Vasoactive intestinal peptide gene expression from embryos to aging rats.


:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.






Gozes I,Schächter P,Shani Y,Giladi E




Has Abstract


1988-01-01 00:00:00












  • Connections of medial preoptic neurons with the median eminence and amygdala. An electrophysiological study in the rat.

    abstract::An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...


    pub_type: 杂志文章


    authors: Layton BS,Lafontaine S,Renaud LP

    更新日期:1981-01-01 00:00:00

  • Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.

    abstract::G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....


    pub_type: 杂志文章


    authors: Sutton SW,Bonaventure P,Kuei C,Roland B,Chen J,Nepomuceno D,Lovenberg TW,Liu C

    更新日期:2004-01-01 00:00:00

  • Effects of sex steroid hormones on the expression of somatostatin receptors sst1 and sst5 in goldfish pituitary and forebrain.

    abstract::In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...


    pub_type: 杂志文章


    authors: Canosa LF,Lin X,Peter RE

    更新日期:2003-08-01 00:00:00

  • Effects of pinealectomy, anosmia and blinding on serum and pituitary prolactin in intact and castrated male rats.

    abstract::Serum prolactin was measured in lightly etherized rats between 4 and 5 a.m. and between 11 a.m. and 12 noon at various times after operation in intact rats and rats that had been operated on. Serum prolactin was elevated in the late nocturnal samples from intact rats and this elevation was prevented by pinealectomy. W...


    pub_type: 杂志文章


    authors: Ronnekleiv OK,McCann SM

    更新日期:1975-01-01 00:00:00

  • The Neuroendocrine and Metabolic Outcomes of Bariatric Surgery Depend on Presurgical Control over Eating.

    abstract:BACKGROUND:The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. OBJECTIVE:We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcome...


    pub_type: 杂志文章


    authors: Muñoz-Rodríguez JR,Rodríguez-Cano T,Polo F,Sáenz-Mateos L,Agarrado A,Segura E,Casas G,Martín-Fernández J,Beato-Fernández L,Salas E,González-Martín C,Alguacil LF

    更新日期:2020-01-01 00:00:00

  • Is reverse triiodothyronine a physiological nonactive competitor for the action of triiodothyronine upon the electrical properties of GH3 cells?

    abstract::The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...


    pub_type: 杂志文章


    authors: du Pont JS

    更新日期:1991-08-01 00:00:00

  • Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro.

    abstract::The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...


    pub_type: 杂志文章


    authors: Auernhammer CJ,Renner U,Müller OA,Stalla J,Stalla GK

    更新日期:1993-06-01 00:00:00

  • Purification and characterization of urotensin II and parvalbumin from an elasmobranch fish, Scyliorhinus canicula (common dogfish).

    abstract::The caudal portion of the spinal cord of elasmobranch fish incorporates a diffuse neuroendocrine system. Using an antiserum raised against urotensin II from a teleost fish (goby) to facilitate purification, a peptide structurally related to urotensin II was isolated in pure form from an extract of neuroendocrine tissu...


    pub_type: 杂志文章


    authors: Conlon JM,O'Harte F,Smith DD,Balment RJ,Hazon N

    更新日期:1992-02-01 00:00:00

  • Intrauterine exposure to cigarette smoke is associated with increased ghrelin concentrations in adulthood.

    abstract:BACKGROUND:The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin syste...


    pub_type: 杂志文章


    authors: Paslakis G,Buchmann AF,Westphal S,Banaschewski T,Hohm E,Zimmermann US,Laucht M,Deuschle M

    更新日期:2014-01-01 00:00:00

  • Innate Obesity, Revealed by Selection Markers, Confers Significant Imprint of Hypothalamic Genes Controlling Energy Expenditure.

    abstract::The incidence of obesity is rapidly escalating and has reached epidemic proportions. In all species, including rodents, humans, and sheep, there is large variation in the degree of weight gain across individuals in response to an obesogenic environment. This individual variation is, at least in part, determined by inn...


