Evidence for a free-running circadian rhythm in pituitary-adrenal function in blinded adult female rats.


:To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorometrically in serial blood samples obtained from a tail vein at 4-h intervals for 44-h periods, 3 and 10 weeks after surgery. At 3 weeks after surgery, blinded and intact rats demonstrated comparable rhythms in corticosterone levels. At 10 weeks, steroid fluctuations in individual blinded rats still had an approximate 24-h periodicity. However, these fluctuations were no longer synchronized with the light-dark cycle or with those of other rats. These findings suggest that rats blinded as adults have a free-running pituitary-adrenal circadian rhythm.






Wilson MM,Rice RW,Critchlow V




Has Abstract


1976-01-01 00:00:00












  • Effect of chronic alcohol consumption on the pregnant mare serum gonadotropin-induced luteinizing hormone surge.

    abstract::The studies reported in this paper were undertaken to investigate the effect of chronic (10 day) alcohol consumption on female pituitary-gonadal function. The immature female rat model treated with pregnant mare serum gonadotropin (PMSG) was used since it results in a highly reproducible luteinizing hormone (LH) surge...


    pub_type: 杂志文章


    authors: Sundberg DK,Bo WJ,Reilly J

    更新日期:1987-10-01 00:00:00

  • Regulation of Dexras1 expression by endogenous steroids.

    abstract::Dexras1, a newly identified member of the Ras superfamily of proteins, was discovered in AtT-20 corticotrope cells because its expression was induced in response to glucocorticoids (dexamethasone; Dex). As yet, the function of Dexras1 is unknown, but its rapid induction in response to glucocorticoids suggests the poss...


    pub_type: 杂志文章


    authors: Brogan MD,Behrend EN,Kemppainen RJ

    更新日期:2001-10-01 00:00:00

  • Regulation of His-dTrp-Ala-Trp-dPhe-Lys-NH2 (GHRP-6)-induced GH secretion in the rat.

    abstract::His-dTrp-Ala-Trp-dPhe,Lys-NH2(GHRP-6) is a synthetic compound that releases GH in a dose-response and specific manner in several species and that may well be related to an endogenous compound of similar structure. The aim of this study was to investigate the in vivo GH responses to GHRP-6 in pentobarbital anesthetized...


    pub_type: 杂志文章


    authors: Mallo F,Alvarez CV,Benitez L,Burguera B,Coya R,Casanueva FF,Dieguez C

    更新日期:1993-01-01 00:00:00

  • Neurosecretion of human hypothalamic immunoreactive beta-endorphin: in vitro regulation by dopamine.

    abstract::An in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 microM pulse of DA consistently elicited a mean (+/- SE) 88 +/- 9% increase (p less ...


    pub_type: 杂志文章


    authors: Rasmussen DD,Liu JH,Wolf PL,Yen SS

    更新日期:1987-03-01 00:00:00

  • Epidemiology of Cushing's syndrome.

    abstract::Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or ...


    pub_type: 杂志文章,评审


    authors: Steffensen C,Bak AM,Rubeck KZ,Jørgensen JO

    更新日期:2010-01-01 00:00:00

  • Release of pro-opiomelanocortin-derived peptides from the pars intermedia and pars distalis of the rat pituitary: effect of corticotrophin-releasing factor and somatostatin.

    abstract::The parenchymal cells of the pars intermedia (PI) and corticotrophs of the pars distalis (PD) synthesize pro-opiomelanocortin (POMC), which, through posttranslational processing, gives rise to a group of structurally related peptides, including MSHs, ACTH, CLIP, LPHs and endorphins. We investigated the control of rele...


    pub_type: 杂志文章


    authors: Kraicer J,Gajewski TC,Moor BC

    更新日期:1985-11-01 00:00:00

  • Estrogen receptors and signaling pathways in lactotropes and somatotropes.

    abstract::Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant...


    pub_type: 杂志文章,评审


    authors: Zárate S,Seilicovich A

    更新日期:2010-01-01 00:00:00

  • Cerebrospinal fluid levels of acetylcholinesterase, monoamines and oxytocin during labour, parturition, vaginocervical stimulation, lamb separation and suckling in sheep.

    abstract::Acetylcholinesterase (AChE) activity, and concentrations of monoamines, monoamine metabolites and oxytocin (OT) were measured in the cerebrospinal fluid (CSF) of sheep during late pregnancy, labour, parturition, vaginocervical stimulation, lamb separation and suckling. Concentrations of AChE, 4-hydroxy-3 methoxyphenyl...


    pub_type: 杂志文章


    authors: Kendrick KM,Keverne EB,Baldwin BA,Sharman DF

    更新日期:1986-01-01 00:00:00

  • Effect of adrenalectomy and demedullation on the stress-induced impairment of long-term potentiation.

    abstract::In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further r...


    pub_type: 杂志文章


    authors: Shors TJ,Levine S,Thompson RF

    更新日期:1990-01-01 00:00:00

  • Effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the uterus, pituitary, and forebrain of the female rat.

