Improvement of Fatigue and Quality of Life in Patients with Quiescent Inflammatory Bowel Disease Following a Personalized Exercise Program.

Abstract:

BACKGROUND AND AIMS:Fatigue significantly impacts the quality of life of patients with inflammatory bowel disease (IBD). This study aimed to assess the effect of a personalized, intensive exercise program on fatigue, health-related quality of life (HRQoL), and cardiorespiratory fitness in patients with quiescent IBD and severe fatigue. METHODS:A pilot study was performed including IBD patients in remission with severe fatigue. The 12-week exercise program consisted of three times per week 1-h sessions, including aerobic- and progressive-resistance training at personalized intensity based on a cardiopulmonary exercise test (CPET) and one-repetition maximum. CPET was repeated after 12 weeks. Fatigue and HRQoL were assessed using the checklist individual strength and 32-item IBD questionnaire. RESULTS:Twenty-five IBD patients with mean age of 45 (± 2.6) years were included of which 22 (88%) completed the exercise program. Fatigue significantly improved from 105 (± 17) points on the checklist individual strength before, to 66 (± 20) after completion of exercise program (p < 0.001). Patients' HRQoL significantly improved from 156 (± 21) to 176 (± 19) (p < 0.001). When looking at the subdomains of HRQoL, significant improvement was seen in emotional (58 ± 12 vs. 69 ± 9.1, p = 0.003), systemic (19 ± 3.9 vs. 24 ± 4.7, p < 0.001), and social function (25 ± 5.4 vs. 30 ± 3.9, p < 0.001). Bowel symptoms did not change (53 ± 7.7 vs. 55 ± 7.3, p = 0.208). Repeat CPET showed a significant improvement in maximum power patients were able to deliver (2.4 ± 0.5 vs. 2.7 ± 0.5 W/kg, p = 0.002). CONCLUSIONS:A personalized, intensive exercise program can lead to significant improvement of fatigue, HRQoL, and cardiorespiratory fitness in patients with quiescent IBD and severe fatigue.

journal_name

Dig Dis Sci

authors

van Erp LW,Roosenboom B,Komdeur P,Dijkstra-Heida W,Wisse J,Horjus Talabur Horje CS,Liem CS,van Cingel REH,Wahab PJ,Groenen MJM

doi

10.1007/s10620-020-06222-5

subject

Has Abstract

pub_date

2020-04-01 00:00:00

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-020-06222-5

pub_type

杂志文章
  • Evaluating disorders with a complex genetics basis. the future roles of meta-analysis and systems biology.

    abstract::Growing evidence suggests that complex gene and environment interactions underlie a number of diseases including chronic inflammatory diseases of the digestive system. The rapid advances in information and technology provide opportunities to discover the risks or etiology for a variety of disorders within individual p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-005-3033-7

    authors: Whitcomb DC,Aoun E,Vodovotz Y,Clermont G,Barmada MM

    更新日期:2005-12-01 00:00:00

  • Interferon-alpha therapy may induce insulin autoantibody development in patients with chronic viral hepatitis.

    abstract::Development of type 1 insulin-dependent diabetes mellitus has been recently reported in patients who underwent interferon-alpha (IFN-alpha) therapy because of chronic viral hepatitis. Furthermore IFN-alpha seems to be involved in the immunological events that lead to beta-cell destruction and development of type 1 dia...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02087923

    authors: di Cesare E,Previti M,Russo F,Brancatelli S,Ingemi MC,Scoglio R,Mazzù N,Cucinotta D,Raimondo G

    更新日期:1996-08-01 00:00:00

  • Intravenous versus high-dose oral proton pump inhibitor therapy after endoscopic hemostasis of high-risk lesions in patients with acute nonvariceal upper gastrointestinal bleeding.

    abstract::Intravenous proton pump inhibitors (IV PPIs) decrease rebleeding following endoscopic hemostasis of bleeding peptic ulcers. Oral PPIs may be equally efficacious and may significantly reduce health care costs. This study aimed to compare outcomes in patients receiving oral versus IV PPI therapy following endoscopic hem...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9684-1

    authors: Murthy S,Keyvani L,Leeson S,Targownik LE

    更新日期:2007-07-01 00:00:00

  • Simultaneous endoluminal sonography and manometry to assess anal sphincter complex in normal subjects.

