Abstract：
:To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorometrically in serial blood samples obtained from a tail vein at 4-h intervals for 44-h periods, 3 and 10 weeks after surgery. At 3 weeks after surgery, blinded and intact rats demonstrated comparable rhythms in corticosterone levels. At 10 weeks, steroid fluctuations in individual blinded rats still had an approximate 24-h periodicity. However, these fluctuations were no longer synchronized with the light-dark cycle or with those of other rats. These findings suggest that rats blinded as adults have a free-running pituitary-adrenal circadian rhythm.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Wilson MM,Rice RW,Critchlow Vdoi
10.1159/000122495subject
Has Abstractpub_date
1976-01-01 00:00:00pages
289-95issue
4eissn
0028-3835issn
1423-0194journal_volume
20pub_type
杂志文章abstract：:The role of beta-endorphin in the stimulation of growth hormone secretion elicited by administration of clonidine (Clon), an alpha2-adrenergic agonist, was investigated in awake, freely moving male rats. Animals were infused slowly with either 1 ml of normal rabbit serum (NRS), beta-endorphin antiserum (beta-end-AS) o...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125263
更新日期：1989-10-01 00:00:00
abstract：:Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agen...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000095338
更新日期：2006-01-01 00:00:00
abstract：:The effects of ablation of the nucleus medianus on drinking and vasopressin secretion were studied in male Long-Evans rats. The amount of water drunk in 1 h was assessed after subcutaneous injection of 5.8% NaCl (13.34 mosm/kg) or of angiotensin II (1.5 mg/kg). In a separate test with no water available, plasma vasopr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123518
更新日期：1983-07-01 00:00:00
abstract：:Activin A immunoreactivity has been localized within the nucleus tractus solitarius and its projections into regions of the hypothalamus such as the paraventricular nucleus. However, the function of activin within the central nervous system is unclear. Because these regions of the brain are involved in the regulation ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126399
更新日期：1993-03-01 00:00:00
abstract：:Prolactin-releasing (PRF) activity was found in Pitressin (a commercial extract from posterior pituitary for vasopressin). Injection of Pitressin into conscious free-moving rats implanted with a permanent atrial indwelling cannula, produced a transient increase in prolactin concentration in the circulation. In order t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123277
更新日期：1982-01-01 00:00:00
abstract：:In previous studies we obtained evidence that serotonin release by p-chloroamphetamine (PCA) causes an increase in corticosterone secretion but that this effect is not mediated via the raphe nuclei in the midbrain. In contrast, PCA-induced prolactin secretion was abolished by dorsal raphe lesions. In the present study...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124205
更新日期：1985-11-01 00:00:00
abstract：:In previous studies, we have shown that male Wistar rats exposed to a single inescapable stressor session (15 min restraint) exhibited 24 h later an anxiogenic-like behavior in the elevated plus-maze (EPM), which was reversed by inhibition of corticosterone (CS) synthesis with metyrapone (75 mg/kg i.p.) 3 h before str...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054643
更新日期：2001-04-01 00:00:00
abstract：:The site of inhibitory action of glucocorticoids on the hypothalamic corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) was studied using a combination of glucocorticoid implantation and immunohistochemistry. Adrenalectomy increased the number and the staining intensity of the neurons containing CRF-l...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124650
更新日期：1986-01-01 00:00:00
abstract：:The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122841
更新日期：1979-01-01 00:00:00
abstract：:We have investigated the variations in growth hormone (GH) and somatostatin (SOM) mRNAs in adult, middle-aged and aging rats of both sexes using quantitative in situ hybridization. cDNA probes complementary to GH mRNA and SOM mRNA were used on fixed pituitary and hypothalamic sections, respectively. A clear sexual dim...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125967
更新日期：1991-12-01 00:00:00
abstract：:Serum Glucose concentrations were measured before and after electrical stimulation in the ventromedial and supramamillary nuclei of the hypothalamus. 27 fed rats of both sexes were anesthetized with Sodium Pentobarbital. A 36 gauge nichrome electrode was positioned stereotaxically within the rat brain. Stimulus parame...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122864
