Effects of adrenalectomy and glucocorticoids on rat brain dopamine receptors.

abstract：:Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...

journal_title：Neuroendocrinology

authors： Prague JK,Dhillo WS

更新日期：2015-01-01 00:00:00

abstract：:Patients with active acromegaly are frequently insulin resistant, glucose intolerant, and at risk for developing overt type 2 diabetes. At the same time, these patients have a relatively lean phenotype associated with mobilization and oxidation of free fatty acids. These features are reversed by curative surgical remo...

journal_title：Neuroendocrinology

authors： Dal J,List EO,Jørgensen JO,Berryman DE

更新日期：2016-01-01 00:00:00

abstract：:Characteristic increases in neuronal activity coincident with the pulsatile release of luteinizing hormone from the pituitary gland have been recorded from electrodes chronically implanted in the medial basal hypothalamus of the rhesus monkey. This electrophysiologic manifestation of the hypothalamic 'pulse generator'...

journal_title：Neuroendocrinology

authors： Wilson RC,Kesner JS,Kaufman JM,Uemura T,Akema T,Knobil E

更新日期：1984-09-01 00:00:00

abstract：:The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H3 receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats wi...

journal_title：Neuroendocrinology

authors： Knigge U,Søe-Jensen P,Jorgensen H,Kjaer A,Møller M,Warberg J

更新日期：1999-01-01 00:00:00

abstract：:To examine the role of excitatory amino acid neurotransmitters in the regulation of LH and FSH secretion in ovariectomized (ovx) adult rats treated with estradiol and progesterone, we measured the release rates of the excitatory amino acid neurotransmitters, glutamate and aspartate, as well as the neurally inactive am...

journal_title：Neuroendocrinology

authors： Ping L,Mahesh VB,Wiedmeier VT,Brann DW

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND/AIMS:Stress exacerbates neuron loss in many CNS injuries via the actions of adrenal glucocorticoid (GC) hormones. For some injuries, this GC endangerment of neurons is accompanied by greater immune cell activation in the CNS, a surprising outcome given the potent immunosuppressive properties of GCs. METHODS...

journal_title：Neuroendocrinology

authors： Sorrells SF,Munhoz CD,Manley NC,Yen S,Sapolsky RM

更新日期：2014-01-01 00:00:00

abstract：:The present study was designed to investigate whether the vasoactive intestinal peptide (VIP) concentration in hypothalamic nuclei, dorsal raphe nucleus (DR) and pituitary lobes of lactating rats changes in physiological situations when prolactin (PRL) secretion is stimulated (suckling) or inhibited (pup separation). ...

journal_title：Neuroendocrinology

authors： Chiocchio SR,de las Nieves Parisi M,Vitale ML,Tramezzani JH

更新日期：1991-07-01 00:00:00

abstract：:The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...

journal_title：Neuroendocrinology

authors： Sowers JR,Resch G,Walker S,Sollars E

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low g...

journal_title：Neuroendocrinology

authors： Oversoe SK,Sorensen BS,Tabaksblat EM,Gronbaek H,Kelsen J

更新日期：2021-01-18 00:00:00

abstract：:Following the procedure of Jeffcoate et al. [1974] we have successfully obtained a specific antiserum to LH-RH in rabbits, and are utilizing our antibody to study the synthesis of LH-RH by rat hypothalamic tissues in vitro. Our antibody, used at a dilution of 1:20,000, binds 37% of added 125I-labelled LH-RH, and cross...

journal_title：Neuroendocrinology

authors： Hall RW,Steinberger E

更新日期：1976-01-01 00:00:00

abstract：:The role of endogenous corticoids in fever responses caused by recombinant murine interleukin (IL)-1 beta and IL-6 was studied in adult male Wistar rats. Adrenalectomy diminished the development of fever after intracerebroventricular (icv) injection of these ILs and lowered body temperature. Intraperitoneal administra...

journal_title：Neuroendocrinology

authors： Schöbitz B,Holsboer F,Sutanto W,Gross G,Schönbaum E,de Kloet ER

更新日期：1994-04-01 00:00:00

abstract：:Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...

journal_title：Neuroendocrinology

authors： Grove KL,Cook VI,Speth RC

更新日期：1992-08-01 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) or intracarotid (i.a.) administration of amylin (AMY) on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were examined in conscious male rats. Amylin (25 ng-5 micrograms/rat, i.c.v. or 10 micrograms/rat, i.a.) was administered 10 min before GHRH (2 mic...

journal_title：Neuroendocrinology

authors： Netti C,Sibilia V,Pagani F,Lattuada N,Coluzzi M,Pecile A,Guidobono F

更新日期：1995-09-01 00:00:00

abstract：:We have studied some of the neuroendocrine and social correlates of dexamethasone resistance in a nonhuman primate population. Subjects were 51 male Macaca fascicularis monkeys with known behavioral histories and who had been given dexamethasone (DEX) suppression tests a week prior to killing. We compared the subset o...

journal_title：Neuroendocrinology

authors： Brooke SM,de Haas-Johnson AM,Kaplan JR,Manuck SB,Sapolsky RM

更新日期：1994-08-01 00:00:00

abstract：:Adrenocorticotropic hormone (ACTH) is the major regulator of adrenocortical steroidogenesis in mammals. By comparing the sensitivity to ACTH of isolated adrenocortical cells from two sources of the same strain (Sprague-Dawley, SD) of outbred rats, we have identified a source of rat with low sensitivity to ACTH in vitr...

journal_title：Neuroendocrinology

authors： Matthys L,Castello R,Zilz A,Widmaier EP

更新日期：1998-06-01 00:00:00

abstract：:Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...

