Influence of ACTH on tyrosine hydroxylase activity in the locus coeruleus of mouse brain.

Abstract:

:Tyrosine hydroxylase activity in noradrenergic neurons of the locus coeruleus was found to rise in bilaterally adrenalectomized adult mice, with maximum increase of the enzyme activity (52% above control) occurring 7 days after the surgery. No such increase of tyrosine hydroxylase activity was found in dopaminergic neurons of the substantia nigra. The increase of enzyme activity in the locus coeruleus following adrenalectomy was totally prevented by corticosterone replacement. Moreover, the adrenalectomy effect was abolished by hypophysectomy, indicating the involvement of the pituitary rather than the adrenocortical function. Chronic administration of ACTH (20 IU/kg, i.p., daily) resulted in an increase of tyrosine hydroxylase activity in the locus coeruleus, with a time course and magnitude similar to those found after adrenalectomy. Additionally, the effects of four ACTH analogs were determined. ACTH 1-24 and ACTH 4-10 were as effective as the whole ACTH molecule, whereas ACTH 4-10,7-D-Phe and ACTH 11-24 were ineffective. The effect of ACTH 4-10, a peptide fragment with no adrenocorticotrophic activity, further indicates that glucocorticoids are not involved. From these data, it appears that tyrosine hydroxylase in the locus coeruleus neurons is under the regulatory influence of pituitary ACTH. It remains to be determined whether the hormone can be transported from its pituitary origin to the locus coeruleus and exerts a direct action on the noradrenergic neurons. Regardless of the mechanism, the response of the noradrenergic neurons to pituitary activity may be an important component in physiological adaptation of the central nervous system to chronic stress.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Markey KA,Sze PY

doi

10.1159/000123902

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

269-75

issue

4

eissn

0028-3835

issn

1423-0194

journal_volume

38

pub_type

杂志文章
  • Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period.

    abstract::Dehydration is a classic homeostatic stressor in rats that leads to a series of endocrine responses including stimulation of the hypothalamo-pituitary-adrenal (HPA) axis. During the last decade, it has been well established that perinatal food restriction is associated with the onset of diseases in adults. Our previou...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000078098

    authors: Sebaai N,Lesage J,Breton C,Vieau D,Deloof S

    更新日期:2004-01-01 00:00:00

  • Rat interleukin-1 beta binding sites in rat hypothalamus and pituitary gland.

    abstract::In this study, radiolabeled recombinant rat interleukin-1 beta (r125I-IL-1 beta) was used to localize and characterize IL-1 beta binding in rat hypothalamus and pituitary gland by quantitative autoradiography. The ability of this ligand to bind to type I IL-1 receptor was first tested on murine lymphoma cells (EL-4). ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127026

    authors: Marquette C,Van Dam AM,Ban E,Lanièce P,Crumeyrolle-Arias M,Fillion G,Berkenbosch F,Haour F

    更新日期:1995-10-01 00:00:00

  • Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats.

    abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122865

    authors: Davis PG,Barfield RJ

    更新日期:1979-01-01 00:00:00

  • GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.

    abstract::The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123288

    authors: Vincent SR,Hökfelt T,Wu JY

    更新日期:1982-02-01 00:00:00

  • Vasoactive intestinal peptide gene expression from embryos to aging rats.

    abstract::Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124886

    authors: Gozes I,Schächter P,Shani Y,Giladi E

    更新日期:1988-01-01 00:00:00

  • Cells co-expressing luteinising hormone and thyroid-stimulating hormone are present in the ovine pituitary pars distalis but not the pars tuberalis: implications for the control of endogenous circannual rhythms of prolactin.

    abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000350790

    authors: Hodson DJ,Townsend J,Tortonese DJ

    更新日期:2013-01-01 00:00:00

  • Chromogranin A in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms: a large series from a single institution.

    abstract:BACKGROUND/AIMS:Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. PATIENTS AND METHODS...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000369818

    authors: Massironi S,Rossi RE,Casazza G,Conte D,Ciafardini C,Galeazzi M,Peracchi M