更新日期：1979-01-01 00:00:00
abstract：:Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000064428
更新日期：2002-08-01 00:00:00
abstract：:The aim of this study was to examine the occurrence of endogenous oscillations of Per1, Per2, Bmal1 and Rev-erbα genes in rat pineal explants and to investigate their regulation by adrenergic ligands. Our results show a significant and sustained rhythm of Per2,Bmal1 and Rev-erbα gene expression for up to 48 h in cultu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000327430
更新日期：2011-01-01 00:00:00
abstract：:The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000084872
更新日期：2005-01-01 00:00:00
abstract：:The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125064
更新日期：1988-11-01 00:00:00
abstract：:The ability of the flutamide metabolite Sch 16423 to block androgen receptor binding and inhibit masculine copulatory behavior in male rats was examined. Restoration of copulatory behavior was prevented in Sch 16423-treated rats given two 10-mm testosterone (T)-filled Silastic capsules plus 15 mg Sch 16423 daily for 1...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124510
更新日期：1986-01-01 00:00:00
abstract：:Hypertension in male and aging female rodents is associated with glutamate-dependent plasticity in the hypothalamus, but existing models have failed to capture distinct transitional menopausal phases that could have a significant impact on the synaptic plasticity and emergent hypertension. In rodents, accelerated ovar...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000446073
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin syste...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000363325
更新日期：2014-01-01 00:00:00
abstract：:The effects of hepatic vagotomy upon the circadian rhythm of lipogenesis and body fat store levels were tested in seasonally obese Syrian hamsters. Lipogenesis was studied 8 weeks after surgery by measuring the incorporation of label into epididymal and retroperitoneal fat pad lipid in animals killed 30 min after intr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125531
更新日期：1990-07-01 00:00:00
abstract：:The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000495806
更新日期：2019-01-01 00:00:00
abstract：:The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126418
更新日期：1993-04-01 00:00:00
abstract：:In vitro and in vivo perfusion techniques were used to examine the changes in the release of beta-endorphin, methionine-enkephalin (met-enkephalin), dynorphin and luteinizing hormone releasing hormone (LHRH) in response to the corticotropin releasing factor (CRF) receptor antagonist, alpha-helical CRF9-41. All four pe...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124967
更新日期：1988-06-01 00:00:00
abstract：:This study was designed to investigate the effects of penfluridol, a potent neuroleptic calmodulin inhibitor, on basal and secretagogue-stimulated secretion of thyroid-stimulating hormone (TSH), growth hormone (GH), and luteinizing hormone (LH). The drug had no effect on basal TSH or LH release, but decreased GH relea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123548
更新日期：1983-09-01 00:00:00
abstract：:A role for glutamate in signalling mechanisms in the mammalian pineal gland is suggested by the high concentration of the transmitter in pinealocytes and the expression of glutamate receptor subunits in the rat gland. A single type of glutamate binding site has been characterized in the rat and bovine pineal gland, pr...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126847
更新日期：1995-03-01 00:00:00
abstract：:The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122711
更新日期：1977-01-01 00:00:00
abstract：:Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000089749
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000472717
更新日期：2018-01-01 00:00:00
abstract：:An experiment was performed on 21-day-old male rats to determine the combined effects of pinealectomy, constant light and darkness, and intraperitoneal (i.p.) thyrotropin-releasing hormone (TRH) on pituitary and plasma radioimmunoassayable thyrotropin (TSH), serum thyroxine (T4), and pituitary, thyroid and body weight...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122751
更新日期：1978-01-01 00:00:00
abstract：:Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000126831
更新日期：1995-02-01 00:00:00
abstract：:Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons. Therefore, we tested the hypothesis ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000443765
更新日期：2016-01-01 00:00:00
