Abstract：
:The present study investigated the effects of short-term exposure to constant light, initiated at the time of ovariectomy, on the ability of estradiol (E2) treatment alone or in conjunction with progesterone (P) to induce afternoon surges of LH and prolactin (PRL). Adult Fischer 344 rats, which had been ovariectomized (OVX) and placed into constant light (LL) on day 0, were implanted with Silastic capsules containing E2 on day 7 and an atrial cannula on day 8. On the following day (day 9), hourly blood samples were collected between 12.00 and 20.00 h from LL-exposed animals which had received E2 treatment alone or from LL E2-treated animals which had also received P at 12.20 h. Blood samples from control animals which were OVX and treated with E2, but maintained under a 12-hour light:12-hour dark photoperiod, were also collected. Exposure to 9 days of LL abolished the ability of E2 treatment to induce an afternoon surge of LH or PRL. The addition of P treatment to LL E2-treated animals failed to reinstate an LH or PRL surge. While P treatment in LL E2-treated animals induced a rise in PRL levels, it is unlikely, given the timing, duration, and magnitude of PRL release, that this enhancement was initiated by the same mechanisms which normally generate the afternoon surge. The results from the present study demonstrate that short-term exposure to LL, initiated at the time of OVX, abolishes the E2-induced afternoon surges of LH and PRL.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Sterner MR,Cohen IRdoi
10.1159/000127009subject
Has Abstractpub_date
1995-09-01 00:00:00pages
231-7issue
3eissn
0028-3835issn
1423-0194journal_volume
62pub_type
杂志文章abstract：:Previous studies have shown that the hypothalamic concentration of pro-opiomelanocortin (POMC) mRNA and several POMC-derived peptides increases in the rat 4 weeks after orchiectomy and that this increase can be prevented by testosterone replacement. In this study, we have examined the short-term effects of orchiectomy...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125638
更新日期：1990-11-01 00:00:00
abstract：:Galanin-like peptide (GALP) is a 60-amino-acid peptide with structural similarities to galanin and a high affinity for galanin receptors. GALP is expressed by a discrete population of neurons in the arcuate nucleus (ARC) and median eminence of the hypothalamus of several species, including the rat. GALP neurons expres...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000079752
更新日期：2004-01-01 00:00:00
abstract：:After in vivo treatment, progesterone initially decreases tyrosine hydroxylase (TH) activity in the TIDA neurons, but subsequently increases TH activity with prolonged treatment. In order to explore the cellular mechanism for progesterone's effect, this study examined the acute inhibitory action of progesterone on TH ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000057336
更新日期：2002-05-01 00:00:00
abstract：:We have investigated the variations in growth hormone (GH) and somatostatin (SOM) mRNAs in adult, middle-aged and aging rats of both sexes using quantitative in situ hybridization. cDNA probes complementary to GH mRNA and SOM mRNA were used on fixed pituitary and hypothalamic sections, respectively. A clear sexual dim...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125967
更新日期：1991-12-01 00:00:00
abstract：:Oxytocin receptors are regulated during parturition and lactation. Gonadal steroids are thought to be key players in this regulation. It is not well documented how oxytocin receptor gene expression is regulated in the CNS. In this study we analyzed potential estrogen effects on the oxytocin receptor mRNA levels in som...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127160
更新日期：1997-01-01 00:00:00
abstract：:The effect of pinealectomy or immunization against melatonin (Mel) and N-acetylserotonin (NAS) on plasma prolactin (Prl) levels was studied in rats following pineal stimulation induced by blinding or exposure to short photoperiods (1 h light and 23 h darkness daily). Blinding alone or together with pinealectomy or imm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122650
更新日期：1977-01-01 00:00:00
abstract：:The relationship between concentrations of vasopressin in plasma and cerebrospinal fluid (CSF) was examined under basal and hypoxic conditions in unanesthetized and unrestrained adult female sheep. Under basal conditions mean (+/- SE) concentration of vasopressin (4.1 +/- 0.3 pg/ml) in CSF was significantly (p less th...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123933
更新日期：1984-06-01 00:00:00
abstract：:Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127172
更新日期：1997-02-01 00:00:00
abstract：:Thyroid hormones and nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling play a significant role in the structural development of the cerebellum, respectively. In the present study, the possible contribution of neuronal NO synthase (NOS) and cGMP in the thyroid hormone-induced structural changes was invest...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000203644
更新日期：2009-01-01 00:00:00
abstract：:The primary treatment of gastroenteropancreatic neuroendocrine tumors (GEPNETs) is surgery with curative intent or debulking of the tumor mass. In case of metastatic disease, cytoreductive options are limited. A relatively new therapeutic modality, peptide receptor radionuclide therapy (PRRT) with radiolabeled somatos...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000335018
更新日期：2013-01-01 00:00:00
abstract：:In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels in the dentate gyrus of the hippocampus 4 h after the last seizure, and these levels rem...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126691
更新日期：1994-05-01 00:00:00
abstract：:Hereditary cases of growth hormone (GH)-secreting tumors have been classified into three clinical entities: the multiple endocrine neoplasia type 1 (MEN1) syndrome, the Carney complex (CNC) and the isolated familial somatotropinomas (IFS). The genomic defects associated with MEN1 are all linked to various mutations of...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000095525
更新日期：2006-01-01 00:00:00
abstract：:The purpose of these studies was to determine the temporal requirements and time of day required for progesterone (P4) to amplify versus extinguish LH surges. The experimental animal model used in these studies was the 7-day ovariectomized rat (day 0) treated continuously with estradiol (E2) for 2-4 days (days 2, 3 or...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124241
更新日期：1986-01-01 00:00:00
abstract：:Hemicastration of male rats produced rapid changes in plasma testosterone (T) levels both in summer and in winter. However, in winter, after unilateral castration, the duration of T maximum decrease was found to be longer, but the compensatory increase of blood T following its drop was more dramatic as compared to the...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122791
更新日期：1978-01-01 00:00:00
abstract：:There is a great deal of conflicting data regarding the issue of whether androgens influence opiate receptors in the whole male rat brain. Although Hahn and Fishman initially reported that long-term castration produced a large increase in the density of opiate-binding sites, relative to controls, no other independent ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124816
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. METHODS:All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified ...
