Abstract:
:The relationship between concentrations of vasopressin in plasma and cerebrospinal fluid (CSF) was examined under basal and hypoxic conditions in unanesthetized and unrestrained adult female sheep. Under basal conditions mean (+/- SE) concentration of vasopressin (4.1 +/- 0.3 pg/ml) in CSF was significantly (p less than 0.001) higher than the concentration in arterial plasma (2.4 +/- 0.2 pg/ml). There was a significant positive correlation between CSF and plasma vasopressin concentrations (r = 0.66, p less than 0.01). The introduction of severe hypoxia by exposure of the sheep to an inspired gas mixture of 5% O2 in N2, a known stimulus to systemic release of vasopressin, was associated with an increase in the concentration of vasopressin in plasma to 339 +/- 65 pg/ml and CSF to 19 +/- 3.9 pg/ml. This increase of vasopressin in CSF was delayed in time with respect to the increases in the plasma and of a lesser magnitude. With moderate hypoxia (10% O2 in N2 exposure) no increase in CSF or plasma vasopressin concentration was observed, suggesting a threshold response. Intravenous infusion of vasopressin to achieve plasma values comparable to those seen with hypoxia was not accompanied by a significant increase in CSF vasopressin concentration. Thus, severe hypoxia is a potent stimulus for release of vasopressin into both CSF and plasma. Furthermore, data suggest that vasopressin may be released into CSF via a separate route from that released into plasma.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Stark RI,Daniel SS,Husain MK,Zubrow AB,James LSdoi
10.1159/000123933subject
Has Abstractpub_date
1984-06-01 00:00:00pages
453-60issue
6eissn
0028-3835issn
1423-0194journal_volume
38pub_type
杂志文章abstract::Acute electrolytic stimulation of the median raphe (MR) nucleus (MR Stim) between 13:00 and 16:00 h on proestrus blocked ovulation in 10 of the 21 rats tested, whereas all sham-treated (MR Sham, no current) animals ovulated normally (n = 12). MR Stim at 16:00 h on proestrus in individual cannulated rats 'turned off' t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122884
更新日期:1979-01-01 00:00:00
abstract::Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126424
更新日期:1993-04-01 00:00:00
abstract::The potential involvement of the sympathoadrenal system in stress-induced secretion of peptides from the intermediate lobe of the pituitary gland and the activation of the pituitary-adrenal axis was studied. Male Wistar rats were subjected to control procedures, to sympathectomy by chronic administration (8 weeks) of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124746
更新日期:1987-04-01 00:00:00
abstract::Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NEN are subdivided according to their differentiation into well differentiated gastroenteropancreatic neuroendocrine tumors (NET...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000509864
更新日期:2020-07-02 00:00:00
abstract::Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal beta-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. beta-Adrenoceptor density and binding affinity both showed time-...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124225
更新日期:1985-12-01 00:00:00
abstract::Increases in the level of cAMP stimulate the secretion of GnRH from GT1 GnRH neuronal cells. We hypothesized that cyclic nucleotide phosphodiesterases (PDEs), the enzymes that hydrolyze cAMP, may constitute a negative feedback signaling mechanism for GnRH regulation by decreasing the level of cAMP. GT1 cells were show...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054386
更新日期:1998-12-01 00:00:00
abstract::Neuroendocrine mechanisms governing growth hormone (GH) secretion are sensitive to nutritional status since the normal pulsatile pattern of GH release is disrupted during conditions of food deprivation or malnutrition. A reasonable hypothesis for this occurrence is the alteration of somatostatin and GH-releasing hormo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127172
更新日期:1997-02-01 00:00:00
abstract::Allopregnanolone is a neuroactive steroid synthesized in rat gonads, adrenal cortex, and central nervous system. It has been suggested that sex steroid hormones might influence allopregnanolone concentrations but no clear data have ever been reported. The aim of the present study was to investigate the effects of admi...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054583
更新日期:2000-09-01 00:00:00
abstract::Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic-pituitary-adrenal (HPA) axis responses to systemic interleukin-1beta (IL-1beta). However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054629
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000329043
更新日期:2012-01-01 00:00:00
abstract::In this study, radiolabeled recombinant rat interleukin-1 beta (r125I-IL-1 beta) was used to localize and characterize IL-1 beta binding in rat hypothalamus and pituitary gland by quantitative autoradiography. The ability of this ligand to bind to type I IL-1 receptor was first tested on murine lymphoma cells (EL-4). ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127026
更新日期:1995-10-01 00:00:00
abstract::We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126743
更新日期:1994-08-01 00:00:00
abstract::In 2016, the third version of guidelines for the diagnosis and treatment of neuroendocrine tumors (NETs) has been published by the European Neuroendocrine Tumor Society (ENETS). These guidelines reflect the progress in treatment of NETs, and by comparing the newest guidelines with the first guidelines of 2001, this pr...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000486096
更新日期:2018-01-01 00:00:00