    pub_type: 杂志文章,评审


    authors: Henry BA

    更新日期:2017-01-01 00:00:00

  • Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells.

    abstract::The polyphenol curcumin (diferuloylmethane) is the active componenet of the spice plant Curcuma longa and has been shown to exert multiple actions on mammalian cells. We have studied its effect on folliculostellate (FS) TtT/GF mouse pituitary cells, representative of a multifunctional, endocrine inactive cell type of ...


    pub_type: 杂志文章


    authors: Schaaf C,Shan B,Onofri C,Stalla GK,Arzt E,Schilling T,Perone MJ,Renner U

    更新日期:2010-01-01 00:00:00

  • Role of BK potassium channels shaping action potentials and the associated [Ca(2+)](i) oscillations in GH(3) rat anterior pituitary cells.

    abstract::Measurements of electrical activity and intracellular Ca(2+) levels were performed in perforated-patch clamped GH(3) cells to determine the contribution of large-conductance calcium-activated K(+) (BK) channels to action potential repolarization and size of the associated Ca(2+) oscillations. By examining the dependen...


    pub_type: 杂志文章


    authors: Miranda P,de la Peña P,Gómez-Varela D,Barros F

    更新日期:2003-03-01 00:00:00

  • Prolactin suppression by serotonin antagonists in man: further evidence for serotoninergic control of prolactin secretion.

    abstract::To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...


    pub_type: 临床试验,杂志文章


    authors: Ferrari C,Caldara R,Romussi M,Rampini P,Telloli P,Zaatar S,Curtarelli G

    更新日期:1978-01-01 00:00:00

  • Memory performance and the growth hormone/insulin-like growth factor axis in elderly: a positron emission tomography study.

    abstract::The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...


    pub_type: 杂志文章


    authors: Arwert LI,Veltman DJ,Deijen JB,Lammertsma AA,Jonker C,Drent ML

    更新日期:2005-01-01 00:00:00

  • New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors.

    abstract::Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NET molecular biology, ther...


    pub_type: 杂志文章,评审


    authors: Cigrovski Berkovic M,Cacev T,Catela Ivkovic T,Zjacic-Rotkvic V,Kapitanovic S

    更新日期:2014-01-01 00:00:00

  • Site-specific induction of Fos immunoreactivity in preoptic and hypothalamic NADPH-positive neurons during glucoprivation.

    abstract::Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...


    pub_type: 杂志文章


    authors: Briski KP,Sylvester PW

    更新日期:1999-03-01 00:00:00

  • Sympathoadrenal activity facilitates beta-endorphin and alpha-MSH secretion but does not potentiate ACTH secretion during immobilization stress.

    abstract::The potential involvement of the sympathoadrenal system in stress-induced secretion of peptides from the intermediate lobe of the pituitary gland and the activation of the pituitary-adrenal axis was studied. Male Wistar rats were subjected to control procedures, to sympathectomy by chronic administration (8 weeks) of ...


    pub_type: 杂志文章


    authors: Kvetnansky R,Tilders FJ,van Zoest ID,Dobrakovova M,Berkenbosch F,Culman J,Zeman P,Smelik PG

    更新日期:1987-04-01 00:00:00

  • Subfornical organ efferents influence the excitability of neurohypophyseal and tuberoinfundibular paraventricular nucleus neurons in the rat.

    abstract::Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase...


    pub_type: 杂志文章


    authors: Ferguson AV,Day TA,Renaud LP

    更新日期:1984-11-01 00:00:00

  • Diurnal rhythms in pineal N-acetyltransferase and hippocampal norepinephrine: effects of water deprivation, blinding and hypothalamic lesions.

    abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...


    pub_type: 杂志文章


    authors: Moore RY,Traynor ME

    更新日期:1976-01-01 00:00:00

  • Differential suppression of follicle-stimulating hormone and luteinizing hormone secretion in vivo by a gonadotropin-releasing hormone antagonist.

    abstract::Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...