journal_title：Neuroendocrinology

authors： De Vito WJ,Connors JM,Hedge GA

更新日期：1985-07-01 00:00:00

abstract：:The effect of frontal deafferentation of the medial basal hypothalamus on pro-opiomelanocortin (POMC) gene expression was studied in the intermediate lobe (IL) and anterior lobe (AL) of the pituitary gland in the absence and presence of corticosterone (CORT). The lesion in the basal hypothalamus removed neural inputs ...

journal_title：Neuroendocrinology

authors： Seger MA,van Eekelen JA,Kiss JZ,Burbach JP,de Kloet ER

更新日期：1988-04-01 00:00:00

abstract：:An influence of thyroid status on the secretory activity of hypothalamic dopaminergic neurons was observed in adult rats and its involvement in the regulation of prolactin (PRL) secretion was examined. The secretory activity of the tuberoinfundibular dopaminergic (TIDA) neurons was evaluated by measurement of dopamine...

journal_title：Neuroendocrinology

authors： Reymond MJ,Benotto W,Lemarchand-Béraud T

更新日期：1987-06-01 00:00:00

abstract：:Avian prolactin (PRL) secretion is regulated by vasoactive intestinal peptide (VIP) neurons residing in the infundibular nuclear complex (INF) of the hypothalamus. This VIPergic activity is modulated by stimulatory dopaminergic inputs. Dynorphin, serotonin (5-HT), dopamine (DA) and VIP all appear to stimulate PRL secr...

journal_title：Neuroendocrinology

authors： Youngren O,Chaiseha Y,Al-Zailaie K,Whiting S,Kang SW,El Halawani M

更新日期：2002-03-01 00:00:00

abstract：:An electrophysiological investigation was conducted on the connection of medial preoptic neurons with the median eminence and the basal and corticomedial amygdala in pentobarbital anesthesized male Sprague-Dawley rats. Of 411 medial preoptic neurons tested with median eminence stimuli, antidromic responses (mean laten...

journal_title：Neuroendocrinology

authors： Layton BS,Lafontaine S,Renaud LP

更新日期：1981-01-01 00:00:00

abstract：:Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by trans...

journal_title：Neuroendocrinology

authors： Grandison L,Hodson C,Chen HT,Advis J,Simpkins J,Meites J

更新日期：1977-01-01 00:00:00

abstract：:Parturition is initiated in sheep by an increase in the activity of the fetal hypothalamus-pituitary-adrenal (HPA) axis. Prostaglandins, known to augment the activity of this endocrine axis, have long been proposed as involved in the initiation of paturition. We have previously demonstrated that endogenously produced ...

journal_title：Neuroendocrinology

authors： Deauseault D,Giroux D,Wood CE

更新日期：2000-05-01 00:00:00

abstract：:To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...

journal_title：Neuroendocrinology

authors： Ferrari C,Caldara R,Romussi M,Rampini P,Telloli P,Zaatar S,Curtarelli G

更新日期：1978-01-01 00:00:00

abstract：INTRODUCTION:The pituitary gland has a high expression of somatostatin receptors (SSTRs) and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment. OBJECTIVE:To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based ...

journal_title：Neuroendocrinology

authors： Sundlöv A,Sjögreen-Gleisner K,Tennvall J,Dahl L,Svensson J,Åkesson A,Bernhardt P,Lindgren O

更新日期：2020-04-08 00:00:00

abstract：OBJECTIVE:The expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance as somatostatin analogues and dopamine agonists can be used for their localization and/or treatment. The objective of this study is to examine the expression of the five SSTR subty...

journal_title：Neuroendocrinology

authors： Kanakis G,Grimelius L,Spathis A,Tringidou R,Rassidakis GZ,Öberg K,Kaltsas G,Tsolakis AV

更新日期：2015-01-01 00:00:00

abstract：:The effects of ovariectomy on the ultrastructure of neurons within the SCH nuclei of the rabbit were investigated. All SCH neurons of the intact controls were similar in that they showed no morphological evidence of enhanced neurosecretory activity. In contrast, two distinct types of neurons were present within the SC...

journal_title：Neuroendocrinology

authors： Clattenburg RE,Montemurro DG,Bruni JE

更新日期：1975-01-01 00:00:00

abstract：:Hereditary cases of growth hormone (GH)-secreting tumors have been classified into three clinical entities: the multiple endocrine neoplasia type 1 (MEN1) syndrome, the Carney complex (CNC) and the isolated familial somatotropinomas (IFS). The genomic defects associated with MEN1 are all linked to various mutations of...

journal_title：Neuroendocrinology

authors： Lytras A,Tolis G

更新日期：2006-01-01 00:00:00

abstract：:alpha-Methyl-p-tyrosine (alpha-MT), a competitive inhibitor of tyrosine hydroxylase, was used to block the synthesis of hypothalamic catecholamines in immature female rats of 14, 16 and 30 days of age and in castrated adults. The administration of alpha-MT (300 mg/kg body weight, free base) induced a significant decay...

journal_title：Neuroendocrinology

authors： Moguilevsky JA,Arias P,Szwarcfarb B,Carbone S,Rondina D

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course...

journal_title：Neuroendocrinology

authors： Izakova L,Hlavacova N,Segeda V,Kapsdorfer D,Morovicsova E,Jezova D

更新日期：2020-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors were characterized and their function investigated in mouse pituitary neurointermediate lobe explants. We show that mouse neurointermediate lobes can be maintained for up to 1 month in defined medium. After 8 days in culture, these explants are devoi...

journal_title：Neuroendocrinology

authors： René F,Monnier D,Gaiddon C,Félix JM,Loeffler JP

更新日期：1996-07-01 00:00:00