Abstract：
INTRODUCTION:Small-intestinal neuroendocrine tumors (SI-NET) are situated preferentially within the ileum. The aim was to describe a potential difference in location between unifocal and multiple ileal-NET. METHODS:Between December 2010 and December 2019, all consecutive patients who underwent resection in our European Neuroendocrine Tumor Society Center of Excellence, of at least one non-duodenal SI-NET, were retrospectively included. The main objective was to prove that multiple ileal-NET were mostly located on the left side of the superior mesenteric artery (SMA) axis (defined as 40cm from the ileocecal valve), and unifocal ones on the right-side. RESULTS:Ninety-four patients were included, six with unifocal jejunal-NET located 35cm (range, 10-60) from the duodenojejunal angle (DJA), 44 (47%) with unifocal ileal-NET, and 44 (47%) with multiple ileal-NET. The median number of tumors in multiple ileal-NET was 7 (range, 2-95), within a median small bowel segment of 105cm (10-240). The median length between the proximal tumor and the DJA was 428cm (300-635) and 540cm (350-725) for the distal one; 40 (91%) of them were located on the left side of the SMA axis. In contrast, unifocal ileal-NET were located at a median distance of 577cm (305-820) from the DJA (p<0.001, compared to multiple ileal-NET); 30 (68%) of them were on the right side of the SMA axis (p<0.001). CONCLUSION:Multiple ileal-NET are mostly located on the left side of the SMA axis. Further studies are warranted to explore the embryological origin of unifocal versus multiple ileal-NET.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Kalifi M,Walter T,Milot L,Hervieu V,Millot I,Gibert B,Roche C,Forestier J,Lombard-Bohas C,Pasquer A,Poncet Gdoi
10.1159/000511849subject
Has Abstractpub_date
2020-09-30 00:00:00eissn
0028-3835issn
1423-0194pii
000511849pub_type
杂志文章abstract：:Previous reports have shown that dopamine (DA) in the zona incerta (ZI) has a stimulatory effect on gonadotrophin release. We have now investigated the possibility that steroids exert their feedback effects on the release of luteinizing hormone (LH) via catecholamine systems in the ZI. Since the same steroid regimes a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125708
更新日期：1991-02-01 00:00:00
abstract：:The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123957
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:Activation of somatostatin receptors (sstr1-5) by somatostatin and its analogues exerts an inhibitory effect on hormone secretion and provides the basis for the treatment of a range of endocrine diseases such as acromegaly, Cushing's disease and neuroendocrine tumors (NET). The lack of well-characterized com...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000330616
更新日期：2012-01-01 00:00:00
abstract：:As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123586
更新日期：1983-12-01 00:00:00
abstract：:The expression of the mouse metallothionein-I (mMT) promoter/human growth hormone (hGH) fusion gene in transgenic mice leads to female sterility and major alterations in the function of the hypothalamic-adenohypophyseal system. These alterations include increases in median-eminence norepinephrine turnover and plasma L...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125743
更新日期：1991-04-01 00:00:00
abstract：:Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000095548
更新日期：2006-01-01 00:00:00
abstract：:The purpose of these studies was to determine the temporal requirements and time of day required for progesterone (P4) to amplify versus extinguish LH surges. The experimental animal model used in these studies was the 7-day ovariectomized rat (day 0) treated continuously with estradiol (E2) for 2-4 days (days 2, 3 or...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124241
更新日期：1986-01-01 00:00:00
abstract：:The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123389
更新日期：1982-10-01 00:00:00
abstract：:The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122974
更新日期：1980-01-01 00:00:00
abstract：:Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126539
更新日期：1993-08-01 00:00:00
abstract：:Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126225
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000441897
更新日期：2017-01-01 00:00:00
abstract：:Our previous studies on annexin 5, a member of the annexin family of proteins, have shown its expression in the anterior pituitary gland, its preferential distribution in gonadotropes, and its increase after ovariectomy. In the present study, we examined (1) whether annexin 5 is synthesized in gonadotropes, (2) whethe...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000048216
更新日期：2002-01-01 00:00:00
