Hypoprolactinemia induced by hypophysectomy and long-term bromocriptine treatment decreases tuberoinfundibular dopaminergic neuronal activity and the responsiveness of these neurons to prolactin.

Abstract:

:The effect of long-term decreases in circulating concentrations of prolactin was determined on the responsiveness of tuberoinfundibular dopamine (DA) neurons to this hormone. The activity of these neurons in ovariectomized rats was estimated by measuring the rate of DA synthesis (DOPA accumulation after the administration of a decarboxylase inhibitor) in the median eminence at various times after serum concentrations of prolactin had been reduced by hypophysectomy or the chronic administration of a DA agonist (bromocriptine, 3 mg/kg/day). The concentration of DA in the median eminence, but not in striatum, declined progressively up to 12 days after hypophysectomy, but did not change at any time during bromocriptine treatment. On the other hand, norepinephrine concentrations in the median eminence were increased 12 days after both treatments. Within 24 h after hypophysectomy or the first injection of bromocriptine the rate of DA synthesis in the median eminence was decreased; this decrease was maintained for at least 12 days suggesting that tuberoinfundibular DA neuronal activity is normally maintained by endogenous prolactin. Intracerebroventricular (ICV) injections of prolactin (10 micrograms, 12 h prior to sacrifice) increased the rate of DA synthesis in the median eminence of control, 24-hour hypophysectomized and 24-hour bromocriptine-treated rats. After longer periods (6-12 days) of bromocriptine treatment or after hypophysectomy the responsiveness of tuberoinfundibular DA neurons to prolactin was reduced. Dose-response studies revealed that the sensitivity and magnitude of response to ICV prolactin was markedly reduced in 12-day hypophysectomized rats.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Demarest KT,Riegle GD,Moore KE

doi

10.1159/000124100

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

369-76

issue

5

eissn

0028-3835

issn

1423-0194

journal_volume

40

pub_type

杂志文章
  • Gonadotropin-releasing hormone modifies action potential generation in sheep pars distalis gonadotropes.

    abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126605

    authors: Heyward PM,Chen C,Clarke IJ

    更新日期:1993-12-01 00:00:00

  • Progesterone, but not LHRH or prostaglandin E2, induces sequential inhibition of lordosis to various lordogenic agents.

    abstract::In experiment I we studied the capacity of progesterone (P) and two nonsteroidal agents that activate lordosis, but do not bind to the progestin receptor (PR), i.e. luteinizing hormone-releasing hormone (LHRH) and prostaglandin E2 (PGE2) to induce sequential inhibition (SI) in ovariectomized estradiol-primed rats. The...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126457

    authors: González-Mariscal G,Melo AI,Beyer C

    更新日期:1993-05-01 00:00:00

  • Neuropeptide W influences the excitability of neurons in the rat hypothalamic arcuate nucleus.

    abstract::Neuropeptide W (NPW) is a ligand of the recently deorphaned receptor GPR7. Intracerebroventricular injection of this peptide results in reduced serum growth hormone concentration. Using whole-cell patch clamp recordings from somatostatin (SS) neurons in the hypothalamic arcuate nucleus, identified post-hoc using singl...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000117577

    authors: Price CJ,Samson WK,Ferguson AV

    更新日期:2008-01-01 00:00:00

  • The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain.

    abstract::Leptin exerts important effects on the regulation of food intake and energy expenditure by acting in the brain. Leptin action is mediated by the interaction with a receptor that is alternatively spliced, resulting in at least five different isoforms. The long form (OB-Rb) has a long intracellular domain that is essent...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054536

    authors: Burguera B,Couce ME,Long J,Lamsam J,Laakso K,Jensen MD,Parisi JE,Lloyd RV

    更新日期:2000-03-01 00:00:00

  • Morphology of luteinizing hormone-releasing hormone neurons as a function of age and hormonal condition in the male rat.

    abstract::Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or 'thorny'. To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125138

    authors: Witkin JW

    更新日期:1989-04-01 00:00:00

  • Neuropeptide TLQP-21, a VGF internal fragment, modulates hormonal gene expression and secretion in GH3 cell line.

    abstract::In the present study we demonstrated that TLQP-21, a biologically active peptide derived from the processing of the larger pro-VGF granin, plays a role in mammotrophic cell differentiation. We used an established in vitro model, the GH3 cell line, which upon treatment with epidermal growth factor develops a mammotroph...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000339855

    authors: Petrocchi Passeri P,Biondini L,Mongiardi MP,Mordini N,Quaresima S,Frank C,Baratta M,Bartolomucci A,Levi A,Severini C,Possenti R

    更新日期:2013-01-01 00:00:00

  • Penfluridol decreases secretagogue-induced TSH, GH, and LH secretion in vitro: a possible role for calcium-calmodulin.

