Evidence for a free-running circadian rhythm in pituitary-adrenal function in blinded adult female rats.


:To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorometrically in serial blood samples obtained from a tail vein at 4-h intervals for 44-h periods, 3 and 10 weeks after surgery. At 3 weeks after surgery, blinded and intact rats demonstrated comparable rhythms in corticosterone levels. At 10 weeks, steroid fluctuations in individual blinded rats still had an approximate 24-h periodicity. However, these fluctuations were no longer synchronized with the light-dark cycle or with those of other rats. These findings suggest that rats blinded as adults have a free-running pituitary-adrenal circadian rhythm.






Wilson MM,Rice RW,Critchlow V




Has Abstract


1976-01-01 00:00:00












  • Repetitive injections of L-glutamic acid, in contrast to those of N-methyl-D,L-aspartic acid, fail to elicit sustained hypothalamic GnRH release in the prepubertal male rhesus monkey (Macaca mulatta).

    abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...


    pub_type: 杂志文章


    authors: Medhamurthy R,Gay VL,Plant TM

    更新日期:1992-06-01 00:00:00

  • Ventral premammillary nuclei mediate pheromonal-induced LH release stimuli in the rat.

    abstract::The rise in the concentration of LH in the serum that takes place in ovariectomized, estrogen-primed rats exposed to the odors from a cage with bedding soiled by a male rat was completely prevented by bilateral lesions destroying the ventral premammillary (PMv) nuclei. These results suggest that the pheromonal stimuli...


    pub_type: 杂志文章


    authors: Beltramino C,Taleisnik S

    更新日期:1985-08-01 00:00:00

  • Investigation of the effects of progesterone on neuropeptide Y-stimulated luteinizing hormone-releasing hormone secretion from the median eminence of ovariectomized and estrogen-treated rats.

    abstract::We have investigated the hypothesis that administration of progesterone to estrogen-treated ovariectomized (OVX) rats enhances the stimulatory effects of neuropeptide Y (NPY) on the secretion of luteinizing hormone-releasing hormone (LHRH) from median eminence (ME) fragments in vitro. Adult rats were bilaterally OVX a...


    pub_type: 杂志文章


    authors: Sabatino FD,Collins P,McDonald JK

    更新日期:1990-12-01 00:00:00

  • Dual action of GABAA receptors on the secretory process of melanotrophs of Xenopus laevis.

    abstract::The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagon...


    pub_type: 杂志文章


    authors: Jenks BG,de Koning HP,Valentijn K,Roubos EW

    更新日期:1993-07-01 00:00:00

  • Effects of heterologous growth hormones on hypothalamic and pituitary function in transgenic mice.

    abstract::The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma L...


    pub_type: 杂志文章


    authors: Steger RW,Bartke A,Parkening TA,Collins T,Buonomo FC,Tang KC,Wagner TE,Yun JS

    更新日期:1991-04-01 00:00:00

  • Vasoactive intestinal peptide gene expression from embryos to aging rats.

    abstract::Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...


    pub_type: 杂志文章


    authors: Gozes I,Schächter P,Shani Y,Giladi E

    更新日期:1988-01-01 00:00:00

  • Pre- and postnatal influence of an estrogen antagonist and an androgen antagonist on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats.

    abstract::The volume of the sexually dimorphic nucleus in the preoptic area (SDN-POA) of the rat brain is severalfold larger in adult male rats than in adult females. This sex difference in brain structure was previously shown to develop under the influence of androgenic and estrogenic hormones during the perinatal period. We t...


    pub_type: 杂志文章


    authors: Döhler KD,Coquelin A,Davis F,Hines M,Shryne JE,Sickmöller PM,Jarzab B,Gorski RA

    更新日期:1986-01-01 00:00:00

  • Vasopressin has a direct effect on prolactin release in male rats.

    abstract::Prolactin-releasing (PRF) activity was found in Pitressin (a commercial extract from posterior pituitary for vasopressin). Injection of Pitressin into conscious free-moving rats implanted with a permanent atrial indwelling cannula, produced a transient increase in prolactin concentration in the circulation. In order t...


    pub_type: 杂志文章


    authors: Shin SH

    更新日期:1982-01-01 00:00:00

  • Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat.

    abstract::Previous work has demonstrated that physiological concentrations of 17beta-estradiol can protect the female rat brain against middle cerebral artery occlusion (MCAO)-induced ischemic damage. The present study examined whether therapeutic doses of the clinically relevant selective estrogen receptor modulator (SERM), ta...


    pub_type: 杂志文章


    authors: Mehta SH,Dhandapani KM,De Sevilla LM,Webb RC,Mahesh VB,Brann DW

    更新日期:2003-01-01 00:00:00

  • Stress symptoms induced by repeated morphine withdrawal in comparison to other chronic stress models in mice.

