Abstract：
INTRODUCTION:Several studies have suggested that diet, especially one enriched in microbiota-fermented fibers or fat, regulates behavior. The underlying mechanisms are currently unknown. We previously reported that certain macronutrients (fermentable fiber and protein) regulate energy homeostasis via the activation of intestinal gluconeogenesis (IGN), which generates a neural signal to the brain. We hypothesized that these nutriments might control behavior using the same gut-brain circuit. METHODS:Wild-type and IGN-deficient mice were fed chow or diets enriched in protein or fiber. Changes in their behavior were assessed using suited tests. Hippocampal neurogenesis, extracellular levels of serotonin and protein expression levels were assessed by immunofluorescence, in vivo dialysis or western-blotting respectively. Rescue of IGN was performed by infusing glucose in the portal vein of IGN-deficient mice. RESULTS:We show here that both fiber- and protein-enriched diets exert beneficial actions on anxiety-like and depressive-like behaviors. These benefits do not occur in mice lacking IGN. Consistently, IGN-deficient mice display hallmarks of depressive-like disorders, including decreased hippocampal neurogenesis, basal hyperactivity and deregulation of the hypothalamic-pituitary-adrenal axis, which are associated with increased expression of the precursor of corticotropin releasing hormone in the hypothalamus and decreased expression of the glucocorticoid receptor in the hippocampus. These neurobiological alterations are corrected by portal glucose infusion mimicking IGN. CONCLUSION:IGN translates nutritional information allowing the brain to finely coordinate energy metabolism and behavior.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Sinet F,Soty M,Zemdegs J,Guiard B,Estrada J,Malleret G,Silva M,Mithieux G,Gautier-Stein Adoi
10.1159/000514289subject
Has Abstractpub_date
2021-01-11 00:00:00eissn
0028-3835issn
1423-0194pii
000514289pub_type
杂志文章abstract：:The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123577
更新日期：1983-11-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054373
更新日期：1998-10-01 00:00:00
abstract：:Knowledge of specific neurotransmitters as well as the pathways and mechanisms regulating appetite in ruminants that continually graze, such as sheep, is incomplete. Although fundamentally agouti-related protein (AGRP) has a similar function across species to increase food intake, the regulation of AGRP may vary acros...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000082735
更新日期：2004-01-01 00:00:00
abstract：:The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125064
更新日期：1988-11-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126576
更新日期：1993-10-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126381
更新日期：1993-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054402
更新日期：1999-01-01 00:00:00
abstract：:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122452
更新日期：1975-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123225
更新日期：1981-09-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000079752
更新日期：2004-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000328128
更新日期：2011-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123135
更新日期：1981-02-01 00:00:00
abstract：:The pressor effect of intravenous angiotensin II (AII) was compared in the unrestrained rat before and after electrolytic lesions of the subfornical organ (SFO), the circumventricular organ of the dorsal third cerebral ventricle. Abdominal aortic and venal caval catheters were used to measure arterial pressure and to ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123107
更新日期：1980-12-01 00:00:00
abstract：:The sleep-wakefulness pattern and brain protein levels were determined in rats for 3 h following these conditions: administration of an inhibitor of protein synthesis (anisomycin), administration of several doses of rat growth hormone (GH) or thyrotropin, and administration of a combination of anisomycin + GH or thyro...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000122377
更新日期：1975-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126186
更新日期：1992-06-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127121
更新日期：1996-09-01 00:00:00
abstract：INTRODUCTION:Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological therapy is often required. Unfortunately, many patients are/become unresponsive to available drugs (somatostati...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000505923
更新日期：2020-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000335018
更新日期：2013-01-01 00:00:00
abstract：:Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126424
更新日期：1993-04-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126952
更新日期：1996-02-01 00:00:00
abstract：:The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122357
更新日期：1975-01-01 00:00:00
abstract：:The neurotransmitter and andrenoceptors involved in the inhibition of luteinizing hormone (LH) release induced by stimulating the locus ceruleus nucleus (LC) have been characterized in ovariectomized, estrogen-primed rats in which the release of LH was triggered by electrical stimulation of the medial preoptic area. B...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123858
更新日期：1984-01-01 00:00:00
abstract：:The effect of amphetamine (AMPH) on plasma corticosterone was studied in the conscious, unstressed rat. AMPH (0.5-5.0 mg/kg) produced a dose-dependent increase in plasma corticosterone. This rise in plasma corticosterone was not altered by the adrenergic blocking agents phenoxybenzamine or propranolol. In contrast, th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122912
更新日期：1979-01-01 00:00:00
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journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123067
更新日期：1980-08-01 00:00:00
abstract：:[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125608
更新日期：1990-10-01 00:00:00
abstract：:Experiments were carried out to increase the endogenous levels of TRH in brain and spinal cord. After 7 days of continuous oral ingestion of TRH analogs (D-pGlu-Leu-ProNH2, pGlu-Leu-Pro, pGlu-Pro-ProNH2, or pGlu-Leu-pyrrolidide), spinal cord and brain levels of TRH were elevated, whereas the content of TRH metabolite,...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125118
更新日期：1989-02-01 00:00:00
abstract：:In experiment I we studied the capacity of progesterone (P) and two nonsteroidal agents that activate lordosis, but do not bind to the progestin receptor (PR), i.e. luteinizing hormone-releasing hormone (LHRH) and prostaglandin E2 (PGE2) to induce sequential inhibition (SI) in ovariectomized estradiol-primed rats. The...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126457
更新日期：1993-05-01 00:00:00
abstract：:The reuptake of dopamine into nerve terminals is the primary mechanism of inactivation of this neurotransmitter in the synaptic cleft. We report sex differences and estrous cycle variations of rat striatal dopamine uptake sites. During the estrous cycle, peak density of striatal dopamine uptake sites labelled with [3H...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126507
更新日期：1993-07-01 00:00:00
abstract：:The ligand specificities of sites binding tritium-labeled arginine vasopressin (3H-AVP) were investigated in membrane preparations of rat anterior pituitary gland and liver. Labeled AVP interacted with high-affinity, low-capacity binding sites in liver as well as in pituitary membrane fractions. Binding displacement s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123976
更新日期：1984-08-01 00:00:00
abstract：:Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000064428
更新日期：2002-08-01 00:00:00
