Salivary Aldosterone, Cortisol, and Their Morning to Evening Slopes in Patients with Depressive Disorder and Healthy Subjects: Acute Episode and Follow-Up 6 Months after Reaching Remission.

Abstract:

BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course of clinical depression with the assumption that aldosterone is a state marker of depression. METHODS:A total of 78 adult subjects (39 patients with depressive disorder and 39 healthy controls) participated in a prospective non-interventional clinical study. Patients were investigated at the time of an acute episode and 6 months after reaching remission. The clinical and personal characteristics, and morning and evening salivary concentrations of aldosterone and cortisol were evaluated. RESULTS:Patients with an acute depressive episode exhibited higher evening aldosterone and lower morning cortisol concentrations compared to healthy subjects. In these patients, both hormone concentrations showed flatter morning to evening slopes. Salivary aldosterone, but not cortisol concentrations, were lower in patients 6 months after reaching remission compared to those in the acute state. Similarly, 6 months of remission resulted in a steeper morning to evening slope of salivary aldosterone compared to the acute state. The cortisol rhythm remained dysregulated. A significant negative correlation between trait anxiety scores and morning cortisol concentrations in patients at 6 months of clinical remission was observed. CONCLUSION:Diurnal changes in salivary aldosterone concentrations appear to be a state marker, whilst those of cortisol a trait marker of depression.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Izakova L,Hlavacova N,Segeda V,Kapsdorfer D,Morovicsova E,Jezova D

doi

10.1159/000505921

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1001-1009

issue

11-12

eissn

0028-3835

issn

1423-0194

pii

000505921

journal_volume

110

pub_type

杂志文章
  • Distribution of a renin-releasing factor in the central nervous system of the rat.

    abstract::We have previously shown that the serotonergic regulation of renin secretion from the kidneys is mediated by a renin-releasing factor (RRF) that is present in both plasma and hypothalamus. The present studies were designed to determine the distribution of RRF in the brain and peripheral tissues and to test whether RRF...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126170

    authors: Urban JH,Brownfield MS,Levine JE,Van de Kar LD

    更新日期:1992-05-01 00:00:00

  • Characterization of the effect of Mycoplasma fermentans on the hypothalamo-pituitary-adrenal axis.

    abstract::The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later....

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127241

    authors: Wohlman A,Gallily R,Yirmiya R,Weidenfeld J

    更新日期:1997-09-01 00:00:00

  • Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus and brainstem.

    abstract::Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054548

    authors: Deauseault D,Giroux D,Wood CE

    更新日期:2000-05-01 00:00:00

  • Developmental patterns of the hypothalamic-pituitary axis in the euthyroid and hypothyroid male rat.

    abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123011

    authors: Sowers JR,Resch G,Walker S,Sollars E

    更新日期:1980-05-01 00:00:00

  • Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death.

    abstract::Introduction Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic neuroendocrine neoplastic (pNEN) cells l...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000512567

    authors: Matrood S,de Prisco N,Wissniowski T,Wiese D,Jabari S,Griesmann H,Wanzel M,Stiewe T,Neureiter D,Klieser E,Mintziras I,Buchholz M,Bartsch DK,Gennarino V,Di Fazio P

    更新日期:2020-10-27 00:00:00

  • Effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the uterus, pituitary, and forebrain of the female rat.

    abstract::Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127160

    authors: Quiñones-Jenab V,Jenab S,Ogawa S,Adan RA,Burbach JP,Pfaff DW

    更新日期:1997-01-01 00:00:00

  • Adrenal medullary secretory response to stimulation of the medulla oblongata in the rat.

    abstract::In rats anesthetized with sodium pentobarbital, adrenal venous blood samples were collected and analyzed for epinephrine and norepinephrine by the fluorometric method. Stimulation of the inferior fovea or adjacent areas resulted in a significant increase in epinephrine secretion. Stimulation of some other areas of the...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122949

    authors: Matsui H

    更新日期:1979-01-01 00:00:00

  • Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouse.

    abstract::Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000064428

    authors: Pannell C,Simonian SX,Gillies GE,Luscher B,Herbison AE

    更新日期:2002-08-01 00:00:00

  • Opioid peptidergic control of gonadotropin-releasing hormone pulse generator activity in the ovariectomized goat.

    abstract::The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126418

    authors: Ito K,Tanaka T,Mori Y

    更新日期:1993-04-01 00:00:00

  • Prolonged food deprivation abolishes the circadian adrenocortical rhythm, but not the endogenous rhythm in rats.

    abstract::An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122924

    authors: Kobayashi K,Takahashi K

    更新日期:1979-01-01 00:00:00

  • Adjustment of pineal melatonin and N-acetyltransferase rhythms to change from long to short photoperiod in the Djungarian hamster Phodopus sungorus.

