Vasoactive intestinal peptide gene expression from embryos to aging rats.


:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.






Gozes I,Schächter P,Shani Y,Giladi E




Has Abstract


1988-01-01 00:00:00












  • Medical treatment of acromegaly: comorbidities and their reversibility by somatostatin analogs.

    abstract::Relief of symptoms can be achieved following surgery for growth hormone (GH)-secreting adenomas, as well as after pharmacological therapy with somatostatin analogs. Recently, long-acting somatostatin analog depot formulations, octreotide LAR and lanreotide SR have become available. Somatostatin analogs control GH/insu...


    pub_type: 杂志文章,评审


    authors: Tolis G,Angelopoulos NG,Katounda E,Rombopoulos G,Kaltzidou V,Kaltsas D,Protonotariou A,Lytras A

    更新日期:2006-01-01 00:00:00

  • Role of gonadal steroids in the corticotropin-releasing hormone and proopiomelanocortin gene expression response to Delta(9)-tetrahydrocannabinol in the hypothalamus of the rat.

    abstract::Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...


    pub_type: 杂志文章


    authors: Corchero J,Manzanares J,Fuentes JA

    更新日期:2001-09-01 00:00:00

  • Phase relation between episodic fluctuations of spontaneous locomotor activity and plasma corticosterone in rats with suprachiasmatic nuclei lesions.

    abstract::Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...


    pub_type: 杂志文章


    authors: Watanabe K,Hiroshige T

    更新日期:1981-07-01 00:00:00

  • Brain-Derived Neurotrophic Factor and Supraoptic Vasopressin Neurons in Hyponatremia.

    abstract::Hyponatremia due to elevated arginine vasopressin (AVP) secretion increases mortality in liver failure patients. The mechanisms causing dysregulation of AVP secretion are unknown. Our hypothesis is that inappropriate AVP release associated with liver failure is due to increased brain-derived neurotrophic factor (BDNF)...


    pub_type: 杂志文章


    authors: Balapattabi K,Little JT,Bachelor M,Cunningham JT

    更新日期:2020-01-01 00:00:00

  • Splanchnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats.

    abstract::An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...


    pub_type: 杂志文章


    authors: Jasper MS,Engeland WC

    更新日期:1994-02-01 00:00:00

  • Central stimulatory influence of oxytocin on preovulatory gonadotropin-releasing hormone requires more than the median eminence.

    abstract::The study was designed to determine whether the ability of central oxytocin (OT) to stimulate gonadotropin-releasing hormone (GnRH) on the afternoon of proestrus (PE) in the cycling female rat is mediated at the level of GnRH terminals within the median eminence (ME), or at higher hypothalamic levels where GnRH cell b...


    pub_type: 杂志文章


    authors: Selvage D,Johnston CA

    更新日期:2001-08-01 00:00:00

  • Cardiometabolic Risks in Polycystic Ovary Syndrome: Non-Traditional Risk Factors and the Impact of Obesity.

    abstract::Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the patho...


    pub_type: 杂志文章,评审


    authors: Chiu WL,Boyle J,Vincent A,Teede H,Moran LJ

    更新日期:2017-01-01 00:00:00

  • Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure.

    abstract::Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovar...


    pub_type: 杂志文章


    authors: Marques-Lopes J,Tesfaye E,Israilov S,Van Kempen TA,Wang G,Glass MJ,Pickel VM,Iadecola C,Waters EM,Milner TA

    更新日期:2017-01-01 00:00:00

  • Neurosecretion of human hypothalamic immunoreactive beta-endorphin: in vitro regulation by dopamine.

    abstract::An in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 microM pulse of DA consistently elicited a mean (+/- SE) 88 +/- 9% increase (p less ...


    pub_type: 杂志文章


    authors: Rasmussen DD,Liu JH,Wolf PL,Yen SS

    更新日期:1987-03-01 00:00:00

  • The luteinizing hormone but not the cortisol response to arginine vasopressin is prevented by naloxone and a corticotropin-releasing hormone antagonist in the ovariectomized rhesus monkey.

    abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...


    pub_type: 杂志文章


    authors: Xiao E,Xia-Zhang L,Thornell D,Shalts E,Ferin M

    更新日期:1996-09-01 00:00:00

  • Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat.