    abstract::The purpose of this study was to use simultaneous anal manometry and high-frequency endoluminal ultrasonography (EUS) to determine the relationship between resting anal pressure and cross-sectional area of the internal and external anal sphincters. Eleven normal subjects underwent simultaneous anal EUS and manometry u...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026605409557

    authors: Wong RF,Bonapace ES Jr,Chung CY,Liu JB,Parkman HP,Miller LS

    更新日期:1998-11-01 00:00:00

  • Prognostic index for survival in patients after treatment for primary hepatocellular carcinoma.

    abstract::We retrospectively evaluated clinical factors affecting long-term survival after treatment for hepatocellular carcinoma (HCC) to predict the reliability of the prognosis of patients with HCC. We analyzed 157 patients who received treatment for HCC. The prognostic index (PI) was evaluated using the Cox regression model...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9137-x

    authors: Kogo M,Kano A,Kiuchi Y,Mitamura K,Yoneyama K

    更新日期:2007-09-01 00:00:00

  • Bismuth subsalicylate suppression of Helicobacter pylori in nonulcer dyspepsia: a double-blind placebo-controlled trial.

    abstract::Gastritis caused by Helicobacter pylori (HP) is common in patients with nonulcer dyspepsia (NUD), but an etiologic relationship between the histologic lesion and clinical symptoms is unproven. HP is inhibited by bismuth subsalicylate (BSS), a traditional remedy for dyspeptic complaints. The aim of this study was to as...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01303177

    authors: Marshall BJ,Valenzuela JE,McCallum RW,Dooley CP,Guerrant RL,Cohen H,Frierson HF Jr,Field LG,Jerdack GR,Mitra S

    更新日期:1993-09-01 00:00:00

  • Carbohydrate malabsorption syndromes and early signs of mental depression in females.

    abstract::Fructose and lactose malabsorption are characterized by impaired duodenal fructose transport or by the deficiency of mucosal lactase, respectively. As a consequence, the nonabsorbed saccharides reach the colon, where they are broken down by bacteria to short fatty acids, CO2, and H2. Bloating, cramps, osmotic diarrhea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005527230346

    authors: Ledochowski M,Widner B,Sperner-Unterweger B,Propst T,Vogel W,Fuchs D

    更新日期:2000-07-01 00:00:00

  • The overlap syndromes of autoimmune hepatitis.

    abstract::Autoimmune hepatitis has two major variant phenotypes in which the features of classical disease are co-mingled with those of primary biliary cirrhosis or primary sclerosing cholangitis. These overlap syndromes lack codified diagnostic criteria, established pathogenic mechanisms, and confident management strategies. T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-012-2367-1

    authors: Czaja AJ

    更新日期:2013-02-01 00:00:00

  • Gastric acid normosecretion is not essential in the pathogenesis of mild erosive gastroesophageal reflux disease in relation to Helicobacter pylori status.

    abstract::In the pathogenesis of gastroesophageal reflux disease (GERD), gastric acid is considered to be one of the most important factors, but little is known about the degree of gastric acid secretion in GERD patients. In this study, we evaluated it in GERD patients and control subjects by 24-h intragastric pH, and serologic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000030090.84412.2a

    authors: Shimatani T,Inoue M,Harada N,Horikawa Y,Nakamura M,Tazuma S

    更新日期:2004-05-01 00:00:00

  • Relative Adrenal Insufficiency in Patients with Cirrhosis: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Relative adrenal insufficiency (RAI) is frequently observed in patients with cirrhosis. We sought to identify evidence in the literature regarding the impact of RAI on clinical outcomes in cirrhotic patients. METHODS:We conducted a systematic review (SR) and meta-analysis (MA) using the Ovid-MEDLINE, EMBASE...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10620-017-4471-8

    authors: Kim G,Huh JH,Lee KJ,Kim MY,Shim KY,Baik SK

    更新日期:2017-04-01 00:00:00

  • Anorectal manometric anomalies in seven patients with frontal lobe brain damage.

    abstract::We studied the anorectal manometric and urodynamic pattern of seven patients who had right and/or left frontal lobe injury to investigate the possibility that the frontal lobe area plays an important role in control of anorectal motility as it does for the urinary bladder. We found that the disturbances of anorectal m...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536767

    authors: Weber J,Delangre T,Hannequin D,Beuret-Blanquart F,Denis P

    更新日期:1990-02-01 00:00:00

  • Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis.

    abstract:BACKGROUND:Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-015-3886-3

    authors: Taleban S,Van Oijen MG,Vasiliauskas EA,Fleshner PR,Shen B,Ippoliti AF,Targan SR,Melmed GY

