Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole.

abstract：UNLABELLED:Mediobasal hypothalamic slices of adult ovariectomized (OVX) rats treated or not with 17 beta-estradiol (E2) were superfused in buffered (pH 7.2) Locke medium containing bacitracin. A 6-min pulse of K+ (56 m M) was less effective in releasing luteinizing hormone releasing hormone (LH-RH) from mediobasal hypo...

journal_title：Neuroendocrinology

authors： Drouva SV,Laplante E,Gautron JP,Kordon C

更新日期：1984-02-01 00:00:00

abstract：:The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on the importance of this tachykinin in the control of GnRH secretion. In a number of species, NKB neurons in the arcuate nucleus also produce two other neuropept...

journal_title：Neuroendocrinology

authors： Goodman RL,Coolen LM,Lehman MN

更新日期：2014-01-01 00:00:00

abstract：:Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...

journal_title：Neuroendocrinology

authors： Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon C

更新日期：1993-08-01 00:00:00

abstract：:The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats. Lordosis behavior triggered by...

journal_title：Neuroendocrinology

authors： Sirinathsinghji DJ

更新日期：1984-09-01 00:00:00

abstract：:Met-enkephalin concentrations in the anterior pituitary gland were shown to decline dramatically within the first 24 h after reserpine treatment, with effects apparent as early as 6 h. This was followed by subsequent repletion and late augmentation of Met-enkephalin levels 3 weeks following reserpine. Treatment with t...

journal_title：Neuroendocrinology

authors： George SR,Kertesz M

更新日期：1988-02-01 00:00:00

abstract：:The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...

journal_title：Neuroendocrinology

authors： Sowers JR,Resch G,Walker S,Sollars E

更新日期：1980-05-01 00:00:00

abstract：:Glass microknife lesions and immunocytochemistry were used to evaluate luteinizing hormone-releasing hormone (LH-RH)- and somatostatin (SS)-immunoreactive pathways from the preoptic region to the rat median eminence. Cuts were so placed that axons of more caudally located neurons in the periventricular hypothalamic ar...

journal_title：Neuroendocrinology

authors： Jew JY,Léránth C,Arimura A,Palkovits M

更新日期：1984-03-01 00:00:00

abstract：:Although glutamate is the predominant excitatory amino acid in the vertebrate central nervous system (CNS) where it affects a variety of physiological processes and pathophysiological states, the role that glutamate receptors may play outside the CNS has not been clearly established. In the present study, the effects ...

journal_title：Neuroendocrinology

authors： Giovannucci DR,Stuenkel EL

更新日期：1995-08-01 00:00:00

abstract：:The secretion of gonadotropins and the role exerted by the endogenous opioid system on luteinizing hormone (LH) secretion were investigated in 6 postmenopausal women affected by idiopathic Parkinson's disease (PD) as well as in 6 age- and weight-matched normal postmenopausal women as controls. The mean plasma follicle...

journal_title：Neuroendocrinology

authors： Cagnacci A,Melis GB,Soldani R,Bonuccelli U,Piccini P,Napolitano A,Muratorio A,Fioretti P

更新日期：1991-06-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...

journal_title：Neuroendocrinology

authors： Valentino RJ,Wehby RG

更新日期：1988-12-01 00:00:00

abstract：:There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent ...

journal_title：Neuroendocrinology

authors： Cicero TJ,O'Connor LH,Bell RD

更新日期：1987-08-01 00:00:00

abstract：:The effects of intracerebroventricularly (i.c.v.) injected interleukin-1 beta (IL-1 beta: 1, 2.5, 10, and 25 ng) were studied on plasma growth hormone (GH) and prolactin (PRL) concentrations in freely moving rats chronically implanted with i.c.v. cannulas and intracardial catheters. Significant changes in PRL secretio...

journal_title：Neuroendocrinology

authors： Payne LC,Obal F Jr,Opp MR,Krueger JM

更新日期：1992-07-01 00:00:00

abstract：:Serum prolactin was measured in lightly etherized rats between 4 and 5 a.m. and between 11 a.m. and 12 noon at various times after operation in intact rats and rats that had been operated on. Serum prolactin was elevated in the late nocturnal samples from intact rats and this elevation was prevented by pinealectomy. W...

journal_title：Neuroendocrinology

authors： Ronnekleiv OK,McCann SM

更新日期：1975-01-01 00:00:00

abstract：:The expression of the alpha-subunit of the glycoprotein hormones was studied in the developing rat pituitary by in situ hybridization and immunocytochemical techniques. The alpha-subunit mRNA labelling was detected in Rathke's pouch at 12 days' gestation (E12); at E13, it was exclusively concentrated in the pars tuber...

journal_title：Neuroendocrinology

authors： Stoeckel ME,Hindelang C,Klein MJ,Poissonnier M,Félix JM

更新日期：1993-12-01 00:00:00

abstract：:Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 ...

