Characterization and distribution of receptors for gonadotropin-releasing hormone in the rat hippocampus.

abstract：:Plasma and hypothalamic LHRH was measured by specific radioimmuno-assay in intact and ovariectomized rats, and the values were correlated with peripheral plasma (PP) FSH and LH titers. At most stages of the estrous cycle, plasma LHRH was either undetectable or present at very minimal values. An increase in PP LHRH con...

journal_title：Neuroendocrinology

authors： Wheaton JE,McCann SM

更新日期：1976-01-01 00:00:00

abstract：:The injection of purified alpha-bungarotoxin (alpha-BTX), an antagonist of the muscle nicotinic cholinergic receptors, into the third ventricle (3rd V) of ovariectomized rats decreased the frequency of pulses of luteinizing hormone (LH) but had no significant effect on the amplitude or nadir of LH secretion. Approxima...

journal_title：Neuroendocrinology

authors： Kalash J,Romita V,Billiar RB

更新日期：1989-05-01 00:00:00

abstract：:We have investigated the effects of hyperprolactinemia, produced by pituitary isografts under the kidney capsule (16-20 days), on the LH releasing action and priming effect of LH-releasing hormone (LHRH) in normal and hypogonadal (hpg) female mice. The pituitary grafts increased the plasma prolactin concentrations abo...

journal_title：Neuroendocrinology

authors： Lewis CE,Fink G,Dow RC,Morris JF

更新日期：1986-01-01 00:00:00

abstract：:We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...

journal_title：Neuroendocrinology

authors： Carr JA,Saland LC,Samora A,Benavidez S,Krobert K

更新日期：1991-12-01 00:00:00

abstract：:After the combined treatment with dexamethasone, morphine and pentobarbitone, the electrical stimulation in the rat tuber cinereum induces a rise in plasma corticosterone (CS) level, probably by direct stimulation of the corticoliberin-producing neural elements and the consecutive ACTH release. We have attempted to lo...

journal_title：Neuroendocrinology

authors： Makara GB,Stark E,Palkovits M

更新日期：1978-01-01 00:00:00

abstract：:The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, th...

journal_title：Neuroendocrinology

authors： Knych ET,Eisenberg RM

更新日期：1979-01-01 00:00:00

abstract：:The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...

journal_title：Neuroendocrinology

authors： Weidenfeld J,Abramsky O,Ovadia H

更新日期：1989-12-01 00:00:00

abstract：:In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-p...

journal_title：Neuroendocrinology

authors： Dluzen DE,Ramirez VD

更新日期：1987-04-01 00:00:00

abstract：:Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...

journal_title：Neuroendocrinology

authors： Kueng W,Wirz-Justice A,Menzi R,Chappuis-Arndt E

更新日期：1976-01-01 00:00:00

abstract：:Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...

journal_title：Neuroendocrinology

authors： Buller K,Xu Y,Dayas C,Day T

更新日期：2001-02-01 00:00:00

abstract：:Experiments were carried out to increase the endogenous levels of TRH in brain and spinal cord. After 7 days of continuous oral ingestion of TRH analogs (D-pGlu-Leu-ProNH2, pGlu-Leu-Pro, pGlu-Pro-ProNH2, or pGlu-Leu-pyrrolidide), spinal cord and brain levels of TRH were elevated, whereas the content of TRH metabolite,...

journal_title：Neuroendocrinology

authors： Prasad C,Eloby-Childress S,Iriuchijima T,Wilber JF,Szirtes T,Kisfaludy L

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...

journal_title：Neuroendocrinology

authors： Somnay Y,Chen H,Kunnimalaiyaan M

更新日期：2013-01-01 00:00:00

abstract：:Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...

journal_title：Neuroendocrinology

authors： Shin SH,Barton RE

更新日期：1993-04-01 00:00:00

abstract：:A reproductive facet of ghrelin, a stomach-derived orexigenic peptide involved in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models. Yet, the modulatory actions of ghrelin on the gonadotropic axi...

journal_title：Neuroendocrinology

authors： Fernández-Fernández R,Tena-Sempere M,Navarro VM,Barreiro ML,Castellano JM,Aguilar E,Pinilla L

更新日期：2005-01-01 00:00:00

abstract：:Characteristic increases in neuronal activity coincident with the pulsatile release of luteinizing hormone from the pituitary gland have been recorded from electrodes chronically implanted in the medial basal hypothalamus of the rhesus monkey. This electrophysiologic manifestation of the hypothalamic 'pulse generator'...

journal_title：Neuroendocrinology

authors： Wilson RC,Kesner JS,Kaufman JM,Uemura T,Akema T,Knobil E

更新日期：1984-09-01 00:00:00

abstract：:Progesterone is readily reduced in humans to its A-ring metabolites, allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one) and pregnanolone (3 alpha-hydroxy-5 beta-pregnan-20-one). The latter have been reported to have anxiolytic, hypnotic and anesthetic actions when administered to laboratory animals and (or) hum...

