Abstract：
:The effect of smoking on interdigestive gastrointestinal motility is little studied but may play a role in gastrointestinal morbidity. We studied gastroduodenal motility in 10 volunteers (five smokers and five nonsmokers) using a water-perfused pressure catheter. A pH probe was placed in the duodenal bulb. Baseline motility was recorded until phase III of the migrating-motor complex had occurred in the stomach three times in order to record two complete cycles of MMC activity. Subjects then began smoking until phase III activity occurred again (mean duration of smoking 117 min). During the control period, all subjects had normal MMC cycles and there were no differences between smokers and nonsmokers. While smoking, no gastric phase III was observed in any subject and gastric motility was markedly reduced. In seven of 10 subjects, smoking did not prevent the occurrence of normal duodenal phase III activity. Three subjects had no duodenal phase III activity during smoking. The duodenal pH profile did not change during smoking and motilin levels continued to fluctuate in conjunction with phase III activity. In conclusion, smoking abolished phase III activity in the stomach without affecting the plasma motilin cyclic fluctuations or duodenal bulb pH. In contrast, smoking has little effect on duodenal motility.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
McDonnell WM,Owyang Cdoi
10.1007/BF02220449subject
Has Abstractpub_date
1995-12-01 00:00:00pages
2608-13issue
12eissn
0163-2116issn
1573-2568journal_volume
40pub_type
杂志文章abstract：BACKGROUND AND AIM:Dietary fiber shortens gut transit time, but data on the effects of fiber components (including resistant starch, RS) on intestinal contractility are limited. We have examined RS effects in male Sprague-Dawley rats fed either a high-amylose maize starch (HAMS) or a wholemeal made from high-amylose wh...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3537-8
更新日期：2015-06-01 00:00:00
abstract：:A 65-year-old man with Crohn's disease died of acute myeloblastic leukemia after treatment for 11.8 years with 6-mercaptopurine, 1.5 mg/kg/day (100 mg/day). On cytogenetic analysis, most of the malignant bone marrow cells had deletion of chromosome 7, the most frequently reported cytogenetic abnormality in chemotherap...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018896006155
更新日期：1998-08-01 00:00:00
abstract：:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and visceral hypersensitivity. In this study, resting blood pressure and heart rate were recorded in 20 IBS patients and 23 controls. We assessed pain intensity and unpleasantness to visceral and cutaneous stim...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1016424007454
更新日期：2002-08-01 00:00:00
abstract：:Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and reg...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537224
更新日期：1990-01-01 00:00:00
abstract：:In this study we investigated the relative vascular response of different locations of the gastrointestinal tract to continuous intravenous infusion of isoproterenol (0.1 microgram kg-1 min-1 for 10 min). The vascular response of some nonsplanchnic organs was also examined. Blood flow of the arteries was measured by e...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536997
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:A new prepared oral viscous budesonide (PVB) has been effective in inducing clinical and histological remission in pediatric eosinophilic esophagitis (EoE). AIMS:To evaluate the efficacy of a 12-week maintenance therapy on clinical, endoscopic, and histological remission using half of the dose used in the i...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-018-5449-x
更新日期：2019-06-01 00:00:00
abstract：:The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308176
更新日期：1992-02-01 00:00:00
abstract：:These studies were done to determine the effects of fluoride (F) on the structure and function of the canine gastric mucosa and the possible protective effects of 16,16-dimethyl-prostaglandin E2 (dmPGE2). A portion of the stomach with its vascular supply intact was mounted in a two-compartment chamber, one side of whi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018895207333
更新日期：1997-10-01 00:00:00
abstract：:The effects of chronic normovolemic anemia on gastric microcirculation and gastric mucosal susceptibility to ethanol-induced gastric damage were investigated in anesthetized rats. Blood exchange by a plasma expander during four consecutive days rendered the animals anemic with a 34% decrease in the baseline hematocrit...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087418
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency is common in patients with inflammatory bowel diseases. The vitamin D receptor (VDR) is a nuclear hormone receptor mediating the activity of vitamin D hormone. Our previous studies showed that intestinal epithelial VDR signaling inhibits colitis by protecting the mucosal epithelial barri...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3634-8
更新日期：2015-07-01 00:00:00
abstract：:Because of the technical difficulty during subsequent surgical intervention, adhesion remains the most important predictor of outcome in the staged procedures following emergent colorectal surgery. The aim of this study was to assess the long-term effects of hyaluronan (HA)-based adhesion barriers 3 months following t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000034571.30602.36
更新日期：2004-06-01 00:00:00
abstract：:The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1024799303676
更新日期：2003-08-01 00:00:00
abstract：:Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026107429546
更新日期：2003-10-01 00:00:00
abstract：:Under physiological conditions, the human gut adapts intestinal gas propulsion and evacuation to prevent intestinal gaseous complaints In this study we aimed to determine influences of the jejunum versus ileum on intestinal gas dynamics during a balanced meal. Paired studies were randomly performed with seven women an...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9344-5