    abstract::The present study was aimed at evaluating chronic stress models in mice with special attention to morphine treatment. We hypothesized that repeated periods of drug withdrawal induce chronic stress. To verify this hypothesis, mice were made dependent on morphine and then subjected to several types of repeated withdrawa...


    pub_type: 杂志文章


    authors: Zelena D,Barna I,Mlynarik M,Gupta OP,Jezova D,Makara GB

    更新日期:2005-01-01 00:00:00

  • Progesterone induces dephosphorylation and inactivation of tyrosine hydroxylase in rat hypothalamic dopaminergic neurons.

    abstract::After in vivo treatment, progesterone initially decreases tyrosine hydroxylase (TH) activity in the TIDA neurons, but subsequently increases TH activity with prolonged treatment. In order to explore the cellular mechanism for progesterone's effect, this study examined the acute inhibitory action of progesterone on TH ...


    pub_type: 杂志文章


    authors: Arbogast LA,Voogt JL

    更新日期:2002-05-01 00:00:00

  • Hypothalamic catecholamine levels in dogs with spontaneous hyperadrenocorticism.

    abstract::Hypothalamic norepinephrine (NE) and dopamine content was studied in dogs with spontaneous and iatrogenic hypercortisolism and in untreated normal dogs. The concentration of NE in the hypothalamus was subnormal in 4 of 8 dogs with pituitary-dependent hyperadrenocorticism (PDH), whereas long-term administration of cort...


    pub_type: 杂志文章


    authors: Meijer JC,Croughs RJ,Rijnberk A,Versteeg DH,van Ree JM

    更新日期:1981-04-01 00:00:00

  • Correlations between the hypothalamic density of 3H-clonidine-binding sites and plasma testosterone levels in mice.

    abstract::Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between h...


    pub_type: 杂志文章


    authors: Shishkina GT,Naumenko EV

    更新日期:1995-06-01 00:00:00

  • Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?

    abstract::Interactions between the hypothalamic-pituitary-adrenocortical (HPA) system and melatonin secretion have been demonstrated, but only the effects of melatonin on the activity of the HPA system have been studied in man. Alterations of melatonin secretion described as low-melatonin syndrome have been demonstrated in pati...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kellner M,Yassouridis A,Manz B,Steiger A,Holsboer F,Wiedemann K

    更新日期:1997-04-01 00:00:00

  • Carboplatin in Combination with Oral or Intravenous Etoposide for Extra-Pulmonary, Poorly-Differentiated Neuroendocrine Carcinomas.

    abstract:BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...


    pub_type: 杂志文章,多中心研究


    authors: Frizziero M,Spada F,Lamarca A,Kordatou Z,Barriuso J,Nuttall C,McNamara MG,Hubner RA,Mansoor W,Manoharan P,Fazio N,Valle JW

    更新日期:2019-01-01 00:00:00

  • Intrauterine exposure to cigarette smoke is associated with increased ghrelin concentrations in adulthood.

    abstract:BACKGROUND:The appetite-stimulating hormone ghrelin is a fundamental regulator of human energy metabolism. A series of studies support the notion that long-term appetite and weight regulation may be already programmed in early life and it could be demonstrated that the intrauterine environment affects the ghrelin syste...


    pub_type: 杂志文章


    authors: Paslakis G,Buchmann AF,Westphal S,Banaschewski T,Hohm E,Zimmermann US,Laucht M,Deuschle M

    更新日期:2014-01-01 00:00:00

  • Skeletal diseases in Cushing's syndrome: osteoporosis versus arthropathy.

    abstract::Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and gr...


    pub_type: 杂志文章,评审


    authors: Kaltsas G,Makras P

    更新日期:2010-01-01 00:00:00

  • Short-term secretion patterns of corticotropin-releasing hormone, arginine vasopressin and ACTH as shown by intensive sampling of pituitary venous blood from horses.

    abstract::To characterize the short-term ACTH secretion pattern and to investigate factors regulating it, pituitary venous (PV) blood was collected using our nonsurgical method from 8 unperturbed horses every 20 or 30 s for approximately 1 h. In all but 1 horse, sampling occurred during the broad circadian maximum in plasma cor...


    pub_type: 杂志文章


    authors: Alexander SL,Irvine CH,Donald RA

    更新日期:1994-09-01 00:00:00

  • Ability of the CRF immunoreactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Immunohistochemical demonstration in adrenalectomized guinea pigs and rats.

    abstract::In the paraventricular nucleus of normal or adrenalectomized colchicine-treated guinea pigs and rats, corticotropin-releasing factor (CRF), vasopressin (VP) and oxytocin (OX) immunoreactivities were compared. In the control animals, respective stainings for these three peptides are distinct. Adrenalectomy resulted in ...


