Abstract:
:Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal conditions and after stimulation with thyrotropin-releasing hormone. Animals with lesions showed a reduction of both the number of somatotrophic cells and growth hormone granules. After injection of thyrotropin-releasing hormone exocytosis of growth hormone granules from somatotrophs was frequent in rats with lesions of the median eminence but rare in sham-operated animals. The differences were statistically significant.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Rossi GL,Probst D,Panerai AE,Cocchi D,Locatelli V,Müller EEdoi
10.1159/000122911subject
Has Abstractpub_date
1979-01-01 00:00:00pages
100-9issue
2eissn
0028-3835issn
1423-0194journal_volume
29pub_type
杂志文章abstract::In the Siberian hamster the pituitary content of bioassayable MSH has been shown to be seasonally variable, being greater during the long days of spring and summer than during the short days of autumn and winter. Similar changes in the pituitary content of both bioassayable MSH and immunoreactive alpha MSH can be indu...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123019
更新日期:1980-05-01 00:00:00
abstract::To characterize the short-term ACTH secretion pattern and to investigate factors regulating it, pituitary venous (PV) blood was collected using our nonsurgical method from 8 unperturbed horses every 20 or 30 s for approximately 1 h. In all but 1 horse, sampling occurred during the broad circadian maximum in plasma cor...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126755
更新日期:1994-09-01 00:00:00
abstract::Multiple unit activity (MUA) was recorded from the adrenocorticotropic area (n. posterior medialis hypothalami, PMH) of unrestrained resting pigeons throughout the 24 h period and compared with plasma corticosterone levels (B). Bilateral electrolytic lesions of the hippocampus suppressed diurnal variations of MUA and ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122750
更新日期:1978-01-01 00:00:00
abstract::Follicle-stimulating hormone (FSH) is involved in the regulation and maintenance of gametogenesis. It exists in multiple molecular forms with different oligosaccharide structures which in turn are influenced by the hormonal milieu. Previous studies from our laboratory demonstrated that antiandrogen administration to i...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054484
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND/AIMS:Stress exacerbates neuron loss in many CNS injuries via the actions of adrenal glucocorticoid (GC) hormones. For some injuries, this GC endangerment of neurons is accompanied by greater immune cell activation in the CNS, a surprising outcome given the potent immunosuppressive properties of GCs. METHODS...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000367849
更新日期:2014-01-01 00:00:00
abstract::Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125387
更新日期:1990-05-01 00:00:00
abstract::Recordings were made of single unit activity through chronically implanted electrodes within the hypothalamic paraventricular nucleus of freely moving male rats also bearing chronically implanted stimulating electrodes in the preoptic area (POA) and indwelling jugular cannulae. High frequency electrical stimulation of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124269
更新日期:1986-01-01 00:00:00
abstract::Corticotropin-releasing factor (CRF) has been characterized on the basis of its intrinsic activity to release corticotropin from cultured rat anterior pituitary cells. Injected in intact rats, CRF increases adrenocorticotropic hormone (ACTH) release. Endogenous CRF-like immunoreactivity was detected in the cytoplasm a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125186
更新日期:1989-06-01 00:00:00
abstract::Using specific antibodies to corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) we have immunocytochemically located cells and fibres containing these peptides in sheep fetuses. CRF neurones were first detected, in low frequency, in the paraventricular nuclei of fetuses of 90 days of gestation (term ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124860
更新日期:1987-11-01 00:00:00
abstract::Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agen...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000095338
更新日期:2006-01-01 00:00:00
abstract::(+/-)p-Chloroamphetamine hydrochloride, at doses of 1-8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123057
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to ki...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000227806
更新日期:2009-01-01 00:00:00
abstract::Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by trans...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122679
更新日期:1977-01-01 00:00:00
abstract::Serotonin, a biologically active amine, is related to carcinoid syndrome in functioning neuroendocrine tumors (NETs). Telotristat ethyl is a novel inhibitor of the tryptophan hydroxylase (TPH), a key enzyme in the production of serotonin. While its use in patients with carcinoid syndrome and uncontrolled diarrhea unde...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000502200
更新日期:2020-01-01 00:00:00
abstract::There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124816
更新日期:1987-08-01 00:00:00
abstract::Electrical stimulation in the subfornical organ (SFO) alters the excitability of antidromically identified paraventricular nucleus neurons. Extracellular recordings demonstrate that the dominant effect of single stimuli delivered to the SFO on neurohypophyseal oxytocin and vasopressin containing neurons is an increase...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124015
更新日期:1984-11-01 00:00:00
abstract::In goldfish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1, 2, 3, and 6 often result in an antagonist in goldfish, an observation w...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126706
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000441897
更新日期:2017-01-01 00:00:00
abstract::We have previously shown that the serotonergic regulation of renin secretion from the kidneys is mediated by a renin-releasing factor (RRF) that is present in both plasma and hypothalamus. The present studies were designed to determine the distribution of RRF in the brain and peripheral tissues and to test whether RRF...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126170
更新日期:1992-05-01 00:00:00
abstract::Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000321683
更新日期:2010-01-01 00:00:00
abstract::Dexras1, a newly identified member of the Ras superfamily of proteins, was discovered in AtT-20 corticotrope cells because its expression was induced in response to glucocorticoids (dexamethasone; Dex). As yet, the function of Dexras1 is unknown, but its rapid induction in response to glucocorticoids suggests the poss...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054691
更新日期:2001-10-01 00:00:00
abstract::The effect of steroids on the two gonadotropin-releasing hormone (GnRH) forms present in the eel (mammalian GnRH, mGnRH and chicken GnRH-II, cGnRH-II), as well as on gonadotropin (GTH), was studied using specific radioimmunoassays. Female silver eels received chronic treatments with various steroids (estradiol, testos...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126876
更新日期:1995-05-01 00:00:00
abstract::Ciliary neurotropic factor (CNTF) is a neuroregulatory cytokine belonging to the interleukin-6 type cytokine superfamily. Although a few studies have reported a facilitatory action of CNTF on the reproductive axis in rodents, information along this line is still very limited. In this study, we examined a possible role...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054695
更新日期:2001-11-01 00:00:00
abstract::To elucidate the mechanisms of the impaired pituitary response to growth hormone-releasing hormone (GHRH) in aged animals on a cellular basis, a reverse hemolytic plaque assay was performed on dispersed pituitary cells from young (8-month-old) and old (26-month-old) male F344 rats. The proportion of growth hormone (GH...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126799
更新日期:1994-12-01 00:00:00
abstract::Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054685
更新日期:2001-09-01 00:00:00
abstract::A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125853
更新日期:1991-07-01 00:00:00
abstract::The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000495806
更新日期:2019-01-01 00:00:00
abstract::A patch-clamp study was conducted on cultured frog pituitary melanotrophs, in order to investigate the effects of adrenaline on the electrical activity of these cells. In the whole-cell configuration, adrenaline (1 microM) caused hyperpolarization that was accompanied by a fall in membrane input resistance and a block...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126633
更新日期:1994-01-01 00:00:00
abstract::Many aspects of reproductive neuroendocrine function and sexual behavior are responsive to both androgens and estrogens, suggesting that receptors for these steroid hormones may reside within single cells in brain regions that control reproductive function. We determined the distribution of estrogen receptor-containin...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127039
更新日期:1995-11-01 00:00:00
abstract::Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signalling pathways, facilitating intracellular Ca2+ release and protein kinase C activation. A sixth class of phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCeta) has recently been discovered in mammals. Rece...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000107795
更新日期:2007-01-01 00:00:00