine were related to alterations in the monoamine neurotransmitters. Adrenergic and dopaminergic mechanisms may have opposing roles in the maintenance of Met-enkephalin concentrations in the anterior pituitary gland.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

George SR,Kertesz M

doi

10.1159/000124905

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

149-53

issue

2

eissn

0028-3835

issn

1423-0194

journal_volume

47

pub_type

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