journal_title：Neuroendocrinology

authors： Freeman EW,Purdy RH,Coutifaris C,Rickels K,Paul SM

更新日期：1993-10-01 00:00:00

abstract：:In the present study the effects of intravenously administered corticotropin-releasing hormone (CRH) on the release of proopiomelanocortin (POMC) derivatives such as adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-END) as well as direct effects of CRH on pain sensitivity were ex...

journal_title：Neuroendocrinology

authors： Matejec R,Uhlich H,Hotz C,Mühling J,Harbach HW,Bödeker RH,Hempelmann G,Teschemacher H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...

journal_title：Neuroendocrinology

authors： Kanakis G,Grimelius L,Spathis A,Tringidou R,Rassidakis GZ,Öberg K,Kaltsas G,Tsolakis AV

更新日期：2015-01-01 00:00:00

abstract：:The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopr...

journal_title：Neuroendocrinology

authors： Mangiapane ML,Thrasher TN,Keil LC,Simpson JB,Ganong WF

更新日期：1983-07-01 00:00:00

abstract：:The arcuate nucleus-median eminence complex (AM) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. Those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary glan...

journal_title：Neuroendocrinology

authors： Rodriguez-Sierra JF,Heydorn WE,Creed GJ,Jacobowitz DM

更新日期：1987-06-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...

journal_title：Neuroendocrinology

authors： Gozes I,Schächter P,Shani Y,Giladi E

更新日期：1988-01-01 00:00:00

abstract：:Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agen...

journal_title：Neuroendocrinology

authors： Liu B,Dluzen DE

更新日期：2006-01-01 00:00:00

abstract：:The effect of estrogen on prolactin (PRL) synthesis at a single-cell level was studied by in situ hybridization and immunohistochemistry. Long-term estrogen treatment increased PRL-containing cells from 10-20% of total cell population to 80-90%, as revealed by immunohistochemistry. PRL mRNA containing cells also incre...

journal_title：Neuroendocrinology

authors： Yamamoto N,Seo H,Suganuma N,Matsui N,Nakane T,Kuwayama A,Kageyama N

更新日期：1986-01-01 00:00:00

abstract：:Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...

journal_title：Neuroendocrinology

authors： Frankfurt M,Gould E,Woolley CS,McEwen BS

更新日期：1990-05-01 00:00:00

abstract：INTRODUCTION:Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological therapy is often required. Unfortunately, many patients are/become unresponsive to available drugs (somatostati...

journal_title：Neuroendocrinology

authors： Vázquez-Borrego MC,Fuentes-Fayos AC,Herrera-Martínez AD,Venegas-Moreno E,L-López F,Fanciulli A,Moreno-Moreno P,Alhambra-Expósito MR,Barrera-Martín A,Dios E,Blanco-Acevedo C,Solivera J,Granata R,Kineman RD,Gahete MD,Soto-Mor

更新日期：2020-01-01 00:00:00

abstract：:The release of the decapeptide gonadotropin-releasing hormone (GnRH) from neuroterminals in the median eminence varies depending upon the stage of development, time of day, reproductive season, and day of the ovarian cycle. With respect to the biosynthetic events responsible for such alterations in GnRH release, we ha...

journal_title：Neuroendocrinology

authors： Gore AC

更新日期：1998-10-01 00:00:00

abstract：:To examine the role of excitatory amino acid neurotransmitters in the regulation of LH and FSH secretion in ovariectomized (ovx) adult rats treated with estradiol and progesterone, we measured the release rates of the excitatory amino acid neurotransmitters, glutamate and aspartate, as well as the neurally inactive am...

journal_title：Neuroendocrinology

authors： Ping L,Mahesh VB,Wiedmeier VT,Brann DW

更新日期：1994-04-01 00:00:00

abstract：:We studied the effects of selected leukotrienes and hydroxyeicosatetraenoic acids (HETEs) on prolactin release from primary cultures of female rats anterior pituitary cells. Leukotrienes B4, C4, and D4 had no effect on basal prolactin release; however, they did enhance prolactin release that was stimulated by 1 or 5 n...

journal_title：Neuroendocrinology

authors： Judd AM,Spangelo BL,Ehreth JT,MacLeod RM

更新日期：1988-10-01 00:00:00

abstract：:The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...

journal_title：Neuroendocrinology

authors： Cheung CY,Neill AC,Weiner RI

更新日期：1981-06-01 00:00:00

abstract：INTRODUCTION:Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). OBJECTIVE:This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain and disability. METHODS:Thirty-eight ...

journal_title：Neuroendocrinology

authors： Cellini M,Biamonte E,Mazza M,Trenti N,Ragucci P,Milani D,Ferrante E,Rossini Z,Lavezzi E,Sala E,Mantovani G,Arosio M,Fornari M,Balzarini L,Lania AG,Mazziotti G

更新日期：2020-09-25 00:00:00