Vasoactive intestinal peptide gene expression from embryos to aging rats.

Abstract:

:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Gozes I,Schächter P,Shani Y,Giladi E

doi

10.1159/000124886

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

27-31

issue

1

eissn

0028-3835

issn

1423-0194

journal_volume

47

pub_type

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