Abstract:
:The possibility was investigated that centrally administered rat prolactin (PRL), i.e., intracerebroventricularly (ICV) or intrathecally (IT), may influence mammary contractility in urethane-anesthetized lactating rats. In addition to the monomer (23 kD PRL), the 16- and 7-kD PRL fragments were also tested and their effects were determined on isometrically recorded intramammary pressure (IMP) responses to exogenous oxytocin (OXY). ICV injection of 23 kD PRL provoked increased IMP responses; similar, but inconsistent effects were obtained after 16 kD PRL, and no effect occurred after either saline or the 7 kD PRL fragment. The 23 kD PRL effect had a latency of about 5 min, reached plateau at 10-15 min and its magnitude was dose-dependent. Also, a stronger dose-related effect was shown by 23 kD PRL after IT than after ICV administration, which suggests that lower threshold for the PRL actions exist at the spinal level. On the other hand, ICV or IT injections of antiserum to PRL, but not of normal rabbit serum, fully prevented the respective facilitatory effects of 23 kD PRL on mammary contractility. Further experiments into the mechanisms involved showed that neither adrenalectomy nor hypophysectomy prevented the PRL effect whereas complete blockage occurred after either spinal cord transection, ventral root section (T8-T10 level), or i.v. or ICV administration of the adrenergic beta-blocker propranolol. These results indicate that central effects of PRL upon mammary contractility were neurally mediated and may have resulted from depressed beta-adrenergic control of ductal tone.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Morales MT,Mena Fdoi
10.1159/000127006subject
Has Abstractpub_date
1995-08-01 00:00:00pages
207-14issue
2eissn
0028-3835issn
1423-0194journal_volume
62pub_type
杂志文章abstract::Intestinal gluconeogenesis is a recently described function in intestinal glucose metabolism. In particular, the intestine contributes around 20-25% of total endogenous glucose production during fasting. Intestinal gluconeogenesis appears to regulate energy homeostasis via a neurally mediated mechanism linking the ent...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000369070
更新日期:2014-01-01 00:00:00
abstract::The growth hormone secretagogue receptor subtype 1a (GHSR-1a) is involved in biological actions of ghrelin by triggering intracellular second messengers coupled to heterotrimeric G-protein complex involving Galpha(q/11). Adenosine is a partial agonist of the GHSR-1a, binding to a binding pocket distinct from the one d...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000076042
更新日期:2004-01-01 00:00:00
abstract::In the course of the search for the prolactin-releasing factor (PRF), we noticed that the posterior pituitary contained strong PRF activity and subsequently traced this activity to that of bovine neurophysin-II (NP-II). NP-II prepared in our lab was judged to be a homogeneous preparation according to Sephadex G-75 gel...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124190
更新日期:1985-10-01 00:00:00
abstract::In order to characterize plasma prolactin (Prl) patterns during the estrous cycle and pseudopregnancy (PSP), I collected sequential blood samples between 8.00 and 19.00 h at 1-hour, 1.5-min or 1-min intervals from conscious, unrestrained female rats. During the afternoon of proestrus and estrus a single Prl surge was ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123247
更新日期:1981-11-01 00:00:00
abstract::An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122924
更新日期:1979-01-01 00:00:00
abstract::Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000321683
更新日期:2010-01-01 00:00:00
abstract::Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124638
更新日期:1986-01-01 00:00:00
abstract::A reproductive facet of ghrelin, a stomach-derived orexigenic peptide involved in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models. Yet, the modulatory actions of ghrelin on the gonadotropic axi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000092753
更新日期:2005-01-01 00:00:00
abstract::The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E1, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123451
更新日期:1983-02-01 00:00:00
abstract::Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000439133
更新日期:2015-01-01 00:00:00
abstract::The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122841
更新日期:1979-01-01 00:00:00
abstract::Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical mu agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in additio...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125762
更新日期:1991-05-01 00:00:00
abstract::Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal beta-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. beta-Adrenoceptor density and binding affinity both showed time-...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124225
更新日期:1985-12-01 00:00:00