    abstract::In the Djungarian hamster Phodopus sungorus, the daily temporal pattern of synthesis and release of pineal hormone melatonin, mainly the length of the period of elevated melatonin levels, may be involved in transferring the information on day length to the neuroendocrine-gonadal axis. The present study investigated th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123895

    authors: Illnerová H,Hoffmann K,Vanĕcek J

    更新日期:1984-03-01 00:00:00

  • Ultrastructure of somatotrophs of rats with median eminence lesions: studies in basal conditions and after thyrotropin-releasing hormone stimulation.

    abstract::Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal condit...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122911

    authors: Rossi GL,Probst D,Panerai AE,Cocchi D,Locatelli V,Müller EE

    更新日期:1979-01-01 00:00:00

  • Diurnal variation in hypothalamic monoamines and plasma corticosterone in the turkey after inhibition of tyrosine hydroxylase or tryptophan hydroxylase.

    abstract::Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA trea...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123299

    authors: Martin JT,El Halawani M,Phillips RE

    更新日期:1982-03-01 00:00:00

  • Hypoprolactinemia induced by hypophysectomy and long-term bromocriptine treatment decreases tuberoinfundibular dopaminergic neuronal activity and the responsiveness of these neurons to prolactin.

    abstract::The effect of long-term decreases in circulating concentrations of prolactin was determined on the responsiveness of tuberoinfundibular dopamine (DA) neurons to this hormone. The activity of these neurons in ovariectomized rats was estimated by measuring the rate of DA synthesis (DOPA accumulation after the administra...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124100

    authors: Demarest KT,Riegle GD,Moore KE

    更新日期:1985-05-01 00:00:00

  • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats.

    abstract::There is evidence that alpha-melanocyte-stimulating hormone (alpha-MSH) has immunomodulatory and anti-inflammatory actions within the brain. In this study, we tested whether these actions are due to inhibition of the synthesis of nitric oxide (NO) and prostaglandins induced by lipopolysaccharide (LPS). Since melanocor...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000079321

    authors: Caruso C,Mohn C,Karara AL,Rettori V,Watanobe H,Schiöth HB,Seilicovich A,Lasaga M

    更新日期:2004-01-01 00:00:00

  • In vivo and in vitro interference of phosphatidylserine liposomes on prolactin secretion in the rat.

    abstract::The effect of sonicated suspensions of phosphatidylserine (PS), an acidic phospholipid, was investigated on prolactin secretion utilizing in vivo and in vitro approaches. Acute and chronic administration of PS reduced plasma prolactin levels during different phases of circadian rhythms. The phospholipid was able to in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123261

    authors: Canonico PL,Annunziato L,Toffano G,Bernardini R,Stanzani S,Foti M,Clementi G,Drago F,Scapagnini U

    更新日期:1981-12-01 00:00:00

  • Glucose and Fat Metabolism in Acromegaly: From Mice Models to Patient Care.

    abstract::Patients with active acromegaly are frequently insulin resistant, glucose intolerant, and at risk for developing overt type 2 diabetes. At the same time, these patients have a relatively lean phenotype associated with mobilization and oxidation of free fatty acids. These features are reversed by curative surgical remo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000430819

    authors: Dal J,List EO,Jørgensen JO,Berryman DE

    更新日期:2016-01-01 00:00:00

  • Prostaglandins and the release of LHRH from hypothalamic synaptosomes. Effects of indomethacin pretreatment.

    abstract::The possible role of prostaglandins (PGs) in the hypothalamic control of ovulation has been investigated by studying the effects of indomethacin (ID) and PGs on the release of luteinizing hormone-releasing hormone (LHRH) from hypothalamic synaptosomes. Female rats were chronically pretreated with ID on diestrus 2 (D2)...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122888

    authors: Linton EA,Bennett GW,Whitehead SA

    更新日期:1979-01-01 00:00:00

  • Effects of centrally administered prolactin upon mammary contractility in anesthetized lactating rats.

    abstract::The possibility was investigated that centrally administered rat prolactin (PRL), i.e., intracerebroventricularly (ICV) or intrathecally (IT), may influence mammary contractility in urethane-anesthetized lactating rats. In addition to the monomer (23 kD PRL), the 16- and 7-kD PRL fragments were also tested and their e...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127006

    authors: Morales MT,Mena F

    更新日期:1995-08-01 00:00:00

  • Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia.

    abstract::Studies were undertaken to characterize the secretion of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) into the hypophysial-portal circulation of the conscious sheep. In addition, we examined the temporal relationship between the secretion of these two hypothalamic peptides and the secretion of t...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125141

    authors: Engler D,Pham T,Fullerton MJ,Ooi G,Funder JW,Clarke IJ

    更新日期:1989-04-01 00:00:00

  • Effects of castration or testosterone implants upon pituitary function in hypogonadal mice bearing normal foetal preoptic area grafts.

