Effects of melatonin and an aqueous pineal extract on adrenal secretion of reduced steroid metabolites in female rats.

abstract：:Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...

journal_title：Neuroendocrinology

authors： Johnson AE,Coirini H,McEwen BS,Insel TR

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low g...

journal_title：Neuroendocrinology

authors： Oversoe SK,Sorensen BS,Tabaksblat EM,Gronbaek H,Kelsen J

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...

journal_title：Neuroendocrinology

authors： Frizziero M,Spada F,Lamarca A,Kordatou Z,Barriuso J,Nuttall C,McNamara MG,Hubner RA,Mansoor W,Manoharan P,Fazio N,Valle JW

更新日期：2019-01-01 00:00:00

abstract：:Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innerva...

journal_title：Neuroendocrinology

authors： Anesten F,Mishra D,Dalmau Gasull A,Engström-Ruud L,Bellman J,Palsdottir V,Zhang F,Trapp S,Skibicka KP,Poutanen M,Jansson JO

更新日期：2019-01-01 00:00:00

abstract：:We determined the effect of 17 beta-estradiol (E2) on synthesis and release of luteinizing hormone (LH) induced by drugs which activate intracellular signal transduction mechanisms in rat anterior pituitary cells. Cells were pretreated with E2 (6 x 10(-10) M) or diluent for 24 h, then washed and incubated for 4 h with...

journal_title：Neuroendocrinology

authors： Liu TC,Jackson GL

更新日期：1990-06-01 00:00:00

abstract：:Peptidyl-glycine alpha-amidation activity has been detected in human cerebrospinal fluid (CSF) and in several regions of the central nervous system. Activity was monitored by measuring conversion of mono-125I-D-Tyr-Val-Gly into mono-125I-D-Tyr-Val-NH2. The alpha-amidation activity in CSF is dependent on molecular oxyg...

journal_title：Neuroendocrinology

authors： Wand GS,Ney RL,Mains RE,Eipper BA

更新日期：1985-12-01 00:00:00

abstract：:In pituitary cells, c-fos transcription induced by releasing hormones and growth factors results from enhanced initiation of transcription, and sustained elongation of transcripts beyond the first intron. We studied the regulatory role of the first intron of the mouse c-fos gene for the control of its transcription in...

journal_title：Neuroendocrinology

authors： van Haasteren G,Li S,Ryser S,Schlegel W

更新日期：2000-12-01 00:00:00

abstract：:The effect of in vivo corticosterone manipulation on binding sites for the excitatory neurotransmitter glutamate was determined using radioligand binding to rat brain cryostat sections and crude synaptic membranes. 3H-glutamate binding to regions of the dorsal hippocampal formation was significantly decreased in adren...

journal_title：Neuroendocrinology

authors： Halpain S,McEwen BS

更新日期：1988-09-01 00:00:00

abstract：:Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...

journal_title：Neuroendocrinology

authors： Kovács GL,De Wied D

更新日期：1983-10-01 00:00:00

abstract：:The hypothalamic peptide kisspeptin (metastin), the endogenous ligand of the G protein-coupled receptor KISS1R, plays a critical role in controlling GnRH release from hypothalamic GnRH neurons and thereby regulates hypothalamic-pituitary-gonadal functions. Although the therapeutic potential of kisspeptin is attractive...

journal_title：Neuroendocrinology

authors： Matsui H,Asami T

更新日期：2014-01-01 00:00:00

abstract：:Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...

journal_title：Neuroendocrinology

authors： Frankfurt M,Gould E,Woolley CS,McEwen BS

更新日期：1990-05-01 00:00:00

abstract：:In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels in the dentate gyrus of the hippocampus 4 h after the last seizure, and these levels rem...

journal_title：Neuroendocrinology

authors： Clark M,Smith MA,Weiss SR,Post RM

更新日期：1994-05-01 00:00:00

abstract：:In man and other mammals, starvation is accompanied by a severe suppression of luteinizing hormone-releasing hormone (LHRH) and luteinizing-hormone (LH) secretion, which is caused by unknown alterations in hypothalamic functions. Prostaglandin E2 (PGE2), endorphins and testosterone (T) are know to be strongly involved...