abstract::Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by trans...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122679
更新日期:1977-01-01 00:00:00
abstract::Chronic hyperprolactinemia in the rat is associated with suppression of plasma gonadotropin concentrations. The reduction of gonadotropins is considered to be due to either an inhibitory effect of prolactin (PRL) on pituitary gonadotropin secretion and/or suppression of hypothalamic gonadotropin-releasing hormone (GnR...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126355
更新日期:1993-01-01 00:00:00
abstract::In previous studies we obtained evidence that serotonin release by p-chloroamphetamine (PCA) causes an increase in corticosterone secretion but that this effect is not mediated via the raphe nuclei in the midbrain. In contrast, PCA-induced prolactin secretion was abolished by dorsal raphe lesions. In the present study...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124205
更新日期:1985-11-01 00:00:00
abstract::Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054629
更新日期:2001-02-01 00:00:00
abstract::Dexras1, a newly identified member of the Ras superfamily of proteins, was discovered in AtT-20 corticotrope cells because its expression was induced in response to glucocorticoids (dexamethasone; Dex). As yet, the function of Dexras1 is unknown, but its rapid induction in response to glucocorticoids suggests the poss...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054691
更新日期:2001-10-01 00:00:00
abstract::Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124922
更新日期:1988-03-01 00:00:00
abstract::Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122536
更新日期:1976-01-01 00:00:00
abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127068
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known in this population. AIM:To evaluate the clinicopathological features and therapeutic outcomes of CP diagnosed in the elderly. PATIENTS AND METHODS:A retrospective, multicenter, national study of C...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000512161
更新日期:2020-10-09 00:00:00
abstract::We have previously reported that luteinizing hormone releasing hormone (LH-RH) levels in the medial basal hypothalamus (MBH) of adult male rats castrated for 2 weeks can be raised by testosterone (T) or estradiol (E2) treatment for 3-4 days. The present study was undertaken to determine the time after castration when ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124188
更新日期:1985-09-01 00:00:00
abstract::To assess the neuroendocrine correlates of menstrual status migrainosus (MSM) and menstrual migraine (MM), we evaluated the prolactin (PRL) and cortisol responses to the direct central serotoninergic (5-HT) agonist meta-chlorophenylpiperazine (m-CPP) administered orally (0.5 mg/kg) during the follicular (FP: +6, +8) a...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1159/000071706
更新日期:2003-07-01 00:00:00
abstract::The effect of catecholamines on plasma levels of immunoreactive ACTH (ACTHi), alpha-MSH (alpha-MSHi), beta-endorphin (beta-ENDi), arginine-vasopressin (AVPi) and of corticosterone (B) was studied in female rats. Intravenous infusion of the specific beta-adrenoceptor-stimulating agent l-isoproterenol in Wistar rats und...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123529
更新日期:1983-08-01 00:00:00
abstract::Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive respo...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000328226
更新日期:2011-01-01 00:00:00
abstract::Interactions between the hypothalamic-pituitary-adrenocortical (HPA) system and melatonin secretion have been demonstrated, but only the effects of melatonin on the activity of the HPA system have been studied in man. Alterations of melatonin secretion described as low-melatonin syndrome have been demonstrated in pati...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000127186
更新日期:1997-04-01 00:00:00
abstract::In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations a...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000101029
更新日期:2007-01-01 00:00:00
abstract::The neurotransmitter and andrenoceptors involved in the inhibition of luteinizing hormone (LH) release induced by stimulating the locus ceruleus nucleus (LC) have been characterized in ovariectomized, estrogen-primed rats in which the release of LH was triggered by electrical stimulation of the medial preoptic area. B...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123858
更新日期:1984-01-01 00:00:00
abstract::The effect of in vivo corticosterone manipulation on binding sites for the excitatory neurotransmitter glutamate was determined using radioligand binding to rat brain cryostat sections and crude synaptic membranes. 3H-glutamate binding to regions of the dorsal hippocampal formation was significantly decreased in adren...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125017
更新日期:1988-09-01 00:00:00