    abstract::Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...


    pub_type: 杂志文章


    authors: Quiñones-Jenab V,Jenab S,Ogawa S,Adan RA,Burbach JP,Pfaff DW

    更新日期:1997-01-01 00:00:00

  • Age-related differences in the release of luteinizing hormone and gonadotropin-releasing hormone in ovariectomized rats.

    abstract::The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...


    pub_type: 杂志文章


    authors: Hwang C,Pu HF,Hwang CY,Liu JY,Yao HC,Tung YF,Wang PS

    更新日期:1990-08-01 00:00:00

  • Exposure to a short photoperiod increases sensitivity to dopamine inhibition of prolactin release from Siberian hamster pituitary.

    abstract::Prolactin (PRL) secretion from the anterior pituitary is tonically controlled by the activity of the hypothalamic tuberoinfundibular dopaminergic (TIDA) system. Changes in TIDA activity have been associated with the decrease in basal PRL levels shown by hamsters exposed to a short-day photoperiod. Potential concurrent...


    pub_type: 杂志文章


    authors: Badura LL

    更新日期:1996-12-01 00:00:00

  • The gonadotropin-releasing hormone neuronal system of the male Djungarian hamster: distribution from the olfactory tubercle to the medial basal hypothalamus.

    abstract::The neuroanatomical distribution and morphology of neurons that produce gonadotropin-releasing hormone (GnRH) in the brain of the postpubertal male Djungarian hamster was studied using light microscopic immunocytochemistry. Analysis of every section from the rostral olfactory tubercle to the medial basal hypothalamus ...


    pub_type: 杂志文章


    authors: Yellon SM,Lehman MN,Newman SW

    更新日期:1990-02-01 00:00:00

  • Sympathoadrenal activity facilitates beta-endorphin and alpha-MSH secretion but does not potentiate ACTH secretion during immobilization stress.

    abstract::The potential involvement of the sympathoadrenal system in stress-induced secretion of peptides from the intermediate lobe of the pituitary gland and the activation of the pituitary-adrenal axis was studied. Male Wistar rats were subjected to control procedures, to sympathectomy by chronic administration (8 weeks) of ...


    pub_type: 杂志文章


    authors: Kvetnansky R,Tilders FJ,van Zoest ID,Dobrakovova M,Berkenbosch F,Culman J,Zeman P,Smelik PG

    更新日期:1987-04-01 00:00:00

  • Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus and brainstem.

    abstract::Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...


    pub_type: 杂志文章


    authors: Deauseault D,Giroux D,Wood CE

    更新日期:2000-05-01 00:00:00

  • Comparative aspects of GH and metabolic regulation in lower vertebrates.

    abstract::In all vertebrates, the regulations of growth and energy balance are complex phenomena which involve elaborate interactions between the brain and peripheral signals. Most vertebrates adopt and maintain a life style after birth, but lower vertebrates may have complex life histories involving metamorphoses, migrations a...


    pub_type: 杂志文章,评审


    authors: Rousseau K,Dufour S

    更新日期:2007-01-01 00:00:00

  • New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2 mouse.

    abstract::Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...


    pub_type: 杂志文章,评审


    authors: Garcia-Tornadú I,Perez-Millan MI,Recouvreux V,Ramirez MC,Luque G,Risso GS,Ornstein AM,Cristina C,Diaz-Torga G,Becu-Villalobos D

    更新日期:2010-01-01 00:00:00

  • The growth hormone-releasing hormone-cyclic adenosine-3',5'-monophosphate signal pathway in somatotropes is practically intact during aging.

    abstract::To elucidate the mechanisms of the impaired pituitary response to growth hormone-releasing hormone (GHRH) in aged animals on a cellular basis, a reverse hemolytic plaque assay was performed on dispersed pituitary cells from young (8-month-old) and old (26-month-old) male F344 rats. The proportion of growth hormone (GH...


    pub_type: 杂志文章


    authors: Shimokawa I,Higami Y,Okimoto T,Ikeda T

    更新日期:1994-12-01 00:00:00

  • Niacin (Vitamin B3) Supplementation in Patients with Serotonin-Producing Neuroendocrine Tumor.

    abstract:BACKGROUND/AIMS:Tryptophan is the precursor of serotonin and niacin (vitamin B3). The latter is critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin-producing neuroendocrine tumors (NETs). Niacin deficiency may lead to severe symptoms including pellagra. In patients...


    pub_type: 杂志文章


    authors: Bouma G,van Faassen M,Kats-Ugurlu G,de Vries EG,Kema IP,Walenkamp AM

    更新日期:2016-01-01 00:00:00

  • Evidence for the involvement of corticotropin-releasing factor in the inhibition of gonadotropin release induced by hyperprolactinemia.

    abstract::The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...


    pub_type: 杂志文章


    authors: Kooy A,de Greef WJ,Vreeburg JT,Hackeng WH,Ooms MP,Lamberts SW,Weber RF

    更新日期:1990-03-01 00:00:00

  • Phase relation between episodic fluctuations of spontaneous locomotor activity and plasma corticosterone in rats with suprachiasmatic nuclei lesions.