journal_title：Neuroendocrinology

authors： Küderling I,Dorsch G,Warnhoff M,Pirke KM

更新日期：1984-12-01 00:00:00

abstract：:The release of the decapeptide gonadotropin-releasing hormone (GnRH) from neuroterminals in the median eminence varies depending upon the stage of development, time of day, reproductive season, and day of the ovarian cycle. With respect to the biosynthetic events responsible for such alterations in GnRH release, we ha...

journal_title：Neuroendocrinology

authors： Gore AC

更新日期：1998-10-01 00:00:00

abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...

journal_title：Neuroendocrinology

authors： Lamperti AA,Baldwin DM

更新日期：1982-03-01 00:00:00

abstract：:The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...

journal_title：Neuroendocrinology

authors： Cheung CY,Neill AC,Weiner RI

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...

journal_title：Neuroendocrinology

authors： Hodson DJ,Townsend J,Tortonese DJ

更新日期：2013-01-01 00:00:00

abstract：:The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...

journal_title：Neuroendocrinology

authors： Morris M,Barnard RR Jr,Sain LE

更新日期：1984-11-01 00:00:00

abstract：:Unlike rats, but similar to primates, guinea pigs exhibit prolonged function of the corpus luteum and elevated progesterone secretion after ovulation. The gonadotropins, estrogen (E) and progesterone (P) have been examined throughout the guinea pig estrous cycle. However, neither prolactin secretion nor its regulation...

journal_title：Neuroendocrinology

authors： Bethea CL,Hess DL,Widmann AA,Henningfeld JM

更新日期：1995-06-01 00:00:00

abstract：:The capability of the anterior pituitary gland to secrete growth hormone (GH) in response to an intravenous injection of growth hormone-releasing factor, hpGRF-44, was evaluated in male rats ranging from 22 days to 24 months of age. The increase in GH concentrations following a submaximal dose of hpGRF-44 (0.5 microgr...

journal_title：Neuroendocrinology

authors： Wehrenberg WB,Ling N

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course...

journal_title：Neuroendocrinology

authors： Izakova L,Hlavacova N,Segeda V,Kapsdorfer D,Morovicsova E,Jezova D

更新日期：2020-01-01 00:00:00

abstract：:A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...

journal_title：Neuroendocrinology

authors： Bindoni M,Belluardo N,Marchese AE,Cardile V,Mudò G,Cella S,Laguidara A,Denatale G

更新日期：1986-01-01 00:00:00

abstract：:High affinity binding of 3H-flunitrazepam (FNZP) to crude membrane preparations of bovine pineal membranes was examined by a rapid filtration procedure through Whatman GFB paper. At 0 degrees C binding reached equilibrium in about 20 min. Scatchard analysis of data at equilibrium revealed a single population of bindin...

journal_title：Neuroendocrinology

authors： Lowenstein PR,Cardinali DP

更新日期：1983-08-01 00:00:00

abstract：:The hypothalamic preoptic area (POA) was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Initiation of POA stimulation was followed witin 10-20 min by large increases in plasma levels of prolactin (PRL). The stimulation-induced discharges of PRL were consistently observed in...

journal_title：Neuroendocrinology

authors： Malven PV

更新日期：1975-01-01 00:00:00

abstract：:Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...

journal_title：Neuroendocrinology

authors： Barden N,Chevillard C,Saavedra JM

更新日期：1982-02-01 00:00:00

abstract：CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...

journal_title：Neuroendocrinology

authors： Collins JS,Marshall JC,McCartney CR

更新日期：2012-01-01 00:00:00

abstract：:An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor a...

journal_title：Neuroendocrinology

authors： Kobayashi K,Takahashi K

更新日期：1979-01-01 00:00:00

abstract：:Using specific antibodies to corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) we have immunocytochemically located cells and fibres containing these peptides in sheep fetuses. CRF neurones were first detected, in low frequency, in the paraventricular nuclei of fetuses of 90 days of gestation (term ...

journal_title：Neuroendocrinology

authors： Levidiotis M,Oldfield B,Wintour EM

更新日期：1987-11-01 00:00:00

abstract：:Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...

journal_title：Neuroendocrinology

authors： Chi HJ,Shin SH

更新日期：1978-01-01 00:00:00

abstract：OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...

journal_title：Neuroendocrinology

authors： Kanakis G,Grimelius L,Spathis A,Tringidou R,Rassidakis GZ,Öberg K,Kaltsas G,Tsolakis AV

更新日期：2015-01-01 00:00:00