    abstract::Grafts of normal mouse preoptic area (POA) tissue into the third ventricle of gonadotrophin-releasing hormone (GnRH)-deficient hypogonadal (hpg) mice resulted in an elevation of pituitary GnRH receptors, an increased synthesis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland, a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124762

    authors: Charlton HM,Jones AJ,Ward BJ,Detta A,Clayton RN

    更新日期:1987-05-01 00:00:00

  • Relationship between rhythmic motor activity and plasma luteinizing hormone in ovariectomized sheep.

    abstract::The timing of the episodic secretion of luteinizing hormone (LH) in ovariectomized ewes was investigated with respect to an ultradian rest-activity cycle. Individual sheep were enclosed in a chamber where their physical activity was continuously monitored, and blood samples for LH analysis were collected at 5-min inte...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123187

    authors: Rasmussen DD,Malven PV

    更新日期:1981-06-01 00:00:00

  • Cardiometabolic Risks in Polycystic Ovary Syndrome: Non-Traditional Risk Factors and the Impact of Obesity.

    abstract::Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the patho...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000455233

    authors: Chiu WL,Boyle J,Vincent A,Teede H,Moran LJ

    更新日期:2017-01-01 00:00:00

  • Effects of melatonin and an aqueous pineal extract on adrenal secretion of reduced steroid metabolites in female rats.

    abstract::The effects of melatonin and an aqueous extract of bovine pineal glands on adrenal function were studied in pinealectomized, ovariectomized and hypophysectomized rats. Melatonin (50 microgram i.p., twice daily for 1 week) stimulates adrenal 5 alpha-reductase activity in intact animals and after ovariectomy. A correspo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122659

    authors: Ogle TF,Kitay JI

    更新日期:1977-01-01 00:00:00

  • Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors.

    abstract:BACKGROUND:Activation of somatostatin receptors (sstr1-5) by somatostatin and its analogues exerts an inhibitory effect on hormone secretion and provides the basis for the treatment of a range of endocrine diseases such as acromegaly, Cushing's disease and neuroendocrine tumors (NET). The lack of well-characterized com...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000330616

    authors: Schmid HA,Lambertini C,van Vugt HH,Barzaghi-Rinaudo P,Schäfer J,Hillenbrand R,Sailer AW,Kaufmann M,Nuciforo P

    更新日期:2012-01-01 00:00:00

  • Preoptic LH-RH and somatostatin in the rat median eminence. An experimental light and electron microscopic immunocytochemical study.

    abstract::Glass microknife lesions and immunocytochemistry were used to evaluate luteinizing hormone-releasing hormone (LH-RH)- and somatostatin (SS)-immunoreactive pathways from the preoptic region to the rat median eminence. Cuts were so placed that axons of more caudally located neurons in the periventricular hypothalamic ar...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123886

    authors: Jew JY,Léránth C,Arimura A,Palkovits M

    更新日期:1984-03-01 00:00:00

  • Direct action of serotonin on prolactin, growth hormone, corticotropin and luteinizing hormone release in cocultures of anterior and posterior pituitary lobes: autocrine and/or paracrine action of vasoactive intestinal peptide.

    abstract::There is extensive evidence that serotonin (5-HT) is implicated in the neuroendocrine control regulating the secretion of several anterior pituitary hormones. It has also been reported that the posterior pituitary is necessary for prolactin (PRL) response to 5-HT as well as to suckling, in which 5-HT implication has b...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054381

    authors: Balsa JA,Sánchez-Franco F,Pazos F,Lara JI,Lorenzo MJ,Maldonado G,Cacicedo L

    更新日期:1998-11-01 00:00:00

  • Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms.

    abstract::The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000502776

    authors: Oka N,Kasajima A,Konukiewitz B,Sakurada A,Okada Y,Kameya T,Weichert W,Ishikawa Y,Suzuki H,Sasano H,Klöppel G

    更新日期:2020-01-01 00:00:00

  • The growth hormone-releasing hormone-cyclic adenosine-3',5'-monophosphate signal pathway in somatotropes is practically intact during aging.

    abstract::To elucidate the mechanisms of the impaired pituitary response to growth hormone-releasing hormone (GHRH) in aged animals on a cellular basis, a reverse hemolytic plaque assay was performed on dispersed pituitary cells from young (8-month-old) and old (26-month-old) male F344 rats. The proportion of growth hormone (GH...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126799

    authors: Shimokawa I,Higami Y,Okimoto T,Ikeda T

    更新日期:1994-12-01 00:00:00

  • Correlations between the hypothalamic density of 3H-clonidine-binding sites and plasma testosterone levels in mice.

    abstract::Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between h...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126893

    authors: Shishkina GT,Naumenko EV

    更新日期:1995-06-01 00:00:00