Abstract:
:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Gozes I,Schächter P,Shani Y,Giladi Edoi
10.1159/000124886subject
Has Abstractpub_date
1988-01-01 00:00:00pages
27-31issue
1eissn
0028-3835issn
1423-0194journal_volume
47pub_type
杂志文章abstract::An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123237
更新日期:1981-01-01 00:00:00
abstract::G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to GPCR135, R3 has been shown to be an agonist for GPCR142 (which is a pseudogene in the rat) and to activate LGR7, which is primarily the receptor for relaxin-1/2....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000083656
更新日期:2004-01-01 00:00:00
abstract::In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000071963
更新日期:2003-08-01 00:00:00
abstract::Serum prolactin was measured in lightly etherized rats between 4 and 5 a.m. and between 11 a.m. and 12 noon at various times after operation in intact rats and rats that had been operated on. Serum prolactin was elevated in the late nocturnal samples from intact rats and this elevation was prevented by pinealectomy. W...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122372
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. OBJECTIVE:We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcome...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000500687
更新日期:2020-01-01 00:00:00
abstract::The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125873
更新日期:1991-08-01 00:00:00
abstract::The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126466
更新日期:1993-06-01 00:00:00
abstract::The caudal portion of the spinal cord of elasmobranch fish incorporates a diffuse neuroendocrine system. Using an antiserum raised against urotensin II from a teleost fish (goby) to facilitate purification, a peptide structurally related to urotensin II was isolated in pure form from an extract of neuroendocrine tissu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126119
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin syste...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000363325
更新日期:2014-01-01 00:00:00
abstract::The incidence of obesity is rapidly escalating and has reached epidemic proportions. In all species, including rodents, humans, and sheep, there is large variation in the degree of weight gain across individuals in response to an obesogenic environment. This individual variation is, at least in part, determined by inn...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000455232
更新日期:2017-01-01 00:00:00
abstract::The polyphenol curcumin (diferuloylmethane) is the active componenet of the spice plant Curcuma longa and has been shown to exert multiple actions on mammalian cells. We have studied its effect on folliculostellate (FS) TtT/GF mouse pituitary cells, representative of a multifunctional, endocrine inactive cell type of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000287236
更新日期:2010-01-01 00:00:00
abstract::Measurements of electrical activity and intracellular Ca(2+) levels were performed in perforated-patch clamped GH(3) cells to determine the contribution of large-conductance calcium-activated K(+) (BK) channels to action potential repolarization and size of the associated Ca(2+) oscillations. By examining the dependen...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000069509
更新日期:2003-03-01 00:00:00
abstract::To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1159/000122753
更新日期:1978-01-01 00:00:00
abstract::The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000084872
更新日期:2005-01-01 00:00:00
abstract::Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100,000) and prevalence (35/100,000) of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NET molecular biology, ther...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000362339
更新日期:2014-01-01 00:00:00
abstract::Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054417
更新日期:1999-03-01 00:00:00
abstract::The potential involvement of the sympathoadrenal system in stress-induced secretion of peptides from the intermediate lobe of the pituitary gland and the activation of the pituitary-adrenal axis was studied. Male Wistar rats were subjected to control procedures, to sympathectomy by chronic administration (8 weeks) of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124746
更新日期:1987-04-01 00:00:00
abstract::Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124015
更新日期:1984-11-01 00:00:00
abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122489
更新日期:1976-01-01 00:00:00
abstract::Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124081
更新日期:1985-03-01 00:00:00
abstract::We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126372
更新日期:1993-01-01 00:00:00
abstract::The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126418
更新日期:1993-04-01 00:00:00
abstract::Endocrine pancreatic tumours (EPTs) are uncommon, with a major challenge to alert physicians to their recognition and requirements of treatment. Functioning EPTs cause well-known clinical syndromes of hormone excess. Insulinomas, gastrinomas and glucagonomas are most common; vipomas and somatostatinomas are rare. EPTs...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000080744
更新日期:2004-01-01 00:00:00
abstract::The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000080795
更新日期:2004-01-01 00:00:00
abstract::Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126098
更新日期:1992-01-01 00:00:00
abstract::Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal condit...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122911
更新日期:1979-01-01 00:00:00
abstract::Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124172
更新日期:1985-08-01 00:00:00
abstract::Relief of symptoms can be achieved following surgery for growth hormone (GH)-secreting adenomas, as well as after pharmacological therapy with somatostatin analogs. Recently, long-acting somatostatin analog depot formulations, octreotide LAR and lanreotide SR have become available. Somatostatin analogs control GH/insu...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000095535
更新日期:2006-01-01 00:00:00
abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122750
更新日期:1978-01-01 00:00:00
abstract::The effect of intravertebral infusion of angiotensin II on cardiac vagal efferent activity was studied in anesthetized mongrel dogs. Unilateral infusion of doses of angiotensin II as low as 5 ng/kg/min inhibited basal vagal tone and also decreased the slope of the relationship between cardiac vagal efferent activity a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124120
更新日期:1985-06-01 00:00:00