更新日期：2006-05-01 00:00:00
abstract：:Somatostatin inhibits colonic ion secretion in animal models and cultured intestinal cell lines via somatostatin receptor subtype 2 and subtype 1, respectively. In a recent in vitro ion transport study of the human colon, somatostatin was shown to stimulate short-circuit current, a measure of electrogenic ion transpor...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1012392307462
更新日期：2001-11-01 00:00:00
abstract：:Gastroenterologists are in a unique position to assist women with chronic gastrointestinal disorders in order to optimize their health prior to pregnancy. Women, whether with chronic conditions or not, and their infants are more likely to be healthy when pregnancies are planned. Achieving a planned pregnancy at the id...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-016-4383-z
更新日期：2017-01-01 00:00:00
abstract：:The practice of following benign-appearing gastric ulcers until healing was critically evaluated in a retrospective manner by reviewing all gastric ulcers that were followed with serial endoscopy and all gastric cancers diagnosed at the University of Alabama at Birmingham. The stated purpose of following ulcers to hea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01307545
更新日期：1993-02-01 00:00:00
abstract：:Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplantation. In this retrospective study, we compared the efficacy, safety, and renal protective effect of sirolimus monotherapy (Group A; n = 26) with sirolimus in combination (Group B; n = ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-9026-8
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND AND AIMS:The Chronic Hepatitis Cohort Study (CHeCS) is a longitudinal observational study of risks and benefits of treatments and care in patients with chronic hepatitis B (HBV) and C (HCV) infection from four US health systems. We hypothesized that comparative effectiveness methods-including a centralized d...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3272-6
更新日期：2014-12-01 00:00:00
abstract：:The diagnosis of irritable bowel syndrome requires the exclusion of any associated organic disease: a positive diagnosis would avoid expensive and potentially dangerous diagnostic procedures. A scoring system has been proposed for positive diagnosis where more than 44 points excluded organic digestive disease. The aim...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308166
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. AIMS:To apply, for the first time in gastrointestinal (GI) patien...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1777-9
更新日期：2011-12-01 00:00:00
abstract：:Intestinal mast cells are thought to contribute to the mucosal inflammation in ulcerative colitis and Crohn's disease through release of inflammatory mediators. Since sulfasalazine and its metabolite 5-aminosalicylic acid are effective therapeutic agents in inflammatory bowel disease and have been shown to inhibit gen...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300753
更新日期：1991-02-01 00:00:00
abstract：:Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296114
更新日期：1993-10-01 00:00:00
abstract：:Clinical observations reveal that alcohol intake is associated with an increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates lower this risk. Nitroglycerin, a gastric vasodilator that can increase gastric fluid volume, protects the rodent stomach against...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9692-1
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Interpretation of video capsule data is time-consuming. Olympus capsule endoscopy (CE) software systems are equipped with auto-speed-adjusted and express-selected playback modes and overview function in an effort to reduce reading times. The clinical efficacy of these new playback features is unknown. Our ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2074-y
更新日期：2012-06-01 00:00:00
abstract：:Since celiac disease screening by traditional IgA anti-endomysial antibody test is limited by high costs of monkey esophagus commercial kits as well as by rising ethical problems related to the endangered species, the identification of an inexpensive and commonly available substrate for this antibody determination is ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02208653
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:Partially covered metal stents (PCMS) have been increasingly used for both malignant and benign biliary indications. This study reports their complications and subsequent management. METHODS:Over 5 years, all patients receiving biliary PCMS were followed prospectively until stent-related dysfunction or deat...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0756-x
更新日期：2010-02-01 00:00:00
abstract：:To study the clinicopathologic features of hepatitis C viremic patients negative for hepatitis C antibodies (anti-HCV) by current second-generation assay, we categorized 139 consecutive histologically verified patients with chronic non-A, non-B hepatitis into three groups: 121 (87%) were positive for second-generation...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02208599
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Fatigue significantly impacts the quality of life of patients with inflammatory bowel disease (IBD). This study aimed to assess the effect of a personalized, intensive exercise program on fatigue, health-related quality of life (HRQoL), and cardiorespiratory fitness in patients with quiescent IBD an...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06222-5
更新日期：2020-04-01 00:00:00
abstract：:Autoregulation of blood flow in the denervated, autoperfused dog stomach was studied before and during local intraarterial infusion of histamine. Histamine caused an increase in gastric blood flow and oxygen uptake. The increased oxygen uptake was due entirely to an increased blood flow, ie, oxygen extraction was not ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01393761
更新日期：1982-08-01 00:00:00