    更新日期:2016-02-01 00:00:00

  • Control of nocturnal gastric acidity: a role for low dose bedtime ranitidine to supplement daily omeprazole.

    abstract::In some patients, proton pump inhibitors do not abolish nocturnal gastric acidity and additional evening antisecretory medication may be required. In 16 subjects with chronic heartburn, 24-hr gastric and esophageal pH were measured at baseline and again after six days of 20 mg omeprazole alone at 08:00 hr followed by ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1013749501241

    authors: Robinson M,Rodriguez-Stanley S,Ciociola AA,Filinto J,Zubaidi S,Miner PB Jr,Gardner JD

    更新日期:2002-02-01 00:00:00

  • Endoscopic management of Barrett's esophagus: advances in endoscopic techniques.

    abstract::Barrett's esophagus (BE) is a well-known premalignant condition that can be associated with the development of dysplasia and adenocarcinoma. In the past, esophagectomy was the standard treatment for patients with BE with high grade dysplasia (HGD) and early cancer (EC). However, esophagectomy is not necessarily the on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-012-2279-0

    authors: Azarm A,Lukolic I,Shukla M,Concha-Parra R,Gress F

    更新日期:2012-12-01 00:00:00

  • The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

    abstract::Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-016-4109-2

    authors: To H,Clemons NJ,Duong CP,Trainer AH,Phillips WA

    更新日期:2016-07-01 00:00:00

  • Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis.

    abstract::We postulated that coadministration of cholylsarcosine with ursodeoxycholic acid might provide additional benefit to primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid. Our aim was to test the tolerability and the effect of adjuvant cholylsarcosine on liver tests and plasma choleste...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018868126743

    authors: Ricci P,Hofmann AF,Hagey LR,Jorgensen RA,Rolland Dickson E,Lindor KD

    更新日期:1998-06-01 00:00:00

  • Biliary and pancreatic duct pressures measured by ERCP manometry in patients with suspected papillary stenosis.

    abstract::Papillary stenosis is an imprecisely defined clinical syndrome which eludes definitive diagnosis. In this study we evaluated 26 patients with suspected papillary stenosis by manometric examination of the sphincter of Oddi done during ERCP examination. Basal pressure in the sphincter of Oddi was elevated in 14 of the p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308431

    authors: Bar-Meir S,Geenen JE,Hogan WJ,Dodds WJ,Stewart ET,Arndorfer RC

    更新日期:1979-03-01 00:00:00

  • Prevalence, etiology, and prognostic significance of upper gastrointestinal hemorrhage in diabetic ketoacidosis.

    abstract::We reviewed the discharge records of all diabetic ketoacidosis hospitalizations over 30 months for the presence of clinically significant upper gastrointestinal hemorrhage. Of 284 hospitalizations in 193 patients, hemorrhage occurred in 26 hospitalizations (9%) in 25 patients (13%). None required invasive therapy to a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02208576

    authors: Faigel DO,Metz DC

    更新日期:1996-01-01 00:00:00

  • Role of food in appearance of growth-stimulating activity in rat proximal intestine after small-bowel resection.

    abstract::The oral intake of food is important for the observed compensatory hyperplasia in the remnant small intestine after resection but the molecular events governing this response are not known. Peptides, of molecular weight 4500 and 1000 daltons, present in the the proximal intestine for 96 hr after resection and mitogeni...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536635

    authors: Grey VL,Morin CL

    更新日期:1988-01-01 00:00:00

  • Effects of growth hormone deficiency and recombinant growth hormone therapy on postprandial gallbladder motility and cholecystokinin release.

    abstract::In addition to cholecystokinin, other hormones have been suggested to be involved in regulation of postprandial gallbladder contraction. We aimed to evaluate effects of growth hormone (GH) on gallbladder contractility and cholecystokinin release. Gallbladder and gastric emptying (by ultrasound) and cholecystokinin rel...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000020515.75879.2f

    authors: Moschetta A,Twickler TB,Rehfeld JF,van Ooteghem NA,Cabezas MC,Portincasa P,van Berge-Henegouwen GP,van Erpecum KJ

    更新日期:2004-03-01 00:00:00

  • Diabetes mellitus, and not obesity, is associated with lower survival following liver transplantation.

    abstract:BACKGROUND AND AIMS:The impact of obesity on survival following liver transplantation is unclear, and existing studies report conflicting results. Our current study aims to further delineate the impact of obesity using population-based registry data from the USA. METHODS:All US adult liver transplant recipients from 2...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3469-8

    authors: Wong RJ,Cheung R,Perumpail RB,Holt EW,Ahmed A

    更新日期:2015-04-01 00:00:00

  • Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure.