    pub_type: 杂志文章


    authors: Tramu G,Croix C,Pillez A

    更新日期:1983-12-01 00:00:00

  • Corticosteroids influence the action potential firing pattern of hippocampal subfield CA3 pyramidal cells.

    abstract::Corticosteroids regulate gene expression through the activation of mineralocorticoid and glucocorticoid receptors. The hippocampus contains the highest density of mineralocorticoid and glucocorticoid receptors in the central nervous system. The modulation of neuron excitability by corticosteroids in hippocampal subfie...


    pub_type: 杂志文章


    authors: Okuhara DY,Beck SG

    更新日期:1998-01-01 00:00:00

  • Effect of steroids on vasoactive intestinal peptide in discrete brain regions and peripheral tissues.

    abstract::The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...


    pub_type: 杂志文章


    authors: Rotsztejn WH,Besson J,Briaud B,Gagnant L,Rosselin G,Kordon C

    更新日期:1980-10-01 00:00:00

  • Evidence for the presence of receptors for pituitary adenylate cyclase-activating polypeptide in the neurohypophysis that are positively coupled to cyclic AMP formation and neurohypophyseal hormone secretion.

    abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...


    pub_type: 杂志文章


    authors: Lutz-Bucher B,Monnier D,Koch B

    更新日期:1996-08-01 00:00:00

  • Dexamethasone resistance among nonhuman primates associated with a selective decrease of glucocorticoid receptors in the hippocampus and a history of social instability.

    abstract::We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset o...


    pub_type: 杂志文章


    authors: Brooke SM,de Haas-Johnson AM,Kaplan JR,Manuck SB,Sapolsky RM

    更新日期:1994-08-01 00:00:00

  • Decreased expression of the two D2 dopamine receptor isoforms in bromocriptine-resistant prolactinomas.

    abstract::Bromocriptine or other dopamine agonists are usually effective for the treatment of prolactin-secreting adenomas. Five to 18% of prolactinomas, however, do not respond to such therapy. We have shown previously that such resistance to bromocriptine correlates with reduced binding to the D2 receptor subtype of dopamine,...


    pub_type: 杂志文章


    authors: Caccavelli L,Feron F,Morange I,Rouer E,Benarous R,Dewailly D,Jaquet P,Kordon C,Enjalbert A

    更新日期:1994-09-01 00:00:00

  • Evidence that serotonin stimulates a prolactin-releasing factor in the rat.

    abstract::Methanol extracts of rat plasma resulted in release of prolactin (PRL) from rat hemipituitaries in vitro with a linear log-dose relationship. This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulat...


    pub_type: 杂志文章


    authors: Garthwaite TL,Hagen TC

    更新日期:1979-01-01 00:00:00

  • Growth Hormone Response to Oral Glucose Load: From Normal to Pathological Conditions.

    abstract::The exact physiological basis of acute growth hormone (GH) suppression by oral glucose is not fully understood. Glucose-mediated increase in hypothalamic somatostatin seems to be the most plausible explanation. Attempts to better understand its underlying mechanisms are compromised by species disparities in the respon...


    pub_type: 杂志文章,评审


    authors: Hage M,Kamenický P,Chanson P

    更新日期:2019-01-01 00:00:00

  • Neuropeptide TLQP-21, a VGF internal fragment, modulates hormonal gene expression and secretion in GH3 cell line.

    abstract::In the present study we demonstrated that TLQP-21, a biologically active peptide derived from the processing of the larger pro-VGF granin, plays a role in mammotrophic cell differentiation. We used an established in vitro model, the GH3 cell line, which upon treatment with epidermal growth factor develops a mammotroph...


    pub_type: 杂志文章


    authors: Petrocchi Passeri P,Biondini L,Mongiardi MP,Mordini N,Quaresima S,Frank C,Baratta M,Bartolomucci A,Levi A,Severini C,Possenti R

    更新日期:2013-01-01 00:00:00

  • Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia.

    abstract::Studies were undertaken to characterize the secretion of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) into the hypophysial-portal circulation of the conscious sheep. In addition, we examined the temporal relationship between the secretion of these two hypothalamic peptides and the secretion of t...


    pub_type: 杂志文章


    authors: Engler D,Pham T,Fullerton MJ,Ooi G,Funder JW,Clarke IJ

    更新日期:1989-04-01 00:00:00

  • Glucose affects the release of thyrotropin-releasing hormone from the rat hypothalamus.

    abstract::We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...


    pub_type: 杂志文章


    authors: Yamaguchi M,Iriuchijima T,Michimata T,Mori M

    更新日期:1991-04-01 00:00:00

  • Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

    abstract::The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...


    pub_type: 杂志文章


    authors: D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

    更新日期:2004-01-01 00:00:00