    abstract::The obese gene (OB) product, leptin, has been shown to exert control on metabolic processes such as food intake and body weight homeostasis, possibly through a neuropeptide Y (NPY) neurotransmission. More recently, leptin has been shown to control several neuroendocrine axes, modulating pituitary hormone secretions in...


    pub_type: 杂志文章


    authors: Vuagnat BA,Pierroz DD,Lalaoui M,Englaro P,Pralong FP,Blum WF,Aubert ML

    更新日期:1998-05-01 00:00:00

  • Corticosteroids influence the action potential firing pattern of hippocampal subfield CA3 pyramidal cells.

    abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...


    pub_type: 杂志文章


    authors: Okuhara DY,Beck SG

    更新日期:1998-01-01 00:00:00

  • Ontogeny and tissue-specific regulation of ghrelin mRNA expression suggest that ghrelin is primarily involved in the control of extraendocrine functions in the rat.

    abstract::Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...


    pub_type: 杂志文章


    authors: Torsello A,Scibona B,Leo G,Bresciani E,Avallone R,Bulgarelli I,Luoni M,Zoli M,Rindi G,Cocchi D,Locatelli V

    更新日期:2003-02-01 00:00:00

  • Acute intrahippocampal injection of human interleukin-1beta stimulates the anterior pituitary POMC transcription and increases plasma levels of ACTH and corticosterone in the male rat.

    abstract::It has been well documented that interleukin-1beta (IL-1beta) is a major mediator for recruiting the hypothalamo-pituitary-adrenal (HPA) axis following infectious disease. The recent localization of IL-1beta receptors in neurons of the hippocampus provides further support for the role of IL-1beta as a neurotransmitter...


    pub_type: 杂志文章


    authors: Mélik Parsadaniantz S,Daugé V,Roques BP,Kerdelhué B

    更新日期:1999-02-01 00:00:00

  • Altered luteinizing hormone and prolactin responses to excitatory amino acids during lactation.

    abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...


    pub_type: 杂志文章


    authors: Abbud R,Smith MS

    更新日期:1993-10-01 00:00:00

  • Biphasic effect of orchiectomy on pro-opiomelanocortin gene expression in the hypothalamus.

    abstract::Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...


    pub_type: 杂志文章


    authors: Wardlaw SL,Blum M

    更新日期:1990-11-01 00:00:00

  • Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period.

    abstract::Dehydration is a classic homeostatic stressor in rats that leads to a series of endocrine responses including stimulation of the hypothalamo-pituitary-adrenal (HPA) axis. During the last decade, it has been well established that perinatal food restriction is associated with the onset of diseases in adults. Our previou...


    pub_type: 杂志文章


    authors: Sebaai N,Lesage J,Breton C,Vieau D,Deloof S

    更新日期:2004-01-01 00:00:00

  • IL-1 beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala.

    abstract::In addition to the magnocellular hypothalamic nuclei, arginine vasopressin (AVP)-containing neurons have also been identified in limbic structures, including the hippocampus and amygdala. In the present study, we compared the qualitative properties of the in vitro release of AVP from the dissected hypothalamus with th...


    pub_type: 杂志文章


    authors: Raber J,Pich EM,Koob GF,Bloom FE

    更新日期:1994-03-01 00:00:00

  • Opioid receptor subtype involvement in maternal behavior in lactating rats.

    abstract::Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical mu agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in additio...


    pub_type: 杂志文章


    authors: Mann PE,Kinsley CH,Bridges RS

    更新日期:1991-05-01 00:00:00

  • Corticotrophin-releasing factor and arginine vasopressin fibre projections to the median eminence of fetal sheep.

    abstract::Using specific antibodies to corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) we have immunocytochemically located cells and fibres containing these peptides in sheep fetuses. CRF neurones were first detected, in low frequency, in the paraventricular nuclei of fetuses of 90 days of gestation (term ...


    pub_type: 杂志文章


    authors: Levidiotis M,Oldfield B,Wintour EM

    更新日期:1987-11-01 00:00:00

  • Effects of centrally administered prolactin upon mammary contractility in anesthetized lactating rats.