    更新日期:2014-01-01 00:00:00

  • Evidence for a common neural mechanism mediating growth hormone-releasing factor-induced and somatostatin-induced feeding.

    abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126372

    authors: Feifel D,Vaccarino FJ,Rivier J,Vale WW

    更新日期:1993-01-01 00:00:00

  • Bone remodeling, bone mass and weight gain in patients with stabilized schizophrenia in real-life conditions treated with long-acting injectable risperidone.

    abstract:BACKGROUND:Prolactin-raising antipsychotics, risperidone (antidopaminergic activity), may be associated with low bone mass. On the other hand, risperidone may cause an increase in body weight thought to be favorable for bone. OBJECTIVES:(1) To determine bone remodeling parameters and bone mass in patients with schizop...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000329391

    authors: Doknic M,Maric NP,Britvic D,Pekic S,Damjanovic A,Miljic D,Stojanovic M,Radojicic Z,Jasovic Gasic M,Popovic V

    更新日期:2011-01-01 00:00:00

  • Release of pro-opiomelanocortin-derived peptides from the pars intermedia and pars distalis of the rat pituitary: effect of corticotrophin-releasing factor and somatostatin.

    abstract::The parenchymal cells of the pars intermedia (PI) and corticotrophs of the pars distalis (PD) synthesize pro-opiomelanocortin (POMC), which, through posttranslational processing, gives rise to a group of structurally related peptides, including MSHs, ACTH, CLIP, LPHs and endorphins. We investigated the control of rele...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124203

    authors: Kraicer J,Gajewski TC,Moor BC

    更新日期:1985-11-01 00:00:00

  • Diurnal variations in rat posterior pituitary catecholamine levels.

    abstract::Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123292

    authors: Barden N,Chevillard C,Saavedra JM

    更新日期:1982-02-01 00:00:00

  • Substance P-containing neurons innervating LHRH-containing neurons in the septo-preoptic area of rats.

    abstract::Neuroanatomical attempts have been made to determine the synapses between luteinizing hormone-releasing hormone (LHRH)-containing neurons and substance P (SP)-containing neurons in the hypothalamus of female rats. Wheat germ agglutinin was injected into the septo-preoptic area (SPA) and found to be incorporated into c...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125724

    authors: Tsuruo Y,Kawano H,Hisano S,Kagotani Y,Daikoku S,Zhang T,Yanaihara N

    更新日期:1991-03-01 00:00:00

  • Glycemic responses induced by hypothalamic stimulation.

    abstract::Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122864

    authors: Gisel EG,Innes DL

    更新日期:1979-01-01 00:00:00

  • Positive feedback in hypogonadal female mice with preoptic area brain transplants.

    abstract::When fetal preoptic area (POA) brain grafts that contain gonadotropin-releasing hormone cells are transplanted into the third ventricle of adult female hypogonadal mice, the animals respond with sexual maturation, persistent estrus, and the ability to ovulate reflexively after mating. However, the absence of normal sp...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124998

    authors: Gibson MJ,Kokoris GJ,Silverman AJ

    更新日期:1988-08-01 00:00:00

  • G protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphic.

    abstract::Introduction The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol on arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000509583

    authors: Marraudino M,Carrillo B,Bonaldo B,Llorente R,Campioli E,Garate I,Pinos H,Garcia-Segura LM,Collado P,Grassi D

    更新日期:2020-06-22 00:00:00

  • Effect of serotonin-releasing drugs on serum corticosterone concentration in rats.

    abstract::(+/-)p-Chloroamphetamine hydrochloride, at doses of 1-8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123057

    authors: Fuller RW,Snoddy HD

    更新日期:1980-08-01 00:00:00

  • Comparison between hypothalamic multiple-unit activity and corticotropic function after bilateral destruction of the hippocampus.

    abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122750

    authors: Bouillé C,Baylé JD

    更新日期:1978-01-01 00:00:00

  • Grade Increases in Gastroenteropancreatic Neuroendocrine Tumor Metastases Compared to the Primary Tumor.