abstract：:TRPM8 is a member of the melastatin-type transient receptor potential ion channel family. Activation by cold or by agonists (menthol, icilin) induces a transient rise in intracellular free calcium concentration ([Ca(2+)](i)). Our previous study demonstrated that Ca(2+)-permeable cation channels play a role in IGF-1-in...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000101693
更新日期：2007-01-01 00:00:00
abstract：:The effect of altering gamma-aminobutyric acid (GABA) activity on growth hormone (GH) secretion of freely moving chronically cannulated male rats was studied. Systemic injection of the GABA agonist muscimol (2 mg/kg i.v.) inhibited the anticipated secretory episode. Increasing brain GABA levels by gamma-acetylenic-GAB...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124031
更新日期：1984-12-01 00:00:00
abstract：:The orphanin-FQ/nociceptin (OFQ/N) receptor (previously, ORL1, LC132) has been shown to be coupled to an inwardly rectifying K+ conductance in several neuronal populations. Although OFQ/N receptor mRNA is densely expressed in the supraoptic nucleus (SON), little is known about its coupling to effector system(s). The p...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054441
更新日期：1999-05-01 00:00:00
abstract：:Visual average evoked responses (AERs) to 4 intensities of light were studied in 5 patients with adrenal cortical insufficiency. Patients were tested off all medications, on ACTH while off all medications, and during replacement with carbohydrate-active steroids. Off treatment, when steroid levels were low, AERs were ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122452
更新日期：1975-01-01 00:00:00
abstract：:Correlations between the specific binding of radiolabelled adrenoligands in frontal cortex and hypothalamus, and plasma testosterone levels were investigated in inbred mouse strains. Binding values were structure and genotype dependent. There were significant negative intrastrain and interstrain correlations between h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126893
更新日期：1995-06-01 00:00:00
abstract：:The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124755
更新日期：1987-05-01 00:00:00
abstract：UNLABELLED:Mediobasal hypothalamic slices of adult ovariectomized (OVX) rats treated or not with 17 beta-estradiol (E2) were superfused in buffered (pH 7.2) Locke medium containing bacitracin. A 6-min pulse of K+ (56 m M) was less effective in releasing luteinizing hormone releasing hormone (LH-RH) from mediobasal hypo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123883
更新日期：1984-02-01 00:00:00
abstract：:Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122517
更新日期：1976-01-01 00:00:00
abstract：:The effect of castration and adrenalectomy was studied on vasoactive intestinal peptide (VIP) concentrations in various brain and peripheral structures of male rats. Castration has no effect on any of the structures studied, whereas 4 weeks adrenalectomy (ADX) decreases VIP concentrations in the hippocampus and increa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123090
更新日期：1980-10-01 00:00:00
abstract：INTRODUCTION:Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, in...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000368607
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000381061
更新日期：2015-01-01 00:00:00
abstract：:Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054304
更新日期：1998-02-01 00:00:00
abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123296
更新日期：1982-03-01 00:00:00
abstract：:Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126098
更新日期：1992-01-01 00:00:00
abstract：:Tissue-specific stem cells are uncovered in a growing number of organs by their molecular expression profile and their potential for self-renewal, multipotent differentiation and tissue regeneration. Whether the pituitary gland also contains a pool of versatile 'master' cells that drive homeostatic, plastic and regene...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000100278
更新日期：2007-01-01 00:00:00
abstract：:This study was carried out to clarify the central effects of neuropeptide Y (NPY) on gonadotropin and prolactin (PRL) release in the male rat and to evaluate the hypothesis that it may play a role in negative feedback regulation of gonadotropin secretion in the male. NPY (4 micrograms in 2 microliters 0.9% NaCl) or an...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126481
更新日期：1993-06-01 00:00:00
abstract：:In addition to its traditional role as a circulating vasoactive peptide, vasopressin (VP) has been shown to play significant roles in central cardiovascular processing. The recent description of VP receptors within the subfornical organ (SFO) has suggested this circumventricular organ (CVO) as a potential locus for fe...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127230
更新日期：1997-08-01 00:00:00