    abstract::The possibility was investigated that centrally administered rat prolactin (PRL), i.e., intracerebroventricularly (ICV) or intrathecally (IT), may influence mammary contractility in urethane-anesthetized lactating rats. In addition to the monomer (23 kD PRL), the 16- and 7-kD PRL fragments were also tested and their e...


    pub_type: 杂志文章


    authors: Morales MT,Mena F

    更新日期:1995-08-01 00:00:00

  • A role for agouti-related protein in appetite regulation in a species with continuous nutrient delivery.

    abstract::Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary acros...


    pub_type: 杂志文章


    authors: Wagner CG,McMahon CD,Marks DL,Daniel JA,Steele B,Sartin JL

    更新日期:2004-01-01 00:00:00

  • Intravertebral angiotensin II inhibits cardiac vagal efferent activity in dogs.

    abstract::The effect of intravertebral infusion of angiotensin II on cardiac vagal efferent activity was studied in anesthetized mongrel dogs. Unilateral infusion of doses of angiotensin II as low as 5 ng/kg/min inhibited basal vagal tone and also decreased the slope of the relationship between cardiac vagal efferent activity a...


    pub_type: 杂志文章


    authors: Potter EK,Reid IA

    更新日期:1985-06-01 00:00:00

  • Properties and distribution of glucocorticoid-binding sites in cytosol of the spinal cord.

    abstract::We have examined the spinal cord for the presence of glucocorticoid-binding sites. For this purpose, cytosol from the spinal cord of adrenalectomized rats was incubated with (3H)-dexamethasone. Maximal binding was obtained after 20 h of incubation at 0 degree C in the presence of 20 mM molybdate, whereas at 20 degrees...


    pub_type: 杂志文章


    authors: Orti E,Coirini H,De Nicola AF

    更新日期:1985-03-01 00:00:00

  • Glucose and Fat Metabolism in Acromegaly: From Mice Models to Patient Care.

    abstract::Patients with active acromegaly are frequently insulin resistant, glucose intolerant, and at risk for developing overt type 2 diabetes. At the same time, these patients have a relatively lean phenotype associated with mobilization and oxidation of free fatty acids. These features are reversed by curative surgical remo...


    pub_type: 杂志文章,评审


    authors: Dal J,List EO,Jørgensen JO,Berryman DE

    更新日期:2016-01-01 00:00:00

  • Treatment of gastroenteropancreatic neuroendocrine tumors with peptide receptor radionuclide therapy.

    abstract::The primary treatment of gastroenteropancreatic neuroendocrine tumors (GEPNETs) is surgery with curative intent or debulking of the tumor mass. In case of metastatic disease, cytoreductive options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatos...


    pub_type: 杂志文章,评审


    authors: van Vliet EI,Teunissen JJ,Kam BL,de Jong M,Krenning EP,Kwekkeboom DJ

    更新日期:2013-01-01 00:00:00

  • Testosterone modulates oxytocin binding in the hypothalamus of castrated male rats.

    abstract::Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...


    pub_type: 杂志文章


    authors: Johnson AE,Coirini H,McEwen BS,Insel TR

    更新日期:1989-08-01 00:00:00

  • Release of pro-opiomelanocortin-derived peptides from the pars intermedia and pars distalis of the rat pituitary: effect of corticotrophin-releasing factor and somatostatin.

    abstract::The parenchymal cells of the pars intermedia (PI) and corticotrophs of the pars distalis (PD) synthesize pro-opiomelanocortin (POMC), which, through posttranslational processing, gives rise to a group of structurally related peptides, including MSHs, ACTH, CLIP, LPHs and endorphins. We investigated the control of rele...


    pub_type: 杂志文章


    authors: Kraicer J,Gajewski TC,Moor BC

    更新日期:1985-11-01 00:00:00

  • Sex and estrous cycle variations of rat striatal dopamine uptake sites.

    abstract::The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...


    pub_type: 杂志文章


    authors: Morissette M,Di Paolo T

    更新日期:1993-07-01 00:00:00

  • New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors.

    abstract::Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NET molecular biology, ther...


    pub_type: 杂志文章,评审


    authors: Cigrovski Berkovic M,Cacev T,Catela Ivkovic T,Zjacic-Rotkvic V,Kapitanovic S

    更新日期:2014-01-01 00:00:00