    abstract::This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123548

    authors: Schettini G,Judd AM,MacLeod RM

    更新日期:1983-09-01 00:00:00

  • Testosterone modulates oxytocin binding in the hypothalamus of castrated male rats.

    abstract::Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125222

    authors: Johnson AE,Coirini H,McEwen BS,Insel TR

    更新日期:1989-08-01 00:00:00

  • Neurosecretion of human hypothalamic immunoreactive beta-endorphin: in vitro regulation by dopamine.

    abstract::An in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 microM pulse of DA consistently elicited a mean (+/- SE) 88 +/- 9% increase (p less ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124725

    authors: Rasmussen DD,Liu JH,Wolf PL,Yen SS

    更新日期:1987-03-01 00:00:00

  • Effects and therapeutic potentials of kisspeptin analogs: regulation of the hypothalamic-pituitary-gonadal axis.

    abstract::The hypothalamic peptide kisspeptin (metastin), the endogenous ligand of the G protein-coupled receptor KISS1R, plays a critical role in controlling GnRH release from hypothalamic GnRH neurons and thereby regulates hypothalamic-pituitary-gonadal functions. Although the therapeutic potential of kisspeptin is attractive...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000357809

    authors: Matsui H,Asami T

    更新日期:2014-01-01 00:00:00

  • Demonstration of contacts between neurons staining for LHRH in the preoptic area of the rat brain.

    abstract::It has been recently demonstrated that luteinizing hormone-releasing hormone (LHRH) can inhibit LHRH release by the hypothalamus, suggesting an ultrashort feedback of LHRH on LHRH neurons. In order to test this hypothesis, immunocytochemical localization of LHRH was conducted in the preoptic area of the rat brain. Con...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124861

    authors: Pelletier G

    更新日期:1987-11-01 00:00:00

  • Developmental patterns of the hypothalamic-pituitary axis in the euthyroid and hypothyroid male rat.

    abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123011

    authors: Sowers JR,Resch G,Walker S,Sollars E

    更新日期:1980-05-01 00:00:00

  • Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats.

    abstract::Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125951

    authors: Mendelson SD,McEwen BS

    更新日期:1991-11-01 00:00:00

  • Epidemiology of Cushing's syndrome.

    abstract::Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000314297

    authors: Steffensen C,Bak AM,Rubeck KZ,Jørgensen JO

    更新日期:2010-01-01 00:00:00

  • Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine.

    abstract::The growth hormone secretagogue receptor subtype 1a (GHSR-1a) is involved in biological actions of ghrelin by triggering intracellular second messengers coupled to heterotrimeric G-protein complex involving Galpha(q/11). Adenosine is a partial agonist of the GHSR-1a, binding to a binding pocket distinct from the one d...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000076042

    authors: Carreira MC,Camiña JP,Smith RG,Casanueva FF

    更新日期:2004-01-01 00:00:00

  • Relationship between rhythmic motor activity and plasma luteinizing hormone in ovariectomized sheep.

    abstract::The timing of the episodic secretion of luteinizing hormone (LH) in ovariectomized ewes was investigated with respect to an ultradian rest-activity cycle. Individual sheep were enclosed in a chamber where their physical activity was continuously monitored, and blood samples for LH analysis were collected at 5-min inte...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123187

    authors: Rasmussen DD,Malven PV

    更新日期:1981-06-01 00:00:00

  • Early expression of the glycoprotein hormone alpha-subunit in the pars tuberalis of the rat pituitary gland during ontogenesis.

    abstract::The expression of the alpha-subunit of the glycoprotein hormones was studied in the developing rat pituitary by in situ hybridization and immunocytochemical techniques. The alpha-subunit mRNA labelling was detected in Rathke's pouch at 12 days' gestation (E12); at E13, it was exclusively concentrated in the pars tuber...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126600

    authors: Stoeckel ME,Hindelang C,Klein MJ,Poissonnier M,Félix JM

    更新日期:1993-12-01 00:00:00

  • Estrogen receptors and signaling pathways in lactotropes and somatotropes.

    abstract::Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000321683

    authors: Zárate S,Seilicovich A

    更新日期:2010-01-01 00:00:00

  • An ultrastructural and radioimmunoassay study of anterior pituitary somatotrophs following pituitary portal vessel infusion of growth hormone releasing factor.

    abstract::The hypophysial portal vessels and anterior pituitary glands of adult male rats were surgically exposed, cannulated and infused for 1 min with saline, growth hormone-releasing factor (GH-RF), and dbcAMP. After cessation of infusion, anterior pituitary glands were collected at 1, 5, 15, 30 or 60 min for electron micros...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122421

    authors: Wilbur DL,Worthington WC Jr,Markwald RR

    更新日期:1975-01-01 00:00:00

  • Central stimulatory influence of oxytocin on preovulatory gonadotropin-releasing hormone requires more than the median eminence.