abstract::Both the pituitary-adrenal axis and the pituitary-gonadal axis are under the tonic inhibitory control of endogenous opioid peptides in man. However, the precise opioid receptor involved in the modulation of these hormones remains unknown. The effect of a dose of intravenous naloxone on serum levels of luteinising horm...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124463
更新日期:1986-01-01 00:00:00
abstract::Pituitary transcription factor-1 (Pit-1 or GHF-1) is a transcription factor specific to the anterior pituitary and is involved in the expression and regulation of the growth hormone (GH), prolactin (PRL) and thyroid-stimulating hormone (TSH) beta-subunit genes. The expression of these three genes can be modulated by c...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126930
更新日期:1996-01-01 00:00:00
abstract::The arcuate nucleus-median eminence complex (AM) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. Those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary glan...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124775
更新日期:1987-06-01 00:00:00
abstract::The effect of the antidiarrheal drug loperamide, a mu-opiate agonist, on ACTH secretion and biosynthesis, cAMP generation and phosphoinositide turnover was studied in rat anterior pituitary cell cultures. The cAMP-dependent protein kinase A pathway was stimulated with both corticotropin-releasing hormone (CRH; 2-5 nM)...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126466
更新日期:1993-06-01 00:00:00
abstract::The possible role of prostaglandins (PGs) in the hypothalamic control of ovulation has been investigated by studying the effects of indomethacin (ID) and PGs on the release of luteinizing hormone-releasing hormone (LHRH) from hypothalamic synaptosomes. Female rats were chronically pretreated with ID on diestrus 2 (D2)...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122888
更新日期:1979-01-01 00:00:00
abstract::The hypothalamic peptide kisspeptin (metastin), the endogenous ligand of the G protein-coupled receptor KISS1R, plays a critical role in controlling GnRH release from hypothalamic GnRH neurons and thereby regulates hypothalamic-pituitary-gonadal functions. Although the therapeutic potential of kisspeptin is attractive...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000357809
更新日期:2014-01-01 00:00:00
abstract::Plasma and hypothalamic LHRH was measured by specific radioimmuno-assay in intact and ovariectomized rats, and the values were correlated with peripheral plasma (PP) FSH and LH titers. At most stages of the estrous cycle, plasma LHRH was either undetectable or present at very minimal values. An increase in PP LHRH con...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122496
更新日期:1976-01-01 00:00:00
abstract::The release of endogenous noradrenaline in the anterior hypothalamus was studied with microdialysis perfusion in freely moving rats that were subjected to immobilization stress. Experiments were carried out in sham-adrenalectomized and adrenalectomized rats that were first given drinking water containing corticosteron...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126442
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000441897
更新日期:2017-01-01 00:00:00
abstract::Somatotropes and GC cells, a GH-producing cell line, exhibit [Ca(2+)](i) oscillations that result from rhythmic Ca(2+) action potentials. Determination of this operating mode required simultaneous recording of both parameters by fura-2 imaging and patch-clamp techniques. In order to test whether patch recording induce...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054495
更新日期:1999-11-01 00:00:00
abstract::Bromocriptine or other dopamine agonists are usually effective for the treatment of prolactin-secreting adenomas. Five to 18% of prolactinomas, however, do not respond to such therapy. We have shown previously that such resistance to bromocriptine correlates with reduced binding to the D2 receptor subtype of dopamine,...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126764
更新日期:1994-09-01 00:00:00
abstract::The properties of neuronal-type nicotinic acetylcholine receptors (nAChRs) present on the neuroendocrine cells of the porcine pars intermedia of the pituitary were studied in intact single cell using measurements of the free intracellular Ca2+ concentration ([Ca]i) with the calcium-sensitive dye fura 2. Local applicat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126772
更新日期:1994-10-01 00:00:00
abstract::We have used excitatory amino acids as tools to elucidate changes in hypothalamic function associated with lactation, focusing on the regulation of luteinizing hormone (LH) and prolactin secretion. In these studies, we have compared the responsiveness to NMA (N-methyl-D,L-aspartate), an agonist for the N-methyl-D-aspa...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126576
更新日期:1993-10-01 00:00:00
abstract::Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124196
更新日期:1985-10-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124886
更新日期:1988-01-01 00:00:00
abstract::The regulation of prolactin secretion by tuberoinfundibular dopamine (DA) neurons appears to be altered in the aged rat: the concentration of prolactin in the serum increases and the activity of the tuberoinfundibular DA neurons decreases. In the young female rat a brief period of stress reduces the tuberoinfundibular...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124755
更新日期:1987-05-01 00:00:00
abstract::The relationship between the growth hormone/insulin-like growth factor (GH-IGF)-I status and memory performance is studied in 24 elderly males and females, aged 75-85 years. Positron emission tomography (PET) was used to measure differences in regional cerebral blood flow during the performance of a delayed-non-match-...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000084872
更新日期:2005-01-01 00:00:00