    abstract::This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the gre...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2866-4

    authors: Xing J,Felsher J,Brody F,Soffer E

    更新日期:2005-08-01 00:00:00

  • Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.

    abstract:BACKGROUND:Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1 (SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury is unclear. AIMS:To explore the function of SIRT1 and IRF9 in hyperlipidemia acute p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06331-1

    authors: Liu Y,Sun Y,Xue BH,Wang XD,Yu WL

    更新日期:2020-05-28 00:00:00

  • Women's health training in gastroenterology fellowship: a national survey of fellows and program directors.

    abstract:BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1532-7

    authors: Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

    更新日期:2011-03-01 00:00:00

  • Characteristics and treatment of pyoderma gangrenosum in inflammatory bowel disease.

    abstract:BACKGROUND:Pyoderma gangrenosum is a serious cutaneous complication seen in approximately 1 % of patients with inflammatory bowel disease (IBD). Oral corticosteroids are the mainstay treatment, although the evidence supporting their use is weak. AIMS:The purpose of this study was to investigate the characteristics of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-013-2762-2

    authors: Argüelles-Arias F,Castro-Laria L,Lobatón T,Aguas-Peris M,Rojas-Feria M,Barreiro-de Acosta M,Soto-Escribano P,Calvo-Moya M,Ginard-Vicens D,Chaparro-Sánchez M,Hernández-Durán M,Castro-Senosiain B,Fernández-Villaverde A,García-Sán

    更新日期:2013-10-01 00:00:00

  • Risk factors and prognosis of pulmonary complications after endoscopic submucosal dissection for gastric neoplasia.

    abstract:BACKGROUND:Hospital-acquired pneumonia after an endoscopic submucosal dissection (ESD) can prolong the patient's stay in the hospital, leading to greater healthcare costs. However, little is known of the characteristics and risk factors associated with this complication. AIMS:To analyze the clinical features of pneumo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2376-0

    authors: Park CH,Kim H,Kang YA,Cho IR,Kim B,Heo SJ,Shin S,Lee H,Park JC,Shin SK,Lee YC,Lee SK

    更新日期:2013-02-01 00:00:00

  • Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up.

    abstract::The prevalence of the recently described deamidated gliadin peptide antibodies was compared with that of the routinely used antigliadin, antiendomysial, and tissue transglutaminase antibodies in the sera of 128 untreated celiac patients and 134 controls. Sensitivity and specificity for celiac disease were 83.6 and 90....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-0058-0

    authors: Volta U,Granito A,Fiorini E,Parisi C,Piscaglia M,Pappas G,Muratori P,Bianchi FB

    更新日期:2008-06-01 00:00:00

  • Endoscopic photodynamic therapy with hematoporphyrin derivative for primary treatment of gastrointestinal neoplasms in inoperable patients.

    abstract::Endoscopic photodynamic therapy with hematoporphyrin derivative was used in the primary treatment of 54 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups including 24 with esophageal squamous cell carcinoma, 14 with adenocarcinoma of the stomach or lower third of the esophagu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01540400

    authors: Patrice T,Foultier MT,Yactayo S,Adam F,Galmiche JP,Douet MC,Le Bodic L

    更新日期:1990-05-01 00:00:00

  • Prevalence and Impact of Post-traumatic Stress Disorder in Gastrointestinal Conditions: A Systematic Review.

    abstract::Psychological distress is often observed in patients with gastrointestinal illness. To date, there has been limited research conducted to assess the prevalence and impact of post-traumatic stress disorder (PTSD) in gastrointestinal cohorts. The aim of this systematic review is to review the evidence for the prevalence...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06798-y

    authors: Glynn H,Möller SP,Wilding H,Apputhurai P,Moore G,Knowles SR

    更新日期:2021-01-12 00:00:00

  • Achalasia is not associated with measles or known herpes and human papilloma viruses.

    abstract::Achalasia is an esophageal motility disorder of unknown etiology. Several studies suggest possible herpes or measles virus etiology, but results are inconclusive. The aim of this study was to test whether herpesvirus (HV), measles (MV), or human papilloma virus (HPV) sequences could be detected in myotomy specimens fr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018805600276

    authors: Birgisson S,Galinski MS,Goldblum JR,Rice TW,Richter JE

    更新日期:1997-02-01 00:00:00