Abstract:
:Changes in antidiuretic substance (i.e., vasopressin) release from the cut pituitary stalk and the intact pituitary gland were observed during electrical stimulation of amygdala medial nucleus. Electrical pulses of 4 or 36 cycles per second (cps) were used and in both cases the same energy (about 2.160 nanowatt seconds) per 1.5 sec-train of electrical pulses remained constant. Antidiuretic substance release from the hypothalamic end of the cut pituitary stalk and from the intact pituitary gland increased during the 36-cps electrical stimulation of amygdala medial nucleus, however the 4-cps electrical stimulation of this structure did not produce any changes in these processes. The results obtained indicate that the medial nucleus of amygdala is able to change the function of the hypothalamo-hypophysial system and can be motivated with high frequency stimulating pulses.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Tomas Tdoi
10.1159/000122349subject
Has Abstractpub_date
1975-01-01 00:00:00pages
139-46issue
2eissn
0028-3835issn
1423-0194journal_volume
17pub_type
杂志文章abstract::The mechanisms involved in the activation of the hypothalamus-pituitary-adrenal axis after administration of Mycoplasma fermentans were examined. Male rats were injected intracerebroventricularly (i.c.v.) with heat-inactivated M. fermentas (6 micrograms protein/10 microliters/rat) or vehicle and were killed 2 h later....
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127241
更新日期:1997-09-01 00:00:00
abstract::Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,0...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125071
更新日期:1988-12-01 00:00:00
abstract::Hypothalamic norepinephrine (NE) and dopamine content was studied in dogs with spontaneous and iatrogenic hypercortisolism and in untreated normal dogs. The concentration of NE in the hypothalamus was subnormal in 4 of 8 dogs with pituitary-dependent hyperadrenocorticism (PDH), whereas long-term administration of cort...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123158
更新日期:1981-04-01 00:00:00
abstract::In addition to the magnocellular hypothalamic nuclei, arginine vasopressin (AVP)-containing neurons have also been identified in limbic structures, including the hippocampus and amygdala. In the present study, we compared the qualitative properties of the in vitro release of AVP from the dissected hypothalamus with th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126661
更新日期:1994-03-01 00:00:00
abstract::Leptin, the product of the obese gene, is a protein that is secreted primarily from adipocytes. Leptin can influence the function of the pituitary gland through its action on the hypothalamus, but it can also directly act at the level of the pituitary gland. The ability of leptin to induce an increase in intracellular...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000081843
更新日期:2004-01-01 00:00:00
abstract::The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000084872
更新日期:2005-01-01 00:00:00
abstract::In order to characterize plasma prolactin (Prl) patterns during the estrous cycle and pseudopregnancy (PSP), I collected sequential blood samples between 8.00 and 19.00 h at 1-hour, 1.5-min or 1-min intervals from conscious, unrestrained female rats. During the afternoon of proestrus and estrus a single Prl surge was ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123247
更新日期:1981-11-01 00:00:00
abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127068
更新日期:1996-05-01 00:00:00
abstract::Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124081
更新日期:1985-03-01 00:00:00
abstract::To study the role of the hypothalamus in the regulation of growth hormone (GH) synthesis, the rate of amino acid incorporation into GH in vitro was examined in rats with anterolateral deafferentation of the medial basal hypothalamus. Amino acid incorporation into GH (GH synthesis) decreased significantly 7 days after ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124946
更新日期:1988-05-01 00:00:00
abstract::An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122924
更新日期:1979-01-01 00:00:00
abstract::As part of an assessment of endocrine influences on the actions of morphine, we have studied the effects of intracerebroventricular administration of somatostatin and thyrotropin releasing hormone (TRH) on the antinociceptive, temperature and cataleptic responses to subcutaneous morphine in both intact and hypophysect...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123586
更新日期:1983-12-01 00:00:00
abstract::Three control point enzymes of the Embden-Meyerhof pathway, hexokinase (HK), phosphofructokinase (PFK) and pyruvate kinase (PK) were measured by quantitative histochemical methods in individual hypothalamic nuclei of adult neonatally androgenized female rats. HK activity was significantly increased in anterior hypotha...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122715
更新日期:1977-01-01 00:00:00
abstract::The effect of intraventricular and intravenous (i.v.) hypertonic saline on plasma and perfusate arginine vasopressin (AVP) and oxytocin (OT) levels was determined. A push-pull technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious unrestrained rat. Intraventricular perfusion of hyper...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124008
更新日期:1984-11-01 00:00:00
abstract::In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels in the dentate gyrus of the hippocampus 4 h after the last seizure, and these levels rem...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126691
更新日期:1994-05-01 00:00:00
abstract::Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-fe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000155137
更新日期:2008-01-01 00:00:00
abstract::In order to search for candidate genes related to pituitary adenoma aggressiveness, the present investigation was intended to compare the mRNA expression profile from a pool of four nonfunctional pituitary adenomas (NFPA) with a spinal cord metastasis of a nonfunctional pituitary carcinoma (MNFPC). The metallothionein...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000092521
更新日期:2005-01-01 00:00:00
abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126186
更新日期:1992-06-01 00:00:00
abstract::There is evidence that alpha-melanocyte-stimulating hormone (alpha-MSH) has immunomodulatory and anti-inflammatory actions within the brain. In this study, we tested whether these actions are due to inhibition of the synthesis of nitric oxide (NO) and prostaglandins induced by lipopolysaccharide (LPS). Since melanocor...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000079321
更新日期:2004-01-01 00:00:00
abstract::Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123294
更新日期:1982-03-01 00:00:00
abstract::A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124479
更新日期:1986-01-01 00:00:00
abstract::The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essential...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123288
更新日期:1982-02-01 00:00:00
abstract::Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000064428
更新日期:2002-08-01 00:00:00
abstract::The effects of GABAa receptor activation on the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH) from the superfused pars intermedia of the amphibian Xenopus laevis were examined. The GABAa receptor agonist isoguvacine inhibited secretion of alpha-MSH from the pars intermedia, an action completely antagon...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126516
更新日期:1993-07-01 00:00:00
abstract::Pulsatile gonadotropin-releasing hormone (GnRH) release from the median eminence is critical for the appropriate function of the pituitary gonadotropes and for the generation of a preovulatory gonadotropin surge. The mechanisms by which many GnRH axon terminals are synchronized to release GnRH in a coordinated fashion...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054304
更新日期:1998-02-01 00:00:00
abstract::Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122517
更新日期:1976-01-01 00:00:00
abstract::Studies were performed to determine the role of thyroid hormone in the suppression of thyrotropin (TSH) by opiates. Serum samples were collected by decapitation 1, 3, 6, 12, 24, or 48 h after rats were implanted with 1 sustained-release morphine (75 mg) or placebo pellet. Morphine decreased TSH by 44% at 1 h and by 83...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125602
更新日期:1990-09-01 00:00:00
abstract::Introduction Dysregulation of the mTORC1-dependent pathways in pancreatic neuroendocrine neoplasms (PanNENs) underlies the introduction of the mTORC1 inhibitor everolimus as treatment of advanced progressive PanNENs. Although everolimus significantly increases progression free survival, most patients acquire secondary...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509865
更新日期:2020-07-02 00:00:00
abstract::The hypothesis was tested that corticotropin-releasing factor (CRF) is involved in the inhibition of gonadotropin secretion during chronic hyperprolactinemia. Two models of hyperprolactinemia were used, namely inoculation with the prolactin (PRL)-secreting tumor 7315b and implantation of isogenic pituitary glands. Gon...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125348
更新日期:1990-03-01 00:00:00
abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127121
更新日期:1996-09-01 00:00:00