    abstract::The study was designed to determine whether the ability of central oxytocin (OT) to stimulate gonadotropin-releasing hormone (GnRH) on the afternoon of proestrus (PE) in the cycling female rat is mediated at the level of GnRH terminals within the median eminence (ME), or at higher hypothalamic levels where GnRH cell b...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054678

    authors: Selvage D,Johnston CA

    更新日期:2001-08-01 00:00:00

  • Postnatal morphological changes in rat LHRH neurons correlated with sexual maturation.

    abstract::The postnatal development of the luteinizing hormone-releasing hormone (LHRH) system in male and female rats was investigated using light microscopic immunocytochemistry. An identical number of immunoreactive LHRH cells (about 1,300) was observed for males and females throughout development. Two LHRH cell types, based...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124516

    authors: Wray S,Hoffman G

    更新日期:1986-01-01 00:00:00

  • Diurnal rhythms in pineal N-acetyltransferase and hippocampal norepinephrine: effects of water deprivation, blinding and hypothalamic lesions.

    abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122489

    authors: Moore RY,Traynor ME

    更新日期:1976-01-01 00:00:00

  • Nutrient control of energy homeostasis via gut-brain neural circuits.

    abstract::Intestinal gluconeogenesis is a recently described function in intestinal glucose metabolism. In particular, the intestine contributes around 20-25% of total endogenous glucose production during fasting. Intestinal gluconeogenesis appears to regulate energy homeostasis via a neurally mediated mechanism linking the ent...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000369070

    authors: Mithieux G

    更新日期:2014-01-01 00:00:00

  • Estrogen regulates the gene expression of vasoactive intestinal peptide in the anterior pituitary.

    abstract::Vasoactive intestinal peptide (VIP), a prolactin (PRL)-releasing factor, has been shown to be synthesized within the anterior pituitary. To test the hypothesis that estrogens increase PRL secretion, at least in part, by stimulating VIP secretion, the concentrations of VIP, peptide histidine isoleucine (PHI) and prepro...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125622

    authors: Lam KS,Srivastava G,Lechan RM,Lee T,Reichlin S

    更新日期:1990-11-01 00:00:00

  • Role of serotonin in feedback control of hypothalamic-pituitary-testicular complex in male rats.

    abstract::Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122791

    authors: Naumenko EV,Shishkina GT

    更新日期:1978-01-01 00:00:00

  • 68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management.

    abstract:BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000472717

    authors: Lamarca A,Pritchard DM,Westwood T,Papaxoinis G,Nonaka D,Vinjamuri S,Valle JW,Manoharan P,Mansoor W

    更新日期:2018-01-01 00:00:00

  • Central oxytocin mediates inhibition of sodium appetite by naloxone in hypovolemic rats.

    abstract::Pituitary oxytocin (OT) secretion is inversely related to saline consumption in several experimental models of sodium appetite in rats. Because systemic OT administration does not inhibit sodium appetite, release of OT as a neurotransmitter within the brain, coincident with its secretion from the pituitary, may be rel...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126236

    authors: Blackburn RE,Stricker EM,Verbalis JG

    更新日期:1992-08-01 00:00:00

  • Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells.

    abstract::TRPM8 is a member of the melastatin-type transient receptor potential ion channel family. Activation by cold or by agonists (menthol, icilin) induces a transient rise in intracellular free calcium concentration ([Ca(2+)](i)). Our previous study demonstrated that Ca(2+)-permeable cation channels play a role in IGF-1-in...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000101693

    authors: Mergler S,Strowski MZ,Kaiser S,Plath T,Giesecke Y,Neumann M,Hosokawa H,Kobayashi S,Langrehr J,Neuhaus P,Plöckinger U,Wiedenmann B,Grötzinger C

    更新日期:2007-01-01 00:00:00

  • Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity.

    abstract::In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were ex...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000091980

    authors: Matejec R,Uhlich H,Hotz C,Mühling J,Harbach HW,Bödeker RH,Hempelmann G,Teschemacher H

    更新日期:2005-01-01 00:00:00

  • Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death.

    abstract::Introduction Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic neuroendocrine neoplastic (pNEN) cells l...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000512567

    authors: Matrood S,de Prisco N,Wissniowski T,Wiese D,Jabari S,Griesmann H,Wanzel M,Stiewe T,Neureiter D,Klieser E,Mintziras I,Buchholz M,Bartsch DK,Gennarino V,Di Fazio P

    更新日期:2020-10-27 00:00:00