    abstract:BACKGROUND/AIM:The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable for prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the tumor and little is known on whether grade varies between primary and s...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000439434

    authors: Grillo F,Albertelli M,Brisigotti MP,Borra T,Boschetti M,Fiocca R,Ferone D,Mastracci L

    更新日期:2016-01-01 00:00:00

  • The effect of exposure to ether on prolactin secretion and the half-life of endogenous prolactin in normal and castrated male rats.

    abstract::Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122826

    authors: Chi HJ,Shin SH

    更新日期:1978-01-01 00:00:00

  • Expression of Somatostatin Receptors 1-5 and Dopamine Receptor 2 in Lung Carcinoids: Implications for a Therapeutic Role.

    abstract:OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000381061

    authors: Kanakis G,Grimelius L,Spathis A,Tringidou R,Rassidakis GZ,Öberg K,Kaltsas G,Tsolakis AV

    更新日期:2015-01-01 00:00:00

  • Salt appetite in salt-replete rats: involvement of mesolimbic structures in deoxycorticosterone-induced salt craving behavior.

    abstract::Chronic administration of the mineralocorticoid deoxycorticosterone acetate (DOCA) induces a steady and robust increase in salt appetite and plasma Na(+) over the course of treatment. Interestingly, salt appetite behavior persists in rats even with elevated plasma Na(+) levels. Since there is evidence that the pathway...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054559

    authors: Lucas LR,Pompei P,McEwen BS

    更新日期:2000-06-01 00:00:00

  • Progesterone enhancement of lysergic acid diethylamide and levo-5-hydroxytryptophan stimulation of the copulatory response in the female rat.

    abstract::Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123499

    authors: Sietnieks A,Meyerson BJ

    更新日期:1983-06-01 00:00:00

  • A role for agouti-related protein in appetite regulation in a species with continuous nutrient delivery.

    abstract::Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary acros...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000082735

    authors: Wagner CG,McMahon CD,Marks DL,Daniel JA,Steele B,Sartin JL

    更新日期:2004-01-01 00:00:00

  • Different opioid mechanisms are involved in the modulation of ACTH and gonadotrophin release in man.

    abstract::Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124463

    authors: Grossman A,Moult PJ,Cunnah D,Besser M

    更新日期:1986-01-01 00:00:00

  • Effects of an intraventricular injection of synthetic ACTH on plasma testosterone, progesterone and LH levels and on sexual behavior in male and female rabbits.

    abstract::Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122441

    authors: Haun CK,Haltmeyer GC

    更新日期:1975-01-01 00:00:00

  • Elevated brain glucose and glycogen concentrations in an animal model of depression.

    abstract:INTRODUCTION:Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000368607

    authors: Detka J,Kurek A,Basta-Kaim A,Kubera M,Lasoń W,Budziszewska B

    更新日期:2014-01-01 00:00:00

  • Pressor responses to central angiotensin II, prostaglandin E1 and prostaglandin E2. Effects of ovarian steroids.

    abstract::The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E1, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123451

    authors: Skoog KM,Kenney NJ

    更新日期:1983-02-01 00:00:00

  • Dual action of GABAA receptors on the secretory process of melanotrophs of Xenopus laevis.

    abstract::The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagon...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126516

    authors: Jenks BG,de Koning HP,Valentijn K,Roubos EW

    更新日期:1993-07-01 00:00:00

  • Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary.

    abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125622

    authors: Lam KS,Srivastava G,Lechan RM,Lee T,Reichlin S

    更新日期:1990-11-01 00:00:00

  • Neuroanatomical localization of sex steroid-concentrating cells in the Japanese quail (Coturnix japonica): autoradiography with [3H]-testosterone, [3H]-estradiol, and [3H]-dihydrotestosterone.

    abstract::Steroid autoradiography was undertaken to determine the neuroanatomical loci which might be involved in the activation of steroid-sensitive behaviors in the Japanese quail (Coturnix japonica). Male and female quail were either surgically gonadectomized or photically regressed and implanted with androgen or estrogen to...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125091

    authors: Watson JT,Adkins-Regan E

    更新日期:1989-01-01 00:00:00