    abstract::Phase relation between plasma corticosterone and locomotor activity rhythms was analyzed in individual rats with selective lesions of suprachiasmatic nuclei (SCN). SCN in Wistar male rats were selectively coagulated electrically and the extent of SCN destruction was examined histologically. Spontaneous locomotor activ...


    pub_type: 杂志文章


    authors: Watanabe K,Hiroshige T

    更新日期:1981-07-01 00:00:00

  • Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms.

    abstract::The accuracy and reproducibility of the World Health Organization (WHO) 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO 2019), and to analyze its accura...


    pub_type: 杂志文章


    authors: Oka N,Kasajima A,Konukiewitz B,Sakurada A,Okada Y,Kameya T,Weichert W,Ishikawa Y,Suzuki H,Sasano H,Klöppel G

    更新日期:2020-01-01 00:00:00

  • Stress symptoms induced by repeated morphine withdrawal in comparison to other chronic stress models in mice.

    abstract::The present study was aimed at evaluating chronic stress models in mice with special attention to morphine treatment. We hypothesized that repeated periods of drug withdrawal induce chronic stress. To verify this hypothesis, mice were made dependent on morphine and then subjected to several types of repeated withdrawa...


    pub_type: 杂志文章


    authors: Zelena D,Barna I,Mlynarik M,Gupta OP,Jezova D,Makara GB

    更新日期:2005-01-01 00:00:00

  • Preferential distribution of C-terminal fragments of [hydroxyproline9]LHRH in the rat hippocampus and olfactory bulb.

    abstract::Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...


    pub_type: 杂志文章


    authors: Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon C

    更新日期:1993-08-01 00:00:00

  • Differences in cardiovascular and hypothalamic-pituitary-adrenal axis functions between high-altitude visitors and natives during a trek on the Annapurna circuit.

    abstract:OBJECTIVE:Differences in the cardiovascular and hypothalamic-pituitary-adrenal (HPA) axis functions at high altitudes (HAs) between visitors to and natives of HA were examined. METHODS:The cardiovascular functions and peripheral oxygen saturation (SPO2) were monitored, and the cortisol awakening response (CAR) and nig...


    pub_type: 杂志文章


    authors: Park JY,Hwang TK,Park HK,Ahn RS

    更新日期:2014-01-01 00:00:00

  • The effect of exposure to ether on prolactin secretion and the half-life of endogenous prolactin in normal and castrated male rats.

    abstract::Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...


    pub_type: 杂志文章


    authors: Chi HJ,Shin SH

    更新日期:1978-01-01 00:00:00

  • Differential suppression of FSH and LH secretion by follicular fluid in the presence or absence of GnRH.

    abstract::The differential role of porcine follicular fluid (pFF) in regulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release in vivo in situations of different gonadotropin releasing hormone (GnRH) backgrounds was studied. In experiment 1, 2-week ovariectomized rats injected intravenously with 4, 16 o...


    pub_type: 杂志文章


    authors: Charlesworth MC,Grady RR,Shin L,Vale WW,Rivier C,Rivier J,Schwartz NB

    更新日期:1984-03-01 00:00:00

  • Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats.

    abstract::Allopregnanolone is a neuroactive steroid synthesized in rat gonads, adrenal cortex, and central nervous system. It has been suggested that sex steroid hormones might influence allopregnanolone concentrations but no clear data have ever been reported. The aim of the present study was to investigate the effects of admi...


    pub_type: 杂志文章


    authors: Genazzani AR,Bernardi F,Stomati M,Monteleone P,Luisi S,Rubino S,Farzati A,Casarosa E,Luisi M,Petraglia F

    更新日期:2000-09-01 00:00:00

  • Sexual maturation modifies the catecholaminergic control of gonadotrophin secretion and the effect of ovarian hormones on hypothalamic neurotransmitters in female rats.

    abstract::alpha-Methyl-p-tyrosine (alpha-MT), a competitive inhibitor of tyrosine hydroxylase, was used to block the synthesis of hypothalamic catecholamines in immature female rats of 14, 16 and 30 days of age and in castrated adults. The administration of alpha-MT (300 mg/kg body weight, free base) induced a significant decay...


    pub_type: 杂志文章


    authors: Moguilevsky JA,Arias P,Szwarcfarb B,Carbone S,Rondina D

    更新日期:1990-10-01 00:00:00

  • Effects of melatonin and an aqueous pineal extract on adrenal secretion of reduced steroid metabolites in female rats.

    abstract::The effects of melatonin and an aqueous extract of bovine pineal glands on adrenal function were studied in pinealectomized, ovariectomized and hypophysectomized rats. Melatonin (50 microgram i.p., twice daily for 1 week) stimulates adrenal 5 alpha-reductase activity in intact animals and after ovariectomy. A correspo...


    pub_type: 杂志文章


    authors: Ogle TF,Kitay JI

    更新日期:1977-01-01 00:00:00