journal_title：Neuroendocrinology

authors： Sietnieks A,Meyerson BJ

更新日期：1983-06-01 00:00:00

abstract：:In human African trypanosomiasis (sleeping sickness), sleep and wake episodes are sporadically distributed throughout the day and the night. Plasma melatonin, sleep-wakefulness and rectal temperature rhythms were studied in 9 Congolese patients suffering from sleeping sickness compared to 6 healthy controls submitted ...

journal_title：Neuroendocrinology

authors： Claustrat B,Buguet A,Geoffriau M,Bogui P,Mouanga G,Stanghellini A,Dumas M

更新日期：1998-07-01 00:00:00

abstract：:Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signalling pathways, facilitating intracellular Ca2+ release and protein kinase C activation. A sixth class of phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCeta) has recently been discovered in mammals. Rece...

journal_title：Neuroendocrinology

authors： Stewart AJ,Morgan K,Farquharson C,Millar RP

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...

journal_title：Neuroendocrinology

authors： Merola E,Sbrozzi-Vanni A,Panzuto F,D'Ambra G,Di Giulio E,Pilozzi E,Capurso G,Lahner E,Bordi C,Annibale B,Delle Fave G

更新日期：2012-01-01 00:00:00

abstract：:Tyrosine hydroxylase activity in noradrenergic neurons of the locus coeruleus was found to rise in bilaterally adrenalectomized adult mice, with maximum increase of the enzyme activity (52% above control) occurring 7 days after the surgery. No such increase of tyrosine hydroxylase activity was found in dopaminergic ne...

journal_title：Neuroendocrinology

authors： Markey KA,Sze PY

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:We previously presented data of this multicentric, phase II study showing that everolimus plus octreotide long-acting repeatable (LAR) for advanced neuroendocrine neoplasms (NENs), in the first line setting, is an active and safe treatment. We now present updated data at 5 years. METHODS:Patients with advan...

journal_title：Neuroendocrinology

authors： Bajetta E,Catena L,Pusceddu S,Spada F,Iannacone C,Sarno I,Di Menna G,Dottorini L,Marte AM

更新日期：2018-01-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) is involved in the regulation and maintenance of gametogenesis. It exists in multiple molecular forms with different oligosaccharide structures which in turn are influenced by the hormonal milieu. Previous studies from our laboratory demonstrated that antiandrogen administration to i...

journal_title：Neuroendocrinology

authors： Rulli SB,Creus S,Pellizzari E,Cigorraga SB,Calandra RS,Campo S

更新日期：1999-10-01 00:00:00

abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...

journal_title：Neuroendocrinology

authors： Lamperti AA,Baldwin DM

更新日期：1982-03-01 00:00:00

abstract：:Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...

journal_title：Neuroendocrinology

authors： Hojvat S,Emanuele NV,Kirsteins L,Lawrence AM

更新日期：1986-01-01 00:00:00

abstract：:Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...

journal_title：Neuroendocrinology

authors： Quiñones-Jenab V,Jenab S,Ogawa S,Adan RA,Burbach JP,Pfaff DW

更新日期：1997-01-01 00:00:00

abstract：:Primary cultures from fetal rat brain contain angiotensin II immunoreactivity in neurons. To study the origin of this immunoreactivity, primary cultures were incubated with [3H]-valine or [3H]-isoleucine. A time-dependent incorporation of radioactivity into immunoprecipitable angiotensin II was observed. Incubation of...

journal_title：Neuroendocrinology

authors： Raizada MK,Phillips MI,Gerndt JS

更新日期：1983-01-01 00:00:00

abstract：:We have found thyroxine 5'-deiodinase in rat posterior pituitary. The isozyme pattern was different in intermediate and neural lobes. The former contained only type I enzyme. In the neural lobe, in euthyroidism only type I was found while in hypothyroidism type II was a prominent form. Since type II 5'-deiodinase has ...

journal_title：Neuroendocrinology

authors： Tanaka K,Murakami M,Greer MA

更新日期：1987-12-01 00:00:00

abstract：:In the course of the search for the prolactin-releasing factor (PRF), we noticed that the posterior pituitary contained strong PRF activity and subsequently traced this activity to that of bovine neurophysin-II (NP-II). NP-II prepared in our lab was judged to be a homogeneous preparation according to Sephadex G-75 gel...

journal_title：Neuroendocrinology

authors： Shin SH,Obonsawin MC

更新日期：1985-10-01 00:00:00

abstract：:Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...

journal_title：Neuroendocrinology

authors： Okamura H,Murakami S,Chihara K,Nagatsu I,Ibata Y

更新日期：1985-08-01 00:00:00

abstract：:The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats. We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 1...

journal_title：Neuroendocrinology

authors： D'Souza DN,Zhang Y,Damjanoska KJ,Carrasco GA,Sullivan NR,Garcia F,Battaglia G,Doncarlos LL,Muma NA,Van de Kar LD

更新日期：2004-01-01 00:00:00

abstract：:The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...

journal_title：Neuroendocrinology

authors： Dufy-Barbe L,Rodriguez F,Arsaut J,Verrier D,Vincent JD

更新日期：1982-10-01 00:00:00