    pub_type: 杂志文章


    authors: Grady RR,Shin L,Charlesworth MC,Cohen-Becker IR,Smith M,Rivier C,Rivier J,Vale W,Schwartz NB

    更新日期:1985-03-01 00:00:00

  • Evidence for a common neural mechanism mediating growth hormone-releasing factor-induced and somatostatin-induced feeding.

    abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...


    pub_type: 杂志文章


    authors: Feifel D,Vaccarino FJ,Rivier J,Vale WW

    更新日期:1993-01-01 00:00:00

  • Opioid peptidergic control of gonadotropin-releasing hormone pulse generator activity in the ovariectomized goat.

    abstract::The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...


    pub_type: 杂志文章


    authors: Ito K,Tanaka T,Mori Y

    更新日期:1993-04-01 00:00:00

  • Surgical treatment of endocrine pancreatic tumours.

    abstract::Endocrine pancreatic tumours (EPTs) are uncommon, with a major challenge to alert physicians to their recognition and requirements of treatment. Functioning EPTs cause well-known clinical syndromes of hormone excess. Insulinomas, gastrinomas and glucagonomas are most common; vipomas and somatostatinomas are rare. EPTs...


    pub_type: 杂志文章,评审


    authors: Akerström G,Hellman P,Hessman O,Osmak L

    更新日期:2004-01-01 00:00:00

  • Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

    abstract::The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...


    pub_type: 杂志文章


    authors: D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

    更新日期:2004-01-01 00:00:00

  • Fetal development of delta-sleep-inducing-peptide-like immunoreactivity in hypothalamus of guinea pig with special regard to the prenatal colocalization with gonadotropin-releasing-hormone-like immunoreactivity.

    abstract::Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...


    pub_type: 杂志文章


    authors: Pu LP,Dubois PM

    更新日期:1992-01-01 00:00:00

  • Ultrastructure of somatotrophs of rats with median eminence lesions: studies in basal conditions and after thyrotropin-releasing hormone stimulation.

    abstract::Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal condit...


    pub_type: 杂志文章


    authors: Rossi GL,Probst D,Panerai AE,Cocchi D,Locatelli V,Müller EE

    更新日期:1979-01-01 00:00:00

  • Coexistence of growth hormone releasing factor-like and tyrosine hydroxylase-like immunoreactivities in neurons of the rat arcuate nucleus.

    abstract::Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...


    pub_type: 杂志文章


    authors: Okamura H,Murakami S,Chihara K,Nagatsu I,Ibata Y

    更新日期:1985-08-01 00:00:00

  • Medical treatment of acromegaly: comorbidities and their reversibility by somatostatin analogs.

    abstract::Relief of symptoms can be achieved following surgery for growth hormone (GH)-secreting adenomas, as well as after pharmacological therapy with somatostatin analogs. Recently, long-acting somatostatin analog depot formulations, octreotide LAR and lanreotide SR have become available. Somatostatin analogs control GH/insu...


    pub_type: 杂志文章,评审


    authors: Tolis G,Angelopoulos NG,Katounda E,Rombopoulos G,Kaltzidou V,Kaltsas D,Protonotariou A,Lytras A

    更新日期:2006-01-01 00:00:00

  • Comparison between hypothalamic multiple-unit activity and corticotropic function after bilateral destruction of the hippocampus.

    abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...


    pub_type: 杂志文章


    authors: Bouillé C,Baylé JD

    更新日期:1978-01-01 00:00:00

  • Intravertebral angiotensin II inhibits cardiac vagal efferent activity in dogs.

    abstract::The effect of intravertebral infusion of angiotensin II on cardiac vagal efferent activity was studied in anesthetized mongrel dogs. Unilateral infusion of doses of angiotensin II as low as 5 ng/kg/min inhibited basal vagal tone and also decreased the slope of the relationship between cardiac vagal efferent activity a...


    pub_type: 杂志文章


    authors: Potter EK,Reid IA

    更新日期:1985-06-01 00:00:00