journal_title：Neuroendocrinology
pub_type： 杂志文章,多中心研究
doi：10.1159/000472717
更新日期：2018-01-01 00:00:00
abstract：:Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123296
更新日期：1982-03-01 00:00:00
abstract：:Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126098
更新日期：1992-01-01 00:00:00
abstract：:The response of folliculo-stellate (FS) cells of the anterior pituitary to estrogen has been studied in two strains of rat which differ in estrogen responsiveness. Fischer 344 (F344) rats are highly estrogen-responsive in comparison to Sprague-Dawley (S-D) rats. Ovariectomized adults were implanted with silastic capsu...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125064
更新日期：1988-11-01 00:00:00
abstract：:Studies were undertaken to characterize the secretion of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) into the hypophysial-portal circulation of the conscious sheep. In addition, we examined the temporal relationship between the secretion of these two hypothalamic peptides and the secretion of t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125141
更新日期：1989-04-01 00:00:00
abstract：:After the combined treatment with dexamethasone, morphine and pentobarbitone, the electrical stimulation in the rat tuber cinereum induces a rise in plasma corticosterone (CS) level, probably by direct stimulation of the corticoliberin-producing neural elements and the consecutive ACTH release. We have attempted to lo...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122803
更新日期：1978-01-01 00:00:00
abstract：:The effect of long-term decreases in circulating concentrations of prolactin was determined on the responsiveness of tuberoinfundibular dopamine (DA) neurons to this hormone. The activity of these neurons in ovariectomized rats was estimated by measuring the rate of DA synthesis (DOPA accumulation after the administra...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124100
更新日期：1985-05-01 00:00:00
abstract：:The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127143
更新日期：1996-11-01 00:00:00
abstract：:The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000076631
更新日期：2004-02-01 00:00:00
abstract：:Many aspects of reproductive neuroendocrine function and sexual behavior are responsive to both androgens and estrogens, suggesting that receptors for these steroid hormones may reside within single cells in brain regions that control reproductive function. We determined the distribution of estrogen receptor-containin...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000127039
更新日期：1995-11-01 00:00:00
abstract：:Arginine-vasopressin (AVP) is regarded as a potent stimulator of pituitary adrenocorticotropin (ACTH) secretion and participates therefore in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis function in concert with the physiological activator of the axis, hypothalamic corticotropin-releasing hormone (C...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126787
更新日期：1994-11-01 00:00:00
abstract：CONTEXT:Early pubertal luteinizing hormone (LH), and by inference gonadotropin-releasing hormone (GnRH), pulse secretion is marked by high nocturnal but low daytime frequency; however, the underlying mechanisms remain unclear. Plasma concentrations of progesterone, the major regulator of GnRH frequency in women, increa...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000336395
更新日期：2012-01-01 00:00:00
abstract：:The effect of frontal deafferentation of the medial basal hypothalamus on pro-opiomelanocortin (POMC) gene expression was studied in the intermediate lobe (IL) and anterior lobe (AL) of the pituitary gland in the absence and presence of corticosterone (CORT). The lesion in the basal hypothalamus removed neural inputs ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124936
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND/AIMS:Both prostaglandin E2 (PGE2) and estradiol stimulate fetal ACTH secretion and augment fetal ACTH responses to stress. We have reported that estradiol increases prostaglandin endoperoxide synthase-2 (PGHS-2), and we have proposed that there is a positive feedback relationship between estrogen and fetal h...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000109664
更新日期：2008-01-01 00:00:00
abstract：:In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125777
更新日期：1991-06-01 00:00:00
