Abstract：
BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subgroups. METHODS:Using a linked database containing SEER tumor registry data and Medicare claims, we identified patients aged ≥69 years with colorectal cancer who underwent colonoscopy within 6 months of diagnosis. Patients with an additional colonoscopy from 36 to 6 months prior to cancer diagnosis were characterized as having interval cancers. We compared characteristics of patients with interval cancers and detected cancers according to a diagnosis of diverticulosis not associated with a colonoscopy procedure from 1991 through the date of the most recent colonoscopy in both univariate and multivariate models. RESULTS:A previous diagnosis of diverticulosis was documented in 14,452 (26.9 %) patients with detected cancers compared to 2,905 (69.3 %) patients with interval cancers (p < 0.001); these results were consistent in multivariable analysis. Moreover, the association was found as well in the proximal colon (OR 2.88, 95 % CI 2.66, 3.12), distal colon (OR 3.56, 95 % CI 3.09, 4.11), and rectum (OR 4.07, 95 % CI 3.34, 4.95). The vast majority of diverticulosis diagnoses were without complications such as hemorrhage or diverticulitis. CONCLUSIONS:Diverticulosis was strongly associated with interval colorectal cancers in all segments of the colon. Given its known predominance in the left colon, the findings argue against impaired visualization of lesions at colonoscopy as the only pathogenic factor.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Cooper GS,Xu F,Schluchter MD,Koroukian SM,Barnholtz Sloan JSdoi
10.1007/s10620-014-3246-8subject
Has Abstractpub_date
2014-11-01 00:00:00pages
2765-72issue
11eissn
0163-2116issn
1573-2568journal_volume
59pub_type
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536067
更新日期：1989-02-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01307545
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1999-06-01 00:00:00
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01295733
更新日期：1993-06-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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更新日期：2017-01-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2009-01-01 00:00:00
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journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-018-5063-y
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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